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deepLIFT scores always central to genomic sequence #135

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PelFritz opened this issue Jul 10, 2023 · 0 comments
Open

deepLIFT scores always central to genomic sequence #135

PelFritz opened this issue Jul 10, 2023 · 0 comments

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@PelFritz
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PelFritz commented Jul 10, 2023

Hello,
I have recently observed something strange when applying deeplift to interpret my models trained to differentiate bound from unbound regions of the genomes using binding profiles similar to ATAC-seq (the profile gets the binding of all proteins in the genome).
When i ran deeplift it always created scores that on average were at the center of the sequence. Even when i obtain sequences from the genome were the true bound area was shifted to the left or right, I still get scores that are centered.

Any ideas as to this strange behaviour, will be helpful. Thanks
Best
Fritz

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