From 6121db4f6b15760d9bf8d50c203a0ba347661b94 Mon Sep 17 00:00:00 2001 From: Natalia Florekova Date: Sat, 21 Sep 2024 20:22:38 +0200 Subject: [PATCH 1/3] Added model 233 - breast cancer signalling pathways T47D complete --- .../README.md | 37 ++ .../metadata.json | 17 + .../model.aeon | 369 ++++++++++++++++++ .../model.bnet | 110 ++++++ .../model.sbml | 1 + models/summary.csv | 3 + report/.~lock.online_only_table_1.xlsx# | 1 + report/online_only_table_1.xlsx | Bin 56661 -> 58432 bytes .../citation.bib | 8 + .../metadata.json | 7 + .../notes.md | 11 + .../source.bnet | 110 ++++++ 12 files changed, 674 insertions(+) create mode 100644 models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/README.md create mode 100644 models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/metadata.json create mode 100644 models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.aeon create mode 100644 models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.bnet create mode 100644 models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.sbml create mode 100644 report/.~lock.online_only_table_1.xlsx# create mode 100644 sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/citation.bib create mode 100644 sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/metadata.json create mode 100644 sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/notes.md create mode 100644 sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/source.bnet diff --git a/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/README.md b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/README.md new file mode 100644 index 0000000..e00efe3 --- /dev/null +++ b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/README.md @@ -0,0 +1,37 @@ +# \[233\] BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE + + - Variables: 109 + - Inputs: 8 + - Regulations: 260 + - Publication: https://doi.org/10.1371/journal.pone.0298788 + - Source: https://github.com/Ktaoma/BoolSyn + - Keywords: source (?), curated (?), repaired (?), multi-valued (?) + + +### Modifications + +Removed regulations: +WNT1, WNT1 +PG, PG +NRG1, NRG1 +INS, INS +IGF1, IGF1 +ES, ES +EGF, EGF +DLL_i, DLL_i + + +### Model citation + +``` +@article{bbm-233, + author = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan}, + year = {2024}, + doi = {https://doi.org/10.1371/journal.pone.0298788}, + title = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy}, + publisher = {PLOS ONE} +} + + +``` + diff --git a/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/metadata.json b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/metadata.json new file mode 100644 index 0000000..d50915c --- /dev/null +++ b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/metadata.json @@ -0,0 +1,17 @@ +{ + "id": 233, + "name": "BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE", + "url-publication": "https://doi.org/10.1371/journal.pone.0298788", + "url-model": "https://github.com/Ktaoma/BoolSyn", + "keywords": [ + "source (?)", + "curated (?)", + "repaired (?)", + "multi-valued (?)" + ], + "variables": 109, + "inputs": 8, + "regulations": 260, + "notes": "### Modifications\n\nRemoved regulations:\nWNT1, WNT1\nPG, PG\nNRG1, NRG1\nINS, INS\nIGF1, IGF1\nES, ES\nEGF, EGF\nDLL_i, DLL_i\n", + "bib": "@article{bbm-233,\n\tauthor = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan},\n\tyear = {2024},\n\tdoi = {https://doi.org/10.1371/journal.pone.0298788},\n\ttitle = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy},\n\tpublisher = {PLOS ONE}\n}\n\n" +} \ No newline at end of file diff --git a/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.aeon b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.aeon new file mode 100644 index 0000000..d8edfc8 --- /dev/null +++ b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.aeon @@ -0,0 +1,369 @@ +v_GRB2 -? v_ABL1 +v_ABL1 -? v_ABL2 +v_EGF -? v_AKT_i +v_EGFR -? v_AKT_i +v_IGF1R -? v_AKT_i +v_IRS1 -? v_AKT_i +v_MTORC2_c -? v_AKT_i +v_PDPK1 -? v_AKT_i +v_PIP3 -? v_AKT_i +v_AXIN1 -? v_APC +v_DVL1 -? v_AXIN1 +v_GSK3B -? v_AXIN1 +v_AKT_i -? v_BAD +v_ERK_i -? v_BAD +v_PAK1 -? v_BAD +v_PIM -? v_BAD +v_BID -? v_BAK1 +v_BIM -? v_BAK1 +v_MCL1 -? v_BAK1 +v_P53 -? v_BAK1 +v_BID -? v_BAX +v_BIM -? v_BAX +v_MCL1 -? v_BAX +v_P53 -? v_BAX +v_BAD -? v_BCL2 +v_BIM -? v_BCL2 +v_CREB1 -? v_BCL2 +v_ERK_i -? v_BCL2 +v_BAD -? v_BCLXL +v_BIM -? v_BCLXL +v_CREB1 -? v_BCLXL +v_CASP8 -? v_BID +v_BCL2 -? v_BIM +v_BCLXL -? v_BIM +v_FOXO1 -? v_BIM +v_FOXO3 -? v_BIM +v_CASP8 -? v_CASP3 +v_CASP9 -? v_CASP3 +v_ERK_i -? v_CASP8 +v_FADD -? v_CASP8 +v_SRC -? v_CASP8 +v_AKT_i -? v_CASP9 +v_CASP3 -? v_CASP9 +v_CASP8 -? v_CASP9 +v_CYCS -? v_CASP9 +v_ERK_i -? v_CASP9 +v_CASP3 -? v_CDKN2A +v_MYC -? v_CDKN2A +v_SRC -? v_CDKN2A +v_ABL2 -? v_CEBPB +v_AKT_i -? v_CREB1 +v_SGK1 -? v_CREB1 +v_DC -? v_CTNNB1 +v_WNT1 -? v_CTNNB1 +v_CDKN2A -? v_CYCLIN_D_c +v_EIF4E -? v_CYCLIN_D_c +v_ERK_i -? v_CYCLIN_D_c +v_ESR1 -? v_CYCLIN_D_c +v_FOXO3 -? v_CYCLIN_D_c +v_GSK3B -? v_CYCLIN_D_c +v_IGF1 -? v_CYCLIN_D_c +v_KMT2D -? v_CYCLIN_D_c +v_MYC -? v_CYCLIN_D_c +v_NRG1 -? v_CYCLIN_D_c +v_P21 -? v_CYCLIN_D_c +v_TCF4 -? v_CYCLIN_D_c +v_TEAD1 -? v_CYCLIN_D_c +v_BAK1 -? v_CYCS +v_BAX -? v_CYCS +v_APC -? v_DC +v_GSK3B -? v_DC +v_FZD3 -? v_DVL1 +v_YAP1 -? v_DVL1 +v_PRB -? v_E2F1 +v_EGF -? v_EGFR +v_HER2 -? v_EGFR +v_HER3 -? v_EGFR +v_MEK_i -? v_EGFR +v_RELA -? v_EGFR +v_IVEBP1 -? v_EIF4E +v_MEK_i -? v_ERK_i +v_AKT_i -? v_ESR1 +v_ES -? v_ESR1 +v_FOXO3 -? v_ESR1 +v_KMT2D -? v_ESR1 +v_PGR -? v_ESR1 +v_FAS -? v_FADD +v_TRADD -? v_FADD +v_AKT_i -? v_FAS +v_FASLG -? v_FAS +v_P53 -? v_FAS +v_FASLG -? v_FASLG +v_FOXO3 -? v_FASLG +v_P53 -? v_FASLG +v_AKT_i -? v_FOXO1 +v_SGK1 -? v_FOXO1 +v_AKT_i -? v_FOXO3 +v_WNT1 -? v_FZD3 +v_STAT1 -? v_GATA3 +v_EGFR -? v_GRB2 +v_HER2 -? v_GRB2 +v_IRS1 -? v_GRB2 +v_SRC -? v_GRB2 +v_INSR -? v_GRB7 +v_PRKACA -? v_GRB7 +v_AKT_i -? v_GSK3B +v_ERK_i -? v_GSK3B +v_ESR1 -? v_HER2 +v_FOXO3 -? v_HER2 +v_HER3 -? v_HER2 +v_HER2 -? v_HER3 +v_NRG1 -? v_HER3 +v_NCID -? v_HES1 +v_NCID -? v_HEY1 +v_NF1 -? v_HRAS +v_PIP3 -? v_HRAS +v_SOS1 -? v_HRAS +v_ESR1 -? v_HSP90AA1 +v_PDPK1 -? v_HSP90AA1 +v_ESR1 -? v_IGF1R +v_FOXO3 -? v_IGF1R +v_IGF1 -? v_IGF1R +v_NOS3 -? v_IL1B +v_RELA -? v_IL1B +v_IL1B -? v_IL6 +v_IL6 -? v_IL6 +v_IL6 -? v_IL6R +v_STAT3 -? v_IL6R +v_STAT5 -? v_IL8 +v_FOXO3 -? v_INSR +v_INS -? v_INSR +v_IGF1R -? v_IRS1 +v_INSR -? v_IRS1 +v_S6K1 -? v_IRS1 +v_MTORC1_c -? v_IVEBP1 +v_ABL1 -? v_JAK2 +v_IL6R -? v_JAK2 +v_IL8 -? v_JAK2 +v_IRS1 -? v_JAK2 +v_ERK_i -? v_JUN +v_MAPK8 -? v_JUN +v_PPARG -? v_JUN +v_RELA -? v_JUN +v_AKT_i -? v_KMT2D +v_PAX7 -? v_KMT2D +v_EGFR -? v_KRT14 +v_PAK2 -? v_KRT14 +v_LCK -? v_LATS1 +v_NF2 -? v_LATS1 +v_AKT_i -? v_LCK +v_ERK_i -? v_LCK +v_RAC1 -? v_MAPK8 +v_RND1 -? v_MAPK8 +v_ERK_i -? v_MCL1 +v_GSK3B -? v_MCL1 +v_AKT_i -? v_MDM2 +v_P53 -? v_MDM2 +v_RAF1 -? v_MEK_i +v_IGF1 -? v_MTORC1_c +v_NRG1 -? v_MTORC1_c +v_PIM -? v_MTORC1_c +v_RHEB -? v_MTORC1_c +v_PIP3 -? v_MTORC2_c +v_S6K1 -? v_MTORC2_c +v_CTNNB1 -? v_MYC +v_EIF4E -? v_MYC +v_ERK_i -? v_MYC +v_ESR1 -? v_MYC +v_FOXO3 -? v_MYC +v_GSK3B -? v_MYC +v_IGF1 -? v_MYC +v_JAK2 -? v_MYC +v_KMT2D -? v_MYC +v_NRG1 -? v_MYC +v_PIM -? v_MYC +v_STAT3 -? v_MYC +v_HES1 -? v_MYOD1 +v_NF2 -? v_MYOD1 +v_HEY1 -? v_MYOG +v_MYOD1 -? v_MYOG +v_NOTCH1 -? v_NCID +v_SGK1 -? v_NEDD4L +v_TWIST1 -? v_NF1 +v_NEDD4L -? v_NF2 +v_NOTCH1 -? v_NFKB1 +v_AKT_i -? v_NOS3 +v_HSP90AA1 -? v_NOS3 +v_CTNNB1 -? v_NOTCH1 +v_DLL_i -? v_NOTCH1 +v_LCK -? v_NOTCH1 +v_AKT_i -? v_P21 +v_ERK_i -? v_P21 +v_MYC -? v_P21 +v_MDM2 -? v_P53 +v_PDPK1 -? v_PAK1 +v_RAC1 -? v_PAK1 +v_TCF4 -? v_PAK1 +v_RAC1 -? v_PAK2 +v_SRC -? v_PAK2 +v_MYOG -? v_PAX7 +v_IGF1R -? v_PDPK1 +v_PIP3 -? v_PDPK1 +v_ERK_i -? v_PGR +v_ESR1 -? v_PGR +v_PG -? v_PGR +v_EGFR -? v_PI3K_c +v_ESR1 -? v_PI3K_c +v_IGF1R -? v_PI3K_c +v_IRS1 -? v_PI3K_c +v_NFKB1 -? v_PIM +v_PI3K_c -? v_PIP3 +v_PTEN -? v_PIP3 +v_CEBPB -? v_PPARG +v_GATA3 -? v_PPARG +v_CYCLIN_D_c -? v_PRB +v_STK11 -? v_PRKAA2 +v_AKT_i -? v_PRKACA +v_WNT1 -? v_PRKACA +v_S6K1 -? v_PTEN +v_SRC -? v_PTEN +v_AKT_i -? v_RAC1 +v_DVL1 -? v_RAC1 +v_PI3K_c -? v_RAC1 +v_HRAS -? v_RAF1 +v_RAS_i -? v_RAF1 +v_PIP3 -? v_RAS_i +v_SOS1 -? v_RAS_i +v_NFKB1 -? v_RELA +v_PIM -? v_RELA +v_TSC2 -? v_RHEB +v_DVL1 -? v_RND1 +v_GRB7 -? v_RND1 +v_ERK_i -? v_S6K1 +v_MTORC1_c -? v_S6K1 +v_MTORC1_c -? v_SGK1 +v_MTORC2_c -? v_SGK1 +v_PDPK1 -? v_SGK1 +v_GRB2 -? v_SOS1 +v_PRKACA -? v_SRC +v_EGFR -? v_STAT1 +v_JAK2 -? v_STAT1 +v_SRC -? v_STAT1 +v_IL1B -? v_STAT3 +v_JAK2 -? v_STAT3 +v_MAPK8 -? v_STAT3 +v_SRC -? v_STAT3 +v_JAK2 -? v_STAT5 +v_ERK_i -? v_STK11 +v_FOXO3 -? v_STK11 +v_CTNNB1 -? v_TCF4 +v_JUN -? v_TCF4 +v_YAP1 -? v_TEAD1 +v_KRT14 -? v_TRADD +v_AKT_i -? v_TSC2 +v_ERK_i -? v_TSC2 +v_GSK3B -? v_TSC2 +v_PRKAA2 -? v_TSC2 +v_ERK_i -? v_TWIST1 +v_ABL1 -? v_YAP1 +v_LATS1 -? v_YAP1 +$v_ABL1: v_GRB2 +$v_ABL2: v_ABL1 +$v_AKT_i: (((v_MTORC2_c | v_PDPK1) & v_PIP3) & (v_IRS1 | (v_IGF1R | (v_EGFR & v_EGF)))) +$v_APC: v_AXIN1 +$v_AXIN1: (!v_DVL1 & v_GSK3B) +$v_BAD: !(v_PAK1 | (v_AKT_i | (v_ERK_i | v_PIM))) +$v_BAK1: (((v_BIM & v_P53) | v_BID) & !v_MCL1) +$v_BAX: (((v_BIM & v_P53) | v_BID) & !v_MCL1) +$v_BCL2: (!(v_BAD | v_BIM) & (v_CREB1 & v_ERK_i)) +$v_BCLXL: (!(v_BAD | v_BIM) & v_CREB1) +$v_BID: v_CASP8 +$v_BIM: (!(v_BCL2 | v_BCLXL) & (v_FOXO3 & v_FOXO1)) +$v_CASP3: (v_CASP9 & v_CASP8) +$v_CASP8: (v_FADD & !(v_ERK_i | v_SRC)) +$v_CASP9: (((v_CASP8 & v_CYCS) | v_CASP3) & !(v_AKT_i & v_ERK_i)) +$v_CDKN2A: (!(v_MYC | v_SRC) & v_CASP3) +$v_CEBPB: v_ABL2 +$v_CREB1: (v_AKT_i & v_SGK1) +$v_CTNNB1: (!v_DC & v_WNT1) +$v_CYCLIN_D_c: (((v_TCF4 | v_TEAD1) & !(v_GSK3B | (v_CDKN2A & v_P21))) | ((v_ESR1 & (v_KMT2D & v_FOXO3)) | ((v_MYC & v_EIF4E) | (v_MYC & (v_ERK_i & (v_IGF1 | v_NRG1)))))) +$v_CYCS: (v_BAK1 & v_BAX) +$v_DC: (v_APC & v_GSK3B) +$v_DVL1: (v_FZD3 & !v_YAP1) +$v_E2F1: !v_PRB +$v_EGFR: ((v_EGF & (v_RELA & (v_HER2 & v_HER3))) & !v_MEK_i) +$v_EIF4E: !v_IVEBP1 +$v_ERK_i: v_MEK_i +$v_ESR1: (v_ES | (v_AKT_i | (v_FOXO3 & (v_KMT2D & v_PGR)))) +$v_FADD: (v_TRADD & v_FAS) +$v_FAS: ((v_FASLG | v_P53) | !v_AKT_i) +$v_FASLG: (v_FASLG & (v_P53 & v_FOXO3)) +$v_FOXO1: !(v_SGK1 | v_AKT_i) +$v_FOXO3: !v_AKT_i +$v_FZD3: v_WNT1 +$v_GATA3: !v_STAT1 +$v_GRB2: ((v_IRS1 & v_SRC) & (v_EGFR & v_HER2)) +$v_GRB7: (v_INSR | !v_PRKACA) +$v_GSK3B: !(v_AKT_i | v_ERK_i) +$v_HER2: (v_HER3 | (v_FOXO3 & v_ESR1)) +$v_HER3: (v_NRG1 | v_HER2) +$v_HES1: v_NCID +$v_HEY1: v_NCID +$v_HRAS: ((v_SOS1 & v_PIP3) | !v_NF1) +$v_HSP90AA1: (!v_PDPK1 | v_ESR1) +$v_IGF1R: (v_IGF1 | (v_FOXO3 & v_ESR1)) +$v_IL1B: (v_NOS3 & v_RELA) +$v_IL6: (v_IL1B & v_IL6) +$v_IL6R: (v_IL6 | v_STAT3) +$v_IL8: v_STAT5 +$v_INSR: (v_INS & v_FOXO3) +$v_IRS1: (!v_S6K1 & (v_INSR & v_IGF1R)) +$v_IVEBP1: !v_MTORC1_c +$v_JAK2: ((v_IL6R & (v_ABL1 & v_IL8)) & v_IRS1) +$v_JUN: ((v_RELA & (v_MAPK8 & v_PPARG)) & v_ERK_i) +$v_KMT2D: (v_PAX7 | !v_AKT_i) +$v_KRT14: (v_PAK2 & v_EGFR) +$v_LATS1: (v_NF2 | v_LCK) +$v_LCK: (v_ERK_i | !v_AKT_i) +$v_MAPK8: (v_RAC1 & v_RND1) +$v_MCL1: (!v_GSK3B & v_ERK_i) +$v_MDM2: (v_P53 | v_AKT_i) +$v_MEK_i: v_RAF1 +$v_MTORC1_c: ((v_RHEB | v_PIM) | (v_NRG1 | v_IGF1)) +$v_MTORC2_c: (v_PIP3 | !v_S6K1) +$v_MYC: (((v_CTNNB1 | (v_PIM | v_ERK_i)) & !v_GSK3B) | ((v_STAT3 & v_JAK2) | ((v_ESR1 & (v_KMT2D & v_FOXO3)) | ((v_ERK_i & (v_IGF1 | v_NRG1)) | v_EIF4E)))) +$v_MYOD1: !(v_HES1 | v_NF2) +$v_MYOG: (!v_HEY1 | v_MYOD1) +$v_NCID: v_NOTCH1 +$v_NEDD4L: !v_SGK1 +$v_NF1: !v_TWIST1 +$v_NF2: v_NEDD4L +$v_NFKB1: v_NOTCH1 +$v_NOS3: (v_HSP90AA1 & v_AKT_i) +$v_NOTCH1: (v_DLL_i & (v_CTNNB1 & v_LCK)) +$v_P21: !(v_ERK_i | (v_AKT_i | v_MYC)) +$v_P53: !v_MDM2 +$v_PAK1: (v_TCF4 | (v_RAC1 | v_PDPK1)) +$v_PAK2: (v_RAC1 | v_SRC) +$v_PAX7: !v_MYOG +$v_PDPK1: (v_PIP3 | v_IGF1R) +$v_PGR: (v_PG | !(v_ESR1 & v_ERK_i)) +$v_PI3K_c: ((v_EGFR | v_ESR1) | (v_IRS1 & v_IGF1R)) +$v_PIM: v_NFKB1 +$v_PIP3: (v_PI3K_c | !v_PTEN) +$v_PPARG: (!v_GATA3 & v_CEBPB) +$v_PRB: !v_CYCLIN_D_c +$v_PRKAA2: v_STK11 +$v_PRKACA: (v_AKT_i & v_WNT1) +$v_PTEN: (v_S6K1 | !v_SRC) +$v_RAC1: ((v_PI3K_c & v_DVL1) & !v_AKT_i) +$v_RAF1: (v_HRAS | v_RAS_i) +$v_RAS_i: (v_SOS1 & v_PIP3) +$v_RELA: (v_NFKB1 | v_PIM) +$v_RHEB: !v_TSC2 +$v_RND1: (v_GRB7 | v_DVL1) +$v_S6K1: (v_MTORC1_c & v_ERK_i) +$v_SGK1: ((v_MTORC2_c & v_MTORC1_c) & v_PDPK1) +$v_SOS1: v_GRB2 +$v_SRC: v_PRKACA +$v_STAT1: (v_JAK2 & (v_SRC & v_EGFR)) +$v_STAT3: ((v_IL1B & v_MAPK8) | (v_JAK2 | v_SRC)) +$v_STAT5: v_JAK2 +$v_STK11: (!v_ERK_i & v_FOXO3) +$v_TCF4: (v_CTNNB1 & v_JUN) +$v_TEAD1: v_YAP1 +$v_TRADD: !v_KRT14 +$v_TSC2: (!(v_AKT_i & v_ERK_i) | (v_PRKAA2 | v_GSK3B)) +$v_TWIST1: v_ERK_i +$v_YAP1: (!v_LATS1 | v_ABL1) diff --git a/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.bnet b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.bnet new file mode 100644 index 0000000..121704f --- /dev/null +++ b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.bnet @@ -0,0 +1,110 @@ +targets,factors +v_ABL1, v_GRB2 +v_ABL2, v_ABL1 +v_AKT_i, (((v_MTORC2_c | v_PDPK1) & v_PIP3) & (v_IRS1 | (v_IGF1R | (v_EGFR & v_EGF)))) +v_APC, v_AXIN1 +v_AXIN1, (!v_DVL1 & v_GSK3B) +v_BAD, !(v_PAK1 | (v_AKT_i | (v_ERK_i | v_PIM))) +v_BAK1, (((v_BIM & v_P53) | v_BID) & !v_MCL1) +v_BAX, (((v_BIM & v_P53) | v_BID) & !v_MCL1) +v_BCL2, (!(v_BAD | v_BIM) & (v_CREB1 & v_ERK_i)) +v_BCLXL, (!(v_BAD | v_BIM) & v_CREB1) +v_BID, v_CASP8 +v_BIM, (!(v_BCL2 | v_BCLXL) & (v_FOXO3 & v_FOXO1)) +v_CASP3, (v_CASP9 & v_CASP8) +v_CASP8, (v_FADD & !(v_ERK_i | v_SRC)) +v_CASP9, (((v_CASP8 & v_CYCS) | v_CASP3) & !(v_AKT_i & v_ERK_i)) +v_CDKN2A, (!(v_MYC | v_SRC) & v_CASP3) +v_CEBPB, v_ABL2 +v_CREB1, (v_AKT_i & v_SGK1) +v_CTNNB1, (!v_DC & v_WNT1) +v_CYCLIN_D_c, (((v_TCF4 | v_TEAD1) & !(v_GSK3B | (v_CDKN2A & v_P21))) | ((v_ESR1 & (v_KMT2D & v_FOXO3)) | ((v_MYC & v_EIF4E) | (v_MYC & (v_ERK_i & (v_IGF1 | v_NRG1)))))) +v_CYCS, (v_BAK1 & v_BAX) +v_DC, (v_APC & v_GSK3B) +v_DVL1, (v_FZD3 & !v_YAP1) +v_E2F1, !v_PRB +v_EGFR, ((v_EGF & (v_RELA & (v_HER2 & v_HER3))) & !v_MEK_i) +v_EIF4E, !v_IVEBP1 +v_ERK_i, v_MEK_i +v_ESR1, (v_ES | (v_AKT_i | (v_FOXO3 & (v_KMT2D & v_PGR)))) +v_FADD, (v_TRADD & v_FAS) +v_FAS, ((v_FASLG | v_P53) | !v_AKT_i) +v_FASLG, (v_FASLG & (v_P53 & v_FOXO3)) +v_FOXO1, !(v_SGK1 | v_AKT_i) +v_FOXO3, !v_AKT_i +v_FZD3, v_WNT1 +v_GATA3, !v_STAT1 +v_GRB2, ((v_IRS1 & v_SRC) & (v_EGFR & v_HER2)) +v_GRB7, (v_INSR | !v_PRKACA) +v_GSK3B, !(v_AKT_i | v_ERK_i) +v_HER2, (v_HER3 | (v_FOXO3 & v_ESR1)) +v_HER3, (v_NRG1 | v_HER2) +v_HES1, v_NCID +v_HEY1, v_NCID +v_HRAS, ((v_SOS1 & v_PIP3) | !v_NF1) +v_HSP90AA1, (!v_PDPK1 | v_ESR1) +v_IGF1R, (v_IGF1 | (v_FOXO3 & v_ESR1)) +v_IL1B, (v_NOS3 & v_RELA) +v_IL6, (v_IL1B & v_IL6) +v_IL6R, (v_IL6 | v_STAT3) +v_IL8, v_STAT5 +v_INSR, (v_INS & v_FOXO3) +v_IRS1, (!v_S6K1 & (v_INSR & v_IGF1R)) +v_IVEBP1, !v_MTORC1_c +v_JAK2, ((v_IL6R & (v_ABL1 & v_IL8)) & v_IRS1) +v_JUN, ((v_RELA & (v_MAPK8 & v_PPARG)) & v_ERK_i) +v_KMT2D, (v_PAX7 | !v_AKT_i) +v_KRT14, (v_PAK2 & v_EGFR) +v_LATS1, (v_NF2 | v_LCK) +v_LCK, (v_ERK_i | !v_AKT_i) +v_MAPK8, (v_RAC1 & v_RND1) +v_MCL1, (!v_GSK3B & v_ERK_i) +v_MDM2, (v_P53 | v_AKT_i) +v_MEK_i, v_RAF1 +v_MTORC1_c, ((v_RHEB | v_PIM) | (v_NRG1 | v_IGF1)) +v_MTORC2_c, (v_PIP3 | !v_S6K1) +v_MYC, (((v_CTNNB1 | (v_PIM | v_ERK_i)) & !v_GSK3B) | ((v_STAT3 & v_JAK2) | ((v_ESR1 & (v_KMT2D & v_FOXO3)) | ((v_ERK_i & (v_IGF1 | v_NRG1)) | v_EIF4E)))) +v_MYOD1, !(v_HES1 | v_NF2) +v_MYOG, (!v_HEY1 | v_MYOD1) +v_NCID, v_NOTCH1 +v_NEDD4L, !v_SGK1 +v_NF1, !v_TWIST1 +v_NF2, v_NEDD4L +v_NFKB1, v_NOTCH1 +v_NOS3, (v_HSP90AA1 & v_AKT_i) +v_NOTCH1, (v_DLL_i & (v_CTNNB1 & v_LCK)) +v_P21, !(v_ERK_i | (v_AKT_i | v_MYC)) +v_P53, !v_MDM2 +v_PAK1, (v_TCF4 | (v_RAC1 | v_PDPK1)) +v_PAK2, (v_RAC1 | v_SRC) +v_PAX7, !v_MYOG +v_PDPK1, (v_PIP3 | v_IGF1R) +v_PGR, (v_PG | !(v_ESR1 & v_ERK_i)) +v_PI3K_c, ((v_EGFR | v_ESR1) | (v_IRS1 & v_IGF1R)) +v_PIM, v_NFKB1 +v_PIP3, (v_PI3K_c | !v_PTEN) +v_PPARG, (!v_GATA3 & v_CEBPB) +v_PRB, !v_CYCLIN_D_c +v_PRKAA2, v_STK11 +v_PRKACA, (v_AKT_i & v_WNT1) +v_PTEN, (v_S6K1 | !v_SRC) +v_RAC1, ((v_PI3K_c & v_DVL1) & !v_AKT_i) +v_RAF1, (v_HRAS | v_RAS_i) +v_RAS_i, (v_SOS1 & v_PIP3) +v_RELA, (v_NFKB1 | v_PIM) +v_RHEB, !v_TSC2 +v_RND1, (v_GRB7 | v_DVL1) +v_S6K1, (v_MTORC1_c & v_ERK_i) +v_SGK1, ((v_MTORC2_c & v_MTORC1_c) & v_PDPK1) +v_SOS1, v_GRB2 +v_SRC, v_PRKACA +v_STAT1, (v_JAK2 & (v_SRC & v_EGFR)) +v_STAT3, ((v_IL1B & v_MAPK8) | (v_JAK2 | v_SRC)) +v_STAT5, v_JAK2 +v_STK11, (!v_ERK_i & v_FOXO3) +v_TCF4, (v_CTNNB1 & v_JUN) +v_TEAD1, v_YAP1 +v_TRADD, !v_KRT14 +v_TSC2, (!