-
Notifications
You must be signed in to change notification settings - Fork 1
/
gene.dev
15229 lines (14720 loc) · 82.3 KB
/
gene.dev
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
532
533
534
535
536
537
538
539
540
541
542
543
544
545
546
547
548
549
550
551
552
553
554
555
556
557
558
559
560
561
562
563
564
565
566
567
568
569
570
571
572
573
574
575
576
577
578
579
580
581
582
583
584
585
586
587
588
589
590
591
592
593
594
595
596
597
598
599
600
601
602
603
604
605
606
607
608
609
610
611
612
613
614
615
616
617
618
619
620
621
622
623
624
625
626
627
628
629
630
631
632
633
634
635
636
637
638
639
640
641
642
643
644
645
646
647
648
649
650
651
652
653
654
655
656
657
658
659
660
661
662
663
664
665
666
667
668
669
670
671
672
673
674
675
676
677
678
679
680
681
682
683
684
685
686
687
688
689
690
691
692
693
694
695
696
697
698
699
700
701
702
703
704
705
706
707
708
709
710
711
712
713
714
715
716
717
718
719
720
721
722
723
724
725
726
727
728
729
730
731
732
733
734
735
736
737
738
739
740
741
742
743
744
745
746
747
748
749
750
751
752
753
754
755
756
757
758
759
760
761
762
763
764
765
766
767
768
769
770
771
772
773
774
775
776
777
778
779
780
781
782
783
784
785
786
787
788
789
790
791
792
793
794
795
796
797
798
799
800
801
802
803
804
805
806
807
808
809
810
811
812
813
814
815
816
817
818
819
820
821
822
823
824
825
826
827
828
829
830
831
832
833
834
835
836
837
838
839
840
841
842
843
844
845
846
847
848
849
850
851
852
853
854
855
856
857
858
859
860
861
862
863
864
865
866
867
868
869
870
871
872
873
874
875
876
877
878
879
880
881
882
883
884
885
886
887
888
889
890
891
892
893
894
895
896
897
898
899
900
901
902
903
904
905
906
907
908
909
910
911
912
913
914
915
916
917
918
919
920
921
922
923
924
925
926
927
928
929
930
931
932
933
934
935
936
937
938
939
940
941
942
943
944
945
946
947
948
949
950
951
952
953
954
955
956
957
958
959
960
961
962
963
964
965
966
967
968
969
970
971
972
973
974
975
976
977
978
979
980
981
982
983
984
985
986
987
988
989
990
991
992
993
994
995
996
997
998
999
1000
BACKGROUND
:
Ischemic
heart
disease
is
the
primary
cause
of
morbidity
and
mortality
among
diabetics
,
especially
those
who
became
ill
at
a
young
age
.
More
importantly
,
this
fusion
converted
a
less
effective
vaccine
into
one
with
significant
potency
against
established
E7
-
expressing
metastatic
tumors
.
Reverse
transcription
-
PCR
analysis
of
mRNA
from
patients
shows
that
each
of
these
five
mutations
results
in
aberrant
splicing
.
Using
the
postural
and
force
data
as
input
to
a
3
-
D
biomechanical
model
,
the
lumbosacral
spinal
compression
was
calculated
.
Sequence
analysis
revealed
significant
differences
between
the
5
'
region
of
the
beta
subunit
gene
and
the
corresponding
regions
of
the
homologous
GlyR
alpha
subunit
genes
;
it
also
identified
a
novel
exon
(
exon
0
)
that
encodes
most
of
the
5
'-
untranslated
portion
of
the
GlyR
beta
mRNA
.
Therefore
,
we
suggested
that
both
proteins
might
belong
to
the
PLTP
family
.
Influence
of
compression
therapy
on
symptoms
following
soft
tissue
injury
from
maximal
eccentric
exercise
.
STAT5A
mutations
in
the
Src
homology
2
(
SH2
)
and
SH3
domains
did
not
alter
the
BTK
-
mediated
tyrosine
phosphorylation
.
In
the
present
work
,
the
complete
genome
sequences
of
Pyrococcus
horikoshii
and
Pyrococcus
abyssi
,
two
species
in
a
genus
of
hyperthermophilic
archaeon
(
archaebacterium
),
were
compared
to
detect
large
genome
polymorphisms
linked
with
restriction
-
modification
gene
homologs
.
In
addition
,
these
patients
show
both
quantitative
and
qualitative
differences
in
their
infectious
microbiological
spectrum
,
mainly
in
clean
-
contaminated
,
contaminated
and
dirty
surgical
procedures
.