(v_AKT_i & v_ERK_i) | (v_PRKAA2 | v_GSK3B)) +v_TWIST1, v_ERK_i +v_YAP1, (!v_LATS1 | v_ABL1) diff --git a/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.sbml b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.sbml new file mode 100644 index 0000000..be5786a --- /dev/null +++ b/models/[id-233]__[var-109]__[in-8]__[BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE]/model.sbml @@ -0,0 +1 @@ +v_GRB21v_ABL11v_MTORC2_c1v_PDPK11v_PIP31v_IRS11v_IGF1R1v_EGFR1v_EGF1v_AXIN11v_DVL11v_GSK3B1v_PAK11v_AKT_i1v_ERK_i1v_PIM1v_BIM1v_P531v_BID1v_MCL11v_BIM1v_P531v_BID1v_MCL11v_BAD1v_BIM1v_CREB11v_ERK_i1v_BAD1v_BIM1v_CREB11v_CASP81v_BCL21v_BCLXL1v_FOXO31v_FOXO11v_CASP91v_CASP81v_FADD1v_ERK_i1v_SRC1v_CASP81v_CYCS1v_CASP31v_AKT_i1v_ERK_i1v_MYC1v_SRC1v_CASP31v_ABL21v_AKT_i1v_SGK11v_DC1v_WNT11v_TCF41v_TEAD11v_GSK3B1v_CDKN2A1v_P211v_ESR11v_KMT2D1v_FOXO31v_MYC1v_EIF4E1v_MYC1v_ERK_i1v_IGF11v_NRG11v_BAK11v_BAX1v_APC1v_GSK3B1v_FZD31v_YAP11v_PRB1v_EGF1v_RELA1v_HER21v_HER31v_MEK_i1v_IVEBP11v_MEK_i1v_ES1v_AKT_i1v_FOXO31v_KMT2D1v_PGR1v_TRADD1v_FAS1v_FASLG1v_P531v_AKT_i1v_FASLG1v_P531v_FOXO31v_SGK11v_AKT_i1v_AKT_i1v_WNT11v_STAT11v_IRS11v_SRC1v_EGFR1v_HER21v_INSR1v_PRKACA1v_AKT_i1v_ERK_i1v_HER31v_FOXO31v_ESR11v_NRG11v_HER21v_NCID1v_NCID1v_SOS11v_PIP31v_NF11v_PDPK11v_ESR11v_IGF11v_FOXO31v_ESR11v_NOS31v_RELA1v_IL1B1v_IL61v_IL61v_STAT31v_STAT51v_INS1v_FOXO31v_S6K11v_INSR1v_IGF1R1v_MTORC1_c1v_IL6R1v_ABL11v_IL81v_IRS11v_RELA1v_MAPK81v_PPARG1v_ERK_i1v_PAX71v_AKT_i1v_PAK21v_EGFR1v_NF21v_LCK1v_ERK_i1v_AKT_i1v_RAC11v_RND11v_GSK3B1v_ERK_i1v_P531v_AKT_i1v_RAF11v_RHEB1v_PIM1v_NRG11v_IGF11v_PIP31v_S6K11v_CTNNB11v_PIM1v_ERK_i1v_GSK3B1v_STAT31v_JAK21v_ESR11v_KMT2D1v_FOXO31v_ERK_i1v_IGF11v_NRG11v_EIF4E1v_HES11v_NF21v_HEY11v_MYOD11v_NOTCH11v_SGK11v_TWIST11v_NEDD4L1v_NOTCH11v_HSP90AA11v_AKT_i1v_DLL_i1v_CTNNB11v_LCK1v_ERK_i1v_AKT_i1v_MYC1v_MDM21v_TCF41v_RAC11v_PDPK11v_RAC11v_SRC1v_MYOG1v_PIP31v_IGF1R1v_PG1v_ESR11v_ERK_i1v_EGFR1v_ESR11v_IRS11v_IGF1R1v_NFKB11v_PI3K_c1v_PTEN1v_GATA31v_CEBPB1v_CYCLIN_D_c1v_STK111v_AKT_i1v_WNT11v_S6K11v_SRC1v_PI3K_c1v_DVL11v_AKT_i1v_HRAS1v_RAS_i1v_SOS11v_PIP31v_NFKB11v_PIM1v_TSC21v_GRB71v_DVL11v_MTORC1_c1v_ERK_i1v_MTORC2_c1v_MTORC1_c1v_PDPK11v_GRB21v_PRKACA1v_JAK21v_SRC1v_EGFR1v_IL1B1v_MAPK81v_JAK21v_SRC1v_JAK21v_ERK_i1v_FOXO31v_CTNNB11v_JUN1v_YAP11v_KRT141v_AKT_i1v_ERK_i1v_PRKAA21v_GSK3B1v_ERK_i1v_LATS11v_ABL11 \ No newline at end of file diff --git a/models/summary.csv b/models/summary.csv index 36c902f..7af4fa9 100644 --- a/models/summary.csv +++ b/models/summary.csv @@ -229,3 +229,6 @@ ID, name, variables, regulations 228, INTEGRATION-OF-SIGNALING-AND-KINETIC-MODELS, 47, 9, 107 229, CALCIUM-SIGNALING-STOMATAL-CLOSURE, 52, 4, 128 230, HEPATOCYTE-GROWTH-FACTOR, 50, 5, 76 +231, BREAST-CANCER-SIGNALLING-PATHWAYS, 110, 7, 268 +232, BREAST-CANCER-PATHWAYS-MCF7-COMPLETE, 109, 8, 275 +233, BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE, 109, 8, 260 diff --git a/report/.~lock.online_only_table_1.xlsx# b/report/.~lock.online_only_table_1.xlsx# new file mode 100644 index 0000000..fc36eaf --- /dev/null +++ b/report/.~lock.online_only_table_1.xlsx# @@ -0,0 +1 @@ +,natalie,natalie-IdeaPad-5-Pro-14ITL6,21.09.2024 20:21,file:///home/natalie/.config/libreoffice/4; \ No newline at end of file diff --git a/report/online_only_table_1.xlsx b/report/online_only_table_1.xlsx index 9cb26730db1669b9fe76bb5697242ac7efd0f882..d986e5c5eaba19b06cb978d55f39c75cf96ba1bc 100644 GIT binary patch literal 58432 zcmaI61yI~i@;(fK;1=9HxI=IW5Zv7%1a}QC!Gk*lcXyY?-Q8u80KwgD-zDGs-Cey^ z|D%cz%kE6~^wZr>_sou>3=}jb1RNY3M1I^SEr|d6K?J`xa5S-YVrF`KR>XD7_p%@b zpLvGS-F;gB43|>~kd*|GaS(S=+7dK`=Jf?!-hRPAM~bZNjdJkuef?Gdl(l65vQWwB zhpK6XzH6s4@-FHdeRXhW<{Z!U8Ti00p=>8g=NPRZeLc1%Jd*F}93zdeeXxE2Q&5DC12>aKsg($PqtDdgdT$I+ZyEYWG+L}vUy%b z+->N{Ccy~qKojql(T%eN6g(srNx2WnWP7JW*t1PhWG@M$2fuz{w6^Ry+JC!-8E-=m zWHEF0l%w#Lls(PDB4Rg?4%g0n9^J!Gl!1i{O65pB1%oj04gx~){|OT+c!ZlZv#Xt> z)i*mkD<(G^>qwQ=s1+78?=y`rJ|Vizm}rJ#P(KqrW^32IUE<&!9FB*Gv6o6oX6+85 zzi-E!sGo?E#JMpEI+^Yn`#4qR-$4%`RD8p}h1&BQab}tmG&MNoYKOmKa7=V6!RkAH zm$c3R98*{!RIWfJUf19>{rFAb$~!Gl(P4G*6HOTAiYnnShv&uujGL_tM0q~R`|hQx zX2o)`Un!vODKRoO&4Xi2zaH$qA3KuAHnf(b*jFNwZsr7+ZhF2uSkv;&W4}7xa$c6* zXeUtyJw%sT>6`06MHvoF`A4`5mwFrqzOAVh}B~+_RL(FaQDHaTP*rD9mZ5OLG9{=$&*yyb@7$$ z*h>fP3EhYjzUaeMOp)t&_BT$1eQmM`F^#?)`@Sxz?us@Af#O35`QUUrg&E{Jzo%O-qOo_5>&RZ3j%if0Hs_ zydQO`yhWgN{I-nhPik$y6>-McdZs3$Jo~^bAQg*mjE}Gc`e{_elj>akrF5A}TXH6rw=O-=+ zo$Tys$^rq*UERYv#8mnh;3tz3+-N;h9A_$e#?4^#pF-;NF~YhOQ)$HeTr+sR5P1>d zUFAzVmtz(tqonDx%DT?DDcWKkOab#_kn~+ntib^1!GWxVC)k+=9FYTP!)M`b&;$z6 z$xkG}u``ftJn|Q@30Ffhow6rX8N!(nU4VU~SjCpjtg*32KsYk(v{J8Ygk!?FDZcHP zAp{^;U0&-#FEFX0)uKp%$Lfkamg=UhYukKqLj^?*v-^M`U_OuKHVm861|88Lqt4&U zJ>Ov(5G1Rn(A&fD;6D>(te^jm*WBW)mZBg%K)%lEyQMoZ;wKK!#N-Ix>wV(6KM3H)x`)eU`>w zi+%Iy&>iMG|HJfMv_(R5<=K${dY;*4D^)aMq-k`h-_F;|=5dXBZw}wp^)_3Q*DUg9 z*f&e#O;aCa_V_;WKyLyM)?@KJyjxG+AC$ zY<;{R=Xn5Um~jjvL@m7PMx`LO=DbIPb?I~d^9O&V7Ew(}wi^?GW%5%|(`;qOnv1sO z+N*W8&J5c=qz&`zD5o!OhEUY`)bAEj)Krt9+54f$(2@@AjkWJsR@=|P+VuQq873Ki zRyBh8G=WiH$DsBfwfac z)WHeH*Uz@16-<4YTQ*}I)88M%6Ul@{p;G^t@->Iv3@#K~!xq>MpZe`y2@Y2{jT$mI zc9-iNCt5B4dlrAnhR_?w+LvaFdIfpy@h|qjnMg+QB1h7%B{8oU1(Fou53;)f?{(v`$&EHi)Sli+s<6)aa6XxV63NS2eFcnvP7vWy|G?b&`49y_`}jOm^?f8rFh zDTu7k|IGN+Gf65C8Ti~tubAJ(q+dEj(iuw>w>#Ibil)W@T+WQE&g>KwC_N5skdz2Z2RV`Y(WovzFqnueh01Jgw$Z98+(Lnh;CF#K5m^EcgstS2 zBg7g+CDO!l>w|>nysDpojO)ba7cK12<^+oL>uLvj^4b2@otuKeiVWnQSbuI9IqbEp zvMr1qH>RgV`S@yv4};lbznwPH#>yW!Z1(N|VTE%6ft!Qb6IJZ^?uSVOo0HT~LNK9% zcy4gg(v#xSF z3~sU8F<@E__|X+Ia$pZ$c{(iVEBgv!*(R9R!q^*`PR`l-Q}n{B>L=BijAx)F1*11) zn9Genez{%#Gmxhsk}QJHhMS=9?9xs;QxNh|Z)`p$C)@b&rtQA_QIxNRW5y75#^{6T zgXMe$*U4q;vg+)7Zl?9643Aw@E4^%KaVYdn*>zn+VpP0Y>(x__$PbJ_|b< zfR5rHo}gc%OrlaeqVn{wVjgQ~H(7q!y#qFkEts`9i_)uT37QRXGYCZQxbxw8q3wS@ zPNH?O^3g&;48lPmLlD-butC^IBy~e{v8KWlK@Gw|B11m6uu*@3F-O~+OynU$_#6P? zTR9f01j2iF?_?q$gD?frl|}F5uj&T_@v57GL5|J=XWyo%sAZIt6o{rQ9L%qT&+O+jC+G`|Ceeqm8R4~Z?QJXtfXmc z#zbWDpSDxoJ2tn03vS=3p;0i9M^4isH=q`IX-b;;ziOLn@Q-PQqPqlT>PWg5t z6)1I)>+Iiw#a!sQT;)re;a{W#9gvA6Ao9sPJI%-(^B^1KbO~q?HMPr~bB!jaymsCv zgK9+O!z^`aE^F(P|Pswh&5 ze>7Tf%}o@Gz~RLQlPIUCD^iL}VK7pPLtzlv^4n|ZMrJmN9NJ5^--0Q8E@@xVk=9j7 z?yoqv153=UY@?$IJU6}4jfRiZ9V#&caY&DsiTrT`=uof+q=d(U`!O^{yq!P0jo|A3 ztdIEw<(JAqE1~m}kr0as7Z0jG+NM9u^IkXvm^;zj|9WQ=UBg$<-u#6xta*wg(VS!* zS7&5Y8J$Q>uXxf?TDYM7QLkS(j6k%Y==VVNLGre}E>mcn2rQ#53gnA*C5DxS5COfg zP+0kthK(k5i8xYZE}e6rKyYh&hMqca^(PCUl&~n}roww<^6B2AAL$+>mn5_p7iKoEx#7UbW>e@`91l&7>Q>dT5dmSsf+0LICe`|yBf=Xzlk({0QBU;X zhzK;?6&rkGBLg(6JVr!|EQxrW!)|^9y^RkRWj2_-!L|+q?KXpiCQ^R}-7(j*g+AN9 z_`FaD44oA%wfT9b^X&kJU2l~}{{AhOf` zSIde2Ps{mFpZVV>BLAEq#mZUzJwbZG62I%0f;EcZZjTVIdbx)jP}-jAl$%_Hmfb!v3le~!jYV&;MLS=p zWVC>+o?f4Q`F_Wh*VOq^qkY@43;0%})d`4w+?HcDnB=_be;fs*N%2zd$yL$R-SF$! zE<6CzNZcK+R-ZcC7{h8|n<~Ryxlm17UP4GQ>q5K|v0lbG4SGQjZOaw4=pF0cAHq(U zCinV9Gn2~-NW*iP%4_={3%OR07k2>!YV5WiPdD40PirNO6-%0PCiq(`0wQ*3^ooCv;bfbl+v>I`p}4 zfZ)moGfv$h%-oH9hps6Zu_l`dJGo~h@Tj zR(u=H<@c7Mq;@?~HSZ;x1p|+=aSs*Sh4AIvXTSO(FVxpICeMvjJnxBJ2H$IJx1*3< z(GJnl+%eBxQT5x`$Bmc5=Re!evxg+N*kY)_#^egm2ivCQ_5<(rUXd}6T_zozn>eVO zn-Sz+o35|?)nX=s_g2Xy!~&xWx(3U&uZ_`h%HRUS_zmZofBpQAZ0ZQ0V>f$+Cw8^Ix15fbDYs`Ph7Se{|A8K`+ zJY`ezk)qu2Z_5%zyX0dBNfuL2yRne6em74DW_7P$nOCL>ru14rc0ICQ-Vk{`6g`A2 zL7IaK;l%5Uk|XCM@~tjfTgWo4ORx zX9({^y2I9Fh3H4&)bd5FM~kMyMn{ zhPSvL@~HS;DdC|Mfk)b4t}EJMI4&xfwPfawIjp19-${ri3aA)7sOar{8@sFdtOmuC9#I|g@oR1H5>`#P* z!_E8WTdWS}OAqyJEAJipNpN$G@ww|Zgv+hT#PI#Gt2zZj1qFD;uK)_Nngu4*rb=bz zq;!SV6C*E7INxP@bNmCS=Y>1oK~<1{4vL3}N7KB^aZy38}izyhDVd6Z4HENb(xQx zh#(6M-(*`27I9lb=xuN)VuMAKR;!DM8da(7NSki}6bS>a2L`@Z?J!X|HGBel>|i?n zWW7uT#FrqEIF5cwMP!Uo79{`j+lkTAMqJcaKl_}~FOA0c>I3S?0W2;S2%OtC1uXUh z41R|g39~kq>Z-ufZ&3=aUkF-Nye8|NK(|lh59K4Z#x=;DtD%WFKd* zA%JamtQpvZOv6mpnP1GtR{CSI6=~+f{b2?XyJuH(rFl=;pb?4vmjEV2bg5X`_c$ID zup-}+-Ai0@nR$jF<@4{{jUbAOFZx1C9WY@U5et+=gwTm2$p)ZLFigmXlX67$XW*i{ zpfxILrq_Sn$FJnj1qiq}{u1TqZ7C202=cX|$#M*XVgjPO;Gtk3QxFyVP0VC7R%xKG zdjW-8M3JlgdF z3HnO6PgU&#I#{WPOV7WjC7&lQB%91n#a{Je3i7>IK&8O17cP*nk|K2V>&IOFOjYZ= z9m0B%f)T<2!Ho;k)^xM;Xa3jK{(%dkhEP_*d3JX3(AZ_dMrMAVWKFnYlH| z{}|o_t*zU~A?*=gm0f4usb5l;wOKqyLB$h7YmukQwaYnAN;}QDOQiERRuQRA+gc5k zgAFJ4+Vb$Uz92z=XEsj>9(P6isT`58WCrPKeu(2A7V=FaZMbwui58pngL(vZQv9F1 zj`em5+boU4j5|7Ly?Y(1a;~K`5H+PHT=q#7$!H(D#~TFiobfc?Ulf0_{Mv7Ygr zkonMD`A7z(TvDuKTN7>BBnfwZ9m9B{K1b0?S6NLWR;@l-c8Vyw`r91u$+fy4%qu(vqc{4uA79mhh( zM-OagRaeR}T^1&i7{Qg>F?d%m@MpR5@d?|hS#3a=%}Gd;_eZ!@v^p_5`aRNWJXf;HGrO zuzs9Veyv6o=lqR){c=5u_c*UBo|ERLL_uz%v#Mlw*jZN{WJhdFf0m%4P)mP(Ax6X- zL?rY0ULV0@B)Rw9KUj7sIsG(NaP6sshNNrSBkS&HnfY82n2H3s@+eqFg{7TX^jlt05Gy7zdm zFZ*Hth7Rgrl$T^&itnPOGRM~2AvMC?mj zF4cCrgML9#avxmPd>w;9QkO$aR>qXU%;rej<&(UPE8i!teNr8aqx<;% zOUZ7akRAZvdGngr_`-u^k5ydV)~;!uKhT9zjRIC`22>P77Uy!8R80@D zZI@RjpwWKU?A!456pvke2lzh*Czmv@>;*cV242ET6=N|Q0d|x`?}^Sc{Rz3nexw;$ zUZLFO#9!rN0Wt9$hLgf?&R)Ka-bw5NUajlUYl+HpOkQ(^sAU4}a#)7$qIPWXKUV%4 z(}nmL_Hj)oH|Ky2yxrfqK$#CEaNc~Ej2)CSGKA7!;}1Edg=|?yxgdoCRgOZH((3O!=W|dcEx|%k|>Ftv&Ka$riNvjP$+#^ zj+xYr5u5JxUlqSxlMj#@lW41-w(-M}ke+?15=JMpptUcM-bB@%hr!W~9K#+Em7<*J zizjI3SS#Ed!(R58i@C&?pTKiJva5#6|G>~vOa%q3|)9(`EaqCoCqF0!r zzk$qY!0?ygrxG_V^pKCff+)MjoauZ6M!Z`@q=Jc|vkqei#zfi5Djc%9p+1HH*YMbm z;Rml6GX_x%24So(YQ2pX_rL%ST=dm|HU)ioYF@TT$U=+U6r;suBUi7TWuHK)buSEFCl`-haxYmIj9V`HIRQeYjb6sT=ykc!HTAq z5BHQ7o3ocvku_nVwz2RZ47ze`VKKswvIx~pVZ8vdnm*ICc^wbU`703!@>sJ5QJTEL59t zpTj3iW$l^3A1eN~LZQ;pPS43}9~9i?l4Rm}37yxs`&hyh2Y4Uf zMFmXd?~W!~8nVxUcP$L#b01)6g)B)49mh^;$ZRB2J#8F0Rv8XsEYzh?-E{{-xeqk` zK|5v3PF3(O1A8An-Ls~SI|=jNuR>5tNGLeEDDVar`!+o4W1MRhp)`@pkYW@W4F`qFOE1LYYWL5|<^m1d-r=@6ZXO=xwLkh}zL49X~-yWW+}$2K$- zQ*IX3Mqf!Owr&(rLh|15X*N*SP{Yf|TI#S_e^9DwDKb}_Wou_4{$y?l-8><}qCJ$i zfYoeJl;-<@OBeSl;Apxb*m_bQy^Or-f$VuJh{9)6S!Mlsw4-8WJQ8zfmeSecI12-N zax!oK7oDGRT6&unTH(aKb~4_wQh?xDP(8VbHcz?`>5a*Its}vBh{Y9e7mNv^to1;| zhpN*+>rZ@snm4|e)enM0i;~!pwVEO}Y@r#fwX7~uK3a)E?ynWhDM>+uFKSRzhcrTh zasbPS+mUq9S!jJo_|kks)Fk&Eil$9c15HR~%^}Hoe%tQO?c;tK#0%#ga(qR4j0+)2 zrOap})R>|~Z~b$(uC0%hjEks7)tJnhWn{+`Sg@|_Rp$IY+d2|Xi!wzYyfk9Xs8M>R z^2Qb7>f5gsBUIBOVKPrzk@5X#0?fb6#TH2A)AqS~w_FtZFCxUo$LF~D1&-pQwWsUg z*Duw147U0X=E++`C2rR7=7@8GmMD4&M^5X4eQ#?Ucw_LNIj z78b<+>oEwES3fMCh>C*N0zcWnbuOMAk0TEEoY@we>*5pw74nM{l>_bijjr-T3VWh*5?eLY~Q=t z_%0CIo_4n#ADi2uYts1V@;qyO>em3+3Q8^2FKXh-wFZjWI_=#ONxI&27Z>l7(wK!P zrBubR+&||Y4d9ppiDC-JR=Q<}!iF3yy@}!TExTF_`D>wQrnM1s4?lUzV5^+Q9_V4qHAHAbm*@{k=}G&Jsb_U|=s9IzIqZ#u4_*+gqMSX(~&>+bT_ zRpBQUlCuMU46y#$$RxznI?=OQKJS1Q{*I+Jpr-r&^DYOm-0($Lexn&$2AjQHdksB_ z>sdzrucRLq4O+x#VN@gdjXA9w>YX-JcK8dBAEIf6M4~PNPgpghXN$=(3@S9{=Qxyx zTu5*>9@*O9if&RR_xhJpPuY45aObrP{Rrn@RT;MVMDyP96N@SL_`Z&*ep*AE#0<;z z0)gJnxhBh(UJB76AkHoR*9qVU@Hv;UospuWoxKyYk)5N-+xN^i${Pv+ENDJ=Rixe_ z@7PrczJ{g>wDcM4aCFSy4wNdU-f}jAfbR%eo130|t^vS?N z{1WGs_!~=NV0;(ZVw^@~a5`aktd>JOeD4>dt$9uu20D8`)R`#w_;|)#!vx-%pj5yR zUp)?2WCf3hxr}A={ocnZj;Nw~n4LI^BE7HX1794&623)n@afz@Dk~Oe!$d|=DT(;D z!!^2Spk9xVm{pvcZHnDvuhigRYxOQB=PIq6;d4Ap15QgklN!~ zKzE1-VIf_&Jl}bTk-RxXsq*BTG9&~<*#A6uMEh@t7~0#v`6DAn&aUU}D&G^9T3>^d zPNTmfe!ayCyak`Lc@v$C?$DeUjg->E9bz`*p9kZo2I5s_Jq3>;l+A$JLg9~0iZJ4u zC1aJsStmLjU$lO%NeXI0A@hoSwz~Z+)b@Qd&p+m)KRoiv;J$hwbPen{lzgp}v|ali zYod>Y^#(m;m3joeETx*#9CRU^xc}HX)=#Fsd9qg=x(e=foW_&skHmS5=3M7+5pg;z zD?=gb7GHOB<$D_PCnu1l&wue765O0@y|e`~oD(wJe_EwsmtSA3Jv|&ew#}ANc>eLz zSbt1k{L@fd?hdgFxgE1<-6cE@?F5vsfV6D~m=wUkDY_l0K7nCL2ZQ(jzSoEG-@qAt zcXGC~`HS5|4MGnKX3*Ap5!~{sDs1dbeKRk-55z@(SNG{yllfwTrDuhH(epcW` zv>a{ugJladJuL(yG72@L-Ae(tRQK@aSK`3zT^I&{%c3sD`=7&*;S8i!JVlt61xpi~ z$jLlLOcY{v%9#$z98nWJDaYH8@w}?@O3OhQ59D4v4;P1@USv>=H_q;Xc4VG5c|K;V zIB#}sEkOK82Cw=8{QJM{(h;?@bvCheHc)l9H*wN?v#VWgTmfuX=amLSduqdGH!l0; z=Ae>PUtP(`s=AiY40a$0=pstV8xj~aJJWIZ(Mj%2+FRUEW0EtD{(irz>U;mypfzcdt$C0~@T$Ubn zq)5;)TgnBNM^9a_#USKJoU2R8arIiPgf(|S)nAEZgi>9KenMoI_XmByZ?jC(g#G6Q zflAB)z2}Orsu!Z4hkh{tn<#+D^`eI&UHm}~I^AR`N=GCmNXR>%sK}cC@Y_fqg?X6+ z+-5!e0E58X!Yf^t%~VE{A79NF6i=lgnCW$WYw|^ird)kg{El?msa_;5@i!YWs!;RH zcO&XHc<&cZ9gz55p#)R!pVI6LA)Dj0Hz$F?IE8maOMgx;Kb*6dMIze82mO}w+Kt+u zgC?)mcV^y@XI0Ef$KST<^&=@8PnxiDuk{kW((#IkeH3DSfPQn>s6QuzJva!}Vg8rH zaKY~U*9Fsm-Q)Ss4W734@i@xC#PXJ`q90#B)ir;9@Z}ENNxYB+u?MHrgfy9bF%5x1 zkduU>K~khld%2EJq$!i-+X&@uG+)`%Z%h(dr;AFGC@up$oW1_>eZB8B^Ywfht=i~( zI=IW?GH82vu4@wVzB*k!^L@PA@O`ZUSv`>?PYONVyetZNKi#07`FK1%O@c0N7bih~ zNM4&ZUS8IjK^I2`zz%QFa(tIU=j-cLXPYnRO2feC;fTxE{pt5&r_aUdpC%!Jmtog4 zpNEU1I|a}mX3*3M zy77E7*d){rlG{mc67qU^wRq@!-F?dPm9qpr*u(;xI=x=*iaIT|C(AwxzTQ%2U8fRz z2>F1xyR6saKUJWYldO#n&|+2===lZY zaaTl5`f`!%d%vDc0{SiV3Pe_YJJM>_5F0-fAEWdQ|q&U_z^B+kL2??POK2oh`3`1LuO1az{Fng!hf z9=GWGvh@=3k)P;vof#gqIveH-dQcz{oF>Vn+<1B3LPNFlz2EBHxW1a~c<2(yx*mMJ zntVN42atfC#}|e8z2#@qG(cuz zx1#qIe`pra=Qhjt^})iCJ#m}M?cK1l7c{1vnhU%f zXlz04#y1FhL05rXYo~6lPpLJ0(wAoIU$f3Sy+O%E3e_*)(nBgOLKJ>`u}xmw27JnV zb-w@R@fZN|aFp{GeB4>L3vTXsSzRT`d=2>Xy?r1v>U@>5V+{K|WJ3TMwD<>f7l7<@ z|Mg<@QA3&@e0d;rAlwfq$L^9J3D~(9MgGpyojU zqfa~@lfm^>h{As7UCi%6(Wnu!r-v-Zp@ZLK)VncqSN+cl+&jC!$(TpTK=2_}Kren^ z`3u&@v&w6j+||V|l2=%im5zsR_#k*#xhNZsQO;!M%yZCd0LnpjhRf7J_~`C~?B#0b z)J8{0rw`}`9Im5)PTyN+Tf3PY->1Rn1M@0*%x^@U(`V^CnK(Z>w`L8VdoKjjC49XF zk7s?Kk1!sagxVg~lYO76d!i$Dxx}BsrgtJjHgMPJ#nae{hxZ)^q{Xw?IV+8Z@c2Fr zq&vj0?ncB%$V}LGvOa1=@R&Wv;z!;qRw0OamFnmGjQ(U#8+osrmrE|Vhc& zRcj!KcNNdKx^ikQ)Os~)Jdk9H$?jur@Dl0kk?VDLz59AYy(I)H18tDBRuQihf`okT zc3mfbTk)}GO6dHqc{;pE6km1ji7czAaWSZ<`ZVB+y&kyf^tc*4ETVtw>VBmZx!Z!>5APvx7zw*2|8}S5#Yi@A!OS=b5$^-DZVkUYYoSP1ZDtf_h<3zv(@6s$%<$mM?n zbtPGF&<6=@(<}it{;Pe*Nujp!@V46_R2_)KQXfc$rNt=}v{%2Bg&rJ-MO3G@B+ME& z57(!*MA74I=iTk``nN=JuiLK_G|n>Fr&dop=FA$iG;deU0U9$zDVOHQ0+@dGngI_ILx3Q|#Md>>n{#U(YU*ZSqii&8XmW+-Oy zvJp@4$e2n|HE?n)F`cS+yl_%BvTXSLuiaP3S>80#bOzzRP(`5_3zxBRT5^T{(doxe zDyec?n_>L4?J>)O;G3bt#@YLly~_zIIg+E^`D<6{6^;$Gz(QzG#*27_2#ro?%dc%( z_|Z2q)G8vgn@+JfdL&p;#|-L`0qpA%%BBLCB4IK0#I%>jW-7X~OAG93m7M*n316!| z`Y8L|lydRQAs!9aT3akVIT3Lw4L6@#`7o)z}WE2xaW7dQ}utU z{j8X7R;p_g))%(+M6q^{v^{|D%^UQqvR2&&l{aC z#jDVAE7;{>P2iEjz(Hmq0I;j3t*jw{)!DUFX_JG$)!wGY(ya10nW}b;F^HGx-OG^} z*!<*}B1(*f(qStVTe*VYh$_GqtS3Z+$vw$LiVyIs{>Sj_@`A((fSM@ByywqgvA}1! zPL6VNk3b}SW)k}u3Rr4^0?}W)YJgz9z=$pY6=j8)vV73Hqh;^Ff5TqWGB3q3FB2ME z@rA-FG`RgsbVQDBV8~6vrHHmd&JcRJ;iqW|qowsgk#4C;TWWkj=D$_Hr*79F5>si< zH(yd7dcsN$77znZ{*F|gDIzjLT9nA8ZH>GdM$Fnyz~wmIXqmP69>609FjFaV|h2aULuIX4t%e)xxVLB1Q=0E|AzP1H@u00|7+E1 z#`W{z5lLdf{KE{4X%WJO5lJ{J)DDkcs@%1EdY_`&j=owgn;@~7(TL1=B8YiR7B(-O zvRNmV-QHmX>(u<)la_#oY%7O);-gHWK+LB4kvd8?v--9f!Qr~ho>(CUjYx`4xuzr& zm=1?eWCsF(F|f}XMv=fiV_saP>(-aCwoAmbc^OpGG#xUyl^JC-!p*-+z!m{6mDn3k zDbmD8G&7Dy7$!{AjUolT`?G8!Zk3GJI5Mwa+4PTgI`)-A6Y)_tQ6N%BJp=oWz%FXV z4DnEUj=ga}nc~iiybky?{qMkrT}kllU^#~hJyS4zY1=l^)r;stC0*|GqY>)vmLf@b zZ;Fy8R7L{8q2|sY!W)h0ez>OXf_Etxq^A?*oVjiS#&1RM4Zq|go5X+8<*L*bj}d_6 z9&$EQJBqvedz6v6;rHl*PlQO$5P@-Hl3H-vhI13@_a$($cDcDE8kXr|A&>{_nb26p zx}wxKl}0prBu>|k#3;xzFqTEs#1E)=K=$ce;RUGW)z7$FvkmC;PTI0zBFMYD#80ot zfwimAfPHBUPL`7js=NxIalJL$PDO^yD3#HdE=6MOu1S8!os2Vtf|Ol>T(HOw@V%Ab z`Q>IBcoljk|FL~lM@?L(eZ*YLWJtzbW|Yq8OOIk@-)NC1W>g!Fe$G%~m)O6CH}+PCBY85`w5u6Ag99&0ESLc&3H)qRe4e6h_iK|--5MemjgQ^6 z8N`R0m~{@kvK}c>%)jCV4E!r$z^J=4Sw>WPL{8TX#89Uc7)7!UBUJqUk?&K*8IAGhc?aILXSOb_hbe`vnh$0I1`sHx2WH|I~D@UcW zXLQ3IK|&lUh@&z%aRAlBh0(N9Dc{PAy)W#}3H2XAn!xy{o@L}3NDrFb7`8V>0w5%U&!#$W{x z#7?Maqgb;KAQ;8nh0uXhRf-1-A>B*^7aZw@ZfWSp4Sfo9_WCync`A*5aaiJm2%>_x zw^LZh&;|C!?uCjw@8c_sLRbw$_yE0%G?$Kph$TG}aaS?(hj6#I}EE5Hb_+1^NZpY`~_Jt6BJ;*L14XDfAu2d)zSZ>_l?ZIxt8_pmulb=(IcfGC4oU(bAQTFd4%Ae zT(h)Pqj5WKRKZ8$p0s7b1Ovr|n*k=be`hs72U*;py?cN8>ktt`QYP|%n7-;kq6B>Y z6=u|PMv>wU&eH-taBC$WE%pQ%ryP>q`jg&L~p+BM;>Xj2^sdK%Dz-PPas zsvbG5QN`-9fa?fKC@_n3h;1snmZl}Ws_5~%OQ7c6S!^cBM$Q_NDLf-iH z=4TrX=S_aVD45ur0RQDb-?GvDGFQCz%P7QUlj~!)os2`&cE=Ju+w^k#bMLZa#ULkQ z021%yDVUqm&AKo}4KLZb! z6hoE2wbEV)=qiDZSw;BPoWe0P_zta4rf-|oQXnJkUzO&~nGs$U`MsWlI1|IUbz-$Szr6f^3*naGQK9>)ZBalendKcu-GBEfTYA z)syDHAuIX-$65>0a*`M>@U8z-Zz^LQ1Wi$O1AlnL6)jay*4{peOu4tpp+G2r51=DS@ zdX?nRXUiGj90*vqprOmS&Xl^i)dpwcz0`YP8PEdhm}AG?6mQ9b!w!u*0UHunw~?Hq zcUr~>px+_F z?u{b)y6W8bGio%K>5a(8pYU6T2W&}>6=_(q^sJFwYW^EUECSJ+Z$^sxJB;Cxe*NH$ zgC%M}qgVn*)(fXykUyvE*BZY?@zWKL{JY~p4(l+2V^dM3?&QjK>m{py+_;Qe%0&Q` zhTQV;f~|Vld}m=5HQ@5pwxtu?9%Y=B+T%;Dz_<`Zu8rF*CgeXIJN6bfcQbJzyzXf{ zNrF3i6V^*fhh{Z9r1_&rznkDSYIi(MJC4ha)evC|MEk^LpOYq$SWY0!EkR^kakJG? z>}egzVl}O8H6n_b7&alet^e0LHgU^v2q_Rz+|P#CYB$YyTn~GTF%d3#vwC8IDm3T7 zVobtI@p&+m=b7#4vxUvmOx)m%5Q$C8Sbl5M2<@;4jc)vnjJwI2RCUD*He)6s1tQv> znVNWfRJkv$G;%l`MSt0-;-j>H?kj1fu9lHQduZ$OPNaU^CfqCKNDt@o- z3E7j;p>5tSV*V*I_9eJYq&7mjlgzhYFrw`~N@AWPii3n!5|F2CH-zl&Dh3B+r!5lk zyF2#yKWeYVeh3>Nb3NhWOB$`tAL+?OZ-#sDr) z{yG&r*C9{O?yd3pr#So#NqxJBa;_a2grv9m^7(J`!Lh8;ig+MU02$jg}PC2YKjBa{=Hu)h+hDx*+$HdM#k<2dx;LP(SiRUofxVzZT_w|>qOJd;kXRD z`j`$Ek7PTo*?UdUv(l{(s~G zj>6V?E7^I^$k6s+uTS%AwC%xby_<&0yom0xVq0Gk1%m=Yg5Q><(0I1eo&PXaxLHqY zTO0oWXGdmEDr|zw6V=gtOoB_L%MdAA#vQ9qm?+~#_Qr#4a?%ZCB&@(s9}ffpE8v{2 zEd$RlRoua#2PVPaegkiJm#RFPSZh{e&Wg3E3RYtbN>SrybcR;{fcf=0mi(?`>FwS4 z6)dt}lc${4SX|5N!QR6zUoY!8^CLw-t=OS@5sjwsYCquhL`!j8WtV`C1d@5#$Hi-QN5*Tqpy; zZ9D-&K_cMTHXa;FSQQvF{6Usu5b2%s!9Xg}vaAdEyx(Q@t7$phZ1 z!!9_D;`MC*(;{sDmwxHCx9Q9Eg0drs96NQb2(W1vC4}w-8~N7+mlpAQDsiV^@_37Z z4Mo+R0D@b`_P=~2-}D$MbK~>7$43;%*`%A`BPzIlVXyQE{ZMzVL?QJ=n=X9nTcei{ z1~p#k!eJ;BM1EqXvesY8jfqvW1}4Wz*_FTax~tyrP@?aktLZSr7o7b6wf80PP`2OS zQd(%UXD|D{M3#^wlMvZS_BGiRkxVJc-q@umvJ}$TMaI4ik`}UsGAe6Lp<&Ft*UV_q zQ}g`a_x*kTpZEX9=aXl+@9W&>I@h_r=X}q(uSbNwSL-GvPVxS6Lo}0P)P^OPblY&u zfchzgF}@TFy#StRr*eSI7E_68da#$BM$4PC)=j51SRQ*}9A|+00^4h!{;?hLda&%} z0E}jU7IU=?l~KZj-u@w!Mq;Ra`WC3=1hV@W$rn^d1XKymU90x+HHjZNQN;-tnz8NW znLqKZnq%qyk|$|mt~F%tS|H0yZ@mdx|MZE5klq>81j@xE7HOIKY{ zyHk7KSJ4|jK)bTU$P;5T;-DV$cw)LWWcpfQ*O<3nKdpb}M1%SV?vI0^kk}nTf;Wx% zVbd8ecuLay_}Ke{?=DXXsEGS2+ZK}C1jrD3nr>)~Sdr03lA-=}G~>%=bV}5bDBf~r zefh`Lm5x<{RAEz;e(GE1r3Yf38+$QV?S_9V&!`7Ae)7)SU1=zxAug(6k2Dq6ROLqO z;1Zv2m*oW3a6M-vUqM}A5x?o+*e(02j15bD9AU?R2p&Ddv4-*aOT_w6Mh3SIKXg%} ztsa?ImF3-K>|reKYCP61oD}gazt!BGQ(TjeTS8Kp-CyN01eU}sp$X@nt$)S1N4`hg z*fqTBRZ}>jbYgku%rm$z+`G~!|KxpU5oRV4bm`r8bs^(1u^l^@vsh{|&%})x!UIiE zzIx$|eZjNgJFA@%S#k>Ai2K5Azb9zbgTlt*FC!9YA{fm^#F?{9VWpoN)csu!Ck9Y& zIv*o)6H=4!T_xBQKE(};GE*GEn7UfPivuIN{S|hc8)z#XlzM`CI^pV zYG~gS8zfJ!Tq13tA$_x2wiiwi>1#cXy!dGkyg7TB{`^l97jMBy7u-SPF z$E#p~XKfKeD|3wn5|Ng<|y7S}fg}^)D?(j|hVL^~!&Ki*hGrl1Xz5xa+o#yta z(UV7W?4b@R59-uR;+7Dc4yWsIQgN|07(EpwC%B z$T;fWH?ggwVrH56NBCS+~@u%D6dT#vXlfYSl0 z$nUi@ubP*Lj+aYGDa#Rotfx{EaO(Uip?x#PAlKDN){Nrus7gtgSI0dXV%&4C%iRiu zwCQ>EC0CF)&NmSXx7}%V>5f?!QalEQWlcP+9Lpro+Y23x`>{z0v)+1DROLMwG-mB z#hun8@#QICw8U)q_IxKli87$YOw)JbD?dD8IX*Ge-Z7(IV;zu^Fr%Kv%H?R;om85B z2uApq6aq|OIi`{X5`(!Zzk&f__p%7)A0a`2@zmq-V{_Y4nCs61iw+;XJ9uGlCa-ZK z4T__P^{C}nvwgAEcWkuo4qo1y?X3Uo3f0Zxi*M=PrR|_O^MH!os&)(2WZ1;hMvvyk zHmFQZV9u5uCK7gOJA{-)2a*p5Opne-<=fGT6z5D)0zogeQLUSb>4cUjlL}*p_X(YN z6(pZc5LXj2Z3#Zm$g7&iRKJ~94}JH10@d+(PY5&HsbW63w={BRoM{RRiun;FgM~3V z-l}t255c6KiNotB`oP3h`Vl@5;4}p2W&!TqJV|BapojQq=Pv;>UQ@gDp1uOB>8O)f%tb3 z+dEAkr}`h@?GPMDX+(AkdhFK9pBfY7I`&dSNzO&L`(xgXZBgTpstlo#n^f#c@(V-G zy)s0T_6MAEsWy5k<8j|_UsvcAHV5-K(@Hi63-CQ`1QPqTO3%OKN)E(WwxDF{0WiV% z6Fa9%(ONf`983I|L`J?+>Ij!a|Z z7~ES98EPXV_NY6EowN*W)B40I+_6^vq#o*?|GGnoi_SfMNZS_W9$$Wo&v@Q026n<< z_G+(SLeGXJb^&AeBbdO*Y<0zc^B6|YlWzvgGc8^)cm}Q$aGr#5`3BNvaOL$9Cc))k z1Jvhou!}S83)6kQ=^o79BG+qd-%~Ld(4rp_m%%nI;J9MQ8TTJ6Y2BP11bzMxamxOH z8J&n65A{umzsI%et|NR$rG?q6O%!0>(isT7yVj79%fnH!U@a}A`zI@zJOk?jz+&EH zQTgyRaxNnIs=7AM+qPKKN)}pM*0S{)FR0&btIn0#U-9adpnBwBvaN*t;2qBGmZE~T zH-fpFdk7NN2{7af)VzNh0megwZ0$uYfCX(MwmuhBjH!!oy!6n8-Bl@3BaxXVVAr(g zM_bh$&l$c*mOUvYxH8FxmifaCGMYPh;?UsH%zD(an&*QzWWqd00jKBaEIW)Gx@LSF zmcd5jvMUvAgeRQVP|>HPXFE^cVe=@HJhse~t#@LVKkErP5kH<2br64@t5(mE5A5g% zbH6B{x0j2-MHQL8NXotw9jR!n^f=;^T70?=PF#XJ93JyP0B5#dz%Kt$$D{d!(bt|w z>8H0k<8t9+2bl68E~qEY=C)=*qRzIiPt0n)!hD8fsE$Q;exka0yC5{Ey01}YE;Si) z%65#e3T#A`jJxjflvKFw!`*34@dj@D$(tbpH+fUj&rIi@pGvZQS| z`1;l0lD^QfO*|{n)&oAI_YTXf`ciki|aep=QIBXxp0kioXA@J9sA0oi$Y8 z$WmnrGei1E3gQKV9)SXjaUjF~;*h~2LIQnxniBPi6~>JA_|ob8A5es-$Nc0SdM z3iVMdx=;E^6#(4}pYXx=$|0-ZTy!FN$3M2~?fEp8d%Ysg(w4>7u*CYv%H&Hk3w*=~ z`|oMbdc`uif#k9vw&%ibkxFKS$J3hB4g_C7%ES&{w0zq-Ic?5u<|vwL_s#5)RA;}L z-LcxNrDSe0+4!EFeIA?uU?(X(`e<8+W;l)L!d*gMv{i|hHx^BqK5czP!s8ka8djE6 zB7p9gK35DoH7U2Z;8|~oQ;k5y}Hg7vs zE<2wmlmyUn7kzK%8Z9xh!A<$h+s*^o1;Z^Rnp`{)?}59?WyG8+6|nniQSflA7k3~2 zRlK0FXsg+eY44#)i-s!z)GwKPdR>k!r7Vc&xo}iuenwIwa$6WA+lVu8v>Y6a&SyR9 z9#O^@ivkmD9$&#*g8A4BgQ7j{>YhtYcS69UTT3)~zC9Y4fHTCsWLUh|g%`7ZUJNEG z$HcIAWt+`HiZv>k*ukU^)djqXAeij>sf0t2`KLsa?Exlx{{ezp$7)Gw(!bH)YLU22 zewZv1y{_hyv=AHSBbZP8{^3@4B zA};m}LN|yDO^BAn4kZ1Z+FNXgQt-a=yq(%X5x~8j_j%6V{nUI`?d^%1PR(GTQm* zL^Vj;)j=HQ;os9IiTyHm%fi_P_jmQFN`xh(=()4cUpK|*Dktmhsf!#F>}5^hha4z+ zcv@e^PL)2>)44g=4LN0JL0tTmY-jP9c8-ix5!90K{LeB~m$tBl3-eaCG~JI&wvGqG zryiX?Q9>AAu*FyORZho&o*zMKlke1|oYdoIjjfacgb<-2`S@A-$YM04evTuA7a!#s z7GFin0)YjyxsgIdZ`4YR1L+zz|82z1X;Vbl2cV@a!TWs=U;B^{i`q7&K_@;dc$3zI z?R-`k%nvnlgJH<@X`?e#t^#hIw|B|3my)#Yr8~|QhkaO4f!ZCY5V=`OxoVw%(o`no zjhGVkmH|bNu!KIZ!;yL=&Mm?G&EteXNBlqpTOO6EuiS@KdJ1g=02iYA5^I{mg<`Ye zq?-(q&b@x!jv+eGo{+;vwMvBp9ga5%vZt|kPP~nwT5$wYn2(&xOSZgcYrpO>0dmKZ zU%$RKrN>tnc_Qa>#PDPN##V_h7SBPb4&UW=%rnz05DOpqK8K30%SS=NWYzdZla{B; zi2wrjk$Po&)b1N=Jaf*|jEx#j1W24>NBtvIlA=xX2kRqQ5iFxEsSes!h{z8Kdm+XI zGX~j5>v5hRb$6iFx;kpaGsmnH^;G0SWPY*Vv52cg%mm;``XDiKC3vopnPU+i#PytT z&uy@cmsiB4>6|` z@yWz;2WjL_#W&|EX%>Il=xca_&A%EXjEZ}a42FCAGpt*JL+uuWHCN|J(Q_gxmiO$( zlxYcWU>^@3NIVjC#R=FSyADo50f@O=hv`RWZ7cBX{X_>Ksh;eWYt_0{a}STlRbraw z?#2F!_M|85$ez&`xt^?*>0g2Q*gm;fFP#ewQ2GEdCnS1u{XdI%1ZFQScpDNQsgkeQwpZyRrakqT#_S={9|BxzR{C#42L&Y?+?#n}b_yuLjGmHh|7e@}%>Uz9Zs|VkP%eX1I0x8!)8`)AsnSX_Fi5RRw0*(e+Y0vH>?Cot+P?O6 zuRZgwk8MlHgVf`mm=hc_QYhD!Vf!=yfUQ(Ukt?|xktG+_6~*GI~2qPk!*KlVSL-N}FX%&kD7-wGjjdsIn|M`xA(Nv0dhN1UF&g>j>>WWP9U>t$75Yk4XIG?LYBD^CURwBAWFXFk z;QksfGSMK9PdYPHV1!!;;zOr;_t1A=>tcH>C?JZ*af!!CTU@g$Uy$Hgt=Fj*!7CU zupX@}$-Evv`FhIwWB&+<8yqzIi4+f{>Vyv~1aXt^%?UrrxMy{(PA~x4)7P{V4OBN} zdICDzaEzbdS5iq@So0w$tueZBB+2^~5R*R3wY zUQv(qaD-fzI2F>c^jLsNawv5R04nQ}29Wtsbr>G6{Z;jK(n3^`N{>YenNROoeiWb7 z#|(7E*6LhC4#D*TsH3}@BB-V#eC5xS?soPORxAC$ZXu>`00GIO%s zQ~TLg6_erh(Z|bnA;TYj`@Ej~7hBbZy^LohR_$0ojUQ`kE^yE80}l5&qgr$My6M7W z(}zMS^{`Xt0YizP8X`XT_W2a*N6ah!Lc$t}o>|aDIuB!m5cM|MB{09PI#q9v*J+2S z#)wGz_9UGfzP*HGLAlM90M@>u&Q=7LK?3W3c+k>bq3MXhy|!S*qAMOs3yE#Cyp?tR z=>}nT_eyE_g*rFK^L3-qlq;M#5}1I%iN7J8hZTR;1z43dczP;r)lF^WX^V62yjzw6 zPqS~_l@$b&a_YSc{B;o=(F2(Z@dGhaxh(AY$PA%9H<@(wp4FJxHQ;TIV<8+4ihC{X zMbD{3*4G_42%yS+tgAVg5~9dCXnMR>n+g;yNxYI&*I}DvmWyQK4;1aR{R8&$vl^;fSyn4g3OP$)$P+l^Vu-hN7xZOIvQXU)R_o_6jJvqTF$((f& zrWisrLHW^>uc$qB9YPvYS@y*aa=U2(v%aF#?EZt>hx+CZ*PV>t4w=a=2GQn-eR71p z<4D8_9uTbbE=x>Apf_(#Z`CK*kgmCh6l?gt(c^c`seBz-L0f$EGIjJ==f@C6j_#SBF^wRz&DGwBEV}%-?xU>4M(;&bPfXN1bgLbQ+RC zOM@v}{kCxlh|x~gu3*zHfULKk$auabT1?{^C6egA9AZ&nz=Dfz(p|N{^Xt9>PtT#H z3?)jQ$B5JVUu^4mB)=sZHa~n9pbc^6eR%}30`os1Bn(E%?32u_uPeU9oONaNDiTC# z)8qB82r(8gy(>S(*ycsP4s{`$F<(o9>)GEBKerJw`ZPjQw}C!WzfRCnG}oG8`(xAN zbtkEXzd`i3EmvqQ4xmP^8YGAd+zlo3W7HkFuErasg(afyuq04JEb)E&2oy7z7+vJ- zRH^KIzD1YXNS|eDM`Ph#l|w^>1*6S&I=}D`WQRG~j5<6}2G=l$3cc=Nw$ispK~@L! ze$>6H1Q#`@m~8gJdQ3KyklP%-kw(KAtS8?p!MdrC_GSWQwpya`-SXP`BbN zn|iC?rBZdAL|jZspoGj+SMVB-t5?o-0+)A!j4_8?Stt_%y9Sl00m{p9@G5?=Z5T*q zcLcEc!|XTULF=SNs3He_d;nxbZhl^@ufMxikoV+gV|i?+Jh&3*H&0}UV7C$iBnu7o z510>i%(trT&|Jr}unrVO%zLYY)xdV?*KzO|fn){4xMvp7o_@EcK8^Y{}I9*mLim9P{ zaGv~N(~>F%EEtlKzyvwq3(^z!BT5I9PqSUSbKBSyZ8CZv7Lbxu-iX8sTG^MJKJf*l zXLgeS_hwr_A$9y*)bsinD)o-Q;%h0B%u>aGN1a~=p$;oJ48?$|`tx%Ep!mq3BO>A9 z9+pr=yRc9A#2F%2CZ#BVG=FoVr%`~RnccG;lWik-L8C!laS;d0kOmzhFF~%pwZV-r zz6vHp7|%>np*dLm$F_&LyAB)9+NSN;B8L>`CzQW;gL3q7lu0Qh7JlOGh-%$oP^kCO zt{dHccBnp*n4_k^50Vm<73eoEB#f6v3WM>|NcK2WzX;W+!_u)ly1nMyD93oA>=Dl+ z>sD&9kg5owpX>2{QeB}8j;^Se@q{b~$q;9X=@sd4R@s{A^|0zNw}WH+Y!P7(b&rus zRGrR#Qs25PgfhXL_&DaeWagADorrYi*7hA?3Ab1<``rAbSdUnq?I$!vv?XtV4BeYl zT62^+pH6`7d_o+L(=kWRvhc@zb<>8DAa}RuvDd zm}=?{%Q)5D$iFfV+p4-B^B83*CH6)t^khMAq)N{n2KY7`YFv*s%>Bi@Vw{u`!Lnld zgvP>aWInOK!#2G!=SNW-G!{mPjfHJGU>W1(?tsPuo1XiI+pzbLtXkOl>wxW7>Ak+1 zeX2WZ-qLZUJHjl#(jBo+2PGFdV+l{R*kF}9pJy+l!?UodpFm^5 zUlqw#m%Fi2BxSoNT^Hqh!GPGcB2eDBMPN_Q%zO{9Co-#dh{20IT+-MQqBpto9;p<* zTOt?EGCiMtkyPfC%dAWqC>=5VsmC-;>M^}05T-ux-MHi9{p-)-TNfcbb7;{jKCn~F zhMfW9X(JU{2f814d~0pIytF&KEAmaD?D|fN!51DESj!F+1V+_^{T)FY#G0jiDT0ws zyhMb3P&{6vG8A@Us)1vr`Su`mB^r~MgU-EU%RMeed)1~ z%LOOPK$386D$}_;imEh*SiB;9sIO}}X1>zjh?+Z{4!L(>jLBci*1jw65pWw@`Jmqs&A|_2#qV$(rI}Jf}wTP^W zWX*!#2}=mt%x_#~`c}y3RL~edCxGc4%rYuO7DW2+tq!Yu&o4E7CZZjRU`}{*WPTXn zgk|F~NL1MemH>?qzH+Xo;3bR_pwA3s(D6mJi)<{0_Y9r)mI)PA=!+h80mc$pS%GSH z-1s|&Vj~)XAvd>0iDrC|fKXOcU?ZVAcC=|AmW?19$Dt1YcHZQD+xi{ zhgJ)@g5gZ`ZhMHs9cjJ|S2iDsA{#8NKei$#gMd20`ud!+TNdSKC4owH|$iuujO9XD@Xz90oxx@xxN9@3M@c$`{$A zD|lSQQB*2%Q3zp&oJ~e6W(OWzwdPFV7vBxGBF9e~b8+<&fnWTjdi07gva0`9sUrAy z)q#tp19h-OVVg?m`g2R;&hFg5rE-IVoegr+caKm(0ddxr<3rDKRL4sYC#*L zY!K8HPhNF`9BkUZs4h(sMqc&bDRo@-mo@H+A0`STyT)lNGbFpl#JK@se{xUa8WZOR z%tdyM|IJV$T3S>kV+VtIZjp%=GZVm7m=6k`UAy$ptnNxt&FnqXN9~4?Byf z`lf6wQ5ad(f2$O-d9`~2b%?^qx+hSFD2(hHljgQ*wd4J|#=u4-VPx0%-wcJaW0}ms z!i1pqNUmRis<4IfXFQHq*^7$N#_$-BSDh&5$iJxGx+09M>c3U0&vZ3<@)+QV!pN@i zk!;co$*wVRZa^5>eGF_w6h?lH|HV-GfuaV>@hVa%U2P2gYIDAyGp!{g1S8( zfvXaC4b1njdp`&JP7Mj)jS>KWpnu?JRzVo`EyH|ifcv}$WqKV=A0I^}l>T#04n}>? zRwsn;nCsr68W@n#2gmFF;1tAB-xIpIczmFS0@GbANEua;0zdNrFzS19NSNzgb{hR4 zz#?{|=zmT$!Km+vCinvjT>8;eLMnjbTt~0s9$?gW*iA#H?+|JUj!y^71sLFGVgyEg z%iaG=W<$ee<_v-w;)f+sa=)b9y>{!qu`EC;f{-4`Xtr$ZRq~EalCy1f)c6&k5jG@Y zWC8m3O1X-z<^flQNW#cE_O_K7l67q2+<-8$jty)?6h<}(|C^zV47=#nV-e-}-~uhCReKV*%jerr+w(#rTPcV45Z#D?kWPTLwy z{dYdU)=dRXeG=Crbc)xysmOn}cz?|>Ky!C^t(&^mP0b;7in;#Wu3GD+l3wvqA$5vL z-PA95db@IwacbIkxN9qsPTapS)=CCCvQ3S zSz#nZ@D3*)miT-#?+LtKU=O@aj9Fw&Coo~9e| z{zo!_r?2Kc7ab76PsY77%f+hOFbP}z04Z?)H;^hb!SxDs6(7d{P%*6ezQlz4C!T#Q zV0oZZ>{^H|)J=1`gJupf%MJVqgbZuGJAoy}DqX4T5K4j?i2A0L9YAAQC*xy<7 z7>zjKpB93&VsN~J&ia9e;QnuW^E?WA0j)%nfDr5e6a5B=#QXoNhB3N{Dng(ojB!m! zgem6fo^N*PUNEaz-1BYL0Gf%{naS*Nt9)!k0u)XLCjJT$j82s^h1k3VXeqjoT$mzW z$Gs%8$4x}=E-0&lKZmKmLqwCAI|x&bsNsBUD!DL4ybdiUZ*A3;z`&0EEI3Xf9)10}@IWLW$RRknum2d~9d} z{vjC`{wqX)Odmifkt(E24bwGap9Hw3(5hpMvWWvaP$1 z!c+}{#CZUJA`_;DNc`&0VQRPlTa^GUC*#6@g$R)80|+H@9xiea3OEswU;PMB*Fd`fFZ^??9$cc>N6UCo&L9yuQ{`B0?xR zTL1_xMUXfT;7?>AbgifK147B!0u)OCgqA0OSMi3)K`8P1T2G1eGAOzJT9erU0HJm$ zD4}OW211F~*Lq4s2qkL^o5Tg(0m3_UUWASlXgo1}`2LFR`vFnQuWtFVwfUl3lOFrA;7D8;8i@ppU8x%wVu+CFh$N5Akzo$>8B=u zSMfZ^g(>3owVo0&Op&!kli3UiQ|>5Y&xlNzTI(r&doLPFvelpZYhH;hAk#O+>>%(b zG7w6Kcyk`ujiEh0~1+0>hvEzv$b~A=^sb! z$n}(nE{q@?3;WZtueGC2|2Q*9uBSwVP;zIsz)`2qYe${djynC1I&igi)af5#id;{L zl<5>5y{@PKe zU;d{C)+EJ%}Kq$GM5-HOscV=ttsMD_y`hVA7 z0}#4))M+(@lIlNn^8 z=`!PKy!$ZIVnP)c!gkrj6^lGC{rZ+uf7&vB{+J^-7C-bx`!2rFbTMH8T{xIv1z!~D z!GYglRVaSkzdWFgz&uyMVLzwi%ZG88a>U8y(FN#2l?r}l2LeB>vOHi2#SP8kMg$VWG>PyYTH+xSVwShxCbb99ja0i9swia6uQ| z;U}%|Vb~@v9Oj)0ZoUip6_ttq*pd!idY6v>3dO$lAV~Q%fLLyTE@Pm}g$S$@{^RG~ zD=OgEm}!*@q2Nk7)C@NngHZaE9)w#?N8qq6!#JD@ba}K(1z&D8CV_u5iyIj3MJ$ojiI2(n2sdG zDe&8|3oS9#I6Rhzt177)8-s0yVo@H;EmpYcg>?Lv=`QG}Ir`@kcn<8_VeCv&FWwYC zlZ5xj56$Afbm6}YSOs;f;4ocyYz_j`>45{*TbfkCe&P!9!F(u`NLu(Tm(=@q(L_Z# zXc7BzuF$;;x-3_RX<900F2vtrh6W4;eeMDVPsc6h^h$Wt3@4>?BId{54#bt??;yse z3&j!hBcBH@FW{eCF7HLj;oouLP%#Ls+VUh6*DwpkO{ND0;Lw+P3m-2n&dEDWfW z4`ZiiaUZLO@yor2h$UUT6kV-mUnA-L;fe zp)-!3Qfql@c@^t8`BT+4CRc8=&vWzR)(XDMn~Iq;kH^+|o8-JgZ}54T^+_arOwE|l zN><<|^{8ZyfVjj}+1bG`56Rp^@@YKm@s1&PcIv1w$?|8m|{CJWnazK-|jvW)wTPx)4# z*^-h*)wjj!9UVf_xhS>s>Q*%J`Z*NcUNP0?2OmT_3qL%vKb8(hm@#t~o}|p-8>yIi z+W$GO;;>FcE9@TaKy}&aAnK&|r)VE5g>){-sj6;8cm`x&Ii~f{=zYSq55kQ>`6k?s zha2r5(~0ri$nXfX%QzgYt>}G zb>s9|y9+NAK3KmMHZQVQPc(c#Pw}L2qg^k5$WB(-oh5vF#=O)NVdzKQN8c6(aBnE$ z(>Fd8Zt)=swJD0%s@PZHXk}x2_~`A5`93-^kvseHviPj$F;%f5qeY)b_HLuODAHF% zXWq1bT1*E&p6PL*h`v3+T47zj0j1pF>!3E(hn+Cibju1lF_YqB(|*fL=C0=|!5{n- znNoxtx6U80^yV{hXEO0a?%Yop|8b%UvWa3xyZ)nLKcO%UwjVZD31HWBaW*8#A`P)~2L*1=wDsg8OT%l!PQiOTs^xr9ER@>jl<~C2_R)kX6Qb z(^i^+^Zw^y<}{V1fkO}NJJO5&%o=j~YsNa#?Tg6sE{kP~o$!_gQU93Fb*gx=Rh?{Yu_9hCJ2UQVRPzIj?)NM1<}47CcH*JaN@8 z(@_Q?d4;a*xIs$G#v@75%3F0#A28m^=cX#!C7mGHJFXvT8%D$DrOG=~)4GW>zL)i@ zxHyc)DI|iPFZ4J!v*RAW{_r>*>e)ST4Aq9)UwwvSKFO+QjO zbI~rB_Wg+1z$Q4acn1x84pXRU5tAc4v7C!$+rT}zy;ykF4M<vKSal9spkDm-l#!SR;yN*SR%7Dmq=Xhla`>@zrOa|6+4 zqd&HuP4jMSgN($3o11g=!>nw5%LVA`Sq4z-vb|`}z1E4N@KB78sS#!Jm0Rvgj%g}_ zhGQ}(`X?*4uwSsvSuYsCFJ`RyuqnN)ykhj-)~iEPs;~xUzQm(+8=do%+8%W^ys7`l zNO^p0_X)3j6#ns$hhM|uqv6t|)B$&RgR1#lCib9OoHErNOf!^8;fC?x#;*$(m=ubP zb;Im?T;m=^+ztL5&?yr8+2yQGB6I$DS1+SNu`y+g{c`Oz(~_!g2aC6F!Nm5$q{*fS z!>?z@_J67p+ZosTiEXp;&4}KJYMx-ahdl{SsIjckEYrt9Wyh$+3KYv95jZ4CwsZs{vqe2a|kS|&dg7*L-G*%H7Q z1aq;ePjh9z$CRB&+bz9UE%~X54a+?y{;9UtumGDwY0jKr?6Mh@%fC^9vgj-rdtHF_ zh~s8@^x@&wt>6Y%wtLL{V@6*gE+Jvi4Z>S_U)Eo#rWQC_D!HeyUSD5KyEPA;Xh;q2 zk7?U#;}Ut(Nv5qOBe3;QKL2k2W8oSq_jmf+@p|33=)6x)YW%Hvq>;X-#e{24erm2P zh1bnm?e?S2-lt8?f(NyG!#vQQ55>(WZ@Mb!J-x;KW=gh0-LmPt?!{!?gJ;sO?-zI? zb2{+zEoS~&BY$1bMce2Ay5@()qsN{!LMb!WHJ!?-8d(0M(Xl_-dk_7q!%JJl7V|dH zZ$J4)WnK5hz2YO*-k~;>UGOZ&u^UnDkC#gjrZ=}A{CYU7LicukkoP;)69_oudYS=b)C1d{{TH&nq?9PaB}sASQZJgg*s!+=BWA)A?Dc4HeR)B7v> z1%^jHV9&@+N*eK_^aTR);b{r}{Tn)AULp5{-l4boYC~ru^aEMgubrhjJgfP@tlB@P zWDeQTsJ@*t`@I=$673t~OZ%(B_dUT>QKs!J8!ZpAHC@*Rrxb2-FGmFAUh}UpRNE@D zd%v;$XU?6O)U7%R)ar-&TXXgOOWyEn1~=wW@)RR|UVcEO-XD-VDBYx-DnR_Dv zpLZOpm`(T_l`GCmN2*oA(kJQuoc=P>oP zW=1ar?^VWK3dYGbBQwf@#n^3*yPLt!CTU{2@7WYg@9!Vjm#l!k!~id@ZSC62Xv>te z)#ocxO=GK=q<4v@a@_jx(TPvj(t7y>jpa|coZS+|BS-W6rEb3I{$U53tguun;VDt+ zyM$kBz068m=Y1>INI)_gD{3V0Fl@ntf+Y4?^c}VXViG49OZJ^AeW$)9Is=xaAAeBL z+%(N{*0ZzaBK}kVm0DPg19w6tBJ8@djzI#yt;4#ucJ!Ak1C`elwn=DHFcgUTw^h6< zPYOldGMTP${D_h9DmfUE6>_WVbSK;LKB>~$)|d4Xeq6w4!0vc1FW;*EUY@bB{~a_(uX=hSaB7>1k-`ML<_uVGY17ibHbL-*rq zRcb$_zPI#VHvdu>k8DAf%)`pFPQS72jy>;?xVMr*9Al!B*X-@pnq|4I!0$D0jr28t z^_UJ3`b{*86(<^du8vJLsxh}Fcy`y-PwTx#e}eHdF^QR(HjCeRFL34q{jU4sn}*zt z{b&UF8KS!i_kAjKZbR5+`rJ34!tJUlW6dhI6Vxe5{wT0$k}T{JeyK3S#nz@fBg7$1 z*5>#bI98+T{LWznPKa%MJ69RzgWeLe+_J4ge&NE7n69eV+uE%{&vsR#;VRVu{;w{y zb&U;7T}8-FHrURUS#d26y=|DY44f|B;(^^LYgbhrNX@d#4qyYq<=-_dBTSVnPGgO60n6eDlxL8A``x-R0~8M|uXDT>akf_<`^c(H zqKsy$GN!?5IWGxA8~3$o@$GYJJ!^Sv8Rmj1r#qUyN(b>;C1NMEi;l~;Mc2x`rT|*? zp_l8ShhsxXcU2#UZ^Y=uVcXIQEcSB%W~tNjJy(EFrTIza0|SyOF;mmy z^GtZo7N@ApliQmR1T7xHlhAq3P{A8mtg*zUeVtbb-sz<64_Gn+?-F zk0_;}$U3=+;<(m2N(KrBip`rhQ{0W+XBKip=Ee*K1;rCe3JMzV-_>7M-VUxl65@pK zzYcWS#W%hY4Dwq~L9t`iD1mhp6z5ze{5-r*+j@AM7C-0a`s-jzmy3tkHc(K+@1daB zwra2o5C;bPobh*c@cG@)829a$xv42AZl_XE@T?kIyXpILeViQ}&iF`>)F=KRMUeH| ziRgaB1Uv(R_`qaXR|%A+BMKx*`FT3OmD82~YB?K>_;`u}*!SnJWAvmsIoo(U*c+Vj zKIQK8+o|b2n6}ji#tR3U(EcodVjn*Rg}sN}ac>V#9|=1TZ-?Jm=J>fu!zD26CJ?c6 z)$nG4pN89bdj4+oXb;83Brxg|_y_d;=?gFT(`dW1K4(1KekY(kSXR^%Jlc5UuL637 zC@9R;JlxMXxSz2y^!Ie|vG|>UpWSrVPtT{IxF+)J%Kli><62bUfduEJq38yNGaDuR G^uGW~1|3BV(B&E)=mGyKgLTItCEeD~YvP_m4hZ15;8T;D8aUxW*WS5Y{B#d<^ zg^)c4W5_zTu^apNUGE{B?$3Sq`QyI7pWo;4aUMOc`;GT?U9a`|dOfde=Dwt{eFy87 zUAuN|5#}h@+p^)m1K`=oTI{;5iKC^BIp*8LNl_=1byO|Fruf7jhB205X5Ds6g99w* zS&_AxCz!t;wc&akSiv0M=253EY3aI^7geb=H(F(5hnxM~l*R4v;M-qzy0B%ABMvi< zqBDYzN#7&X)uBpPGa}W*(mOL=|f)Zrt>>zZhU>6 z%#e0j;nL#PQqOy*eYg2Yh6v>h3AS7~w@g)t0T@0p{_jhjH zvV~#$mMxclWJ*W0trfT!kMqbWctekB@d(4jep_dm+2p#SV zrh(mM0a>DcGW2HO;r(Mvc<%f$l&G1?3kr1osJ#L z;hY^yy<*1hbK@TzjcH2}fgQA2jmM)(9!n*GF-Y1z&!s`MQeH+$j&)KF64*Ws*|i+&t^DYPTn8sPu+rj8<3UvTDQ9 za>|ziw|4Q+D>SB&60E1bvD@71sVc1S%Gy8&&)L^Y11#g+j-GOgwB9lT*lY>7E@fd@ z3W(GVU!I*!67!hM4Kf^DUB<6Uh!DmvDCXTO6veN&7|$)10L(uLRV*>_YfQ( zi+QnJGsCw$QRzve7?9_RJzeyBJ!7!$b8~xVE%y~JF6@h8ZdIgBXxS((RK+OKdi{z# zm%4`>jh8!&m*&cfJc?U8s3Q-SXGUprtd2!Ic`+gL6Zu%r*}3IHUAcXW!%`h?(*tsG zOH<25vw<f@nsxXzD}VhJ_enfY zT|oi1UMIjZd@{Dr`O?Bfp}mx9RDM$d+VC_Dcbj^7ME;el(#=_lG;J|pHbF~iX88k$ zlE-*ihbM5O=j4)>s;AIggXbba%id!)w>61M8)IB5<1_XE#`KV#f{o8A*RlJm2q8T$ z=bWokFJTah)cLIAlzeqoRyO&netf8}zwcQg2O*W@T}8*-;=*2Z8SBUAS`Wru5Y6Xg zD>pM_F;>U45MJx#S`T|JDAxx+nTc9jY>?}l!&%0lBd8SA)dWAN- zP_+1Zeux9)!K8W7+?*UGYl*bTvfNlRTD3f`)V)j_^q6Utq%F@bkv->}0}UNpKJ1g4 z_DCL|t3iJ#MYJED#7e)6nb%Maoiui&VchL%NasXI>qCx4 z+Qjox4da>lLsirM#6rB`$UaLk^c&A5wv;JCw!=~w4qvdd8!O#c|71#-CLtEO&ymJf zX(UN0%38d&XWr+7f)e)#<->T!d^TZJyG*OXtPVco78O%?%(&I+!M>v%7vV0V1J$|0 zMT^BVy}~)eBSLyP?9J-b-ii@^uC@&H?geabI<12DMz6)&awDmjG7k^SSDuoM957{7 zUS1eV>DXeJR($s%T%h#Pj67;&LPD zg@{ClnnVX>?Qt1rJL|z-rirZ6N)PyCtt!b+C}+fY3|;1g--J(RS6e5S{|ScN5fi-t z{)o@^7{`V>T1#DF|FL%Kz-S))qM!@KFO-1eF%WW|%6t*gw{zJm!5oeyr{h~1+lOD3 z|Jgo#6YX)SM2Xw@Or4SRGbS=EG4(@6>iIgosh*Q>QVBsdac)vdaIdG(@ROz@tgemPV$3f| zj56zL8|cWlIE#xX%U9>9XD4VYmg1LAvNJb)9LSE-=)GNRM%0nSOW`gzHfsiN*tzXh zA1UpodeN&mlg8Tg3F*#Xn*8g#-_s5-g)3e^-%!!*Rq2q*NyI@Smwuag)o|`WM=rc7 z-@WlEP51ovl(_p~hogvN31#tfykR>#Cdfevae=+JtIfFd{VCU5>@2LsDi!D77#m~; zYEoNsb5Cc6JF2D#ilqJ-t#@8K<%0}-pl)p6AjA8~P$f0tAeN|9<|HFrR%3H}2r#xo zHZXQXfMnEg76xN}J8P63ZfIb%xJ$vn#fUWhG(`jzzSa0Az8y6&d^gIokG;vX%gq~7 zgInbrrCJ`PNb(pEdx6DziuS>9^zHGO+*ZfX6cL0d?b3opa7tyG00K48uxF8*DcW<& zyxg_muY`muZ?T~!T&@AJ59r=1848S6lxe{S$>3^^$tqE{OsFc+j#kx(NEu3lu`9B9 z)}c`m8nxTCUK_R=Av{s(C`=Zv%B&$S3njYH|G~quP7#V!YIWbu4pbU0GuNQiNCcH; zlY_hJbWwib7kSdnv)L6%VUlnuq@gv@C>4bPhC@X_h8wVGC`Za=J4(VAY%p0}>cT5i z^Ke(MUX(VU|JA8CqBX*Jn}$Z{kjufI)>ctS`EQC3hqA9k>8Mc}mDGDvBh-(eEpL!# zv^4#E5+{E1>8RyGz3^E%TGyBQowIE^ z*@?WNAWKH&!T#MhH3I#LhLnKs6smC_cV4K7>3Tv|mcM7ikL0ce0^H6sivY^oLdpki zRGuFwZ=01+UXnglM}P0AJU7yX5YAtHykB$9@S;yj*+2;8R?C!4(YxAK=1|1q8$Z9FXSZIB%Kh`QJA(FP0Y=|o{YjCwP1iRmE zQRTZ=TBO*jD&R_KYu7g#A$8d%lqfF@bXwfrOPCZ9XgiAJ{?$p=XyO)UW57=w2E*3( zD-#{fxs0kMbJoH&BmZ`00Ykaz_Q%^k@$xsHyN!6PBsHasu#!KOFK!~4<)IzHb^)GCw?H~cVN zyv01iP!dlRJCRedbRU;%wgSQqj(s7nQrSk9Hsh_4KJmE{Mq+zz6-PbKJ?adi)VP8a zC!YQ1koVSV$!u#EM_g{NHD=vI`Er;_e1xH9o6ZGHWnEid`+nM>&me5-*cDI1id=LN|JKN&&dq>(tW=3ps>q*aDXK&eMmxfyTEvWmU95reU z{D6r{z$?~{m5KL(l|U{f#-FajUdKj}qVjv&Nh0t(!+?>H_%Ub0;(3C-U_wyT zvc_r~ca;dPSu#5kWdm)PyRzW`ePV8JdzA=0+%TXo1gL3xol{tZm%<(x%-+yu>W9Jr zA<_SIj=Zi5Fd{)9wIDCK-gGjtq@@M!DWW-!t2HGOZK=J6l01ev?`!A^`JZ}iEtqE7_R6jq13U{1Re+g zvm~SFbj~7(K#lu;*)a<8d(+0}uLW^Xf3A786DzK7v{X{LZS|MgdqvTC7xIAsTu|12 z6X2i`jr4UQ;eCnHpZm1#gRPo-ygffwE-GHwie1`YFyWM1($Eu*Ohe#cqG;pyW)1I& z{GrmE#=rX@gKvEq=Lp>dH-3Dx(^NgZJ33dt@)UMx-w_h27#h9~Cox!%Q z&3`PNHNeY_uJh zTL6$6z(wD+hGD21pgKy1dS>UkSz_w0xj3~Nv1q1v`J%m~Ilp{9hTRaG^{Dlb42VcBT6Xw}xjVOez#Zlg@Gu#*rY z@H^rf8e23&VLsIkd0_8cC5yN2kfTUZ4UKp?1Y*E$ocXrtO!?)Nzsl@ShkIdlI=Vt z7+UR!3zpD8x-Oo;r}g#DtLA1@rBzGjTg%$vT7b=W8O)s^-T?JsWaM+&2x)jwJ;RS{ zvHz*S`ywNTmuYrZF1?HmiTflp3;?0h=KX2eHY=5)jN7onH?Osko*_v2Eseo9IJErv zc&gI+I4_R127By9|Fr;0dJD55!2K9=^Ohq_n=B=ElWVSHi88LN#hDSXkv+5mge7Hz?LcDH%(^gNWX^aa;!! zuiECujg6!^AVWuEum{KTb4A&C@NO14i-llTw|Bt$gGRlWU4g7DvPy!(B8#I%mN)_J zAF>{@BO}MLBczGJkMTX0&i0uF;a0Eetpw2W*F!1fawdb@X>tZ&GR~4>T~q17m=AnN zE%;bhF_T4cZn2_!!5K-)CpQL1!&Pfi;>nHT($l|aJt8la-Al?=U@DCJW1!zfg7D>a zRt5@Njl)Aupy8tbE zN%yyQc7@?qJq@ibO`%J_I7Bc zO%~2Oj;4s=#Z-36yOb>CB_i15n{lj$FORrQCrp+c>aP>7CP?fY%HpVLxsqqC80gNPX&XQiE+t4v+@zqo zL95g*2?Uv4Ysx3L<}5{xHx_XjyIZ=A=TqyTciF)Li9r+Ih>3zj`nBpkXRrs13Eat9 z+5T8CeK`I+n#{97({90XPvZwxJkYjvl#ZZD7O~7ejv$Oqd4PO3OByaA5sd(zTg)EyUPz{iA8bI`j1)AIFDK=dfyme zBMya&XHjvKMj{SCK|2n=3PT@TXYcgTs;Pq=DBwoCODhs@>WaW*0xvEcw zMdfjPmn)(n5%>Ua?J|n$NXd2=TZe*dfQ2lHJf!=mG=VTQ8=~!uXOhgPx96!KXITW5a zE&ErJ?Kt{vPs{b&SsY5`_q&`BEJ;o89SVLTj=vo^(HsCJ@bY9l9Y#MybxRb;A)HH&wI8{0`5 z=TtBAYuO(Nz4^cZd;eDE(?_-o@24}q1`E&sR5FoQs+oEp<-C`gg_Pv^37|-z;HAx)(w@3AO46y zLS4GEgkk1BEozr@4hH|HBf;tzLM+iq{wLro{;UG#;>NDvGxyzdLt~$P$=%~Sw6el9 zr!}EcQFae-BZpFt5}#-Nb9bk=95o-JC=vxkH$_F(>U_J6MLv_fQa=;hg?(F zy}lHCSPW2|%4to6RHtve1f+%v;6F%x14!Lvf++aOaIB)Lf+Jc}8nor#a5v)PRBuzwdsk z=yy?-hB8(uSw7c9u*ka*0UMR%Q6VmKqPCCbSpO`ClKX=?sGsJMuso&WXgbrb71!(9 zO*+k`QDgnWTv8~yMIw60{y2>9#&-Ap1-}pkXF~{y$Ky@I5$9hw)n!KG>LjbIWgp@! zZ(!+1BOn($`tKTV9ZhVx8h*pgrt6x{#SE+82}4)&6y0vN`P3C&yjWYIy`)ld`dSc- zY{^Bb{5Tx{!NT>%sy9th?Yh${!Z44S&!zRJxdxv3`eOXoUwB9gSfrAlH~w zzHGih`1ICZ9G`>|cTXoN0v%8{=Te{ z92syuH-9fx;Ez5S%v73|Yc^ytueEAb85Y$^b@zOyOo%X))XlzKY~T{9ZuK>v{v=hJ zPml~j5-(s;It7v+ANt>KnFYukc=$=5lcJCwQG&sW2lnA+#sG+I3qus$8fULfJ^`m( z@xfZl`Hhkxdc+GUD4o}mA20a_U-(pqYu%wBM7H*Abf{7@P;GeAs?sphN&&W9oek00 zIe)$IMVl=DghrJQ^CzKgej2oAg@@H?u@y|*;e0O@G?8SK-kN5jHe|u6x2na>jFqz@ z5Z>_v-Ae=hA;#mQNoTwKPvRpm+LqPhK{H{j80Joupn;3-VHbxi*)xAREiG8e9gRa{ z(_x9|Y@(`9xn$p3lRC*&wQqUK<})neq*Q%a1nV{C0hJ(1zWaW8rGXsf6`??Z{ZzD6Lgz-il=@OKqI6-}7{N86~5<+U9KzKWy%Z@PB{iozoAj z>Sr;}zRoS4JZn|ttLdBX;BTQXKt#}8c0J#!%R;jol-Whv0yVl5Yb@IJ`2?9gSix0IZ6TsKIC>%`mZz?O&U zPIQ#A5h6(=`DeperI;TJ1yOJy6DP(wZt!{@i(nOFz6*X;0!}a*Oy1(9=SIzgP-4|k zcaNK)Y6W$bz@&;|HAj(cIxe>t$0tt;BHJXEd+dcsN0`TgoRwRTTl9vstEG3P{d{QX zy5VimV1W>V9@fA$FQY5bQP@T(RT_Dl8pbL-GOx2lP@6SU526SxFc~~(d1g_9;3L1) z#IcwIXjYWH2p(2431mT%oPdpsV^?DRgKicAUr^V_LtbV=_+RrNeGcs(eMymsctcjtZECN~voX zTvkU1M9+7#K1DyJhQAwgdDY&|koiZ#ouWdd6OzYy_s1EU#LGW|%`#^mxOW;s%PlLW zBl33h3A;TRntbaUL@4BGeLj!?pBcc%+eO(RT>Y;*Dd?gR+nvu>ek~s zTeH}c&QX_cj((Cg=%5&C2)jwoEff+pk&rg!)47l5SS|c#l)Ld3@;rF$LtLKtr-M59 zEPqE4wXOIFCT!H6+D0pE-A^gUu6B?HyzkqjgfzIduq8Hw{j$JxIxq z5JfZ`Fo5Dn!Jz)`Os)KaV$Fq+B=e*!k|afF5!v~nyd#?