Here
we
show
that
PKC
and
p44
/
p42MAPK
signalings
are
required
for
the
HBx
-
induced
Sp1
-
mediated
IGF
-
II
P4
transcriptional
activity
since
(
i
)
PKC
activation
by
PMA
or
PKC
expression
vector
increases
Sp1
phosphorylation
and
P4
activity
in
HBx
-
transfected
HepG2
cells
;
(
ii
)
PKC
inhibition
by
PKC
inhibitor
Go6976
reduces
Sp1
phosphorylation
,
P4
activity
,
and
IGF
-
II
mRNA
in
HBx
-
transfected
HepG2
cells
;
and
(
iii
)
the
inhibition
of
MEK
activation
by
U0126
reduces
Sp1
phosphorylation
,
P4
activity
and
IGF
-
II
mRNA
in
HBx
-
transfected
HepG2
cells
.
We
show
that
p73
can
transcriptionally
inhibit
a
number
of
cellular
and
viral
promoters
.
Similarly
,
curcumin
(
diferuloylmethane
),
an
anti
-
inflammatory
agent
,
suppressed
OSM
-
stimulated
STAT1
phosphorylation
,
DNA
-
binding
activity
of
STAT1
,
and
c
-
Jun
N
-
terminal
kinase
activation
without
affecting
JAK1
,
JAK2
,
JAK3
,
ERK1
/
2
,
and
p38
phosphorylation
.
The
effects
of
the
transfected
receptors
were
associated
with
antagonism
of
activator
protein
1
(
AP
-
1
)
activity
.
Furthermore
,
the
soluble
forms
of
ATF6
and
the
G13
gene
product
are
unable
to
bind
to
several
point
mutants
of
the
cis
-
acting
ER
stress
response
element
in
vitro
that
hardly
respond
to
ER
stress
in
vivo
.
PURPOSE
:
The
objective
of
this
study
was
to
assess
first
embryo
cleavage
(
FEC
)
25
-
27
h
after
intracytoplasmic
sperm
injection
(
ICSI
)
as
a
parameter
for
the
embryo
selection
process
.
RESULTS
:
A
significant
correlation
(
p
<
0
.
001
)
was
observed
for
mean
wall
thickness
and
vessel
wall
area
between
MRI
and
histopathology
(
r
=
0
.
87
and
r
=
0
.
85
,
respectively
).
Molecular
cloning
,
genomic
mapping
,
and
expression
of
two
secretor
blood
group
alpha
(
1
,
2
)
fucosyltransferase
genes
differentially
regulated
in
mouse
uterine
epithelium
and
gastrointestinal
tract
.
We
show
that
several
heme
-
responsive
mechanisms
combine
to
regulate
DAN
/
TIR
gene
expression
.
No
'
TATA
'
motif
was
identified
near
either
the
GABPalpha
or
ATPsynCF6
transcription
start
sites
.
These
results
indicate
the
presence
of
TATA
-
unified
transcription
systems
in
contemporary
eukaryotes
and
provide
insight
into
the
residual
need
for
TBP
by
all
three
Pols
in
other
eukaryotes
despite
a
lack
of
TATA
elements
in
their
promoters
.
Different
thermoluminescent
detectors
(
TLD
)
have
been
used
to
measure
the
contribution
of
the
low
linear
energy
transfer
component
(
LET
<
10
keV
/
micrometer
)
and
plastic
nuclear
track
detectors
(
PNTD
)
for
the
high
linear
energy
tranfer
(
LET
)
component
.
However
,
the
beta5L
splice
variant
was
found
only
in
the
retina
.
This
analysis
supports
the
use
of
fluticasone
propionate
88
microg
twice
daily
as
first
-
line
treatment
in
patients
with
persistent
asthma
previously
treated
with
short
-
acting
beta2
-
agonist
alone
.
The
mice
are
phenotypically
normal
and
do
not
develop
spontaneous
tumors
at
an
early
age
,
in
contrast
to
knock
-
out
(
p53
(-/-))
strains
with
a
defective
p53
gene
.
Furthermore
,
stable
expression
of
a
constitutively
active
form
of
chicken
Notch1
or
Notch2
in
a
B
cell
line
results
in
a
down
-
regulation
of
surface
IgM
expression
,
which
is
accompanied
by
the
reduction
of
IgH
gene
transcripts
.
On
Cox
proportional
hazards
regression
adenocarcinoma
(
P
=
0
.
006
),
the
development
of
BPF
(
P
=
0
.
003
),
older
age
(
P
=
0
.
03
)
and
higher
pathological
stage
(
P
=
0
.
02
)
were
independent
adverse
predictors
of
survival
.
We
found
that
RhoA
can
initiate
a
linear
kinase
cascade
leading
to
the
activation
of
ERK6
(
p38
gamma
),
a
recently
identified
member
of
the
p38
family
of
MAPKs
.
Twenty
-
six
(
55
%)
(
95
%
CI
,
41
-
69
%)
patients
experienced
>
or
=
grade
3
acute
toxicity
(
RTOG
).
We
hypothesize
that
proprioception
may
be
used
to
calibrate
the
efference