=IU?ltdQ2@1K>XX@x`7rI&1q zdb2wEN-+gZ({cUtzvgMWj_CZAcG#**2QLAW3zWh#L>%oHbDZzh`GhkT3k$N(#1TV3 z>(1Vqm_cQy(vAP>b&M9$YT;_8J1Z*bnxoKlBDUyL^s8*8&#ey%ay&F6CcTpq<%N25 zJ{1~c1qM5)($&8Od&=Kfgy(og*-QT1h zO?z*<8!UVy8nR#Et2D@W=zL25n(x#J5yg#G$lnQUhS<1N!f#PP1NZQ`p*H1rX-r7x z_Bp{v2%i*!juF1J@FsmaB@a)#+(U`z zH0L`K=t(*5OcO7P+*W6IL{BHAMYQr53=7^Yd7crd1i2vjtp{-5fVVPXmtVm7hHjm| z5)T(b`zr~2{3}&AR4F?U+ztug;fwu&=cTcC52!bittAXrr;f7)R`<>9hQfya zc+FeO);)DRn-`%CtToo}wDV)P&Zp83kI-Hvi8&JI-l;l&z7p%@A(r&KX~tK>e3G93 z9gYj_1ob7S7KVgTw$QX(`+@M{1S>C%vZDMz?L!OIbFeV$Rx)B&W+79I*1|$sj-5JD zSTw3?lua>m(VhNC7rLT`QkAMfU=>9iHj+j1j7x)%pFNuRvt#m2fyv_1hQhuC|FV=J zAUD|No80ur_@1o5eD^3)xs|)v#XOZTyTwRFP48hj2FKenQ4X?VXlvbhQQj*_u-m>G zNtyVr`j*vfgC5-qhJ)&nKxUjAk@`Xha6)3jlHn#jXEy#w}cinYMtX&*8yHGCdO9rMiD#j1_m75Sw6 zme5UitdqTD5uBc4&?6lot=x;I2V09%ti0i6S}kC1VRsS%ml@_1-_0OcTixq@N2*s8 zL@Cu5{%vFW-G-~=SXb*M4R8&24b4N&?DOlB=tkf+!4a6;2j@GHtGgVnCWzn1Rn zwb?UZAp#v8vkE(0>`|SKS;Z;c=tR24*fchdN=wf+?`KI)ndja;ZR=(I(u%x2xEi5E z=y5H+zhrr96Lu#BgsyBHnWu+@CAn8Id25TN{<53$AP8(cw=VWv1=}~Bqtue!D3fyzYY zlr%QMBm-i}PRDTb!}3B%N=BrwL5DE%TX=VrDCrEimZY%A7fwAfGG535MoSwTj2s*6 zPXz|=Uyulzn${t?Usbwrcf$Idpheh7R-~_b2cjfp6&OJ8wg?anO3j4Pk){-kH=OJR zFMIO_z=FFEocs}$QZZ0)8haz+C^+yXdj!MDLTlR-AW2prfq=%#!kz3jo$L!brfv&e zCv-N-j31Cq9YRqWMAIA_M%?U+DpD}(RvU#LS0G_D8yO{BAS+NH>yb^*tO8lM!NrQ2 zk$doak_mUry($&9| zd)i^_9jklpEFFo~oHZUSXN*!*=QURYMNoparf^XOFgVvfY;`bu(1hQ^ufcrRchpoW zhG_p99x!`dU&YF$BsoazyroNTAv_=pT@`2dp7XB0%s2tR^%>4kF|sbL=#8?5qh;W?r*#Jat)j zVE)qFYo-XTTuP%LKTmzI*}>EywxH@~{Q95)NP}OLjacc11hDq_69bVa24*v3%aZpa zRO=^_WtWc&BeJg@K7y?t_EmL+ZAa2)2Ub7hHKflLP0E;CYh9QEs~H2U1$m>i<@2nD z$A^+#MK-#Z=WLzv#-W0ib&}WT&>=GpnA`PsnBfkKKg7G zviD9O!ou0zPX}OQ_)}S~CGq+EyRdH`0)SB^!-P-L0iAa>Z08y;{O24kEL{Q)QY-Ql2$fc7y;!2Tb~(ZQ)>1hPt> zcC19?Q~sOAx}t>)JO(1BG?7Nm83`Ib3_;Bl?_828pD zgMVyE)xw%2i9colOhpkaW1QrE?<%&^dO7Kv?Mn}BGDc43$InIV^QD=n%1{ssj4qmda~>OipSmlkMqv`b0ideSv8g{HBH^2AIo zfS4J`QF_iY62dNWgtfw+{oc%?g1HRa#0QVPBOy@FtN$jr8?@~+c+eB9xoy;2i@+E| zZ`}5~tNP9)yDYrEiITd1*}Oda;zMHqcNDgmwA1c6cw0JSfV-^&Mizc-K(@2N-dBqt zs7R8qnFBtjB%0PZ^eNxW=yA3u*zW$FfSv0Cl*68+>5;n9^Fsmn&F=`%0%?ZXxe2w= z0n2H~OD)Mr_vnsRAG}nN2!P9cX05^$X}bw~Ap}<14p9>Kw}yAf`#gcsC!mJK1(@F6 zX(GxA7iqgQVZTLm!G7^pv5_d#I{&erd|ze4Gri6g>vur#@eMBLkyq`a-t_lBRf0OO znr`p+iF+x<2OAVe>OVBlaNyPY88BJ*xa`78D{~d3{c3F;ay6;5FMi%VxdT)RYE;rh zLe>j}<)IymCY~Yp^p=Lw!t4mO;~-z>ktYX+R}2p_|C`|xM%_*7r;A^7-@gXtPc3m` zX)dokoUFAab@5gxN`6pR`<`!6wujD9{3ut1a9LTqJU^BgBr&wug+-T|b@9 zAypuB!+-xVxGp2o{)TH+{D)_5V6AyyRdYTFtSGBswHmeZc>pZ&U3JsGs#2X73pw`1 zXnUYIwzUt5Yn-j*+ZL*QNNGembW~UpVVu5FYC41^SJAR!^7y=AM4Fg&9 zIe)R872V}KuuFZd4e=PUVV9ElAz|JqcPQ-BK*fUUWchUPvAeXU_#vjiG!9;#hA_UQ z=WO|Vl?pj{qw4K~Vvb@-t?do54dKX>!0u;P>^{JDf3-+Z;ytWtr@hY-nC=H?-GlJL zuG%JkT8;LrGt%Rv##VGbLi23z0=}zyn$2-V@CMZd6BKE&j*-Mg{DK1Z4nc26J=G7ab?R;nT-r}h4cvC1^d4hG*T3B zqWFg2ZHja~SUcq_A*J)0K79sIQ_Q-bT}-O>7Kd}OTG_-(kdY^Fd%H~R)Ef+kMC3J) ze$zZpQ^-#f;cmHcU6tS9Ep!#$7Cq!6kh8Y;$9kPuib0elUc1R<)Ek6M?>&NDRO9Qf zu!LcAY|obje+v-dHB`^ia_OwtTO54Nt`g$HQeqZ)SaH0qU&`04T9>SA8+}T+~#d!gShFjqvFh(S6L#@)_nABi1-0l@_guu?O?>ywvS-H13 z^jh%*z56IlIxDZDxsd61Vpqb@JwkOK>$Nl!f^ccurIUTDjbAA}GJ58Hx#Ze7G3QM_ z?=24NuIYm6SamL}t?kv`p&(J!#BQe`iY?R+#&lo3O)mA7GoOTx5RkXYYn@}$ zOmP&Kx15yFNZZRCjEH8xiixXW$9VjJU)2+W2Zk%Svd<~E=W056I5hoR51{Z3PArS? z);7n7b1yez;!SJ(eH92@Wucd6krkGU7M#~Ida``}3iMSXbiK+=@2Y7LyGB33$VZNE z*nYY=hRa*2jNz;TaJ+073RjoteLjGPTgb1ZYc71sW?JVx`dKPo7H*dxGDD3RI@d1w3_!q}? zEBgYsw~jb*irK()^K6h+cr zqF#o7mPr_3!`QqI!%)Y8w<3@yH<)XxIFbusicnwM%P`EIn|!^xXmvsf3JZq&1DR>U zeQgplZs431K+d;#3tLxtU|uH-6Lf++s}lw|5~56S@p?zlJm~XNI(K5dszt!L2Q|5? z8nz0dYcye%5_eX^K(Mem+FWUqNwn7rW+L-9OoodUOk8MDOYch?r~~ba1m3jj8ytm0 za1>-@e9|(}(8@;Wb*|b~Ops|6%vYl9bDx^DRYiH^{$qjcZ1SE1#+rBg=OxZN(M4ZH zL&Qcj90F(vD-MqUXn5td%#9h%;`%GqeTfwbn0o|TnwGDGW7QJ`onu*jGkDWRgM*#l z^zoNK3j`cY3o3}yU3e3b*l^rANx{ta3b6Sou=%T1n=ky$<}<~S5neJQ1l)^Pa)(j&=tG*GN`<%D>) z_<4kva+yXLC}QH#YH8X7BIA$s_+Fd=9aG26mVhAB`jZv*ufpuKOI~EmK_|r6u#GK; zNjsgfk1_99q%clPJ*f5CdEdlYBL#bpMN%B^re`Zb#(B z(DJS25P9HT4}}ytU37jq+F9^xc|lKbrJ2^<;rZzoX>UI}I7jun^nzOIh`@4hIA$e8 zJRbrQSk!|9=IJ3dQgYt(jf68pd7qqn;fvsWxG1__H>73teBF`cFtC2OJA|s6u1~O% zk%k~wxx=|}4yp%bL0 zEVL6bA*kS&E|=Zc3D_hI;KlZGAG21jBnGzeg2UY=K+Z4;v>44omi$?da0lo3*)IRC z5-#u3_T)$Crzz=p5>rm?{y6!f-b=IRb7*sbFt8Q>5^OtbkVSSJWW}M z6K-vPfNLN?_X7mEM9oG+qO;=*Rtr?9W7WjRW$1u^H0%jV=^4|E@}tu6m>`}>uo@j!$Mj!{iK+JONFl-uC(R~ zV6)thwJQFFYiN>Vdrl!F?ZSg4Zo}lb-tfT%=KfSWQklFTRh0NB4O&5Nl5PsLtFt^! zhbMUcTZzX7Dic-f9Kv0a&f%8kwJCrvJs~Jkil@O<$Hd^fBqtYj0!j;8JPH}WoluqU z8K}Orc0`i&d?=`2Rsr14**DBJ~X?-;aloL5Lp zq~GsAw^jannlypvMGlkjiPU;l#Xly0YZvm}*L+Oz*NJmljYKA$b|F{^18c#=;SRw^ zXx7Lbt(Den^y7AP$1&>Kt(O4S?X0->zGm^~Lo2hNAJ%GI;_%vkto_bcM9Lz`))kb45A%cPI1IbMl#Z|zOZ zH0WRx9^<@`qu2B;j%VyU;-m&Hu{yHq^IsChE@1PIs%sn(C&42CXL}6lNzrBDJiY z&hhQ4@?uYDR&P`oV&G9^L4QhE+tv{?&r~Gp|J=?@)KTQh$1&U}gNq{LYPYepjp$ ztPf|h?5;8GjXvwJ-`DHOmE%k;W;MPtd8iz7|F`CQXNGtGP3w=*2s4Jb3&#XY-abN5 zUmrL}3~_A|a&5A$NvpkRaoIQZDay;?T&MoU;TGME3vNxbZ#$hd{H!|~5%;Y2Ijf-{ zaTmp_I3uh%BW3tkR>q?VSJ~fIMzaN79LhCEww(Tv5&Q0hV9um`-YP=ga^^c@M{eJu zd`?X;#C!Oyc?ox|Ewe?iOl&Xr77PB&VM4dy zF!?)uZ!>RM7Y}o$QYKax+I&mw-_z4gvoESNG|$S`D9K$~y*&c&rNTP_`W`qWha zQ%`iRDf6w!?UAP#q`~BW>5g}|nQv8af0bs~63!^1o*w+xzgF{@yx#+bZtgAXk=3`Q zOy->+<_`GfzgCu;yd~-L)_@-=@lS*^tpRduh?W2C!r9iion&yT-imy-UH-dpO1G`~ zRc_aYaQZ64;AF-;_M zhw_K@|Cw+ASpFXC|I39tm1~YT$zT_`UDk}b|NBr6cKvB1i1ytHz?=aw%=4YY{=p`- zx0(B&%EbOKC1k6&MxBB-|3Utj$;4_yoBtsHf&6wL{{eXX)BL9g01x?&=Ckc!^S|f+ z_bCSCuNB0cDf>~N{1fASj}!k5<6RulH~zd;fqVyKh0FKieP1nN$=tQVm@_|&z>X!9RoJBGO*U_1Foa0leapJD);|G>93GO_SJu=$UCE5k4aeEY-X z{wK!!2jBkKctNg`teAK2Wd69+cjxYR;$6)(f3%@%Fl9a<&9J9}`^2puh2D1ZowLuj z|Mb0YzZdV1uiPh&L7V>oqxM8@|H%y6{9l(SApg7A&s(?u$hScL15ahZ=07N9K>quu z7{KQL+PDA2cwx=o)$RX=@p_{DOSn(iG9L(*`J?AM@$^OxUf<9jg>6@<-Wq?3;o%R( z`y}&+PT!r!-}&|*#gk!p2z>jm+6p?X946nn{0!RsU&9KJ|AY|c-KQV<7RavxeEY+^ zeT;ec^7GciKlJT?ZM=Wz$$o4+P%^YnGF*(@&TqyX_I>F6L&*LN%WzZ<$Gg7gzID#F<^;q3?>cxO2)%SN6RO{@8&RZ)T7^Ai$1X-`0i;>cnPjH{3KNL8{r8ro=LB$Cj!G^0v9*L%h#v!CKb#pQMD=F zH#)y*z0KH*+f0p3U^%u4%bQhW_h!xA>{vEig3Xp-vnBYS;2H~n3Z2$!7IrR<{yP;y zu2Uf@phAV8Sg4;_sDKKY|D6iK*QwAFph993UJ8?5ctC}o{hbO0uTvpUz|{QYO={## zusw{fe`jh=8<<*0ALIWq@zA~ywf?V&?(4SGpH`XV%4H9r)|_U{7T=#{eSaXcrH|3| zDCFX>4aXhtfxEvQvCt&7nmOp+2ObA5=HGA=F{U1U;@drLQ56eS8S?%c;Bnw$#tj#s z1y2Mnu3ozgqbI%GA4A?B1|A14-f+pi6S!M@^}2U~C~sm+_x`4Mo7OAdjJ?g&*aVhM zSpNTa)mT=_8{sD4Sa&_|4@PyD40aU>VHF>bSN~}n$349=5sBM>1XsDW(+!&{8xHKhRWcJ@dwc-YWOW5 z;||DmWC$!G6gmSHI<=;}l&D^6&vZUs?bSbQUqAc1R+xEE<^{utQKKy^w6y54vgk1Z z`g$)e3Yos1c>P$`((Spx=L|K27b2zAGsBFYaIM*ETC*(BdL~!+*-q*?H(iJlSFB^{ zYdIoP&wh>UO7$vA5m-zYSbPAjcS118_dtrg)eB8dAmgO<6Lw3#^hpKR;*Lg0E!ywU zdSOr1lppFwOI#7~2QoTKs`+J>G|xpVbdC-}YI#0~*1K5o;NUcpXZJKE_nl_W}e;+nAr$xU>7qEUVV7(E+P1bNX0HCGAw3okv2|)gh zV7Yg_5)8Mn;8LIkBKjG*T#MJ?J8TVfuhm4qK|l*M|E|@%v7mfdD+4?LyeWgw0{kw; zr5mvu{Je^|%^3pLaA*O^Iu^-|)#Sul4JeCNFac$$H2Td0NV9d|{&T%5QHL3cjnD$H zDM+*RQgU&v0Hm91{ku%lF}-hgoNtU}`3~Rm*4VY$w#b#=v1hdcDw!|4W(@I-bt`=p zplwy6Z9lVKC#9(5s@Z*8==H6pWx0KLp5e`=!&Ynmf5c&%vAo_BZKnAq0&W%uI?vd| zn*X6cWOkkF%udO**kjr&O2LFf!Nh#S zG1y-4^XeJjVham31zI4#pHXfjv&&gycHMy48AA&+D{D2kY&a_Xp#1HCkH?ehwKNDV zAnHxZ#JU;#zu5Aq5dx=l(dmT=ey`z`=N2eM;y+sQ5?pa=vz51#dj4te}%>kH0a(M zZ({+UaJV(?wcWKC%md^4t=*0_#w8%{THHCv$UybF-w%!JpWfKDMk6(ys9ql$S(t|z z8S0>M{bL|MuU+j$jSVyUqzG^~voJr0#`VvW9R6#Kx^=d&FvGQ^-w1I34vp*dPG$cZ zA1%%h;7*Ia^@o=9U(mSjbbp}eDwFgw*ZQ{^Xe^(88|TplUCnJ-|DcHHwV8;{)sK^q zhdt2_OWQpb85Tb(eJ%6ca%}BGC(EU@f`j1B5BjjkqRc`^1Y&v1|5;mZ2HR#fZo<{- zC(ZsdaJ89Yn<=)LVw))z^gq}#ZDPGD!z2f_!ahwtWP&4XM!iDf$*GG;ZLvm)Cgh1HfwwT#6qnbb@)0H}cx& z>%2Bbq0?#F>#%Dvmf`DKl^)n^Dqg4;GzE$Ii) zxPi7ES)*+)0Br+b@ctNm>lbL;K-<*TXqy_KZFw%m4-`7VyayX;+mkig76h&%?WVn0 zT#LaxFs{?KBkQycd>3(GkWql@71R%n>%8{DI;E|d>_<31SkF1nBs%$Lb!>CX1p#_ z81K(`JsyU}gZ2;Sdz#;+Kd$>|q4HMXbGmn3g@r}{<&kUgORCp<*WwHG@u94WyRG%t z=1&%;;)h#U`kIR^%rcLbIebzu(Qz&Qs$g=2KC1A57qRP{GY_$$FMxSufI#3RcVVBEZ zY6a}&<~j&_cmu4@ZFnH{A+D#HIalD}O|1h30zfS=etvoFi$K{=0sas9RZfHT14JI` zsTkT?`?RsBWC`qPX8~$~@y3^vgF)A}m#L_*#2*Cfm$9n|$BW3|&W|w0x3c^+$_Uf~ zx0c%=xVvOLwx1 zJaTiFW8_=^z>+(rMls+Jq$mud|b%mZ&Mm&dz1xugy)k;;q};YA*|-Q8!Vo)88| z4JjV3p9<&Z86+8>lFtZltHOLewvB@MdSqJ}`JMg_&6>M@yCP$@@4s7#`MMAobY!bm z*ai8eCh~>LKVutoV*0$pZ+c+`;c=wo|@xmSF)&Wn~~b<@?{ve!#c$6{(bn z>e1Sc&b~~MY`2MTMM3YZ{CV7gtI?*Lf}_8qo1dCZeC1$>&eo;i#^d#}h%Wi5i9T9)gCgVrljP`2w8N_1E1y_+*Vl<1!Po%C0oS6@wm zUe(WXr8?BSB4uQ|>QSQcq>P(0!<1;sEy_!;_68EkuP%$7`#viqT)aOhFcq z{BF*4QIIeG^BL1a=So?@_mg|G;yjLW@Y}d!54tNCgOHrNtF^9NT z?`)<<(E{+BPRh9~CN#$@gj4<{N-@#xy;%&8zEI|E~S&w;yTV z-jytUAw}9tkNX9j``mHn`s2)T>tzMdPJNT1jP>PObzR^)kYoAb5gCd+UN;2<~Y=b7p74!PR*E;pbx%Q=>wsc^> zXaJt#1*dHkz?tDX7mp&V!#+bB=bgHO8CvY)Xk~tGMNz zCOtmp^3wC$U$NZT8uZ7i@n!Bm7o=hl=fxjYdu}(( zAkLdTeCnK>9^WT0aW5<{&YL?t^E{J+_<#@lJ&XGNBCK^U4jWu}uBMS$`+HEd#UWpQ zSlu}`Sl)B*L$1gtaDm+k{WS&QI_3v*vDuAD@>CnSG)xYtBeMUN55| zZT`4gzgWi4uKJg1{TG;!Th+fsWq4uO2O^I~W?Ud2?~MHRYGvHKfrcdS#$|*9r1INq3mj18ZiN0q+sMZN7dTjPGh>H!LZA8De`jJn=M-`op)}zq_KSm>y}-+ zc5M;nDA(Jv;lIP+*~wbW5p8RQu`n~U!-yH%nptDS=s%nkbwXK-LO(Ym5NKla&r3U( z_T9a^jk4X@d}KyMQeT|7_sy9GpBqe5sIwZGFxBTfF3*k8=BwE#AAQ5p%AU)ddgRj_ zfDIJ*kZXRUdXMMq_@wQ4*ERe=xbDKl9t~;N%h?%?1(ssQ(Mx24l(M{Q9V*2EDWZp3 znix(TsrGQ2PU52>#9oQGYdJQ)&gZbZ@c;Go6+m%r%hrRtI|O%kC&4YaySokUHW1w1 zB@o=*-Q9w_y95XX3%ul<|GsnX`QN=gRa0YoRefuB_wMOlHM7@>eO#)LR%Y zqt`fVE3DS7;2O7+WMNea9Fo_KkVjm>9cT-EKGy;MFY2jsUo(G1uCQ6 z|ILk)nnuunb1}0?JFC=aCXGTd6LjizM+!l|RDW9}28siCELWzm@Z^h}x#lGnp>TdS z%a;I~H`QMt<-5P7G6UaZD-dGmjqVlNe<1BgLG5v?k_>BJ~7L5wnnm+aSje%n?b~Qy%eU z{szv1lCTAXeI2$GQy_38QY9$%+HsBIPQb5|NbY(H=PC^o`wMKY2wQC%Q+2Zo_Z({} zq+C|S1p~TzsOh|Cz4hwrck{*4Tf0w|X|yOqw8jsKL89adKhjE8t)GolJ}JbU&`FSS zexL#ogxeau1;&aS3dV_e21ddIjCX8j4ix;~G^Vh6AlOCO$;88|h2QC-!5_79<$~YM zMDwCT3u+Bh1WS;Z3WItXVibo=e?9`kTA7)FpT!*L5MPQp*aBo&278f=NmO2X%QTwOuyqx%WpD3XLx z@7*6GXx~xY;;{G^q5xJNGa;Lw5`=^x?d^oz$l2k{K8Q|~E##~PqPB9lPsty*X99JY z+jaDEz8oc=u}eqb<+vZ%@(WTQ<3Azua92c4|*(`Ffs~vhSovXgq$r%4=pRXVrK{Ieqp@P!)#rerZCPBq-b_YszpwpfxK$115FVH^Cn?8%J_lmFfYGbH} z&y^b=RB351!EHHBlAf;4nwaNsZ%c1vI~&+&X;A1wLR4avb#xP6`iV0fH+kwvHhuv zH1p_-ZE;FEZ%o%*`0Aa>D)X zY?FrVTm8{?QjXTxS71wzxWGHbJ3i$0L?=V=`-us-3B)IGq~=m8Hg4agDusOt{1GJ) zn&o_{()ZAk5UJ_GgkUW%6;x18{eCRs=o7fN<{-^9%&d=NbTu(sHz{fNTvP#V`pmR+ z60q@hz(;I_&EkGp≪DWar{u2bkUtA(C}_&Ig9WZFB2aRW?qW7JP1I6CV_ z_vYU0>_p7O9gpb{^2$! zTNwp2*9pORr1Kwty>2DBvGrNjbP;p}&)1=OcH?&~33Kl=L1A!BhuQ zNV?L;37GHU4)wZz%W$PP%4nAb4H*8-LR)s6xJdP)y94D^%`=sUWtUm=mt(S$fmbK6 zmMRX((&z^{YglVI&FpDfQ{xRyQiQj!HiAyk@GUmCicD%XL#-X#c=cnmnwKdS)C-8T>4~A`&xL{jv-dA(^bptCsG#=(}Vp?F^ae(Zq{5DLv*~Ta*{!ln?u@fNMPSz^OfcV(^nxZ@8y&(y2~Vye<}HPOuPB ztlk1OA<3j*Bz&Is8b$;QxdS|C3;?H+XaL zQ%PCJEqLP|x_D6On8;(jS@R~xg;^(QPNV9A`Pu~bop85ZY7`Ylgu?okSsC9fW_P6Q z&%u&AGD(@cuF@%__Bb%I##v^OItJ~Xs$4?%ivu4OU$W{4_!fq%4?hkfHRo!#hRGGr z8)kV)h+pk**ze6`L=4W1L>VU6E>UVQ@S+~-6R~h>MB}RUtPl+ zz7rLqu#DAiLuKpflL&kx&OUHCK+LM<5t-E$YmxYi7E#LbV+<8f zmQkn2JWMC`#(J->@t-XB-m~AzQP1#te#f;>Knsb5)GyHUIA-m+bB^E0-0J|MigSg= z3Tv5ein2g|JId%C?Km_=+@5aiAiF`%cjTjCyE4b?Kb+N=)D5z z5Cb)|t%+MBtsA7sectT{I+}%MWd#dq(xl1CC@kg@y4)^zA5l;NE+YsT=SGOfXgdzZ z9==m#zg$(o%<&%>G1y5>)qRQtbYGl_-dbmBFk3Tp-cr^6)ZHdprF1-+w61OIAU)Hm zIZxgA*l==X$Q+*!p*cCk(2vsChZ{zuO?<+8_uwxewlTcX`9%D?EG-pjhme2=01z_( z|D`O&__Hi^u{5(YWB%j*k6Lt6V-2`Yg8DP?6=Juucd3)MU8ycpjaXalwCR++_PVfl z8Jx@NwF}qV&POKSoZQR+e2+bpoxLY+yu2F^3MD9#!@|bWKob=ed*5hmm-FS$`OOn7 zATBL9?J%lh2LtV!_3a6IwW$ajcoIJbeMd-m(jYu38Vx%(j;CIQ zmYqbri57d(PEzk`ZugL2Y(57`y8w@Q&}c*uMnqu(Q$hnODoYk^bZ8JN?e-zXO-jO? zXi^C1M)Y$sO3hBE-Yc3w*P1di5sRLv%p1w7Za%co0c!J7H@*f$pZ5{vhvHp=T`wPe z&?g~rR^2sc?AOimTIdpd|45Sg>h1Dl@ex+k%WrJ8Sve+o;J|i#v5~KVP zvro)_Sk;hwg{ui8J4k<$}l))t70ge zywh31yLx+154y9Hby^q(o%RE6w`375EsNXxIIizr*a#}1YH0)JKFtdHK0-8BcLVCa zrl~?>-h5*t!D4VcH6<9R?K+zW{X*C<>0)Sb z`$2`-W%gL3$4lIS`yl@3gH1={QpQ+CBVZs-EjquI92VNp44V&VOcf$A zjtAfQq?-oynT6Yk?HZPO0=yNVwQYom3KFuw!M z>`QV(VkgEZoKX&o^FS|V%MKB2#rE^<+njE6CXn?WCSc`{@aO6$e+99 zMtyCtW&;^jU$;}D>)^+WePZ1;4|N}tlGhF1oR?GHH1$7x=^9}~Kz184BVgLPYJTQk zUxL7uA4-0lv@m`qn7pLoaO^>Z^hX z7@Nk&EX0gRB0`2D+vw1Qv1G~6v~2W43u>__rsmC2%;{r}S&&0>k_)6$T_N=j-3h+w z35O;liek>6RX?U&^#@ddmaC4?yv@CVZ{#Cl9j^%lD4`T?cHAHP(*(vV$Lr1X_Pc>7 z&vH%p=YVWz07FfR-_MPB@sL`(_>qs)#1&f9;c0AdE$d9&k_6c}FD6>BnqZ07VY)QW zo6*AE!j{v@&6(c_QkBKP0u*qI=b`O%YHiSleH}VkZZ=3R7|S2`&=;``&0L6vp-6w? zJ@HiLA%D|2jc zptdONJT~6x^bZulHTGtg-XgGpH`XseYKgIZJWGD15Qhz92+N3~;DUS4Exo~GN*`UE z10^&0^f1aPl1}v@jQd`SEt(kcAb{R-63Ws=Ed(AHWG|XXY8jEwEu^w7zgHt7lw0JG z#_oTP zBqZ1E7ikngsT*>W>I==7k6vq-0IKQ?U!aJ)K!h|@Yxm_!L=*???(Ayr%lS1m{c$yp zGYJiZu!t94$W#=?Wg2g%Yeb;@J1SK7QVTSy1dYIevJ70CkVbF)(yPXNRSt~G8BB-t zrOyQX!%4|OCSwk#JQGURQkOWZnIM$~qy`Ck@USpM7pyc2tC5Dan7*J8#gn5Hb41Oo z__%O?4+*Tp3TCQBJOoq!5`_Fbay&thvzxaYe%}t?M!HyT4wT>R5WA&msQp@6u6}`>Qz!6Ck(EQm3}szLy8O0(4kV_1_^KYJ(SS1#B`PtQZcF6 zo>RenJww1d$A_s>Q8&%skvs*>3V^B$ZPPb{T0=PGz%VG`P^k)x)|B-3%v>`XbgNOK zAn2kx3`KyUL~;S2w4~8jxAmAPIP-=Ddf;ujFX0~sKWz01n|}8xTE>9-Lao2n55`i7 zY9`*N55RY$=|Q)=?~N$sEI8K%_N8snV!dncr7w-5i42Ka=d0`8GYD5`bn4pw=Awv9 zfy)ps4&=BCxQ_1caRSj%UP|@}5c-fELwyRSNpFLGC_q2lfOKTz^GieZ*QPH+UvZuT zv#LCjztYQf>%(ZsGK_oMg_ku91%tA%h^_S5%xSsz#T0Qdk_J9(4`u&6GUipHkcv=8 zT-**qli{3`9?Y*aAZ@13sKQMH0c=}yMRM!N)X@W2Y!JR%RN*|`m1WoQC@DWww|4|} zmqJJ@yCC5_D|;BjyP-({XIL+D_9^Quq1X~B2_dxk?)uXn=3_*;K{L3}46$Cd5oHM; zbqM8|M!G4sX|3b%L-{ya?NdSN(PDRP92che(R7K9RmWf~AjrL#ee4)k1Hn4cuya%z zi|dVfeDI>xR9Uzn?wq1V#ZZp#2KKIOQ}yY6MUIR-_yU@v(#9VMhr3fE%J}$<+EboF zRid|5e@G?8+@Yv%LHXLyC zcwLau6g1dE$RL+O;yk!d7${U2($SkGbk7QLp<-VEJQp!K|D(t834x zBsg@C_50I#q5)7Q5kjZ*{;G?MESgs`y|^4Ehjbrh48Z~_PZ@io-u$Jh6+$_*8XIm1 zvF>3goT+2=0auZ!F@rpap0WucL!dY$+(u*FMbL>TfWdhQ}NiKiIh_}X`GD00dCTrncj3|Hw;x zoIph?R2PESMej~J-7#`6;!yDlJ@&+cPEJE7u}IbVo_ntKYWxPyWzhG7?O}J3YD!%Q zYKL#G`T=gu9OQ^Uq7@Z?-kE!G!Z2#%ChKBf1Z*IDxVAs?Y>1@fmd*>S2U2E>5c{F| zz|V)QN&}a1e!?a+tBi@1lU<}A9yHSn-w5Woqr*G7GFxdu4z}72B2P$(piOSqP4*7AfV19!o?Q0%R5jeWbr|f7)qpp zLA*+z*cbLNlZ#1GdC2ayiljcl5h~YY0kz}JRJH@kCU4&Z8fZo{Kx{kpJ5e-2U%o0d zUTAnMbaPL(g=DNkz0NvHHrxla1J><_FKi&pVqb@ z2E?Kpi*MMfC1d3*@Ms3(oMYa6K%$71pQCd9VR8yB&%RI6YCx|cI#K2HG&az*b>rKl z?Fjn%s}vE0;A$R;eDrHI@fVbbnha3%89l50yy5o@EA_TV<+22yIk7FUiInap&Me9v zpR9e4nST_Xd0#TEs{GWZ1Ho>LiBX$hUkc5iG?l@j7x~nV#qRs+4jaZ+Wg(7wWwK;E z_{qd8undtq5K+gzasA~3jhihx{T9mM8fWfBZ;Lwb$7hQ8nt1GNpR4Xjf_wjV;5;gv zX`(*|l->dbhaj#egFRoOr=TadR%De_+E^|uTF^q7kamEU0RzM#;3g?e--9qP$e%g9XA2e5C6fF3#MOIn_mSiM_yfs{ z$}CH4m0Z4a5OM(+V`!L4`(?_;>9mGZ;Mx#o6G{N=MqG?!e^aIVdBl)WT2}!D!?Wo1 z=~1xI;)@7fIQ3qXW0`JujmZY06#&IX?wCC(qcJ8EVpYiw`Xu@P*K3w z`qpR;T(ofrM2ePzSpyzE*y01s;-uA211y(Xp8U-H5o~opyvdmu15eLbz>c)q3)LeOAPv6t%xn$SOR1=;^DuMy zoAND+L;kqZTFS-e1eZCZawOMxDJh_|o3FZ&pmGDw0}5BA-b_kF;-Up}q7OEsGQ)?B@ilb0KT1Z9iXh0_1`M1usZf`~uAt?Tw`b6#&k%Yu23MAp7pd zWmDs$WOQMeC+Q&nJ*X;~fMKCoHIb4tKnlt3P&M%o3H=auIrz3SH`vB7Zp^Sg(V4-m zO$P9_YFh&>)abaC+aSN8ms}o?TeMVS4F)$F`qR9M`nwso6p|qa(@73i(bAZoaj-i z0ZuH0a4P1?fc@|n3!CWa4+J`Rk)udIfEs5j0!<&$317v7YfFCslpy<(-$y610Ivp{ z9hSZ>GoQh6n?AUmYQcxUtM#tGrB3!%oBK8UHc83LEXVvY_TO+c?JHnH zYeWU>cE>6iV*O6lY51|eVFla`t>`wHZgY0h#x31ScM)9`N_AKsqdH?v0^a7tg0hSp z3GxU1%;URHGMz>=srF{FD!Qnsv5X*X z@R(1o*W*x^gH>I6`m4k(V9G9*-EcZUauZFDoK&U~RcB>2J0o4B>?-V;TRePye_zpD zZlVba61N+%Mrl7?I^E}<0V8`HFk{Y9g03Tiy3G_qj6}gRzLr zH8nMkBmVg6|GRILeMk*`j|KqTNd33I5z_zb8@YJen*Gr*I?%9FSYttbg?dIw=~gK& zG=`uQR!p%nScc)VGT0cfVt7I4Ws-Tk<6o0Au*B1fN5v?`TysAK} zS~po2IwE^deQTO=n`*n~#4Sf=V73rh=Z!Krknd`ugy&+?*r|7$J#MR^EWf16HWE71 zW~e4f`B(?Q5KBiUmo#0|bLhHocgfmoIv*v8wkj68gaw(LhB_Zmb0_bd`jxQ*f8xe) zjytFBv)fgs;Qr)l$f;W_-!NXS!`UG9ds_KH^-iK0f!BoU)?)Chnd<5{$r?8SXH=F? zKT_P{&c2yd`HFZ~eoE~QezJ^tzw3E^PdsV$y>{s{?f}B+uPgxZk1*y$jJAzpoS>) z5RzT#43~W7vYtZ{arva#1E%Xer+H0Yw-HAaTJOMGWQ7jb7OwfoyX8~&c2UL7XVnXH zU@O1OMhU06Q&2aY<X=D}BU#CAt?dt_UXf<-|ARgK~c|rH07i5sR)C9hicA7UHr;u*Zx*zHf;t zhD62*&_M$3Dv*9pnTI`YMo94(^1H~Hfr!KeE8F@~v3bAR$inoxuNdC;pTx{nju2Yd`)FELA25TmRY= zafKQFu$85{MCFg+S#mU{Yeg`qbIWYCl%#U2Pxske+kB`ZIQrplgD-D0mi0gJy{-dj z-FxXvBG4hdFl>)>psqqwpQ%yP8=Bith_Is4jC8i_^lO&}*jHRx5s~q#mCg4Y zW?Es<-fwY`B4ub6sY}?!w28OUjZ3B<;wc)KMs%vh-8X?d;*!5o^K-~qIN(fJ2`OmM zQCu@PeU@iT2sH5IDi7=z(znoL9F4O&e?+1VtM5|l)^FH63A&F)XZDb1ZMN?fV1T>D zn`7k{dxA)>AXfcQG&mATtlx1OO?EKG)DPuL_+_0#L3VS z>!cSSZ0Ww^Jpe&Tn~}PX#&8he+DOaHGnxhz5p3x}H~s|rAmP3*P(oyZ$L3`DwTN7B zJWayBCDA$w`jKh+$9gw`qHkKoEV$1X1jCEdZ^W5xKt&HS*WB45Vl0Dj3K@GAculHT z3c<~=A%?u3@&tbY&CWl-7_Vs$>g8OzIA6VJ>aA`4CFA+JZ=I%-XU*_pLZYC+dTpOV0RYi*s&aXOt zlx8Khv_`G3Kj11*BNG!R`x$}EVS^)*z! z#%zjo5<+Zvl=5uaJF-96eS|le-5=py!YRnF!?K(=1v%>NV$wIHhVOLz(qg*n57zC% z8WcHyF^&iMn{_a7Ou%1qLKtJKPf)+!gZUM%xW9P+cl#wSG<7m^|2ocva60i0RK6n z{wKiS%ckg#RtV{<-w;ne_L`^_PV${4X8< z%A5aO{P(2tJK6qa=u3Yr{tv15pE!Sy*xxDWFB4n-w}kZ1g@1Rtf9IZg<^K$CMHwjQ S-{|naZW+H)Vd3iUXa565V0&!< diff --git a/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/citation.bib b/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/citation.bib new file mode 100644 index 0000000..595a916 --- /dev/null +++ b/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/citation.bib @@ -0,0 +1,8 @@ +@article{bbm-233, + author = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan}, + year = {2024}, + doi = {https://doi.org/10.1371/journal.pone.0298788}, + title = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy}, + publisher = {PLOS ONE} +} + diff --git a/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/metadata.json b/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/metadata.json new file mode 100644 index 0000000..04aab91 --- /dev/null +++ b/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/metadata.json @@ -0,0 +1,7 @@ +{ + "id": 233, + "name": "BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE", + "url-publication": "https://doi.org/10.1371/journal.pone.0298788", + "url-model": "https://github.com/Ktaoma/BoolSyn", + "keywords": ["source (?)","curated (?)","repaired (?)", "multi-valued (?)"] +} diff --git a/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/notes.md b/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/notes.md new file mode 100644 index 0000000..ba2e26e --- /dev/null +++ b/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/notes.md @@ -0,0 +1,11 @@ +### Modifications + +Removed regulations: +WNT1, WNT1 +PG, PG +NRG1, NRG1 +INS, INS +IGF1, IGF1 +ES, ES +EGF, EGF +DLL_i, DLL_i diff --git a/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/source.bnet b/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/source.bnet new file mode 100644 index 0000000..57db0a2 --- /dev/null +++ b/sources/233_BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE/source.bnet @@ -0,0 +1,110 @@ +IL6, IL1B & IL6 +IL6R, IL6 | STAT3 +JAK2, (IL6R & ABL1 & IL8) & IRS1 +STAT5, JAK2 +IL8, STAT5 +PIM, NFKB1 +STAT3, (IL1B & MAPK8) | JAK2 | SRC +STAT1, JAK2 & SRC & EGFR +GATA3, !STAT1 +PPARG, !GATA3 & CEBPB +FZD3, WNT1 +DVL1, FZD3 & !YAP1 +AXIN1, !DVL1 & GSK3B +APC, AXIN1 +DC, APC & GSK3B +CTNNB1, !DC & WNT1 +TCF4, CTNNB1 & JUN +PAK1, TCF4 | RAC1 | PDPK1 +NOTCH1, DLL_i & CTNNB1 & LCK +NFKB1, NOTCH1 +RELA, NFKB1 | PIM +JUN, (RELA & MAPK8 & PPARG) & ERK_i +NCID, NOTCH1 +HES1, NCID +HEY1, NCID +MYOD1, !(HES1 | NF2) +MYOG, !HEY1 | MYOD1 +PAX7, !MYOG +KMT2D, PAX7 | !AKT_i +IGF1R, IGF1 | (FOXO3 & ESR1) +HER3, NRG1 | HER2 +HER2, HER3 | (FOXO3 & ESR1) +PGR, PG | !(ESR1 & ERK_i) +ESR1, ES | AKT_i | (FOXO3 & (KMT2D & PGR)) +EGFR, (EGF & RELA & (HER2 & HER3)) & !MEK_i +GRB2, (IRS1 & SRC) & (EGFR & HER2) +SOS1, GRB2 +HRAS, (SOS1 & PIP3) | !NF1 +RAS_i, SOS1 & PIP3 +RAF1, (HRAS | RAS_i) +MEK_i, RAF1 +ERK_i, MEK_i +LCK, ERK_i | !AKT_i +TWIST1, ERK_i +NF1, !TWIST1 +PI3K_c, (EGFR | ESR1) | (IRS1 & IGF1R) +PTEN, S6K1 | !SRC +PIP3, PI3K_c | !PTEN +PDPK1, PIP3 | IGF1R +MTORC2_c, PIP3 | !S6K1 +AKT_i, ((MTORC2_c | PDPK1) & PIP3) & (IRS1 | (IGF1R | (EGFR & EGF))) +FOXO3, !AKT_i +FOXO1, !(SGK1 | AKT_i) +CREB1, AKT_i & SGK1 +GSK3B, !(AKT_i | ERK_i) +TSC2, !(AKT_i & ERK_i) | (PRKAA2 | GSK3B) +RHEB, !TSC2 +MTORC1_c, (RHEB | PIM) | (NRG1 | IGF1) +S6K1, MTORC1_c & ERK_i +IRS1, !S6K1 & (INSR & IGF1R) +SGK1, (MTORC2_c & MTORC1_c) & PDPK1 +NEDD4L, !SGK1 +NF2, NEDD4L +LATS1, NF2 | LCK +YAP1, !LATS1 | ABL1 +TEAD1, YAP1 +IVEBP1, !MTORC1_c +EIF4E, !IVEBP1 +MYC, (((CTNNB1 | PIM | ERK_i) & !GSK3B) | ((STAT3 & JAK2) | (ESR1 & KMT2D & FOXO3 ) | (ERK_i & (IGF1 | NRG1)) | EIF4E)) +P21, !(ERK_i | AKT_i | MYC) +CYCLIN_D_c, ((TCF4 | TEAD1) & !(GSK3B | (CDKN2A & P21))) | ((ESR1 & KMT2D & FOXO3) | (MYC & EIF4E) | (MYC & ERK_i & (IGF1 | NRG1))) +PRB, !CYCLIN_D_c +E2F1, !PRB +P53, !MDM2 +MDM2, P53 | AKT_i +MCL1, !GSK3B & ERK_i +BAD, !( PAK1 | AKT_i | ERK_i | PIM) +BCL2, !(BAD | BIM) & (CREB1 & ERK_i) +BCLXL, !(BAD | BIM) & CREB1 +BIM, !(BCL2 | BCLXL) & (FOXO3 & FOXO1) +BID, CASP8 +BAK1, ((BIM & P53) | BID) & !MCL1 +BAX, ((BIM & P53) | BID) & !MCL1 +CYCS, BAK1 & BAX +CASP9, ((CASP8 & CYCS) | CASP3) & !(AKT_i & ERK_i) +CASP3, CASP9 & CASP8 +HSP90AA1, !PDPK1 | ESR1 +NOS3, HSP90AA1 & AKT_i +IL1B, NOS3 & RELA +STK11, !ERK_i & FOXO3 +PRKAA2, STK11 +PAK2, RAC1 | SRC +KRT14, PAK2 & EGFR +TRADD, !KRT14 +FASLG, FASLG & P53 & FOXO3 +FAS, (FASLG | P53) | !AKT_i +FADD, TRADD & FAS +CASP8, FADD & !(ERK_i | SRC) +PRKACA, AKT_i & WNT1 +SRC, PRKACA +ABL1, GRB2 +ABL2, ABL1 +CEBPB, ABL2 +CDKN2A, !(MYC | SRC) & CASP3 +INSR, INS & FOXO3 +GRB7, INSR | !PRKACA +RND1, GRB7 | DVL1 +RAC1, (PI3K_c & DVL1) & !AKT_i +MAPK8, RAC1 & RND1 + From a90fa294e071ff36829a542d42958ebc8285f5e2 Mon Sep 17 00:00:00 2001 From: Natalia Florekova Date: Sat, 21 Sep 2024 21:24:17 +0200 Subject: [PATCH 2/3] Added model 234 - breast cancer signalling pathways MDAMB468 complete --- .../README.md | 45 +++ .../metadata.json | 17 + .../model.aeon | 382 ++++++++++++++++++ .../model.bnet | 112 +++++ .../model.sbml | 1 + models/summary.csv | 1 + report/.~lock.online_only_table_1.xlsx# | 2 +- report/online_only_table_1.xlsx | Bin 58432 -> 58474 bytes .../citation.bib | 8 + .../metadata.json | 7 + .../notes.md | 19 + .../source.bnet | 112 +++++ 12 files changed, 705 insertions(+), 1 deletion(-) create mode 100644 models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/README.md create mode 100644 models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/metadata.json create mode 100644 models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.aeon create mode 100644 models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.bnet create mode 100644 models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.sbml create mode 100644 sources/234_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE/citation.bib create mode 100644 sources/234_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE/metadata.json create mode 100644 sources/234_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE/notes.md create mode 100644 sources/234_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE/source.bnet diff --git a/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/README.md b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/README.md new file mode 100644 index 0000000..29787b0 --- /dev/null +++ b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/README.md @@ -0,0 +1,45 @@ +# \[234\] BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE + + - Variables: 111 + - Inputs: 6 + - Regulations: 271 + - Publication: https://doi.org/10.1371/journal.pone.0298788 + - Source: https://github.com/Ktaoma/BoolSyn + - Keywords: source (?), curated (?), repaired (?), multi-valued (?) + + +### Modifications + +Removed regulations: +PG, PG +NRG1, NRG1 +INS, INS +ES, ES +EGF, EGF +DLL_i, DLL_i + +Regulation: + +CYCLIN_D_c, (((TEAD1 | TCF4 | STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3) + +was updated to: + +CYCLIN_D_c, (((STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3) + +as the analysis + + +### Model citation + +``` +@article{bbm-234, + author = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan}, + year = {2024}, + doi = {https://doi.org/10.1371/journal.pone.0298788}, + title = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy}, + publisher = {PLOS ONE} +} + + +``` + diff --git a/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/metadata.json b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/metadata.json new file mode 100644 index 0000000..bffc4c2 --- /dev/null +++ b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/metadata.json @@ -0,0 +1,17 @@ +{ + "id": 234, + "name": "BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE", + "url-publication": "https://doi.org/10.1371/journal.pone.0298788", + "url-model": "https://github.com/Ktaoma/BoolSyn", + "keywords": [ + "source (?)", + "curated (?)", + "repaired (?)", + "multi-valued (?)" + ], + "variables": 111, + "inputs": 6, + "regulations": 271, + "notes": "### Modifications\n\nRemoved regulations:\nPG, PG\nNRG1, NRG1\nINS, INS\nES, ES\nEGF, EGF\nDLL_i, DLL_i\n\nRegulation:\n\nCYCLIN_D_c, (((TEAD1 | TCF4 | STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3)\n\nwas updated to:\n\nCYCLIN_D_c, (((STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3)\n\nas the analysis\n", + "bib": "@article{bbm-234,\n\tauthor = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan},\n\tyear = {2024},\n\tdoi = {https://doi.org/10.1371/journal.pone.0298788},\n\ttitle = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy},\n\tpublisher = {PLOS ONE}\n}\n\n" +} \ No newline at end of file diff --git a/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.aeon b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.aeon new file mode 100644 index 0000000..333aa21 --- /dev/null +++ b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.aeon @@ -0,0 +1,382 @@ +v_GRB2 -? v_ABL1 +v_SRC -? v_ABL1 +v_ABL1 -? v_ABL2 +v_MTORC2_c -? v_AKT_i +v_PDPK1 -? v_AKT_i +v_PIP3 -? v_AKT_i +v_AXIN1 -? v_APC +v_DVL1 -? v_AXIN1 +v_GSK3B -? v_AXIN1 +v_AKT_i -? v_BAD +v_ERK_i -? v_BAD +v_PAK1 -? v_BAD +v_PIM -? v_BAD +v_BID -? v_BAK1 +v_BIM -? v_BAK1 +v_MCL1 -? v_BAK1 +v_P53 -? v_BAK1 +v_BID -? v_BAX +v_BIM -? v_BAX +v_MCL1 -? v_BAX +v_P53 -? v_BAX +v_BAD -? v_BCL2 +v_BIM -? v_BCL2 +v_CREB1 -? v_BCL2 +v_ERK_i -? v_BCL2 +v_BAD -? v_BCLXL +v_BIM -? v_BCLXL +v_CREB1 -? v_BCLXL +v_CASP8 -? v_BID +v_AKT_i -? v_BIM +v_BCL2 -? v_BIM +v_BCLXL -? v_BIM +v_FOXO1 -? v_BIM +v_FOXO3 -? v_BIM +v_CASP8 -? v_CASP3 +v_CASP9 -? v_CASP3 +v_ERK_i -? v_CASP8 +v_FADD -? v_CASP8 +v_SRC -? v_CASP8 +v_AKT_i -? v_CASP9 +v_BCLXL -? v_CASP9 +v_CASP3 -? v_CASP9 +v_CYCS -? v_CASP9 +v_ERK_i -? v_CASP9 +v_JAK2 -? v_CASP9 +v_PRKACA -? v_CASP9 +v_MYC -? v_CDKN2A +v_ABL2 -? v_CEBPB +v_ERK_i -? v_CEBPB +v_GSK3B -? v_CEBPB +v_INS -? v_CEBPB +v_AKT_i -? v_CREB1 +v_AKT_i -? v_CTNNB1 +v_DC -? v_CTNNB1 +v_SRC -? v_CTNNB1 +v_WNT1 -? v_CTNNB1 +v_CDKN2A -? v_CYCLIN_D_c +v_EIF4E -? v_CYCLIN_D_c +v_GSK3B -? v_CYCLIN_D_c +v_MYC -? v_CYCLIN_D_c +v_P21 -? v_CYCLIN_D_c +v_STAT3 -? v_CYCLIN_D_c +v_BAK1 -? v_CYCS +v_BAX -? v_CYCS +v_APC -? v_DC +v_GSK3B -? v_DC +v_FZD3 -? v_DVL1 +v_YAP1 -? v_DVL1 +v_PRB -? v_E2F1 +v_ABL1 -? v_EGFR +v_CTNNB1 -? v_EGFR +v_EGF -? v_EGFR +v_HER2 -? v_EGFR +v_HER3 -? v_EGFR +v_IVEBP1 -? v_EIF4E +v_MEK_i -? v_ERK_i +v_AKT_i -? v_ESR1 +v_ES -? v_ESR1 +v_FOXO3 -? v_ESR1 +v_KMT2D -? v_ESR1 +v_PGR -? v_ESR1 +v_FAS -? v_FADD +v_TRADD -? v_FADD +v_AKT_i -? v_FAS +v_FASLG -? v_FAS +v_P53 -? v_FAS +v_FASLG -? v_FASLG +v_FOXO3 -? v_FASLG +v_P53 -? v_FASLG +v_SGK1 -? v_FOXO1 +v_AKT_i -? v_FOXO3 +v_ERK_i -? v_FOXO3 +v_NFKB1 -? v_FOXO3 +v_CREB1 -? v_FZD3 +v_WNT1 -? v_FZD3 +v_STAT1 -? v_GATA3 +v_IRS1 -? v_GRB2 +v_SRC -? v_GRB2 +v_INSR -? v_GRB7 +v_AKT_i -? v_GSK3B +v_ERK_i -? v_GSK3B +v_HER3 -? v_HER2 +v_EGFR -? v_HER3 +v_HER2 -? v_HER3 +v_NRG1 -? v_HER3 +v_CASP3 -? v_HES1 +v_NCID -? v_HES1 +v_NCID -? v_HEY1 +v_NF1 -? v_HRAS +v_PIP3 -? v_HRAS +v_SOS1 -? v_HRAS +v_ABL1 -? v_HSP90AA1 +v_PDPK1 -? v_HSP90AA1 +v_IGF1 -? v_IGF1 +v_STAT5 -? v_IGF1 +v_IGF1 -? v_IGF1R +v_IGF1R -? v_IGF1R +v_IL8 -? v_IGF1R +v_INS -? v_IGF1R +v_SRC -? v_IGF1R +v_STAT5 -? v_IGF1R +v_NOS3 -? v_IL1B +v_RELA -? v_IL1B +v_IL1B -? v_IL6 +v_IL6 -? v_IL6 +v_IL6 -? v_IL6R +v_JAK2 -? v_IL8 +v_STAT5 -? v_IL8 +v_TWIST1 -? v_IL8 +v_FOXO3 -? v_INSR +v_INS -? v_INSR +v_S6K1 -? v_IRS1 +v_MTORC1_c -? v_IVEBP1 +v_ABL1 -? v_JAK2 +v_IL6R -? v_JAK2 +v_IL8 -? v_JAK2 +v_IRS1 -? v_JAK2 +v_ERK_i -? v_JUN +v_ESR1 -? v_JUN +v_MAPK8 -? v_JUN +v_PPARG -? v_JUN +v_RELA -? v_JUN +v_AKT_i -? v_KMT2D +v_ESR1 -? v_KMT2D +v_JUN -? v_KMT2D +v_PAX7 -? v_KMT2D +v_EGFR -? v_KRT14 +v_PAK2 -? v_KRT14 +v_LCK -? v_LATS1 +v_NF2 -? v_LATS1 +v_ERK_i -? v_LCK +v_ESR1 -? v_LCK +v_JUN -? v_MAPK8 +v_MYC -? v_MAPK8 +v_RAC1 -? v_MAPK8 +v_RND1 -? v_MAPK8 +v_ERK_i -? v_MCL1 +v_GSK3B -? v_MCL1 +v_MAPK8 -? v_MCL1 +v_AKT_i -? v_MDM2 +v_P53 -? v_MDM2 +v_EGFR -? v_MEK_i +v_RAF1 -? v_MEK_i +v_RHEB -? v_MTORC1_c +v_PIP3 -? v_MTORC2_c +v_S6K1 -? v_MTORC2_c +v_CTNNB1 -? v_MYC +v_EIF4E -? v_MYC +v_ESR1 -? v_MYC +v_GSK3B -? v_MYC +v_JAK2 -? v_MYC +v_PIM -? v_MYC +v_STAT3 -? v_MYC +v_HES1 -? v_MYOD1 +v_NF2 -? v_MYOD1 +v_HEY1 -? v_MYOG +v_MYOD1 -? v_MYOG +v_NOTCH1 -? v_NCID +v_SGK1 -? v_NEDD4L +v_TWIST1 -? v_NF1 +v_NEDD4L -? v_NF2 +v_NOTCH1 -? v_NFKB1 +v_AKT_i -? v_NOS3 +v_HSP90AA1 -? v_NOS3 +v_CTNNB1 -? v_NOTCH1 +v_DLL_i -? v_NOTCH1 +v_LCK -? v_NOTCH1 +v_AKT_i -? v_P21 +v_ERK_i -? v_P21 +v_MYC -? v_P21 +v_MYOG -? v_P21 +v_MDM2 -? v_P53 +v_AKT_i -? v_PAK1 +v_TCF4 -? v_PAK1 +v_RAC1 -? v_PAK2 +v_SRC -? v_PAK2 +v_MYOG -? v_PAX7 +v_IGF1R -? v_PDPK1 +v_PIP3 -? v_PDPK1 +v_AKT_i -? v_PGR +v_ERK_i -? v_PGR +v_ESR1 -? v_PGR +v_P21 -? v_PGR +v_PG -? v_PGR +v_EGFR -? v_PI3K_c +v_ESR1 -? v_PI3K_c +v_IGF1 -? v_PI3K_c +v_IGF1R -? v_PI3K_c +v_IRS1 -? v_PI3K_c +v_JUN -? v_PI3K_c +v_STAT5 -? v_PIM +v_PI3K_c -? v_PIP3 +v_PTEN -? v_PIP3 +v_CEBPB -? v_PPARG +v_GATA3 -? v_PPARG +v_CYCLIN_D_c -? v_PRB +v_STAT1 -? v_PRKAA2 +v_STK11 -? v_PRKAA2 +v_AKT_i -? v_PRKACA +v_WNT1 -? v_PRKACA +v_S6K1 -? v_PTEN +v_SRC -? v_PTEN +v_AKT_i -? v_RAC1 +v_DVL1 -? v_RAC1 +v_PI3K_c -? v_RAC1 +v_HRAS -? v_RAF1 +v_RAS_i -? v_RAF1 +v_PIP3 -? v_RAS_i +v_SOS1 -? v_RAS_i +v_NFKB1 -? v_RELA +v_PIM -? v_RELA +v_TSC2 -? v_RHEB +v_DVL1 -? v_RND1 +v_GRB7 -? v_RND1 +v_ERK_i -? v_S6K1 +v_MTORC1_c -? v_S6K1 +v_MTORC1_c -? v_SGK1 +v_MTORC2_c -? v_SGK1 +v_PDPK1 -? v_SGK1 +v_GRB2 -? v_SOS1 +v_STAT3 -? v_SOS1 +v_ESR1 -? v_SRC +v_PRKACA -? v_SRC +v_EGFR -? v_STAT1 +v_JAK2 -? v_STAT1 +v_SRC -? v_STAT1 +v_EGFR -? v_STAT3 +v_IL1B -? v_STAT3 +v_JAK2 -? v_STAT3 +v_MAPK8 -? v_STAT3 +v_SRC -? v_STAT3 +v_EGFR -? v_STAT5 +v_JAK2 -? v_STAT5 +v_SRC -? v_STAT5 +v_ERK_i -? v_STK11 +v_FOXO3 -? v_STK11 +v_CTNNB1 -? v_TCF4 +v_FOXO1 -? v_TCF4 +v_JUN -? v_TCF4 +v_ABL1 -? v_TEAD1 +v_YAP1 -? v_TEAD1 +v_KRT14 -? v_TRADD +v_NFKB1 -? v_TRADD +v_AKT_i -? v_TSC2 +v_PRKAA2 -? v_TSC2 +v_ERK_i -? v_TWIST1 +v_JUN -? v_TWIST1 +v_MYC -? v_TWIST1 +v_PGR -? v_WNT1 +v_WNT1 -? v_WNT1 +v_LATS1 -? v_YAP1 +$v_ABL1: (v_SRC & v_GRB2) +$v_ABL2: v_ABL1 +$v_AKT_i: ((v_MTORC2_c | v_PDPK1) & v_PIP3) +$v_APC: v_AXIN1 +$v_AXIN1: (!v_DVL1 & v_GSK3B) +$v_BAD: !(v_PAK1 | (v_AKT_i | (v_ERK_i | v_PIM))) +$v_BAK1: (((v_BIM | v_P53) | v_BID) | !v_MCL1) +$v_BAX: (((v_BIM & v_P53) & v_BID) | !v_MCL1) +$v_BCL2: (!(v_BAD | v_BIM) & (v_CREB1 & v_ERK_i)) +$v_BCLXL: (!(v_BAD | v_BIM) & v_CREB1) +$v_BID: v_CASP8 +$v_BIM: (!(v_BCL2 | (v_BCLXL | v_AKT_i)) & (v_FOXO3 & v_FOXO1)) +$v_CASP3: (v_CASP9 & v_CASP8) +$v_CASP8: (v_FADD | !(v_ERK_i & v_SRC)) +$v_CASP9: ((v_CYCS | v_CASP3) & !((v_ERK_i & v_JAK2) | (v_AKT_i & (v_PRKACA & v_BCLXL)))) +$v_CDKN2A: !v_MYC +$v_CEBPB: (v_ERK_i | (v_ABL2 | (v_GSK3B | v_INS))) +$v_CREB1: v_AKT_i +$v_CTNNB1: (!v_DC | (v_WNT1 | (v_SRC | v_AKT_i))) +$v_CYCLIN_D_c: ((v_STAT3 & !(v_GSK3B & (v_CDKN2A & v_P21))) & (v_EIF4E & (v_MYC & v_STAT3))) +$v_CYCS: (v_BAK1 | v_BAX) +$v_DC: (v_APC & v_GSK3B) +$v_DVL1: (v_FZD3 & !v_YAP1) +$v_E2F1: !v_PRB +$v_EGFR: (v_EGF | (v_ABL1 | (v_CTNNB1 | (v_HER2 & v_HER3)))) +$v_EIF4E: !v_IVEBP1 +$v_ERK_i: v_MEK_i +$v_ESR1: (v_ES & (v_AKT_i & (v_PGR & (v_KMT2D & v_FOXO3)))) +$v_FADD: (v_TRADD | v_FAS) +$v_FAS: ((v_FASLG | v_P53) & !v_AKT_i) +$v_FASLG: (v_FASLG & (v_P53 & v_FOXO3)) +$v_FOXO1: !v_SGK1 +$v_FOXO3: (!(v_AKT_i | v_ERK_i) | v_NFKB1) +$v_FZD3: (v_WNT1 | v_CREB1) +$v_GATA3: !v_STAT1 +$v_GRB2: (v_IRS1 & v_SRC) +$v_GRB7: v_INSR +$v_GSK3B: !(v_AKT_i & v_ERK_i) +$v_HER2: v_HER3 +$v_HER3: (v_NRG1 & (v_EGFR & v_HER2)) +$v_HES1: (v_NCID | !v_CASP3) +$v_HEY1: v_NCID +$v_HRAS: ((v_SOS1 & v_PIP3) | !v_NF1) +$v_HSP90AA1: (!v_PDPK1 & v_ABL1) +$v_IGF1: (v_IGF1 & v_STAT5) +$v_IGF1R: ((v_IGF1R & (v_IGF1 & (v_INS & v_SRC))) | (v_IL8 & v_STAT5)) +$v_IL1B: (v_NOS3 & v_RELA) +$v_IL6: (v_IL1B & v_IL6) +$v_IL6R: v_IL6 +$v_IL8: (v_TWIST1 | (v_JAK2 & v_STAT5)) +$v_INSR: (v_INS | v_FOXO3) +$v_IRS1: !v_S6K1 +$v_IVEBP1: !v_MTORC1_c +$v_JAK2: (v_IRS1 | (v_ABL1 & (v_IL8 & v_IL6R))) +$v_JUN: ((v_MAPK8 & v_PPARG) | (v_RELA & (v_ERK_i & v_ESR1))) +$v_KMT2D: ((v_JUN & (v_PAX7 & v_ESR1)) & !v_AKT_i) +$v_KRT14: (v_PAK2 | v_EGFR) +$v_LATS1: (v_NF2 & v_LCK) +$v_LCK: (v_ERK_i & v_ESR1) +$v_MAPK8: (v_RAC1 | (v_RND1 | (v_JUN | v_MYC))) +$v_MCL1: (!v_GSK3B | (v_ERK_i | v_MAPK8)) +$v_MDM2: (v_P53 & v_AKT_i) +$v_MEK_i: (v_RAF1 | v_EGFR) +$v_MTORC1_c: v_RHEB +$v_MTORC2_c: (v_PIP3 & !v_S6K1) +$v_MYC: (((v_ESR1 | (v_CTNNB1 | v_PIM)) & !v_GSK3B) | (v_JAK2 & (v_EIF4E & v_STAT3))) +$v_MYOD1: !(v_HES1 | v_NF2) +$v_MYOG: (!v_HEY1 & v_MYOD1) +$v_NCID: v_NOTCH1 +$v_NEDD4L: !v_SGK1 +$v_NF1: !v_TWIST1 +$v_NF2: v_NEDD4L +$v_NFKB1: v_NOTCH1 +$v_NOS3: (v_HSP90AA1 | v_AKT_i) +$v_NOTCH1: (v_DLL_i | (v_CTNNB1 | v_LCK)) +$v_P21: (!(v_ERK_i | (v_AKT_i | v_MYC)) & v_MYOG) +$v_P53: !v_MDM2 +$v_PAK1: (v_TCF4 | v_AKT_i) +$v_PAK2: (v_RAC1 & v_SRC) +$v_PAX7: !v_MYOG +$v_PDPK1: (v_PIP3 & v_IGF1R) +$v_PGR: ((v_P21 & v_PG) & !(v_ESR1 | (v_ERK_i | v_AKT_i))) +$v_PI3K_c: ((v_JUN | (v_EGFR | v_ESR1)) | (v_IRS1 & (v_IGF1R & v_IGF1))) +$v_PIM: v_STAT5 +$v_PIP3: (v_PI3K_c & !v_PTEN) +$v_PPARG: (!v_GATA3 & v_CEBPB) +$v_PRB: !v_CYCLIN_D_c +$v_PRKAA2: (v_STK11 | v_STAT1) +$v_PRKACA: (v_AKT_i | v_WNT1) +$v_PTEN: (v_S6K1 & !v_SRC) +$v_RAC1: ((v_PI3K_c & v_DVL1) & !v_AKT_i) +$v_RAF1: (v_HRAS & v_RAS_i) +$v_RAS_i: (v_SOS1 | v_PIP3) +$v_RELA: (v_NFKB1 | v_PIM) +$v_RHEB: !v_TSC2 +$v_RND1: (v_GRB7 & v_DVL1) +$v_S6K1: (v_MTORC1_c & v_ERK_i) +$v_SGK1: ((v_MTORC2_c | v_MTORC1_c) & v_PDPK1) +$v_SOS1: (v_GRB2 | v_STAT3) +$v_SRC: (v_PRKACA & v_ESR1) +$v_STAT1: (v_JAK2 | (v_SRC | v_EGFR)) +$v_STAT3: ((v_IL1B | (v_SRC | v_MAPK8)) | (v_JAK2 | v_EGFR)) +$v_STAT5: (v_JAK2 & (v_SRC | v_EGFR)) +$v_STK11: (!v_ERK_i & v_FOXO3) +$v_TCF4: ((v_CTNNB1 & v_JUN) & !v_FOXO1) +$v_TEAD1: (v_YAP1 & v_ABL1) +$v_TRADD: (!v_KRT14 | v_NFKB1) +$v_TSC2: (!v_AKT_i & v_PRKAA2) +$v_TWIST1: (v_ERK_i & (v_JUN & v_MYC)) +$v_WNT1: (v_PGR & v_WNT1) +$v_YAP1: !v_LATS1 diff --git a/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.bnet b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.bnet new file mode 100644 index 0000000..9eac06c --- /dev/null +++ b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.bnet @@ -0,0 +1,112 @@ +targets,factors +v_ABL1, (v_SRC & v_GRB2) +v_ABL2, v_ABL1 +v_AKT_i, ((v_MTORC2_c | v_PDPK1) & v_PIP3) +v_APC, v_AXIN1 +v_AXIN1, (!v_DVL1 & v_GSK3B) +v_BAD, !(v_PAK1 | (v_AKT_i | (v_ERK_i | v_PIM))) +v_BAK1, (((v_BIM | v_P53) | v_BID) | !v_MCL1) +v_BAX, (((v_BIM & v_P53) & v_BID) | !v_MCL1) +v_BCL2, (!(v_BAD | v_BIM) & (v_CREB1 & v_ERK_i)) +v_BCLXL, (!(v_BAD | v_BIM) & v_CREB1) +v_BID, v_CASP8 +v_BIM, (!(v_BCL2 | (v_BCLXL | v_AKT_i)) & (v_FOXO3 & v_FOXO1)) +v_CASP3, (v_CASP9 & v_CASP8) +v_CASP8, (v_FADD | !(v_ERK_i & v_SRC)) +v_CASP9, ((v_CYCS | v_CASP3) & !((v_ERK_i & v_JAK2) | (v_AKT_i & (v_PRKACA & v_BCLXL)))) +v_CDKN2A, !v_MYC +v_CEBPB, (v_ERK_i | (v_ABL2 | (v_GSK3B | v_INS))) +v_CREB1, v_AKT_i +v_CTNNB1, (!v_DC | (v_WNT1 | (v_SRC | v_AKT_i))) +v_CYCLIN_D_c, ((v_STAT3 & !(v_GSK3B & (v_CDKN2A & v_P21))) & (v_EIF4E & (v_MYC & v_STAT3))) +v_CYCS, (v_BAK1 | v_BAX) +v_DC, (v_APC & v_GSK3B) +v_DVL1, (v_FZD3 & !v_YAP1) +v_E2F1, !v_PRB +v_EGFR, (v_EGF | (v_ABL1 | (v_CTNNB1 | (v_HER2 & v_HER3)))) +v_EIF4E, !v_IVEBP1 +v_ERK_i, v_MEK_i +v_ESR1, (v_ES & (v_AKT_i & (v_PGR & (v_KMT2D & v_FOXO3)))) +v_FADD, (v_TRADD | v_FAS) +v_FAS, ((v_FASLG | v_P53) & !v_AKT_i) +v_FASLG, (v_FASLG & (v_P53 & v_FOXO3)) +v_FOXO1, !v_SGK1 +v_FOXO3, (!(v_AKT_i | v_ERK_i) | v_NFKB1) +v_FZD3, (v_WNT1 | v_CREB1) +v_GATA3, !v_STAT1 +v_GRB2, (v_IRS1 & v_SRC) +v_GRB7, v_INSR +v_GSK3B, !(v_AKT_i & v_ERK_i) +v_HER2, v_HER3 +v_HER3, (v_NRG1 & (v_EGFR & v_HER2)) +v_HES1, (v_NCID | !v_CASP3) +v_HEY1, v_NCID +v_HRAS, ((v_SOS1 & v_PIP3) | !v_NF1) +v_HSP90AA1, (!v_PDPK1 & v_ABL1) +v_IGF1, (v_IGF1 & v_STAT5) +v_IGF1R, ((v_IGF1R & (v_IGF1 & (v_INS & v_SRC))) | (v_IL8 & v_STAT5)) +v_IL1B, (v_NOS3 & v_RELA) +v_IL6, (v_IL1B & v_IL6) +v_IL6R, v_IL6 +v_IL8, (v_TWIST1 | (v_JAK2 & v_STAT5)) +v_INSR, (v_INS | v_FOXO3) +v_IRS1, !v_S6K1 +v_IVEBP1, !v_MTORC1_c +v_JAK2, (v_IRS1 | (v_ABL1 & (v_IL8 & v_IL6R))) +v_JUN, ((v_MAPK8 & v_PPARG) | (v_RELA & (v_ERK_i & v_ESR1))) +v_KMT2D, ((v_JUN & (v_PAX7 & v_ESR1)) & !v_AKT_i) +v_KRT14, (v_PAK2 | v_EGFR) +v_LATS1, (v_NF2 & v_LCK) +v_LCK, (v_ERK_i & v_ESR1) +v_MAPK8, (v_RAC1 | (v_RND1 | (v_JUN | v_MYC))) +v_MCL1, (!v_GSK3B | (v_ERK_i | v_MAPK8)) +v_MDM2, (v_P53 & v_AKT_i) +v_MEK_i, (v_RAF1 | v_EGFR) +v_MTORC1_c, v_RHEB +v_MTORC2_c, (v_PIP3 & !v_S6K1) +v_MYC, (((v_ESR1 | (v_CTNNB1 | v_PIM)) & !v_GSK3B) | (v_JAK2 & (v_EIF4E & v_STAT3))) +v_MYOD1, !(v_HES1 | v_NF2) +v_MYOG, (!v_HEY1 & v_MYOD1) +v_NCID, v_NOTCH1 +v_NEDD4L, !v_SGK1 +v_NF1, !v_TWIST1 +v_NF2, v_NEDD4L +v_NFKB1, v_NOTCH1 +v_NOS3, (v_HSP90AA1 | v_AKT_i) +v_NOTCH1, (v_DLL_i | (v_CTNNB1 | v_LCK)) +v_P21, (!(v_ERK_i | (v_AKT_i | v_MYC)) & v_MYOG) +v_P53, !v_MDM2 +v_PAK1, (v_TCF4 | v_AKT_i) +v_PAK2, (v_RAC1 & v_SRC) +v_PAX7, !v_MYOG +v_PDPK1, (v_PIP3 & v_IGF1R) +v_PGR, ((v_P21 & v_PG) & !(v_ESR1 | (v_ERK_i | v_AKT_i))) +v_PI3K_c, ((v_JUN | (v_EGFR | v_ESR1)) | (v_IRS1 & (v_IGF1R & v_IGF1))) +v_PIM, v_STAT5 +v_PIP3, (v_PI3K_c & !v_PTEN) +v_PPARG, (!v_GATA3 & v_CEBPB) +v_PRB, !v_CYCLIN_D_c +v_PRKAA2, (v_STK11 | v_STAT1) +v_PRKACA, (v_AKT_i | v_WNT1) +v_PTEN, (v_S6K1 & !v_SRC) +v_RAC1, ((v_PI3K_c & v_DVL1) & !v_AKT_i) +v_RAF1, (v_HRAS & v_RAS_i) +v_RAS_i, (v_SOS1 | v_PIP3) +v_RELA, (v_NFKB1 | v_PIM) +v_RHEB, !v_TSC2 +v_RND1, (v_GRB7 & v_DVL1) +v_S6K1, (v_MTORC1_c & v_ERK_i) +v_SGK1, ((v_MTORC2_c | v_MTORC1_c) & v_PDPK1) +v_SOS1, (v_GRB2 | v_STAT3) +v_SRC, (v_PRKACA & v_ESR1) +v_STAT1, (v_JAK2 | (v_SRC | v_EGFR)) +v_STAT3, ((v_IL1B | (v_SRC | v_MAPK8)) | (v_JAK2 | v_EGFR)) +v_STAT5, (v_JAK2 & (v_SRC | v_EGFR)) +v_STK11, (!v_ERK_i & v_FOXO3) +v_TCF4, ((v_CTNNB1 & v_JUN) & !v_FOXO1) +v_TEAD1, (v_YAP1 & v_ABL1) +v_TRADD, (!v_KRT14 | v_NFKB1) +v_TSC2, (!v_AKT_i & v_PRKAA2) +v_TWIST1, (v_ERK_i & (v_JUN & v_MYC)) +v_WNT1, (v_PGR & v_WNT1) +v_YAP1, !v_LATS1 diff --git a/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.sbml b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.sbml new file mode 100644 index 0000000..43016c7 --- /dev/null +++ b/models/[id-234]__[var-111]__[in-6]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE]/model.sbml @@ -0,0 +1 @@ +v_SRC1v_GRB21v_ABL11v_MTORC2_c1v_PDPK11v_PIP31v_AXIN11v_DVL11v_GSK3B1v_PAK11v_AKT_i1v_ERK_i1v_PIM1v_BIM1v_P531v_BID1v_MCL11v_BIM1v_P531v_BID1v_MCL11v_BAD1v_BIM1v_CREB11v_ERK_i1v_BAD1v_BIM1v_CREB11v_CASP81v_BCL21v_BCLXL1v_AKT_i1v_FOXO31v_FOXO11v_CASP91v_CASP81v_FADD1v_ERK_i1v_SRC1v_CYCS1v_CASP31v_ERK_i1v_JAK21v_AKT_i1v_PRKACA1v_BCLXL1v_MYC1v_ERK_i1v_ABL21v_GSK3B1v_INS1v_AKT_i1v_DC1v_WNT11v_SRC1v_AKT_i1v_STAT31v_GSK3B1v_CDKN2A1v_P211v_EIF4E1v_MYC1v_STAT31v_BAK11v_BAX1v_APC1v_GSK3B1v_FZD31v_YAP11v_PRB1v_EGF1v_ABL11v_CTNNB11v_HER21v_HER31v_IVEBP11v_MEK_i1v_ES1v_AKT_i1v_PGR1v_KMT2D1v_FOXO31v_TRADD1v_FAS1v_FASLG1v_P531v_AKT_i1v_FASLG1v_P531v_FOXO31v_SGK11v_AKT_i1v_ERK_i1v_NFKB11v_WNT11v_CREB11v_STAT11v_IRS11v_SRC1v_INSR1v_AKT_i1v_ERK_i1v_HER31v_NRG11v_EGFR1v_HER21v_NCID1v_CASP31v_NCID1v_SOS11v_PIP31v_NF11v_PDPK11v_ABL11v_IGF11v_STAT51v_IGF1R1v_IGF11v_INS1v_SRC1v_IL81v_STAT51v_NOS31v_RELA1v_IL1B1v_IL61v_IL61v_TWIST11v_JAK21v_STAT51v_INS1v_FOXO31v_S6K11v_MTORC1_c1v_IRS11v_ABL11v_IL81v_IL6R1v_MAPK81v_PPARG1v_RELA1v_ERK_i1v_ESR11v_JUN1v_PAX71v_ESR11v_AKT_i1v_PAK21v_EGFR1v_NF21v_LCK1v_ERK_i1v_ESR11v_RAC11v_RND11v_JUN1v_MYC1v_GSK3B1v_ERK_i1v_MAPK81v_P531v_AKT_i1v_RAF11v_EGFR1v_RHEB1v_PIP31v_S6K11v_ESR11v_CTNNB11v_PIM1v_GSK3B1v_JAK21v_EIF4E1v_STAT31v_HES11v_NF21v_HEY11v_MYOD11v_NOTCH11v_SGK11v_TWIST11v_NEDD4L1v_NOTCH11v_HSP90AA11v_AKT_i1v_DLL_i1v_CTNNB11v_LCK1v_ERK_i1v_AKT_i1v_MYC1v_MYOG1v_MDM21v_TCF41v_AKT_i1v_RAC11v_SRC1v_MYOG1v_PIP31v_IGF1R1v_P211v_PG1v_ESR11v_ERK_i1v_AKT_i1v_JUN1v_EGFR1v_ESR11v_IRS11v_IGF1R1v_IGF11v_STAT51v_PI3K_c1v_PTEN1v_GATA31v_CEBPB1v_CYCLIN_D_c1v_STK111v_STAT11v_AKT_i1v_WNT11v_S6K11v_SRC1v_PI3K_c1v_DVL11v_AKT_i1v_HRAS1v_RAS_i1v_SOS11v_PIP31v_NFKB11v_PIM1v_TSC21v_GRB71v_DVL11v_MTORC1_c1v_ERK_i1v_MTORC2_c1v_MTORC1_c1v_PDPK11v_GRB21v_STAT31v_PRKACA1v_ESR11v_JAK21v_SRC1v_EGFR1v_IL1B1v_SRC1v_MAPK81v_JAK21v_EGFR1v_JAK21v_SRC1v_EGFR1v_ERK_i1v_FOXO31v_CTNNB11v_JUN1v_FOXO11v_YAP11v_ABL11v_KRT141v_NFKB11v_AKT_i1v_PRKAA21v_ERK_i1v_JUN1v_MYC1v_PGR1v_WNT11v_LATS11 \ No newline at end of file diff --git a/models/summary.csv b/models/summary.csv index 7af4fa9..d56ca1d 100644 --- a/models/summary.csv +++ b/models/summary.csv @@ -232,3 +232,4 @@ ID, name, variables, regulations 231, BREAST-CANCER-SIGNALLING-PATHWAYS, 110, 7, 268 232, BREAST-CANCER-PATHWAYS-MCF7-COMPLETE, 109, 8, 275 233, BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE, 109, 8, 260 +234, BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE, 111, 6, 271 diff --git a/report/.~lock.online_only_table_1.xlsx# b/report/.~lock.online_only_table_1.xlsx# index fc36eaf..edf08c8 100644 --- a/report/.~lock.online_only_table_1.xlsx# +++ b/report/.~lock.online_only_table_1.xlsx# @@ -1 +1 @@ -,natalie,natalie-IdeaPad-5-Pro-14ITL6,21.09.2024 20:21,file:///home/natalie/.config/libreoffice/4; \ No newline at end of file +,natalie,natalie-IdeaPad-5-Pro-14ITL6,21.09.2024 21:23,file:///home/natalie/.config/libreoffice/4; \ No newline at end of file diff --git a/report/online_only_table_1.xlsx b/report/online_only_table_1.xlsx index d986e5c5eaba19b06cb978d55f39c75cf96ba1bc..8582a9c2083f2faaf1ec7d1da80d82ad3f013dab 100644 GIT binary patch literal 58474 zcmaI71yEgG5-kiNxCRLh!QBZi0fM_bgy8OO!GpWITX1)GcfUx0;O=m_?~-rk&HR7W z8>%=3huz(~S9h=Ov+qGc8tOeJ1RNY3#AVuNO^E;cLInS;?_g}@$i(<|t%&Q9>tjX= zKKBfxz5l%N1unO!O-7=Pgq^6H+y=iPG`~OK>h3EBI#Oh9UzEL%@9XzMfQ$`2fSFQS zFH}`C^j!y~p?7ir*sHxe6URiJ&)^3xaV1+3T8C(Pshja_q0s_Qrx+=OgKJso8OT3| zCq@wbUqT#oRb5$MjehP2YMw-(+ncK8E&IN250tgG{A?phOyD8FwxdoOPvSBxC6n(} z%+-#LY#fZ>4lwp^8QVNhK*2>~mXQ6BOtODA{Bf=+iUgQ2c9@ca(b}@_VE6q7W}+QE zklED9QNr*WT%g3ifMDpQ*zzS5*i`*gZEFVccw_A$}DQL-#CK zH7ooQO-TjyOpB7RY8;+u`1OA5|FJ7^VohT)_VHR+!p#i-%1zgI7i&hYc|4`dEf=`r zMl*#n$$45(%d5xzho?)8P;xpe|!E1mghScg2?z0t|QSg zyJ^I}+md@5W`bLe@z`@HaDxswNyTCX3GffTL^Cye#$j&!xg%>t&MlA}`P zM^4v1-0+&y`#`>>kOdCKJ`6a0T%rC~3L*cKLXJ-ER>qER33RG86P3<|>AhL?#b;Ak zI2fKzc!71yLSIdlH&LzZY3m1k$)MPvdAtvB6$g&|PA1N#ArH1IUSPu_4pw{+u@|UujA{?rd)<8ppG14BSsHzCG zf!FtQx2>H&oKms7{@AUwO`3*4>-)(cr@woVqZ6Ogg+QF6eoe+8M$tjy0MZyP;Hm8v z>-&cs^DG6K)B%oTte=L(+-XkLU&~hT)u>@`=@Hx2#h@oh%7b`lwc@pnr}wz2witR% z1=R~G9Omg$bU` zxB*04u$r9arEXwSL#uf)Key#IX)NV!d-smn(55nqDrV0ie!xOL^Ih0Sa%*%%{meRl zFZTlbnYJJqRr$VN_DBEOC?mascRXh1=e1;o83A&2md+OLM2Mf+Q4^0WcJ^XY<&BVx zDv7i)QbWhTnvk-^wgiv&b`;u<4xAJ%)7ykiyd*6@fLL%nAD$}p_F>O2@0U6U&uf+U zMFa#TfQ21%O^7s7jRVHDnVZ|en?my8NpMi#IZIb|+$T&-EnQ~hhd^~k%Bi}QD_*p9 z$%-aTFIdcIr#5MmH*qVch{NAB?dvlZX7kAidm> zy%7mf`Qe+lgTVbK+xJ)XIShtB$)AZF1$*hUdLtYd#G5?{&j`QQ!g~G`^e<_+3`jAE zIjfzib)$6_)HFp6xTVB9L+THgAdszBth3qZfOjCJstB67}Rup1mUGH2a*aFv3S!aQ4fPaiq;n@c)h{OM*!CZ+HL z*{O&8?r=0sG|}&H5l}(rd25!bl1kz^e86x)`XBBnnzYdLuLsuz2)AAp6CKu-F~!H- z^TqP2KMy4*5~)9T$Q<`2;y*In>+D5w#@oP5e z3+x-K=vn*_#(xh1kwEglScU9Ajmgo>*x1RD>7Q=?_ZOBon)%z;7j)Nb@JBv?xrX`u zdkG?sqVgxAWxf9N&(&WtLfoKst%YLA%#8ruxgBbq0viSObZI*Md$<$15Q59K>^xTU z^QFg!$(z1<(a|^$8^}1Rg?x$>3+aF$UU70`&<5X)e3>&g- zXL`HYnl4q0HjQhy`p2#50QPW6^@_y_R?yUfMO}*3wIJuxtp_WRxy8m}adjzuXsX%G z`(hkha6(Vl$|r4RAUykgabk(j)7g1JF1@R&h!}gq!E;A_p7T*M-M#H4hL~qXhjR^R z*!Hr%QntY#=p>5iE!$HwD@Qdj`VeyN+mvQZE$9Q_NZ&K^QOq73hZyHc@#q-u`Wh0! zBQ`4sv)YZiN*yQE2r*2l;NAA5@lEx3p|aWmie2a>UcGo0l zn96~tm^?Hde-_l7Kb#F;mVyHth2eJiSRE@ODQyF%FKuuZmZ z($uEFZCi9f*Eu@Em_~$$O9UWNY!*lo3dOt&Xs$|+;KpyNlFAnI*ePMJC6nv<12>rx_f1<@3B)Fr%LVsr(;85_4c(&9u~5!suT5O6`U_T;i*b-k%GU=@&zQkr`; z@|{{msm_W%IDnn!5~7ihAeq)@T7$&ggUeiCxheL}m%jibRo<($nf{OLUVD&Z)vL~x zq-8+>@~aL{%p&w*>F=>BJxTmiqBv!NO2wcPxQ65?7f%Tcho!Sjxuk0u{>Kd`Rd;^P zltE9G;79!X=3c=a^CyUG_YU9B$kG7`KUUF4#EEoQHMzM>%qcj&aEQtwEw_|K$eWY6 z!oax-j7P^&ou*1!?EewYy24F?pqldb&*qXO>$hVx*2Mlb|7|d5`eiwNrM)$k-t@Xi zi(@VADtt8cIiN|2ttZ)d&rj+{oyo{DJx#8GxJ1zi?tT5~>hbs0_>n=kQdMy{W0W8G zv+V>BoImIS92;$3XY@X+ew&)jWaCmy5+!BagQMcNS`Qm`s$q2ZKD4(q4X`Wt6eSc7 zegDVe;XQZOm`~vxIlXj03-$HG`aLC^rGRYuBd{`$=JpfG153&EafDb_Yaz?S^+YnL-agQ$c87nU)l6PsMR;BYBh|`-n<~<8nJ07qC%RtUB=!dd57+_E)g-69Wrj} z_x&s)ohE#&cb3EN8LC`q5@cMYQ7WG{J+#BwzBtBxi(v%?)>{v~mv6w_OdY(#YS_aX zxH_+fqs4R=_YJGELkmTDj>p0bPVo&aO4a$V{!gk;nuAi}Ll5+ZF-M_W8wF3Shg*D1 zg+I5wJkD+WjY~}eVbG3*;Nq2!t*GelxVcyYRvc>07g1FqO|75;DsrHC+!NOFtF(Y=a#tfSp#`{ncvS~Ij@)?zP7t)V4oG{DUw5WeFofaiH{ z_w#8At(%3H1`1*b4gwj1pe~ga!Y(4I2cnxL4F>3E82BR?;#DUVgA|G#?&8mA1{!pZ z&<{cN{r(aV668w@E0qMa8N}99BDYZ47bpnd%5nG)@ObaJ^r%aIu}Dh`!TJ3s#{*4b>Sti$kXqGWrp10yp~fQ7Zv5t? zdA5~3FK|=j5!wvHp6lSN@coqOU#$2(APb3K__J9~x}h27VGhXgs;x!D#5Qle%k<^<3YW*Rs{t*4IK<4(GAROT;r^iDUX;}Kjc88e zK64_Y#d@cd>`&+-#wL3c+7pYG^0Pv$KWi1DnPG})j3OOheZDB+mlqVm2bQ57Vjj!7 z-mdj$B}cIeeGPgVHb57XF2Vkeq@1Pm&0!~YQn5cU3x)rLr`onL>00w5fpHOCOrd1S z+z@^0Dj$^-pfDh&(?u*Qen4YqI6Lv$%o1wiyPiY2pZ#Es3N-USfJLt7kVbBs$At5btg z)6t}KH>&uHl4T!6@=Fj14We^xY)z9BQLJRsT$QHL;2%13gvdSI2xFAbMPA7UPz*9B4pnDkxtV4BLr5Q ziGsa}U1+jbTlG-K;X5OGE~dlgKa9vvkEfwaE4r8UDN1QK0u7sXb=f)UDS~xz=wy!{ zUPMd`4(XHwxweMsXTwZVQ2kW?2x4Y8pT6$q2lH}k%)Ve7`@s(DAp&E`KSS=A8##hs zY=AyMs(|71;^lTf&kWw(wh`AmMUQPrviSfQVH7i;v;3qLBWK2Sh$(1gRv<93iGL2nH&SgMOU@2EMvCh+^4hl%l_H(J`^Y-dI2G@$U(e5-yXCRt01$ak#=S=$jCo zdm!4vuT?1coV<`X*eT=G{(wkUa(UsW@I1y}wF6H@oNFgbdu{ltbv7Q)w>w?W>!rSV8dnp~O#?f? zwIjn)Yo=K&&@Pk@5w!S z-5Qs`fIC>2YsL# zT2L8pGt9m_JWBSIeJ_<2<}wkYSRizNQzlo$;N4I3HOZCC%v$Cz{K4X_?}RtJ>PmLf z$nPjd=AlQXjYuu>M2+$ekjY8StzbiW?VI6r8cFc`x4Y}&*;}+oXA}ZY@kndTe#jKj zgyJ1(cAh@xkn?^*x#ioDA&hn@_!uNnLN(*Y{E5ZcEFqZ1y?%8;i8`3vYvaWA*lJ}{ z`1MHS2(lDu9x8+bw?9gjl$X%Ax_D`=Pbu(uz@$dt*OVs7dUDWDr-Vy0iOKc*q`|Ek zp#vG^)m}+PghDA&#=}7SQGyG7-XaeBL&DqM;bNiH$U>8Q#2AJ5xb{2_G${wkj}wY` zA_50q^>Z2N<<+G3!^?nnAH0{oi8c%J7$bM&5Z-@ zvo)b>mMP_!Fzpb&J9%oqYYZMg`t*$m&L;YoQ?7iFyA-Rat}3z>_%NCrrJUff4inP} z9bQ}9SQ5MQt}E#qonFijBX30|`!CaEO0WWCv`JeMuV3bkbn$lH5#pnmBORxz<^%n!tk6l9J9Cb)$F0 z0Y3j~I5-Q0nSfxV`QT!k#r|UXvA%s3+J1l-C(j6vt8P>1mlcU9p8vLRR4S!OfZ?i&C_OpoJ%f#+2_LKsd3 zpTHJ7lz}%@FC78#HApy)eSlm68DoqY$^X~g4?2^sJ0;;JMcB9us)HWm`#Homg`zU!jqtHi1s0x2Lb%TOr z(5YkW1df|6OfM_WOc~V5`I#71_545aqRSoBV3x7*N(#g7;5oy;{1nIJwKH2s@WgEM zLL61Ji?dVb|7d!m5!i%G%|y~wP{PVu_G79QY4*dzQ6?dqXLoa@S#SA}A+g=p07gV~ z$yga^Y!5P6VdrG`QkOg??qNu|f_ryEh~kpV{*W?zOqfQ*LPcRgbfQR-!S|;a#v~(2 zxgvVAaM9iG)hlXdHc}qqS956t_+1=QMEH1G3I*B(c-zrr*hfGy0ny#?P%x0GhzbM7 zrZSmp)bDTl+KRRbBi9D<*?P!Bx2(*Dwl-~WF4bgtDxV-+{)pb!P~@f!^FYjE0WqH< zT|VNa(OMi^a$*dqQX~aaXx^JLOAir8{*Ccm2jH z{-oW$UPEbb&GB)4Wn@NA0Dqt>hr1M)tD@sfmQY9{^V3>Eh{GRd(k(+RxC}_~7VC|} zdIYvlct3d@>TTtBm>WkJcD2#^_B&N%UCXE;YRZf`?UE{z(I|Q*8U*g0aMhtNOTJqD z*~Cby9y0dr-WW0i$R5nQJ@j9F^5Sjf&skf|4*uc6>uez^R>TQAuFOPRiI!Br(SHFa zMc>U(&+tyrYu!`^EDQ{~;S>CI#Lo5>q66s68-eGI; z#he**o(LKpKeC=zT`R?On;T1D1Xu3F;9dja&-3Ks6L!+F+W|0JQ;^2c$2e6q+A-RC zy;7>ATmjGFd0V^P7>x(%0GAdf56yGO*ADg9Wt%X-eaOJcb}WO&Wkiip&wS_<&zITT zc38>arVNI#0qiqA%|>OXg3SWGU%F(_*srUeQ)VWFL2e>*DkS$Gv#&czj#(N1EJH=1 zmZf|pLc|?HB=K;rkKi_x*mw31mKjdYIExinf9|9v?w;|;zCT`Jx{v^*AwjM_36xWQ zthU0~nN8VHMac6RBfW;mRnyj^x+rQaDTS%r2079LsM`qMt-nP3n3lZI8(db49t;i1 zo#PTdctGpPd^n&O+xRVe?xUaOF=)%xWyDfr@o9sdv`fYD6z2M6jb5LKD+Hkm_cG@8 zn+5sk06u=C+EhU|$w-~H-8oND%$Ug8^$#9HfT?p%tA%2pL>i3>GLMF<12HLMtP1Jq zFzLRqU0KVO>TXX^3KTil;dRZoaTp{uS;S-|Oliy<_VhhoiMzO82c(sp9=$Ws!qY6z zDnoI!6wY5u_W}iV+wh#WZg`BGb4qcUD!jz5*jyb~mrBrnA!KtdLf zA2uWYgi6sLrA6;3s|XDk`r~M$vE!jX-y>qT>OR4HFq8me6QFY4E11<*9##HWhNf51 zGSTFf%#h3v@otQ7ji1yXz{h0LHjw1&y$r<$1qY(2;_R_4p~9DEGPX*Lhd~OkDesr10Bw;Pr!e6<@uX%!0(t))Ls_hpaXtM!T0N3!(TkOu$Ioxt|Iwq9X$|WMUwmYb1)YJ#+6+T&*e)NH~gPn zBZ3C0+F+}>m67>-8q*#E-aFS{jCxw1hZy?E5fsV8&B6*ozrLc@^1r5WL9L%!yW%ex z!Ku#DLy?9^d|hCMW5nmp1#(%N^{Q^KahJ*Qo*m8i=nnB>(-?EP;yrJRm&VRp;h>dJ z!7@(Dmp!h;OzFgk&UE>&iCwMB1xSvIx7W{D`(cYq%>k=~&`Hc`><9D#H7j2DyT=AKYxx$n++-FP1?=4hZ|5{~#G=I`Gm~b?DWq1D5?+W5+ z`%Fr_Pl#-wfy8mpAVuJFsT(JH2!*cz%AOHN2JfID&o<#FfyB@``|(2~!W<=Kb{U;e zAA>g6@Yv3gN3R%DdJznIA*`>eeU0W1fB<$J^tFI?c|AEQ9@a?6BJ;dd!=)8NSFha_ zpE5Td_GHWqo2)xOS<>X>ktOL*Qo@mw4=~IEQ|PhuudV(br06a2DdjLnya@W_7;-x2 z{#cZRFb`#U;Ez&p#h<)%@tZG=Zn)4~v?hmD^(>aIAc9GUBQLGkDGheik$*U8ab}+0 z^e0!rilqG-=`AZUV=JR1X~IHnXXZN`a%JDfVt^lG7Ob1b0=8v0QREgS7#X3`!3U%J z@vS0FwYN%|JvTH@9hvi00xoG({3F+Ps^S7gp-GI1 zmLSz0-p6-I9#hHL!B|sW<|XjHg??iG0}PFz#U}!X@zWX-Yl$>ZYX|l<`lA?gHAz%= zoxxD9Lk)k>ZuyF16}-#f{)f*GENK&tLOc&^5ai&Jg@`YYeSW@3>0YXwtkQV;=9 z6>9p3T2Mf?%_8D%G(%+Wy&fcdS%Cp+lKU=M)7B?_4M--9VTlDko1U(nlL2YOOQ&5@ zJOw(8OF;?6tY|~jnBqily$iSQZ3=RRB~-&|OeT$Tk`pp4SXZ_xGd`akZE?pX>EaJw z>anI&D81A96Y_EO9XARQD(R6hS*NYYcz)CYW?$!H3ndF^`dz(SE{pt^5MtxwbKU#` z$MDcPGPLpPm+L%6S_!Hd1OzX0Rzqj0sh2{yblrZ=|FU)IS)bC_V-;-6%amc&D`F4M znCvyeEBNigUo35DOCpJIrBJp^boDePhe{ux^qj(2OH5B5e{NT>;#ZO=myY)s#9Tx| z-#K~yoJUd~7Q~nG6okp67Zy)QNk(Iim#ptPAJ2x%9*1+mWb={p@(cnM@~b1IJ^CPW z%Vt%=?hwOm#zpw4D{rZ3Ik`h&QvFOevkv>jeC!Z!CQqQ<%0tv8nD1WSqg`9O06DmuB%v7suQT+r>Q}WNQ<;LPs}6 z<>oEJ&oif^PnyGY8;1lMaQXMP`Ecl3xS>3Gv# zUP33OGYOJQs)%B_f5|%@#5MsC#uSaO_Q(u}4cl9I6Tuf)bhjAr)k0CvXd&huefE_8 zsCwa^5kB)1Qs>gmbhbF=IOB3&Fdtn%pdTdDX)#WBOzGeYBiCth<35m359pd_RGp}c zL!~q>t+H(WPQqz@u^CydyWau)cs7;Y7^T|9O>%tM(75Y4u;09S$WoNC<*<%s9j(=1 zW%1;%v&U0cg_l%B$_Dr`$ns}1ivUyeRM&FlqVv6wGnVF{st)v*J$545k<0FaMpLv* zRy)~_8aiUv^UQ*jq#x!DnnY+}l%sf!xviUOUDlMgc#Du9qG<$$qb>taSu~>ON=PyE zE7TX}*%gOfh_N@HSli)>Z__092UgO~SbOzx7PN}|2o_#d=y!NU^55|hi7NH_zK*MW zUa!nPY-<#RIB?i*5mrn%2NAy=c=Z-~%rsTSEm0TRTT4Lt6*q zw@;m|l}2oOnbA7#=}0#*Ob;z6ge>UfM9bc*mIHJ=;cPI5YGL2`>Qj9|plxyw-*g+C zq*^ON;rNzm;VcwKO$li>BUM=L-_B69%@0rDz~H`NK|PE@keZ<0!Yot&QP0}4JMSI# z!>7{}W@t?kJh4&?I9&VwECd zO{|Yez91lcX3v?KA(uMH#_r)b+wl|Pw&y@_g<;f+-Z=p9e8y|53~#lnetM?5F}!0X z7DG-vQ>XZm(1IzWv9-L)T3p<{gq~47nxp@y$4ACj*;2XaBS>*@VJ)B`R<`LiK{)w> z&ww>NlsVPhO~}!c28I3bVcBOZ|0au{pQ)%o=JyRx1aU9BW&yl3ThfNto$M4;@Z?91 zG7#O)%5ZcT*1|3Y}|KXE^D|8;Bz4K2{5W<-J zeUP=QQ>eHk>?+MiKXfl?Ui{Rf0vN5&vgnl*?k;kYli#lbZFZYN?yu3;F|YGzj#k9d z?2o#V!hJ4NHjr-)Ly5OOOpUFKQ6~;t`kxz6UEO`>sK^Rq9dO^O62F*Ge?oi%Zj^wV z@)-v!j!(^%+NtRqkT|jgXGE z!?NMto@D-KQ6av>mNngd?&e&1+&94sC z33;$zUDxXL9cc|)JveMzTSJPH{dJ|MYigQ;vmXON02dK*o{+$xx!KP9XAk$o+Cwe1 z5rkhDT9GqwsEY5x%o$Z!#F(x_Zt!HO0<1b&w&JGC*Kra7>G;9~bV5oY4Uky0Esb$c zcJgOG>b_KbQ@IrRGMqvWXd(k3*NYqpck>0=Yxj_(DjpM; zA|da7rX*?p!)GmZ9Oh-#<~HZy*ER&mE4tQU-b!OI{_)L}Ug1m%f{9MYx28ataN5;J z+3#4pgAyoyg}2p+QH7dswii*i$@8#yW{<@C3MG*C@SJW}1lb&?wKW9@#xA-iT>f)* z_2Gi8JQC41KIpfs*Iv}Y{Cm=BJtwA3ITnTN47?r7K0o5}iKIzO_gXKJYi+NX*e5}j z$M17ZtKtqEx|{b~{dgCHvbMUA9Do({Z;PoyrF;oS`7YBXEj*K14?-k^<25-%xl zdpv*rY^?Z1r&8gr1_)^y-=zV>*cJBLhzv=s01+si5PM#8cz6CA` zdOzQyp8I$_KTm-!@0O-Oe~4e3Hi5tmCeY=vKA_VZv=ZMf-}U->-PP_3x>ncsc|7Ly zb$|Z7)a7$|_NPgZA2{NA?(=wgd@m3B!vuQWs}clV-5uLzgYt=eA8Ng?OU6*VJydvU%k9f;>N`c;MWeYKtq-~) z_60ur^1*{%Zjzsy&V3(Vfr42}50At?_w=vD`U1~q&%}T(;6T^&ojK#CH?XhDHv9GD zPZbDwn!VWxTFTA_y#PTT_r+A7fS1X>4;#tEpx=ToVDPd9dQlBQC&^%VUavuQk4O4x zoVIDG1*VfAAaJb<^mOFwdk4l0=q|5-=yU@$`+X;P-I6bG8yG^tM|ifu1P@x93-bj%$`cFB5NDBZ0$;Y#P;Gr5 zw)-}3uBSR5yZN(khF-6yUXM50h(RwCOM-mfa&zhGAXB&3D(Hvp>vkVtw5zZ8t3uZ6 zNW1&f94ZL!^>m{R^Z?D#C=`EX-Cm1vOD! zqJjp&>!0t>eO|iVUYqV;`(Aw9@AYkcJ+daQ#jg#l1O?*-EhvJLyLQGvz_l=e=UdP- zmznJTEsH)~P-CjCB|qqpO5OWmt?PAjgnzBBDjVt1UPC_M$+r`92h`6JXuk_DJ!JCc zM9vm_G|KpW3aiZryu26)5qzkk8X`Z)7Y6`Mf{)j_I)K}Uf^K?qmM4d3U9#I_R?y%e z&TWBx^A*(C3aRpay$u)<2=lpK($5wMh?ahy5c7R}U9;VMEg-skOcC?}W=~-NFQ2os zKp_21(C>gq0gWBb)a@%#(8~wlJ(0tU+pr?HkswGJh1;8Nw}7D5yfXy^AJXo{w=2rM zE4Xbpksdvi-q5v^?mMbqV=h2+-3RIxTI1B0`7OAeGg1?2va)|QfbqKNJ554ZKZnBO zZQsI|E#>o!{j}zKu>_8N-#Hk&`>CwSV_BXXTTqH1;psxC@UP#TPnm2(*Y7Sky`I8- zxd0)K2USxc-cQlK-ol`}5YDdWD_dftpXz0B2<;>m7nriUc%#zPVpTBd~EM2bIzTxxYS@~_lAXjv+l=jne5$d-l)%&w@ zVB!(^i{~{Fy8@yjs!C{`ZK;BzJ;gtkEQ-p zBiw_}216k|e5U-gm33b3**G?(Ge%G!Lj~j zUH?H019X!VD~6E}@*!JdEo`$b8c$p!GNH(wOrXWOV8v)!*(q>kIL3qx*M@yU4B1^v zSpd@>?|xs{za@qXV7I2SW{t5BRqiJg&YjRir*p+Fq#aW0xtV8N|KEERA1PTF8&R;fb+ z4WQ_~C&Oht!Y}oXZF4OR`6OfMzQyAB)ZAG0p2KqSATo?H;lo|$rs#}ucUBIwvDis6 z=t(x3%2;Us9X{nf3*~lM_)#sq!}hzR>oQKnNF|10n_PpI=@FzE>ZKX`MYgJjDg;qA zSM5HR+;|q@8NcfjpPr)TK^q+K=7r4*uTSE7^rT-3-u+QM$Hn`IT)V1|r-nSMiW)gf zb~Ed~D>Lgp+HeoKXt*{#W|RvrdA#BsAZs7F!L>}Qp1xx(RlS5RSlaEeU>OqJ5%7|x zgU5l&&k9o&J4SF-Vt3&z9p<#KSnYif%X0E0l-up@0y(pc99Z#>C!|L20iQ|C`QsgEF*T;n$o>QSM1@>l zsh$+O6$PHAH2VpKhY`{qDc`T+1ngN41kt2#$mO9#xP51om;>^Ap!aH&@}CKwGuh$zZQq%j(!| zLSi+pZ=V(jo%@sD8~gdZ%zjrFR(p)mFos*?LmWVvde)O; zpur{Cpj@Y+tLY-E0{x_+|4uD=M(vzc%LVtUsJT!ziz1dge=qS)GV2yI>cybNg5c4* zwSk`PBC;G_@_fZOSk}Hm*906h&lZ3h{GHZ!&+>7zW5LQ^R*~0QeXS(izE2&+^=Mav zazSJP!NRFV{nnZ$Ncm1#x+c_^TvLo}T5aRis+D&R9sjbPI-|zK29~=rxhOPFB{`?@ zHA}qvvX2x*hOZMudhWXV_P4U@N(ONru(VZ}+GbkeXQE#=VqKzwyox6G0U4sjlG{>n^aU&AX%zT&&Q8b>&Ffdu0k}EGM)g zn&It^IUTCT^$X<@NvgqK-@lt{8b@TZXU!sh0;Emh{K6|toHUGQxtn!&iO*HA8?8%^ zShRVwE)0$(WuKn3mF;I->s!iv<9HI=Qync1T(Wn;SJe|x_Uh32n^yeR}!73$i zToS>l!{0V)c1rsn-%-dcxXTYPe+R!44F90vq{uyB!w@qOS$(T6Z|$ zn;VA933GbYmZwC00@DiuF-b8X;U?HTCj|W`W(zRLQiNJA*p6YSXDD- zSFW&|XatUVB7nyQhdpbbixzW*%$ATYLJ~k+b|~>X^$oJ)6NLZZ4bHW}ay0kSC#lWeFC!*3L zWTvJs#(813rmuN8U4-|P8{v?ztxtj4iHH}8XX=a@6CuOY6(q-B& z+w1yZx3P7U6?vfC1G0L1xT7&2w}uvLdULK%5JcX1HE3o9>;Drg1E&SLh$yV!b@6Y9 z8U{LcvZ5_=sDEgHflfp;PDFHIyOn?Kf}PX-$L?P;Z_~ySQ}5_K&@dP_s(u4)at$?e z7Pi}cUro7OxW}+5bM_n9TtMy{P(24=a{Iqky}V(;{B(pYHU%Sc_O0f|ika~$PpXPf z>QiR1-R?PG5NX$Plb$(q!8In~iItV$PXlEgTTYzD(S;(n^fyX-RSTF=w`KO=z`2qe zFEkCXkG(Iu85MPNZ(GP0^S>WHL}T@6#KCrN3UgsL7kHLLO5gEl8<<{XmAqehmRd>p z#zcA7WD(Kn5jj&g81r0A&ui(qSQQdRZuuFUhqBgxNY)VSP$1B-Q|DaIj1gfeMU zCopnvn;2D4VVw1HNi_Hux$T$h8Q*{@sH0nYiq$F{H(1jrr$Akkm#y2%$RSQOmeQ`dypu7>hRkrDBxV%ID|Ii zdf9l|-6i>N1ji0e8Q(-Eh{OhtdOm1A#!5s1LGPiBO^}glEH%%wuEY|jD#I0+$ENmifbW`DSQ_s5M zgQ={*XT7;i{iI?SJz zf)=@l0SD&qGzKqGaoCvO4 zRcfx=mBiqVB(C)`_TZz$!EPy$Ne^5Nb9UQZtR%mswLQbuXav||fgpeFU04ph34G1H zRajn3gmF`Kya2GC|J&JjsIXG1JPKK=XJa6p|0*z=C3G9mJ;S~M4`k``?tH%^Z;0q3 z_ajdnut?md&e*NO@K5AK6b}pTWx|@4-YQX^_CoJg&hT3?$rRgIw_Lt^KzD9E+(j0! z6CAiDWn}u#cq?P4s~!dSCu-pI?Xmg%ui=K;GFILUsYxp`*Q1=JdLgE3KFO~_jEspu z5NWgy>uRUAw)$x>!w@>1PEEk=89beZXitE{ zxPr56HOvs2>^C7s)&%guNpN)?1A@n+6EF3kIf+@0>NT@n8=tl!@(t5ue2xKRmlnkf z&aPGQD-H_k@L2J%z6uY+5MuE}H_diM z2XwWgow9+=;8G0GwWFr3-KwSm{A(Z3LmC}hIGT3Dp5jTd(BfoW%EV%Y3NcHMm{B)b z;PeqI+=}5WJ6rV#yg%8?;24N>=>b;+xC5Mwzl~`-Zsl7z<=6ydh$trFoQ01k*2O0c;L@;fU$Bc< zz>kVW4q1=)#!UVdQ&E1b~Pj?QQUS zqV3QuUj>E9sm3cH~Xgtggg44f4IUjxd3IHgGaZ6!yY1?vEOmQyQTaQ61xQ0+fV_Ij8l0EySOg+i4GzF zhXy*~>MUIwaA~gY{kx?aGi25SDjW=d>DffkbME4^CMnWz?i!k*<~u+V7xO;{ZGll# zZ*NjG=iJrR1n1O*sbJIJ2ZxRS3=>gJtC2MxZ7j7LG3xV4Z%g|y!3uzS9F_>;0RAe) zE&jr_7+%xUFtm14S8z&3x-{jM3|sW+RsK_#muht^YPK9=9QaphgRHa@!RK@jin~&$63SOEOK}5ON$~WnGC#He`9c^S4KWjORZoHHLu60feYRr_WvwxEdI1A@0 z^bE@YmNF-wcgstYBo9CD62YLx&uR{b(<8uYU(gWnv9p7>so{5 zgGjSAE*oX4u`$4pyFLqTk)a#GUg8U^G#kM$O5Q060AYYYmEA>tG-k{F00;PP#(X7Q zkC#i6L3#7Y8OI5fZbP(5(th0-vL}mutE!F6!dPVJUa*%eSjArO3#(U30tcji`~K~t zYA*9>?MAm}TEm{i`O4nk9oYP*!53@q4XSjkr)by=yT&oZE7=U2(h^hd4d6ViHe|0W zP*k&$X4$#!0S>kf?I zGD<&j_^%P+zwE2;{1q>{HBi#aA<14)skxxHKi*tG-4{#0ugY!s< z*Q=9{Pyg~!>w>LL**!k?9sX5g%U<3M{?%brNcb$(aCT5Mp5&_hHj)D<{4`I6z|5r~ zAO4vJ(_AophtXvqx8&!Z9#)u_$?RWxWon|0lD-Z5-5VwXU}@J$2on+5y0n}5KkdB< zJe2MCKdwbWDEpenzKvZdB9$deg=|^I9$7{bkxYqXPm!%CvK46%3CXTOk{0_?h9b!b zVa)umxkp8xo_T)%|M&a*zW%@8!|RoX`@YV7u5+F1ea`!w`zpnpYh^NSf?csU58;FQ zq;y;Oq@RC|c*W(aUV(Wi_Qk%8J0c?A^TD{bD4okZ_uR>h(v+LnoY;82r4TrNcC@r$ zAjYaIrddf}iY<#L&QC|(>g*>Q&naB4*T{#Y`?anZ>({-SdDXHKF)K@a^ew-i-@@IEQzi&)DR=FWbHa&{uVR|HOn9Yq*)EQ$DO?NudSJLj zF5I0hYv-NiR;l5atb&s#)E7>nCU%^Ygo-ji2I39-C@So)wtUyenCFS$101a-HAhyO*x;pQa{g^0?^vxX5Y{%nn4_n>@H z_Qrh;Ql?OLL6dbo=22uqOMyMcsLH(jp?O@PkhPR9iXY*B_OWOi#fwB=6hQF`@v=yx z{ASibvyh>^#jVO7EPkj+mS4FA#uVk9XOnMbp5MIDuUxbtBL5bz6xvvz=(VwO*Ey?U z1*}s7Fp8-oTe*a;SGsk67xNkc8FSPvQ{xs34}wsdquu2JJo3dcabr17rsM40-Kwq5 zgI{xxju>nQM1Iepb5=ynx%Np1o*q<)od=6juSwKTI(_P?Nki+K`$@?rQGsPsauOy{ zm0y=-dL>&xTtA@~8ces>IV&tKalfDD)&Y55o!!LYdw&fFCBsUysw2tWInC0IPNs{@ z{-37pOarL8H;Qwgjb-jTwO7J}rs_nQSkJYr`Ojen&J_lzpRD#pSxy%k2~Rh?8@Q^3Hftu|8Drn^Dl(whgOHO0Og9PU5vma<(* zH-Vg)0=(0Mf$G-J@R3fPmi%wha?e#;eak@c(W~~@NpAn%w)_%l?7Ko+}BY+d;)B&g@1KNzn1Fk5 zsH1kSP8Jd;={_$<$qj!--4igvQzpGfHQiMDL>hxwWtUE>WOzcV;pL=ybgO9f%Uz6Z zpf0X?U8kG_(|*Vx!np)~#^~9p@Y91)zJ|unrYUb8eVFz=>I9|V+U$ui|P*L_r+q9L+a61f@M-2I@oKE(ZjI@bIJvQ3&c4@`(8JO6o{U?1SUh8 z!;(7O$E9(+zjcPsPOJNcpsA;p|0WB2ClT!hmwQ_8%MH&(T!z1KcTrI4VKLY+1{-=@ zUp}Q(ku63v>C3lu#vcmqW&0af-S<}$>=W%xsYmyVPJr(Qo0YEB4@RRig;aMH6}e_P z`2iCs`0Z4o^|5;2r<7S$Y`&q1&1-*6!23x0HuI{>V0^1+BxJnvb63ri!;*5_PV6>~ zzGT*c2v4XmRNI#6+7UhXK?YieewRejGEh#0OYiYE!w-?$m(8ml z03~puw5j#zWl=8h{cs>wO($A#Vt=$i;YH8z_zJ_fiYd(fF6y!?hV=FOwUV3U6=#=H zFE1Mi%sjtlUd~}Sq<}tmVC1}-_@NZT;h`#Yczo)PXUT4`mMI-J?T>&C zZ^2>?wSGSo=9~|&SAf}bavZr)k8ZoNz4IZ@z6?`k#E@oIM@>VcmYDrWBlEeMVftCG zul5={I+>YeOJ5KrDBrQ&JFOXJLmaQWL%`wFHS=UPOUERwZvSmI3bY|6A8bFM4i;6K zzpQf!yTnEtkd%Ep40YxKQPmWKlM^{}jdT7|gB*-2eLJK(k7nf2Y zqc2(|!4b^;=11$gz`pXEqgZmdNP4!0B}4z&;!xM|GMVUCwauL`!SuO0XcW<>kC7hQ?6LRThc@Bt zyg@K|CIRVguo0Jb2%X7f7JdA^;OaZEE|${zqR-|p8@g^5udF{$D@_dMP5V|~ z*hl-6RBL_X>PXjkDJ}dBOGb$@0qL)zEHv#gG~vF-j`QGsk3C^;h^DlTY9npK3e@dL z)NW`S4$U==I_<2}z%Gud9LiPYtg|if(A%OSE}b~+v@O$-&|o-FUqm~!{?<3fmWP=clqx-> z$v@!nxaCINf5D|YyHHi#jU}_aNv5t2BhOC~AOCpc0PAPt?6{FF-#E2x5QB`*swaGxh807rG){HpS*Goef-8|Z{A$(==x(|<>pRW@>_Vq zTpZnBSdgHLGCHbldVFlF603q-y3fbP#c2Ke3UWmYV9ERhIFoPiTfR>+w2Cu{EzzrfU6L+`}bFv=GYS|`>>=p;50Y2?GuYZ3pN8QxP zP@(EMv*-ptS1|47U(=?u`04{Rr@VQ)AnbBwcXP=sSF)+Aqa#ZdfLt8~xdQAEZFRw9 zkMkQHZ_5(NI2dt)iYs{ANR)GS_H+mrZCZ>gLQ&3RSu5LwlVj!4zy#k!eKMDQlT8Gk z`#nU2JC>tvU;VMolu|U&kA{eorg_T*Cz>o&|30%^QJ4+UWHi8J8b_4G8D4&6eEdqW zdFfTzZzfA%pzsANznvu-QjfKtQib2qmY2uHe|oI58kLX(%xKMvF5q zF0rqyUhZ?QOHIs*`fl2mW54^C;8u~!8y6>;iBZ==x3+@A>_DTi0sNcc^&O=)=fZ63)nSYoa(HOkHaTE%32jmA} zj!%H$a#jqd1PpgLk8>mupNX!GcB08kK(q`%=p^uCn*_nS?zfJfjh3&CrHpPB;aNlh zXA_H#!aXVzH2tEjAjhM(u}}4mm)BGXP+%h>Jl@|>Z3D{9=$pL;Z>A)*4Xi7#RqZW= z?f@WnVy8UkWUYbE885OgsCa^X8u=L4FBbcBXj&tBv%L7!jT*|d!=LO&^jLgBtcCCe zfF$XI^iW9fY&{!K3Mz=LQ_MQbhltS}r>aoKHuJUenfrq|5{#(063*zd$X8zEpuGot z{v>xA2d$!baqO8N=~H0G9gYbz*;_^p&GZ3>@>`?4KRgVpMkXK>J_u!kOyXLUDr=AD2ReeFQE_-{3!vy`JJBvTyq(gh5oLgx|Zn9~*;(wU#PsqA4vCx|^P`dO_Ph*{(6wKz~IAQ!k)`^T8{hy6KuL z9C>#!B8Clhx(599@>^pB?4vR?!FG{VgaRG(0Rr0vyCyb1;0Y|9fD6HHgHVAJ9o#x| z)qFlxBQ%5?v_}PKK@RJAFvgImgSgi4*AW*}UL;JJ%C(%ir{E zPRlV?oZ9*I9v&;)mjr&TpgU73tRPg^ySN2&wY~okOZjsSH4RfoK*F@lpKTVw?ym;n zrbAQ_9f#4Q{nxZCO|H4)N&yl#a~rP;l~Au_@EEKip=>UPd~nlon1;I-a`qt z@fU3^4&TjzA8zlj)zprzQ)>FA%O@}UocZTQocgg5K?)CikZXcXuF9ynS-uA(Ib0aF z=>zsoISMuy!<1;HhncT>nm>4iC-lY{X5YTn!AhyZs>b_V*EGT)Z3);`okfmo;@JZd(yF5#LH+fdyP*HBRqS63whQb zz+ZZ0F~s!PATqZ7a(56Lk&@8gAAn1=xH01#9i7Rs^GL9X0 z0*>wssF^R>pTY5bI6GrgFT4L(_XDwxNXo(()EQv=d3y~GC~%Q%A30kAo^C(VZx5bs zQ~zQ4(krv(6Zd!SV)ZODQLd__bkNJky;iP^q4bC<_3r9;O@v|M55(|A(m>@c0%#B& zmve_00&E7J#h~%_J_3h)GGBFBc^P-#E|HDkqU`|?pv0=mD$iW9Hcj=+A8g#F%Ox;n zV?~TX52m)w?Ib#|=dp+_o5zW|QDTW8(k66^l4!ovAITOJ!CV>_OtuX9UwA#Am>!pd*wnBH~KnxTW8xJb+t0SMX=Qxtu7ocd= z$2=;Gwe(pXJw8;9sSe$g7k51WXmHx`jtrhQ?~kyTr0Hv}nZC6BmaHpr1=GYZlAN2c z7{bPt@Zyq)c0s}LlvdUi!_UOM*K~=8HX`ZH?JH{%?Gmu}oR5ON2cIX7=D24;|MjwE zs30QOY8T_2-vH4e9rQI=GQC`yg2kOhbM4(pxf+QpeO7*3Xs?wO5m)vN!KH9a$PGgQ(hJMb%8B`ewR``QSPpPAZ!cq65rk6#V4CU<0vDu*ni{%Gm~TuBt26 zceI=$<*b%Wb$}6vMIR02?vibO9Rcv;WqlXX{2=8%6Y?Vyzv6;~z* z($(G_c>#`l|LUL4jXS#SB=^3823&N|#O`ox&O* zFTeDchwMZChGMEo@OV13i`ESpbfS+26_h@Fv~3KgUxQsQBWG2T3_sb9$mbE~K9a># zVdMW=2c5+ede>^+nd;KJEg)`y484X(@#aY%K%D?0hz~y;tG<*RPp_pGSqXA4ZL6MS znmz2Hn*g2ll#@kW8csGe3}#`W&v%&sH3BzH2(mb-7-oBk6urcLna0^joPELP8(1`! zX;^E$DMi^AQSQJ)65In*dr=oY4d??-yCIW@-UcRWn;pFIchzZ=4vE>0d~$*^p9k_{ z(%~1`5}KRztH>WR?z79%WW1|qiZP~*_yCIE@ z7R?rYDLs;@f~_r*vOlu+4jb*0#Jt<**6dh7jlVbng{)p$UYf+Nbg!@6vI$|6iv9Lgqxs^<4yCY zKCenDvO%)&`H(X)P?kApEZGxT1_`WVW_uG4xxz;Nm~TOWGskgM$1aad@G@X=wf zmRsSIw4U<4wDf+=UL;No91gw)>6YZgCL{Z9*%6Vh3*%^HGf{h5;853?tt24*S+qB9n%|*j$&Q(RZbJ_d zypf8m%rZUGLyf^3oyA3M*I-q@dG&?l_>Ed$;6)(JYuWS|+U$?rs3lMnJE8PNcr@~)n6)(35{+g2*tT+P=;qltG z-w)p42R4kCDJ8`kQ7G1cs)VZ20L)HmRxc^isJ6My2de2T2}D3pvB%mgosklB-HK8 z<;<^T)?_(Etgwpb)cW$dgh-Y~K1CLVu~%mw+E1J5#rd>;GNVLBa^s^6O%S6uIS@B3 zNVHfX#`7c5DwAQ$3XN-519=80DtuYIYVJpSGPJJHHT2TN02^ip`=@0Pr`c$CUi^`0 zP_IceNHez~)-)npJ9Q0f3SG1EE^@HYr_oi43T;z52BLIhFk|Ce64Mh}6=Ok&u#?iI z7ATuJPISFapBi}?nlPJV0i0><2{c;M_8OF#ULPBRX-18X*8INZC{G)TvzHI|1E^u+ z$bKYZW~=2?ESF^H@4Brm_m~VgKn&`kQIssC=)yrO4vHx&(S^$S=7gC{u~AL)0I1Z!U|&k>N-0lnWvuQ56ZPBpE%R03tYq1@)xH>Q-tgk4N_o!fZzuDO8a5)VUC*GN(bHFa@jEFb1B_#gUsZX7*9*+Fd8JgnAV} zXW)*0p`;*H3neEYw+IEviEW#PgB_%i{`E0aI@!h(ha);JVPvZElXno@NCnOb=SbcyBE89NC$6+ZufDN=K9vk|~63gFPlIziz z#jEe_x)${Y1XUVgBTubl2O4_6+zD1^C`WCNq9i3MKa$)47BD`^&=ibMH5^T}$DL8P$aN==!mm+tVdd9>$}dLz+AH2{I4y(8o6(S4#y zv9EM|GD`=OqlSr=^^D6PHWo~sR~idS%D;-@ps}!JjM!Lk_X5k9SxGI4DjK}vEkF@{ zP)VFJrteZ9aUrpa3I>s$CG&C;E8UT2E8P)+B~WsCf(p0@EhMWl5k*R2>M?=uMfR7? zLgTX!zE$GPOFYpnNo)dX5=FdmoM+LgC;s3&bngU zm;pFiM}6%SouszPzv^|zdU(k9&O!9vsLu|(UqngGH^05^E72HY4qmz*<7H}emg%NX zwV`~ZS&c4rYnl-Y;{y+IZg)(P5J(anc{L+FVY%nsiLsRUftg;)vu6*f@Zp&cUsBMW z6ew#3b&J!PePWY*C~V7atbqb&`LU zr(^;gyLZQMj-l@6a>UEb#tfe49GEN|WQnnzG%-IjDqn?PZIbcVBU5c!c|kUlH3C*v z)r+q2CA`=ehqHE;ix zi}I4x87{$U3R>D*9OnEaNPR2BDp*eB(A$KoBFr`=p7<<>xpZpFzJeooF%kBxy>Y!F zAmVrLR~si>HNPR*oFN%6qB3G&2Zom>xzLh^Tk5O~|I+>5Ikuy3QWh^(di3PB@{V@^ zxFx-4%`#PUYb*;`ZuDI`^r56O^PyqHwgy(Vp8fkp_!4iovR*qQG(sK9R*;JPl(c-J zmUWgZRCpH+{Ato(Z>Zo;^#fUvo!a{)?nEC~v7mxxt|;>S2_rUS<0JbUH(Wo>FeT7E}p$WQgg0u1CH_^pK+NFi26# zlMPWqjYfoVyWUeUo~Bo)V2sD9Jzn=b-?Noy%_0=Z9Jws=H`w)-TkJgAQQx@r+EF?# zLM4W7A`^f4FnUv?8~H6(DTbi-q>6DGG9Ni}{kNI2{+ubJLmm?0uHp?7XyTXVR{iav zUyG>zIwE>h!WkxeV^Jx*l&MMX6in{1`hVQE>DO(3dZlbJm|9fx5bihSYP%SknP^@| zaOg#41)&kiSj%kO4Kd!Ax-OY-55Lv;C^*6x9~~;j3%mx*(^T!ogCO)&5>_P}7qj-R zZvimdRi-_%z+)WL6hA17*|gSXGMG)I^#rp_C&{UHKvS(=OD6|AG}Q?8iuu(se)=R~ z3~TLL8^2ohKPt6Kb>b2c)q#Ym-CpAqw8m<`Y$XQNfrJI_TjPnW*@63h`q#?bfUpZ| z9S8hE_0GP6Bvifmcn+`;N!W&h5XF;|jyxfU_e*JXnOjKCuQ73MK-k~8Cuxo4F_19wYy3}!S}?!7D2B8}^Cn@b)|&I>1nL42#(ugdgZ{!M zWBjvtvZ_OJa2Ls|t}cUtgppPKk4ha?T=*G1W1k{0qk#$d?4kV2H8bfo_Uh8=OvBu5uBw=LN_@4}gaYzP06)uLfN2dc^ zS`Ac%O&g(jzY^f$)nze9^cR?n$*T^@5%~wz>sN%4RsD}j{f?eY#&}2=S@#slCe4uS z8bfmf!pQDpU?WHv`8ECrL*)m;5*Nh?wed(hboFmL>vu^1^IgAVthD|DTQ&~FF>--z zT@<=W4un#9V|;78`agtHq%%4_8GGU%{1}qc{tuxvS&SrX&F1>ukN>FD@5_858wUv^ z>&HMHNEmrPCe95ABk#xZ7)Tgdulh$rb(=p?dSi^A;hRATetcuj`0XTYO}1_3z&D}$ zGYJhqBh~J5(;5YV{Q55p)2|HQ$w31x@-ys$|G~%lCWb(7Qic}K>iVcv3CR4Faa>?N7%WSgBv@523m=Ta?u*8 zt)?l&Q9qJHXs#Hb6;pgPrC9oE_5nuy%+|)m2n$!efmVPb1jip)oo|Ctq$l7sjy zYW(ilbSuKh0`wo1`ke;=bs%A69UG_v2_x&+q`A?Nhf821NErEK`kxGiMU~7N2erfx z%3;cWGv_;p4XYggpV=2Fy@ljR{)6gHBq~Q<^*<`*4g*^L@OY3J+z_jVgpma=$(0$B zU1LikvjoD{INtAT3~U4mBfrM$G<9*Era}yRou;nSR8Yw~LZaa7H1!YMd7Y+0mEW~R zJ`&wsr>W%l{5nltRTci9B+u(K^+!VjqTv5iG<9*ErjnXu>ooOei*Ic!W1Xh{FEk0) zY3h16byZ7py_*WEDC;zJou;nSRMPu2f79aq-%V2qNc+#em{LsT)VDl#WZ9#!rJKS$ zE*}jM`S*gekL-&n^EeYVqT{Xe;%OPL@o0I|BR-yw$B>p*Px4Tscs;J5fa41<`Gf}1 zHY|C%9)?K`=&&aWfo_-Ycfyt=2(B3Q0$ff41CJ55;Im2Gz1OUv7Wsj>dUa*akN30{ zRb$gl@ttVo--u9daYJIN^Kpp@gd*&n1G-NWs>F>FdNQVpy=D)LzxrCh@!)Xr=R(qT zxT%_t&hxS&GtGNOmdws5>>Vk(!Ia@~g%&&-X|W(JL2$wx2#XJtIA?NK{E?;|s|4@A zO@#Oh>;QZLAwlrKR2Kw(ym}4cR2XqAtMua%%xd}Ss%0Zy$CZ&;wn0;TFB)k{X664C zA|i?d=gja;XoC3yuLSR&yCas}_xVloBp21d|5bYTm;XW62@YiZFE)XI!m5*T;eUsS zT3Bp)sTuyA$Ol;D)3&0Iy|7n5v8AKTqH>Y%jO+Ke+stw-pu5_Ok1j;k!j3&%wXMbB zKen}dA+GR9+KD?@wor@QK(PhWxqCV$C!zaaXAN7*TitT*wpoCutG4gQNYemOt3WC@ zFz*LQRbi{u{L@0waAxN_*sLE*4Bel28PVo-CdKI-26-N^B$JCoPb1OrA_ewtm%K+w@xO`$WEpmf zoC^~l@qfLD_psRI1j0isuPMHc9E3vGk>nuM4x^rr3nSyg{|*t#EvJzrsz4|q2cbC$ z;Ceb4{{vLw2$6RDeWw4f5CJm%9yp2fRFj2JClbH+{|XTx(+349 zi1R3s3sZm-LHz3P!&GVlvKWgX=feLA5$|F1pjblWJb*uu2~*H@z@Pr!|2#2+1-J?_ zVd~!@Lb=5OWcozT1Naje2!*cmlJP%4s~98*c4Q#*Um*fy`h9Q`=TRpMq5rj3%zr~S z=l>89AkzmB3UMB3auB-SQ~FWb{)hhBd)O4n^og7Y@Fy}53S9^M>F*)*U(r*7+M;A_ zq18K#d}y8$n=Sv2k<8{ zVG6pw-cy3Y6j@s+x12|kI1k`YWWv;XPw7{fB4-Pb>36|NoJXB3gs%6LenBWXTSOGA z0tkg(KRZGWLf3mrzaW&XE#AWlL8f1Xg%f*5WFQo}zTQ)UAe5{vlv~b$7a)nR;sO3d z213_+O1~hKoGk!^f-IC*0=$ZcBnzSIJ*8g|O3oHE#g)h&;yZLv#EuiO@uc(X7284Q z>G80C^P6`6Jp>G7`k)}yfQEWTWL`2|?rI@Lqk0yG7t(~U+*cA&diYOuf2!0gG`_JDjwiZWFQo}4miW#L+E;23UcA~qfY<5 zXSP75zkbwd?NPhI|I(SQ^`lPzab}QQPYHrh0`XYb-yQp^g{7|_by`2_wCXIZH1R+d zU@m_jEXg&5pfvq|w}|zlPQQmKzz@y-zn|G!KkD=!C&Cf`r88UWN1gs7Op)s;L1BvQ zv9I-`PXF7^&|)#v5uXQt*n zl96SIPFw^}wf!fvftG4-v!I6YLh~iRrP7y$eaqijCaUc}m<^;(e^Kq6`%EZ9$T1BQ zrdUt#FC!aX6;>u9F%NJNZ{Vmo@Vobf4Xf@SbY5&r$4`%?6L3h}TzmC0W}Km#P%*f? z;D`Laj39g(%wC+C3L-Edr*jC{rgQ=xPEbV7AQ*7o^YetUYFuYKa(aw_Z&xQEkPGQS z_#EUt30Sk`MC9Tm68A|R=e#_vjvF1sM-Udn;7bOC^ySyR z^XZGT4tO?Pa|_`bZ?ZJ96F<1zycEOhzf4%rR`ZqiUr1kwBYbZeT#T*8^-if1KJ}&( z-cN{R!|^KLo2nQ3r3(ote7`hd1`ka2DV^}CtQwbr#Lc7=7LFiiQU`JUyg~Etkl#Om zM`JtTaH**=gj8YEY++CU?%Trs33z`RVG$8L6FHBNwjoeSZ(5R8$}d*RkWlQm;yR8xdYREWYB1b#{#*TRcj2wQwdz=aJGaPQQY zzu_>O3gPGGXD9oc2p`Lkp4AJzgUiEy)r6(OyrB7X{I}HV<(c%L#aU$T6oP@EUU1U@ z!L^(5GC_B{?Zy5Be#PGnY#D8@-Lhr4-p047wQoz&n^KiHAq}HzZMa2AUA%4iePeh3 z;N4xXzO$H&94LyA?oAhR*Em(1x1Ihp|0#dj5`WC$z)Kn|wbR_gw-qF|g?cTb9?Hs| zG3!m8S~8V**>(CYw&0D>mXr7^57lgGo{2F%6Rf==H)m&Ry5;-6_}do`_K4Q&a!?LD zL<=Eg7?k^m(o#ENaht-+oBa925gtiNY_~_~4h}u@OYb>Cg~M`kXib`4bULHgw{N8F z?ia~QWaiDeuQ6{V#5PeE8>^t^=LhG*@N>$(2KTvrIaEG7Uf=>m_yIbqk6LUb!PbG0N?wEn<55LMX`orQ@ztI*yTKzG<|O78eu zr>HrcFP1uJQ@;7I-m_D~FMDP#JwA9ivN`U~j$YL=x1g4_qL7<~Q z^Dd+j1>-2vxLIb~ApCU_#wW*kFd;=qO{+G?sCaXe&d{-wH(s(+r|dDX40aIo65pkF zHfk$_Qdkgm+^tym=Wz+jdv?7WZ(Phh{i^26efQ_rSS*b0^lnmS;_9nV6bpIzkW0go z(MdCd;;LvN*DVG7J(1FVr3cZvIw<)nRA5frh}+w7L9xWM7N=B1Uz{&J*rMywcG8tP z={)}4i0tUrk5^nKzbLvRXl4`a=p;UWTgz9AJJNbUTF;YAN+YY-06|(F01e>Rw5I20# zmc`z{$fo-~Sf}rN9D}N8;jXWIQgO5=JlI5Z>F*qrYTf^(gjwX)_uZ25&7r3iW2DU0 zIPcmJm{pmdT0H1UZ3rkI?>&S3NU?NO;AM@a;ue&kRBNyDVFP-UqhzbSq_jFKr(!Pn z9C1HItGmTc-D>Qi6syXIg)5DWC8EKml9s`&4R`a8mkPpYLMX@F-x2m$&3e4FnYm^1 zp5?@FLc55M%{!jK*NlbcW;d%V`$t)nMY7Suqc`734o4grMi&v>+N~uV!p&62R9o$0 z8q(NshT=q~(1U#LHD<6)1G*R+_|nH|Z;!;B7D2k7?8Khpd5%J^Ga zo;5b{Al~Y8j0GkAp8luH3)OU8TiED*rQ>wBbQ*8bZc`M_qxTa_T&5q}{jyO4FIXxl zYl1<{_f7;}#qg-OWnZgRK*rVGZKm>-h|{I-tUQmY_Z3h0F64aXoZMeGQPwZ)PD?US zZF1(=DbSi;caQOzV7|`>wHcho9sZn-SI3*^hCVW>aPRAocSRWmOX5qa8YtCI$b7bE zh~USn3l)t13liCL7qtK+!U}-vzAM9QBRmv}1vOZT{KFO-`xx_>r&7h#r zZM;1NfjbeG>DnN90XcXgPQYz8UdQ=`VqS%gxN_mUO8(u2relu&H7D_b)^YM~LSJ=8 z8LT{I=>zOruNJ$R_?@k?lJ;Gm3le%44)?g2bTDRc-xV(@8)PM_&-b0Yxgm#hdFbML8#~TWd!jG}YNInkfE-{TR;#0ttXj}7x3zud141K~| zw+nYYH;oIh+n?^vmd7Ui(d4`4y-@0NMW^l_Pdcu3u)TSk-F|qe6Zq+&$T{utP-_1S ze=v6T#Pa!(9b;RY-x9~Bxo{`*={GZ-7myF3_Am0dYm;=HavGT`ur`ECQeC+S7(AU781awuzcTPdW*`tEr#%OdEWme=DSS;d-IWPpkLX;Nld$f@4$ufiwZt8eJI@V=z8 ze-eLI(3wZS{3^A3#&QVjvPm#CmDF_l1($ssY+f?ubsihrQCZF-DWRTK%O%z3H|h6% zKN$Y_$nDx7?=g*|&b58|pGE#!JmNjKAUyotJdEJ{J8dY{ON@) zn>q)VGMM38sO+sbbW~h(V?_*zc~oI#PQ_iiAQoU+?;7&hU|YYXr3PM5Dy1;!YZ8c$4ixV*7j>Hww@vHF zRTrtJ_7bS0VT&*v9DYnOV7IBhY-7eLO)KeeJ4&q>7Gc)DsxZWj>Y8o!k2ea8p^Gup z=LM+rOdeWaN*1V&7M)b8(>x%PdA z$zY44N*q33KGG6tO6g&6eA3@AIMc;3k6CCtn)OD`I~A)L*&$@5BA?fYL$Z$37X-g! zZ0E78aC3`&*do=v!@g4XhwEsWC^RMX(&VJ(CNXyYVqpDy@I4L64@YRm21+oY-=@c?e`R<`5U$mGfQ-Z^7%iA5zg5GQ`WW;{ z9QQ74H4T%f+2a{?wvt5;lGY!?B<2krx3+l_?~=*$Tz(~=Rf+z zGJH8V{iuCQ^)y#k)a3go$m%X@hVM1^@#5;X_vxBpN8XI`KFJ3=(^Heu&&>IrJ{O6MT`q34k*at<*gO12 z?|Q25AXRLkm1pSzB!Rub_}Bo?rVE$G$7z;a&!1KLJQvG5`xP68!6p{QGWY~8cRH8j z+6^h1Os3`WXN^>=a9>X^*nOWUYx^=Yy*sp!z;INLYAg3OoJ-Cl3X1dAR1`<`Hf&_3 zV5Zo*bt}bm$}Wr06or&86ciLMHd0W~g1^^(!M&Z_PfJS?zyCh)B)ib)7BI+f69oms zno%MfC@9XlOZy?b-RuzvH>tB8?!OPVIeB3}*JcWecs>dWx;2AO0&!sQX&--gr_+BL zy3iZmD?&p-VRe&&LSW6%XH-9*d)mdx$>+2*Nqy)CS)!~zPUOhfg@9K;kPw&*=Nf^^ zjF3Q*l-1MuqnwN05_by02%VD@z`m=$jF?Dsa{u;;;(#y(g(Je@s5ipvw6p`l+v!i1L38gGUIN2z0ukHS41X=MYPg-3*PliYzood4 z2u4kVKS1AAUvy%tMmwB2?St_6lYo|BMVJ?OwCR@L1z>;x%L52cA16;A_%VMkr_yEkxi literal 58432 zcmaI61yI~i@;(fK;1=9HxI=IW5Zv7%1a}QC!Gk*lcXyY?-Q8u80KwgD-zDGs-Cey^ z|D%cz%kE6~^wZr>_sou>3=}jb1RNY3M1I^SEr|d6K?J`xa5S-YVrF`KR>XD7_p%@b zpLvGS-F;gB43|>~kd*|GaS(S=+7dK`=Jf?!-hRPAM~bZNjdJkuef?Gdl(l65vQWwB zhpK6XzH6s4@-FHdeRXhW<{Z!U8Ti00p=>8g=NPRZeLc1%Jd*F}93zdeeXxE2Q&5DC12>aKsg($PqtDdgdT$I+ZyEYWG+L}vUy%b z+->N{Ccy~qKojql(T%eN6g(srNx2WnWP7JW*t1PhWG@M$2fuz{w6^Ry+JC!-8E-=m zWHEF0l%w#Lls(PDB4Rg?4%g0n9^J!Gl!1i{O65pB1%oj04gx~){|OT+c!ZlZv#Xt> z)i*mkD<(G^>qwQ=s1+78?=y`rJ|Vizm}rJ#P(KqrW^32IUE<&!9FB*Gv6o6oX6+85 zzi-E!sGo?E#JMpEI+^Yn`#4qR-$4%`RD8p}h1&BQab}tmG&MNoYKOmKa7=V6!RkAH zm$c3R98*{!RIWfJUf19>{rFAb$~!Gl(P4G*6HOTAiYnnShv&uujGL_tM0q~R`|hQx zX2o)`Un!vODKRoO&4Xi2zaH$qA3KuAHnf(b*jFNwZsr7+ZhF2uSkv;&W4}7xa$c6* zXeUtyJw%sT>6`06MHvoF`A4`5mwFrqzOAVh}B~+_RL(FaQDHaTP*rD9mZ5OLG9{=$&*yyb@7$$ z*h>fP3EhYjzUaeMOp)t&_BT$1eQmM`F^#?)`@Sxz?us@Af#O35`QUUrg&E{Jzo%O-qOo_5>&RZ3j%if0Hs_ zydQO`yhWgN{I-nhPik$y6>-McdZs3$Jo~^bAQg*mjE}Gc`e{_elj>akrF5A}TXH6rw=O-=+ zo$Tys$^rq*UERYv#8mnh;3tz3+-N;h9A_$e#?4^#pF-;NF~YhOQ)$HeTr+sR5P1>d zUFAzVmtz(tqonDx%DT?DDcWKkOab#_kn~+ntib^1!GWxVC)k+=9FYTP!)M`b&;$z6 z$xkG}u``ftJn|Q@30Ffhow6rX8N!(nU4VU~SjCpjtg*32KsYk(v{J8Ygk!?FDZcHP zAp{^;U0&-#FEFX0)uKp%$Lfkamg=UhYukKqLj^?*v-^M`U_OuKHVm861|88Lqt4&U zJ>Ov(5G1Rn(A&fD;6D>(te^jm*WBW)mZBg%K)%lEyQMoZ;wKK!#N-Ix>wV(6KM3H)x`)eU`>w zi+%Iy&>iMG|HJfMv_(R5<=K${dY;*4D^)aMq-k`h-_F;|=5dXBZw}wp^)_3Q*DUg9 z*f&e#O;aCa_V_;WKyLyM)?@KJyjxG+AC$ zY<;{R=Xn5Um~jjvL@m7PMx`LO=DbIPb?I~d^9O&V7Ew(}wi^?GW%5%|(`;qOnv1sO z+N*W8&J5c=qz&`zD5o!OhEUY`)bAEj)Krt9+54f$(2@@AjkWJsR@=|P+VuQq873Ki zRyBh8G=WiH$DsBfwfac z)WHeH*Uz@16-<4YTQ*}I)88M%6Ul@{p;G^t@->Iv3@#K~!xq>MpZe`y2@Y2{jT$mI zc9-iNCt5B4dlrAnhR_?w+LvaFdIfpy@h|qjnMg+QB1h7%B{8oU1(Fou53;)f?{(v`$&EHi)Sli+s<6)aa6XxV63NS2eFcnvP7vWy|G?b&`49y_`}jOm^?f8rFh zDTu7k|IGN+Gf65C8Ti~tubAJ(q+dEj(iuw>w>#Ibil)W@T+WQE&g>KwC_N5skdz2Z2RV`Y(WovzFqnueh01Jgw$Z98+(Lnh;CF#K5m^EcgstS2 zBg7g+CDO!l>w|>nysDpojO)ba7cK12<^+oL>uLvj^4b2@otuKeiVWnQSbuI9IqbEp zvMr1qH>RgV`S@yv4};lbznwPH#>yW!Z1(N|VTE%6ft!Qb6IJZ^?uSVOo0HT~LNK9% zcy4gg(v#xSF z3~sU8F<@E__|X+Ia$pZ$c{(iVEBgv!*(R9R!q^*`PR`l-Q}n{B>L=BijAx)F1*11) zn9Genez{%#Gmxhsk}QJHhMS=9?9xs;QxNh|Z)`p$C)@b&rtQA_QIxNRW5y75#^{6T zgXMe$*U4q;vg+)7Zl?9643Aw@E4^%KaVYdn*>zn+VpP0Y>(x__$PbJ_|b< zfR5rHo}gc%OrlaeqVn{wVjgQ~H(7q!y#qFkEts`9i_)uT37QRXGYCZQxbxw8q3wS@ zPNH?O^3g&;48lPmLlD-butC^IBy~e{v8KWlK@Gw|B11m6uu*@3F-O~+OynU$_#6P? zTR9f01j2iF?_?q$gD?frl|}F5uj&T_@v57GL5|J=XWyo%sAZIt6o{rQ9L%qT&+O+jC+G`|Ceeqm8R4~Z?QJXtfXmc z#zbWDpSDxoJ2tn03vS=3p;0i9M^4isH=q`IX-b;;ziOLn@Q-PQqPqlT>PWg5t z6)1I)>+Iiw#a!sQT;)re;a{W#9gvA6Ao9sPJI%-(^B^1KbO~q?HMPr~bB!jaymsCv zgK9+O!z^`aE^F(P|Pswh&5 ze>7Tf%}o@Gz~RLQlPIUCD^iL}VK7pPLtzlv^4n|ZMrJmN9NJ5^--0Q8E@@xVk=9j7 z?yoqv153=UY@?$IJU6}4jfRiZ9V#&caY&DsiTrT`=uof+q=d(U`!O^{yq!P0jo|A3 ztdIEw<(JAqE1~m}kr0as7Z0jG+NM9u^IkXvm^;zj|9WQ=UBg$<-u#6xta*wg(VS!* zS7&5Y8J$Q>uXxf?TDYM7QLkS(j6k%Y==VVNLGre}E>mcn2rQ#53gnA*C5DxS5COfg zP+0kthK(k5i8xYZE}e6rKyYh&hMqca^(PCUl&~n}roww<^6B2AAL$+>mn5_p7iKoEx#7UbW>e@`91l&7>Q>dT5dmSsf+0LICe`|yBf=Xzlk({0QBU;X zhzK;?6&rkGBLg(6JVr!|EQxrW!)|^9y^RkRWj2_-!L|+q?KXpiCQ^R}-7(j*g+AN9 z_`FaD44oA%wfT9b^X&kJU2l~}{{AhOf` zSIde2Ps{mFpZVV>BLAEq#mZUzJwbZG62I%0f;EcZZjTVIdbx)jP}-jAl$%_Hmfb!v3le~!jYV&;MLS=p zWVC>+o?f4Q`F_Wh*VOq^qkY@43;0%})d`4w+?HcDnB=_be;fs*N%2zd$yL$R-SF$! zE<6CzNZcK+R-ZcC7{h8|n<~Ryxlm17UP4GQ>q5K|v0lbG4SGQjZOaw4=pF0cAHq(U zCinV9Gn2~-NW*iP%4_={3%OR07k2>!YV5WiPdD40PirNO6-%0PCiq(`0wQ*3^ooCv;bfbl+v>I`p}4 zfZ)moGfv$h%-oH9hps6Zu_l`dJGo~h@Tj zR(u=H<@c7Mq;@?~HSZ;x1p|+=aSs*Sh4AIvXTSO(FVxpICeMvjJnxBJ2H$IJx1*3< z(GJnl+%eBxQT5x`$Bmc5=Re!evxg+N*kY)_#^egm2ivCQ_5<(rUXd}6T_zozn>eVO zn-Sz+o35|?)nX=s_g2Xy!~&xWx(3U&uZ_`h%HRUS_zmZofBpQAZ0ZQ0V>f$+Cw8^Ix15fbDYs`Ph7Se{|A8K`+ zJY`ezk)qu2Z_5%zyX0dBNfuL2yRne6em74DW_7P$nOCL>ru14rc0ICQ-Vk{`6g`A2 zL7IaK;l%5Uk|XCM@~tjfTgWo4ORx zX9({^y2I9Fh3H4&)bd5FM~kMyMn{ zhPSvL@~HS;DdC|Mfk)b4t}EJMI4&xfwPfawIjp19-${ri3aA)7sOar{8@sFdtOmuC9#I|g@oR1H5>`#P* z!_E8WTdWS}OAqyJEAJipNpN$G@ww|Zgv+hT#PI#Gt2zZj1qFD;uK)_Nngu4*rb=bz zq;!SV6C*E7INxP@bNmCS=Y>1oK~<1{4vL3}N7KB^aZy38}izyhDVd6Z4HENb(xQx zh#(6M-(*`27I9lb=xuN)VuMAKR;!DM8da(7NSki}6bS>a2L`@Z?J!X|HGBel>|i?n zWW7uT#FrqEIF5cwMP!Uo79{`j+lkTAMqJcaKl_}~FOA0c>I3S?0W2;S2%OtC1uXUh z41R|g39~kq>Z-ufZ&3=aUkF-Nye8|NK(|lh59K4Z#x=;DtD%WFKd* zA%JamtQpvZOv6mpnP1GtR{CSI6=~+f{b2?XyJuH(rFl=;pb?4vmjEV2bg5X`_c$ID zup-}+-Ai0@nR$jF<@4{{jUbAOFZx1C9WY@U5et+=gwTm2$p)ZLFigmXlX67$XW*i{ zpfxILrq_Sn$FJnj1qiq}{u1TqZ7C202=cX|$#M*XVgjPO;Gtk3QxFyVP0VC7R%xKG zdjW-8M3JlgdF z3HnO6PgU&#I#{WPOV7WjC7&lQB%91n#a{Je3i7>IK&8O17cP*nk|K2V>&IOFOjYZ= z9m0B%f)T<2!Ho;k)^xM;Xa3jK{(%dkhEP_*d3JX3(AZ_dMrMAVWKFnYlH| z{}|o_t*zU~A?*=gm0f4usb5l;wOKqyLB$h7YmukQwaYnAN;}QDOQiERRuQRA+gc5k zgAFJ4+Vb$Uz92z=XEsj>9(P6isT`58WCrPKeu(2A7V=FaZMbwui58pngL(vZQv9F1 zj`em5+boU4j5|7Ly?Y(1a;~K`5H+PHT=q#7$!H(D#~TFiobfc?Ulf0_{Mv7Ygr zkonMD`A7z(TvDuKTN7>BBnfwZ9m9B{K1b0?S6NLWR;@l-c8Vyw`r91u$+fy4%qu(vqc{4uA79mhh( zM-OagRaeR}T^1&i7{Qg>F?d%m@MpR5@d?|hS#3a=%}Gd;_eZ!@v^p_5`aRNWJXf;HGrO zuzs9Veyv6o=lqR){c=5u_c*UBo|ERLL_uz%v#Mlw*jZN{WJhdFf0m%4P)mP(Ax6X- zL?rY0ULV0@B)Rw9KUj7sIsG(NaP6sshNNrSBkS&HnfY82n2H3s@+eqFg{7TX^jlt05Gy7zdm zFZ*Hth7Rgrl$T^&itnPOGRM~2AvMC?mj zF4cCrgML9#avxmPd>w;9QkO$aR>qXU%;rej<&(UPE8i!teNr8aqx<;% zOUZ7akRAZvdGngr_`-u^k5ydV)~;!uKhT9zjRIC`22>P77Uy!8R80@D zZI@RjpwWKU?A!456pvke2lzh*Czmv@>;*cV242ET6=N|Q0d|x`?}^Sc{Rz3nexw;$ zUZLFO#9!rN0Wt9$hLgf?&R)Ka-bw5NUajlUYl+HpOkQ(^sAU4}a#)7$qIPWXKUV%4 z(}nmL_Hj)oH|Ky2yxrfqK$#CEaNc~Ej2)CSGKA7!;}1Edg=|?yxgdoCRgOZH((3O!=W|dcEx|%k|>Ftv&Ka$riNvjP$+#^ zj+xYr5u5JxUlqSxlMj#@lW41-w(-M}ke+?15=JMpptUcM-bB@%hr!W~9K#+Em7<*J zizjI3SS#Ed!(R58i@C&?pTKiJva5#6|G>~vOa%q3|)9(`EaqCoCqF0!r zzk$qY!0?ygrxG_V^pKCff+)MjoauZ6M!Z`@q=Jc|vkqei#zfi5Djc%9p+1HH*YMbm z;Rml6GX_x%24So(YQ2pX_rL%ST=dm|HU)ioYF@TT$U=+U6r;suBUi7TWuHK)buSEFCl`-haxYmIj9V`HIRQeYjb6sT=ykc!HTAq z5BHQ7o3ocvku_nVwz2RZ47ze`VKKswvIx~pVZ8vdnm*ICc^wbU`703!@>sJ5QJTEL59t zpTj3iW$l^3A1eN~LZQ;pPS43}9~9i?l4Rm}37yxs`&hyh2Y4Uf zMFmXd?~W!~8nVxUcP$L#b01)6g)B)49mh^;$ZRB2J#8F0Rv8XsEYzh?-E{{-xeqk` zK|5v3PF3(O1A8An-Ls~SI|=jNuR>5tNGLeEDDVar`!+o4W1MRhp)`@pkYW@W4F`qFOE1LYYWL5|<^m1d-r=@6ZXO=xwLkh}zL49X~-yWW+}$2K$- zQ*IX3Mqf!Owr&(rLh|15X*N*SP{Yf|TI#S_e^9DwDKb}_Wou_4{$y?l-8><}qCJ$i zfYoeJl;-<@OBeSl;Apxb*m_bQy^Or-f$VuJh{9)6S!Mlsw4-8WJQ8zfmeSecI12-N zax!oK7oDGRT6&unTH(aKb~4_wQh?xDP(8VbHcz?`>5a*Its}vBh{Y9e7mNv^to1;| zhpN*+>rZ@snm4|e)enM0i;~!pwVEO}Y@r#fwX7~uK3a)E?ynWhDM>+uFKSRzhcrTh zasbPS+mUq9S!jJo_|kks)Fk&Eil$9c15HR~%^}Hoe%tQO?c;tK#0%#ga(qR4j0+)2 zrOap})R>|~Z~b$(uC0%hjEks7)tJnhWn{+`Sg@|_Rp$IY+d2|Xi!wzYyfk9Xs8M>R z^2Qb7>f5gsBUIBOVKPrzk@5X#0?fb6#TH2A)AqS~w_FtZFCxUo$LF~D1&-pQwWsUg z*Duw147U0X=E++`C2rR7=7@8GmMD4&M^5X4eQ#?Ucw_LNIj z78b<+>oEwES3fMCh>C*N0zcWnbuOMAk0TEEoY@we>*5pw74nM{l>_bijjr-T3VWh*5?eLY~Q=t z_%0CIo_4n#ADi2uYts1V@;qyO>em3+3Q8^2FKXh-wFZjWI_=#ONxI&27Z>l7(wK!P zrBubR+&||Y4d9ppiDC-JR=Q<}!iF3yy@}!TExTF_`D>wQrnM1s4?lUzV5^+Q9_V4qHAHAbm*@{k=}G&Jsb_U|=s9IzIqZ#u4_*+gqMSX(~&>+bT_ zRpBQUlCuMU46y#$$RxznI?=OQKJS1Q{*I+Jpr-r&^DYOm-0($Lexn&$2AjQHdksB_ z>sdzrucRLq4O+x#VN@gdjXA9w>YX-JcK8dBAEIf6M4~PNPgpghXN$=(3@S9{=Qxyx zTu5*>9@*O9if&RR_xhJpPuY45aObrP{Rrn@RT;MVMDyP96N@SL_`Z&*ep*AE#0<;z z0)gJnxhBh(UJB76AkHoR*9qVU@Hv;UospuWoxKyYk)5N-+xN^i${Pv+ENDJ=Rixe_ z@7PrczJ{g>wDcM4aCFSy4wNdU-f}jAfbR%eo130|t^vS?N z{1WGs_!~=NV0;(ZVw^@~a5`aktd>JOeD4>dt$9uu20D8`)R`#w_;|)#!vx-%pj5yR zUp)?2WCf3hxr}A={ocnZj;Nw~n4LI^BE7HX1794&623)n@afz@Dk~Oe!$d|=DT(;D z!!^2Spk9xVm{pvcZHnDvuhigRYxOQB=PIq6;d4Ap15QgklN!~ zKzE1-VIf_&Jl}bTk-RxXsq*BTG9&~<*#A6uMEh@t7~0#v`6DAn&aUU}D&G^9T3>^d zPNTmfe!ayCyak`Lc@v$C?$DeUjg->E9bz`*p9kZo2I5s_Jq3>;l+A$JLg9~0iZJ4u zC1aJsStmLjU$lO%NeXI0A@hoSwz~Z+)b@Qd&p+m)KRoiv;J$hwbPen{lzgp}v|ali zYod>Y^#(m;m3joeETx*#9CRU^xc}HX)=#Fsd9qg=x(e=foW_&skHmS5=3M7+5pg;z zD?=gb7GHOB<$D_PCnu1l&wue765O0@y|e`~oD(wJe_EwsmtSA3Jv|&ew#}ANc>eLz zSbt1k{L@fd?hdgFxgE1<-6cE@?F5vsfV6D~m=wUkDY_l0K7nCL2ZQ(jzSoEG-@qAt zcXGC~`HS5|4MGnKX3*Ap5!~{sDs1dbeKRk-55z@(SNG{yllfwTrDuhH(epcW` zv>a{ugJladJuL(yG72@L-Ae(tRQK@aSK`3zT^I&{%c3sD`=7&*;S8i!JVlt61xpi~ z$jLlLOcY{v%9#$z98nWJDaYH8@w}?@O3OhQ59D4v4;P1@USv>=H_q;Xc4VG5c|K;V zIB#}sEkOK82Cw=8{QJM{(h;?@bvCheHc)l9H*wN?v#VWgTmfuX=amLSduqdGH!l0; z=Ae>PUtP(`s=AiY40a$0=pstV8xj~aJJWIZ(Mj%2+FRUEW0EtD{(irz>U;mypfzcdt$C0~@T$Ubn zq)5;)TgnBNM^9a_#USKJoU2R8arIiPgf(|S)nAEZgi>9KenMoI_XmByZ?jC(g#G6Q zflAB)z2}Orsu!Z4hkh{tn<#+D^`eI&UHm}~I^AR`N=GCmNXR>%sK}cC@Y_fqg?X6+ z+-5!e0E58X!Yf^t%~VE{A79NF6i=lgnCW$WYw|^ird)kg{El?msa_;5@i!YWs!;RH zcO&XHc<&cZ9gz55p#)R!pVI6LA)Dj0Hz$F?IE8maOMgx;Kb*6dMIze82mO}w+Kt+u zgC?)mcV^y@XI0Ef$KST<^&=@8PnxiDuk{kW((#IkeH3DSfPQn>s6QuzJva!}Vg8rH zaKY~U*9Fsm-Q)Ss4W734@i@xC#PXJ`q90#B)ir;9@Z}ENNxYB+u?MHrgfy9bF%5x1 zkduU>K~khld%2EJq$!i-+X&@uG+)`%Z%h(dr;AFGC@up$oW1_>eZB8B^Ywfht=i~( zI=IW?GH82vu4@wVzB*k!^L@PA@O`ZUSv`>?PYONVyetZNKi#07`FK1%O@c0N7bih~ zNM4&ZUS8IjK^I2`zz%QFa(tIU=j-cLXPYnRO2feC;fTxE{pt5&r_aUdpC%!Jmtog4 zpNEU1I|a}mX3*3M zy77E7*d){rlG{mc67qU^wRq@!-F?dPm9qpr*u(;xI=x=*iaIT|C(AwxzTQ%2U8fRz z2>F1xyR6saKUJWYldO#n&|+2===lZY zaaTl5`f`!%d%vDc0{SiV3Pe_YJJM>_5F0-fAEWdQ|q&U_z^B+kL2??POK2oh`3`1LuO1az{Fng!hf z9=GWGvh@=3k)P;vof#gqIveH-dQcz{oF>Vn+<1B3LPNFlz2EBHxW1a~c<2(yx*mMJ zntVN42atfC#}|e8z2#@qG(cuz zx1#qIe`pra=Qhjt^})iCJ#m}M?cK1l7c{1vnhU%f zXlz04#y1FhL05rXYo~6lPpLJ0(wAoIU$f3Sy+O%E3e_*)(nBgOLKJ>`u}xmw27JnV zb-w@R@fZN|aFp{GeB4>L3vTXsSzRT`d=2>Xy?r1v>U@>5V+{K|WJ3TMwD<>f7l7<@ z|Mg<@QA3&@e0d;rAlwfq$L^9J3D~(9MgGpyojU zqfa~@lfm^>h{As7UCi%6(Wnu!r-v-Zp@ZLK)VncqSN+cl+&jC!$(TpTK=2_}Kren^ z`3u&@v&w6j+||V|l2=%im5zsR_#k*#xhNZsQO;!M%yZCd0LnpjhRf7J_~`C~?B#0b z)J8{0rw`}`9Im5)PTyN+Tf3PY->1Rn1M@0*%x^@U(`V^CnK(Z>w`L8VdoKjjC49XF zk7s?Kk1!sagxVg~lYO76d!i$Dxx}BsrgtJjHgMPJ#nae{hxZ)^q{Xw?IV+8Z@c2Fr zq&vj0?ncB%$V}LGvOa1=@R&Wv;z!;qRw0OamFnmGjQ(U#8+osrmrE|Vhc& zRcj!KcNNdKx^ikQ)Os~)Jdk9H$?jur@Dl0kk?VDLz59AYy(I)H18tDBRuQihf`okT zc3mfbTk)}GO6dHqc{;pE6km1ji7czAaWSZ<`ZVB+y&kyf^tc*4ETVtw>VBmZx!Z!>5APvx7zw*2|8}S5#Yi@A!OS=b5$^-DZVkUYYoSP1ZDtf_h<3zv(@6s$%<$mM?n zbtPGF&<6=@(<}it{;Pe*Nujp!@V46_R2_)KQXfc$rNt=}v{%2Bg&rJ-MO3G@B+ME& z57(!*MA74I=iTk``nN=JuiLK_G|n>Fr&dop=FA$iG;deU0U9$zDVOHQ0+@dGngI_ILx3Q|#Md>>n{#U(YU*ZSqii&8XmW+-Oy zvJp@4$e2n|HE?n)F`cS+yl_%BvTXSLuiaP3S>80#bOzzRP(`5_3zxBRT5^T{(doxe zDyec?n_>L4?J>)O;G3bt#@YLly~_zIIg+E^`D<6{6^;$Gz(QzG#*27_2#ro?%dc%( z_|Z2q)G8vgn@+JfdL&p;#|-L`0qpA%%BBLCB4IK0#I%>jW-7X~OAG93m7M*n316!| z`Y8L|lydRQAs!9aT3akVIT3Lw4L6@#`7o)z}WE2xaW7dQ}utU z{j8X7R;p_g))%(+M6q^{v^{|D%^UQqvR2&&l{aC z#jDVAE7;{>P2iEjz(Hmq0I;j3t*jw{)!DUFX_JG$)!wGY(ya10nW}b;F^HGx-OG^} z*!<*}B1(*f(qStVTe*VYh$_GqtS3Z+$vw$LiVyIs{>Sj_@`A((fSM@ByywqgvA}1! zPL6VNk3b}SW)k}u3Rr4^0?}W)YJgz9z=$pY6=j8)vV73Hqh;^Ff5TqWGB3q3FB2ME z@rA-FG`RgsbVQDBV8~6vrHHmd&JcRJ;iqW|qowsgk#4C;TWWkj=D$_Hr*79F5>si< zH(yd7dcsN$77znZ{*F|gDIzjLT9nA8ZH>GdM$Fnyz~wmIXqmP69>609FjFaV|h2aULuIX4t%e)xxVLB1Q=0E|AzP1H@u00|7+E1 z#`W{z5lLdf{KE{4X%WJO5lJ{J)DDkcs@%1EdY_`&j=owgn;@~7(TL1=B8YiR7B(-O zvRNmV-QHmX>(u<)la_#oY%7O);-gHWK+LB4kvd8?v--9f!Qr~ho>(CUjYx`4xuzr& zm=1?eWCsF(F|f}XMv=fiV_saP>(-aCwoAmbc^OpGG#xUyl^JC-!p*-+z!m{6mDn3k zDbmD8G&7Dy7$!{AjUolT`?G8!Zk3GJI5Mwa+4PTgI`)-A6Y)_tQ6N%BJp=oWz%FXV z4DnEUj=ga}nc~iiybky?{qMkrT}kllU^#~hJyS4zY1=l^)r;stC0*|GqY>)vmLf@b zZ;Fy8R7L{8q2|sY!W)h0ez>OXf_Etxq^A?*oVjiS#&1RM4Zq|go5X+8<*L*bj}d_6 z9&$EQJBqvedz6v6;rHl*PlQO$5P@-Hl3H-vhI13@_a$($cDcDE8kXr|A&>{_nb26p zx}wxKl}0prBu>|k#3;xzFqTEs#1E)=K=$ce;RUGW)z7$FvkmC;PTI0zBFMYD#80ot zfwimAfPHBUPL`7js=NxIalJL$PDO^yD3#HdE=6MOu1S8!os2Vtf|Ol>T(HOw@V%Ab z`Q>IBcoljk|FL~lM@?L(eZ*YLWJtzbW|Yq8OOIk@-)NC1W>g!Fe$G%~m)O6CH}+PCBY85`w5u6Ag99&0ESLc&3H)qRe4e6h_iK|--5MemjgQ^6 z8N`R0m~{@kvK}c>%)jCV4E!r$z^J=4Sw>WPL{8TX#89Uc7)7!UBUJqUk?&K*8IAGhc?aILXSOb_hbe`vnh$0I1`sHx2WH|I~D@UcW zXLQ3IK|&lUh@&z%aRAlBh0(N9Dc{PAy)W#}3H2XAn!xy{o@L}3NDrFb7`8V>0w5%U&!#$W{x z#7?Maqgb;KAQ;8nh0uXhRf-1-A>B*^7aZw@ZfWSp4Sfo9_WCync`A*5aaiJm2%>_x zw^LZh&;|C!?uCjw@8c_sLRbw$_yE0%G?$Kph$TG}aaS?(hj6#I}EE5Hb_+1^NZpY`~_Jt6BJ;*L14XDfAu2d)zSZ>_l?ZIxt8_pmulb=(IcfGC4oU(bAQTFd4%Ae zT(h)Pqj5WKRKZ8$p0s7b1Ovr|n*k=be`hs72U*;py?cN8>ktt`QYP|%n7-;kq6B>Y z6=u|PMv>wU&eH-taBC$WE%pQ%ryP>q`jg&L~p+BM;>Xj2^sdK%Dz-PPas zsvbG5QN`-9fa?fKC@_n3h;1snmZl}Ws_5~%OQ7c6S!^cBM$Q_NDLf-iH z=4TrX=S_aVD45ur0RQDb-?GvDGFQCz%P7QUlj~!)os2`&cE=Ju+w^k#bMLZa#ULkQ z021%yDVUqm&AKo}4KLZb! z6hoE2wbEV)=qiDZSw;BPoWe0P_zta4rf-|oQXnJkUzO&~nGs$U`MsWlI1|IUbz-$Szr6f^3*naGQK9>)ZBalendKcu-GBEfTYA z)syDHAuIX-$65>0a*`M>@U8z-Zz^LQ1Wi$O1AlnL6)jay*4{peOu4tpp+G2r51=DS@ zdX?nRXUiGj90*vqprOmS&Xl^i)dpwcz0`YP8PEdhm}AG?6mQ9b!w!u*0UHunw~?Hq zcUr~>px+_F z?u{b)y6W8bGio%K>5a(8pYU6T2W&}>6=_(q^sJFwYW^EUECSJ+Z$^sxJB;Cxe*NH$ zgC%M}qgVn*)(fXykUyvE*BZY?@zWKL{JY~p4(l+2V^dM3?&QjK>m{py+_;Qe%0&Q` zhTQV;f~|Vld}m=5HQ@5pwxtu?9%Y=B+T%;Dz_<`Zu8rF*CgeXIJN6bfcQbJzyzXf{ zNrF3i6V^*fhh{Z9r1_&rznkDSYIi(MJC4ha)evC|MEk^LpOYq$SWY0!EkR^kakJG? z>}egzVl}O8H6n_b7&alet^e0LHgU^v2q_Rz+|P#CYB$YyTn~GTF%d3#vwC8IDm3T7 zVobtI@p&+m=b7#4vxUvmOx)m%5Q$C8Sbl5M2<@;4jc)vnjJwI2RCUD*He)6s1tQv> znVNWfRJkv$G;%l`MSt0-;-j>H?kj1fu9lHQduZ$OPNaU^CfqCKNDt@o- z3E7j;p>5tSV*V*I_9eJYq&7mjlgzhYFrw`~N@AWPii3n!5|F2CH-zl&Dh3B+r!5lk zyF2#yKWeYVeh3>Nb3NhWOB$`tAL+?OZ-#sDr) z{yG&r*C9{O?yd3pr#So#NqxJBa;_a2grv9m^7(J`!Lh8;ig+MU02$jg}PC2YKjBa{=Hu)h+hDx*+$HdM#k<2dx;LP(SiRUofxVzZT_w|>qOJd;kXRD z`j`$Ek7PTo*?UdUv(l{(s~G zj>6V?E7^I^$k6s+uTS%AwC%xby_<&0yom0xVq0Gk1%m=Yg5Q><(0I1eo&PXaxLHqY zTO0oWXGdmEDr|zw6V=gtOoB_L%MdAA#vQ9qm?+~#_Qr#4a?%ZCB&@(s9}ffpE8v{2 zEd$RlRoua#2PVPaegkiJm#RFPSZh{e&Wg3E3RYtbN>SrybcR;{fcf=0mi(?`>FwS4 z6)dt}lc${4SX|5N!QR6zUoY!8^CLw-t=OS@5sjwsYCquhL`!j8WtV`C1d@5#$Hi-QN5*Tqpy; zZ9D-&K_cMTHXa;FSQQvF{6Usu5b2%s!9Xg}vaAdEyx(Q@t7$phZ1 z!!9_D;`MC*(;{sDmwxHCx9Q9Eg0drs96NQb2(W1vC4}w-8~N7+mlpAQDsiV^@_37Z z4Mo+R0D@b`_P=~2-}D$MbK~>7$43;%*`%A`BPzIlVXyQE{ZMzVL?QJ=n=X9nTcei{ z1~p#k!eJ;BM1EqXvesY8jfqvW1}4Wz*_FTax~tyrP@?aktLZSr7o7b6wf80PP`2OS zQd(%UXD|D{M3#^wlMvZS_BGiRkxVJc-q@umvJ}$TMaI4ik`}UsGAe6Lp<&Ft*UV_q zQ}g`a_x*kTpZEX9=aXl+@9W&>I@h_r=X}q(uSbNwSL-GvPVxS6Lo}0P)P^OPblY&u zfchzgF}@TFy#StRr*eSI7E_68da#$BM$4PC)=j51SRQ*}9A|+00^4h!{;?hLda&%} z0E}jU7IU=?l~KZj-u@w!Mq;Ra`WC3=1hV@W$rn^d1XKymU90x+HHjZNQN;-tnz8NW znLqKZnq%qyk|$|mt~F%tS|H0yZ@mdx|MZE5klq>81j@xE7HOIKY{ zyHk7KSJ4|jK)bTU$P;5T;-DV$cw)LWWcpfQ*O<3nKdpb}M1%SV?vI0^kk}nTf;Wx% zVbd8ecuLay_}Ke{?=DXXsEGS2+ZK}C1jrD3nr>)~Sdr03lA-=}G~>%=bV}5bDBf~r zefh`Lm5x<{RAEz;e(GE1r3Yf38+$QV?S_9V&!`7Ae)7)SU1=zxAug(6k2Dq6ROLqO z;1Zv2m*oW3a6M-vUqM}A5x?o+*e(02j15bD9AU?R2p&Ddv4-*aOT_w6Mh3SIKXg%} ztsa?ImF3-K>|reKYCP61oD}gazt!BGQ(TjeTS8Kp-CyN01eU}sp$X@nt$)S1N4`hg z*fqTBRZ}>jbYgku%rm$z+`G~!|KxpU5oRV4bm`r8bs^(1u^l^@vsh{|&%})x!UIiE zzIx$|eZjNgJFA@%S#k>Ai2K5Azb9zbgTlt*FC!9YA{fm^#F?{9VWpoN)csu!Ck9Y& zIv*o)6H=4!T_xBQKE(};GE*GEn7UfPivuIN{S|hc8)z#XlzM`CI^pV zYG~gS8zfJ!Tq13tA$_x2wiiwi>1#cXy!dGkyg7TB{`^l97jMBy7u-SPF z$E#p~XKfKeD|3wn5|Ng<|y7S}fg}^)D?(j|hVL^~!&Ki*hGrl1Xz5xa+o#yta z(UV7W?4b@R59-uR;+7Dc4yWsIQgN|07(EpwC%B z$T;fWH?ggwVrH56NBCS+~@u%D6dT#vXlfYSl0 z$nUi@ubP*Lj+aYGDa#Rotfx{EaO(Uip?x#PAlKDN){Nrus7gtgSI0dXV%&4C%iRiu zwCQ>EC0CF)&NmSXx7}%V>5f?!QalEQWlcP+9Lpro+Y23x`>{z0v)+1DROLMwG-mB z#hun8@#QICw8U)q_IxKli87$YOw)JbD?dD8IX*Ge-Z7(IV;zu^Fr%Kv%H?R;om85B z2uApq6aq|OIi`{X5`(!Zzk&f__p%7)A0a`2@zmq-V{_Y4nCs61iw+;XJ9uGlCa-ZK z4T__P^{C}nvwgAEcWkuo4qo1y?X3Uo3f0Zxi*M=PrR|_O^MH!os&)(2WZ1;hMvvyk zHmFQZV9u5uCK7gOJA{-)2a*p5Opne-<=fGT6z5D)0zogeQLUSb>4cUjlL}*p_X(YN z6(pZc5LXj2Z3#Zm$g7&iRKJ~94}JH10@d+(PY5&HsbW63w={BRoM{RRiun;FgM~3V z-l}t255c6KiNotB`oP3h`Vl@5;4}p2W&!TqJV|BapojQq=Pv;>UQ@gDp1uOB>8O)f%tb3 z+dEAkr}`h@?GPMDX+(AkdhFK9pBfY7I`&dSNzO&L`(xgXZBgTpstlo#n^f#c@(V-G zy)s0T_6MAEsWy5k<8j|_UsvcAHV5-K(@Hi63-CQ`1QPqTO3%OKN)E(WwxDF{0WiV% z6Fa9%(ONf`983I|L`J?+>Ij!a|Z z7~ES98EPXV_NY6EowN*W)B40I+_6^vq#o*?|GGnoi_SfMNZS_W9$$Wo&v@Q026n<< z_G+(SLeGXJb^&AeBbdO*Y<0zc^B6|YlWzvgGc8^)cm}Q$aGr#5`3BNvaOL$9Cc))k z1Jvhou!}S83)6kQ=^o79BG+qd-%~Ld(4rp_m%%nI;J9MQ8TTJ6Y2BP11bzMxamxOH z8J&n65A{umzsI%et|NR$rG?q6O%!0>(isT7yVj79%fnH!U@a}A`zI@zJOk?jz+&EH zQTgyRaxNnIs=7AM+qPKKN)}pM*0S{)FR0&btIn0#U-9adpnBwBvaN*t;2qBGmZE~T zH-fpFdk7NN2{7af)VzNh0megwZ0$uYfCX(MwmuhBjH!!oy!6n8-Bl@3BaxXVVAr(g zM_bh$&l$c*mOUvYxH8FxmifaCGMYPh;?UsH%zD(an&*QzWWqd00jKBaEIW)Gx@LSF zmcd5jvMUvAgeRQVP|>HPXFE^cVe=@HJhse~t#@LVKkErP5kH<2br64@t5(mE5A5g% zbH6B{x0j2-MHQL8NXotw9jR!n^f=;^T70?=PF#XJ93JyP0B5#dz%Kt$$D{d!(bt|w z>8H0k<8t9+2bl68E~qEY=C)=*qRzIiPt0n)!hD8fsE$Q;exka0yC5{Ey01}YE;Si) z%65#e3T#A`jJxjflvKFw!`*34@dj@D$(tbpH+fUj&rIi@pGvZQS| z`1;l0lD^QfO*|{n)&oAI_YTXf`ciki|aep=QIBXxp0kioXA@J9sA0oi$Y8 z$WmnrGei1E3gQKV9)SXjaUjF~;*h~2LIQnxniBPi6~>JA_|ob8A5es-$Nc0SdM z3iVMdx=;E^6#(4}pYXx=$|0-ZTy!FN$3M2~?fEp8d%Ysg(w4>7u*CYv%H&Hk3w*=~ z`|oMbdc`uif#k9vw&%ibkxFKS$J3hB4g_C7%ES&{w0zq-Ic?5u<|vwL_s#5)RA;}L z-LcxNrDSe0+4!EFeIA?uU?(X(`e<8+W;l)L!d*gMv{i|hHx^BqK5czP!s8ka8djE6 zB7p9gK35DoH7U2Z;8|~oQ;k5y}Hg7vs zE<2wmlmyUn7kzK%8Z9xh!A<$h+s*^o1;Z^Rnp`{)?}59?WyG8+6|nniQSflA7k3~2 zRlK0FXsg+eY44#)i-s!z)GwKPdR>k!r7Vc&xo}iuenwIwa$6WA+lVu8v>Y6a&SyR9 z9#O^@ivkmD9$&#*g8A4BgQ7j{>YhtYcS69UTT3)~zC9Y4fHTCsWLUh|g%`7ZUJNEG z$HcIAWt+`HiZv>k*ukU^)djqXAeij>sf0t2`KLsa?Exlx{{ezp$7)Gw(!bH)YLU22 zewZv1y{_hyv=AHSBbZP8{^3@4B zA};m}LN|yDO^BAn4kZ1Z+FNXgQt-a=yq(%X5x~8j_j%6V{nUI`?d^%1PR(GTQm* zL^Vj;)j=HQ;os9IiTyHm%fi_P_jmQFN`xh(=()4cUpK|*Dktmhsf!#F>}5^hha4z+ zcv@e^PL)2>)44g=4LN0JL0tTmY-jP9c8-ix5!90K{LeB~m$tBl3-eaCG~JI&wvGqG zryiX?Q9>AAu*FyORZho&o*zMKlke1|oYdoIjjfacgb<-2`S@A-$YM04evTuA7a!#s z7GFin0)YjyxsgIdZ`4YR1L+zz|82z1X;Vbl2cV@a!TWs=U;B^{i`q7&K_@;dc$3zI z?R-`k%nvnlgJH<@X`?e#t^#hIw|B|3my)#Yr8~|QhkaO4f!ZCY5V=`OxoVw%(o`no zjhGVkmH|bNu!KIZ!;yL=&Mm?G&EteXNBlqpTOO6EuiS@KdJ1g=02iYA5^I{mg<`Ye zq?-(q&b@x!jv+eGo{+;vwMvBp9ga5%vZt|kPP~nwT5$wYn2(&xOSZgcYrpO>0dmKZ zU%$RKrN>tnc_Qa>#PDPN##V_h7SBPb4&UW=%rnz05DOpqK8K30%SS=NWYzdZla{B; zi2wrjk$Po&)b1N=Jaf*|jEx#j1W24>NBtvIlA=xX2kRqQ5iFxEsSes!h{z8Kdm+XI zGX~j5>v5hRb$6iFx;kpaGsmnH^;G0SWPY*Vv52cg%mm;``XDiKC3vopnPU+i#PytT z&uy@cmsiB4>6|` z@yWz;2WjL_#W&|EX%>Il=xca_&A%EXjEZ}a42FCAGpt*JL+uuWHCN|J(Q_gxmiO$( zlxYcWU>^@3NIVjC#R=FSyADo50f@O=hv`RWZ7cBX{X_>Ksh;eWYt_0{a}STlRbraw z?#2F!_M|85$ez&`xt^?*>0g2Q*gm;fFP#ewQ2GEdCnS1u{XdI%1ZFQScpDNQsgkeQwpZyRrakqT#_S={9|BxzR{C#42L&Y?+?#n}b_yuLjGmHh|7e@}%>Uz9Zs|VkP%eX1I0x8!)8`)AsnSX_Fi5RRw0*(e+Y0vH>?Cot+P?O6 zuRZgwk8MlHgVf`mm=hc_QYhD!Vf!=yfUQ(Ukt?|xktG+_6~*GI~2qPk!*KlVSL-N}FX%&kD7-wGjjdsIn|M`xA(Nv0dhN1UF&g>j>>WWP9U>t$75Yk4XIG?LYBD^CURwBAWFXFk z;QksfGSMK9PdYPHV1!!;;zOr;_t1A=>tcH>C?JZ*af!!CTU@g$Uy$Hgt=Fj*!7CU zupX@}$-Evv`FhIwWB&+<8yqzIi4+f{>Vyv~1aXt^%?UrrxMy{(PA~x4)7P{V4OBN} zdICDzaEzbdS5iq@So0w$tueZBB+2^~5R*R3wY zUQv(qaD-fzI2F>c^jLsNawv5R04nQ}29Wtsbr>G6{Z;jK(n3^`N{>YenNROoeiWb7 z#|(7E*6LhC4#D*TsH3}@BB-V#eC5xS?soPORxAC$ZXu>`00GIO%s zQ~TLg6_erh(Z|bnA;TYj`@Ej~7hBbZy^LohR_$0ojUQ`kE^yE80}l5&qgr$My6M7W z(}zMS^{`Xt0YizP8X`XT_W2a*N6ah!Lc$t}o>|aDIuB!m5cM|MB{09PI#q9v*J+2S z#)wGz_9UGfzP*HGLAlM90M@>u&Q=7LK?3W3c+k>bq3MXhy|!S*qAMOs3yE#Cyp?tR z=>}nT_eyE_g*rFK^L3-qlq;M#5}1I%iN7J8hZTR;1z43dczP;r)lF^WX^V62yjzw6 zPqS~_l@$b&a_YSc{B;o=(F2(Z@dGhaxh(AY$PA%9H<@(wp4FJxHQ;TIV<8+4ihC{X zMbD{3*4G_42%yS+tgAVg5~9dCXnMR>n+g;yNxYI&*I}DvmWyQK4;1aR{R8&$vl^;fSyn4g3OP$)$P+l^Vu-hN7xZOIvQXU)R_o_6jJvqTF$((f& zrWisrLHW^>uc$qB9YPvYS@y*aa=U2(v%aF#?EZt>hx+CZ*PV>t4w=a=2GQn-eR71p z<4D8_9uTbbE=x>Apf_(#Z`CK*kgmCh6l?gt(c^c`seBz-L0f$EGIjJ==f@C6j_#SBF^wRz&DGwBEV}%-?xU>4M(;&bPfXN1bgLbQ+RC zOM@v}{kCxlh|x~gu3*zHfULKk$auabT1?{^C6egA9AZ&nz=Dfz(p|N{^Xt9>PtT#H z3?)jQ$B5JVUu^4mB)=sZHa~n9pbc^6eR%}30`os1Bn(E%?32u_uPeU9oONaNDiTC# z)8qB82r(8gy(>S(*ycsP4s{`$F<(o9>)GEBKerJw`ZPjQw}C!WzfRCnG}oG8`(xAN zbtkEXzd`i3EmvqQ4xmP^8YGAd+zlo3W7HkFuErasg(afyuq04JEb)E&2oy7z7+vJ- zRH^KIzD1YXNS|eDM`Ph#l|w^>1*6S&I=}D`WQRG~j5<6}2G=l$3cc=Nw$ispK~@L! ze$>6H1Q#`@m~8gJdQ3KyklP%-kw(KAtS8?p!MdrC_GSWQwpya`-SXP`BbN zn|iC?rBZdAL|jZspoGj+SMVB-t5?o-0+)A!j4_8?Stt_%y9Sl00m{p9@G5?=Z5T*q zcLcEc!|XTULF=SNs3He_d;nxbZhl^@ufMxikoV+gV|i?+Jh&3*H&0}UV7C$iBnu7o z510>i%(trT&|Jr}unrVO%zLYY)xdV?*KzO|fn){4xMvp7o_@EcK8^Y{}I9*mLim9P{ zaGv~N(~>F%EEtlKzyvwq3(^z!BT5I9PqSUSbKBSyZ8CZv7Lbxu-iX8sTG^MJKJf*l zXLgeS_hwr_A$9y*)bsinD)o-Q;%h0B%u>aGN1a~=p$;oJ48?$|`tx%Ep!mq3BO>A9 z9+pr=yRc9A#2F%2CZ#BVG=FoVr%`~RnccG;lWik-L8C!laS;d0kOmzhFF~%pwZV-r zz6vHp7|%>np*dLm$F_&LyAB)9+NSN;B8L>`CzQW;gL3q7lu0Qh7JlOGh-%$oP^kCO zt{dHccBnp*n4_k^50Vm<73eoEB#f6v3WM>|NcK2WzX;W+!_u)ly1nMyD93oA>=Dl+ z>sD&9kg5owpX>2{QeB}8j;^Se@q{b~$q;9X=@sd4R@s{A^|0zNw}WH+Y!P7(b&rus zRGrR#Qs25PgfhXL_&DaeWagADorrYi*7hA?3Ab1<``rAbSdUnq?I$!vv?XtV4BeYl zT62^+pH6`7d_o+L(=kWRvhc@zb<>8DAa}RuvDd zm}=?{%Q)5D$iFfV+p4-B^B83*CH6)t^khMAq)N{n2KY7`YFv*s%>Bi@Vw{u`!Lnld zgvP>aWInOK!#2G!=SNW-G!{mPjfHJGU>W1(?tsPuo1XiI+pzbLtXkOl>wxW7>Ak+1 zeX2WZ-qLZUJHjl#(jBo+2PGFdV+l{R*kF}9pJy+l!?UodpFm^5 zUlqw#m%Fi2BxSoNT^Hqh!GPGcB2eDBMPN_Q%zO{9Co-#dh{20IT+-MQqBpto9;p<* zTOt?EGCiMtkyPfC%dAWqC>=5VsmC-;>M^}05T-ux-MHi9{p-)-TNfcbb7;{jKCn~F zhMfW9X(JU{2f814d~0pIytF&KEAmaD?D|fN!51DESj!F+1V+_^{T)FY#G0jiDT0ws zyhMb3P&{6vG8A@Us)1vr`Su`mB^r~MgU-EU%RMeed)1~ z%LOOPK$386D$}_;imEh*SiB;9sIO}}X1>zjh?+Z{4!L(>jLBci*1jw65pWw@`Jmqs&A|_2#qV$(rI}Jf}wTP^W zWX*!#2}=mt%x_#~`c}y3RL~edCxGc4%rYuO7DW2+tq!Yu&o4E7CZZjRU`}{*WPTXn zgk|F~NL1MemH>?qzH+Xo;3bR_pwA3s(D6mJi)<{0_Y9r)mI)PA=!+h80mc$pS%GSH z-1s|&Vj~)XAvd>0iDrC|fKXOcU?ZVAcC=|AmW?19$Dt1YcHZQD+xi{ zhgJ)@g5gZ`ZhMHs9cjJ|S2iDsA{#8NKei$#gMd20`ud!+TNdSKC4owH|$iuujO9XD@Xz90oxx@xxN9@3M@c$`{$A zD|lSQQB*2%Q3zp&oJ~e6W(OWzwdPFV7vBxGBF9e~b8+<&fnWTjdi07gva0`9sUrAy z)q#tp19h-OVVg?m`g2R;&hFg5rE-IVoegr+caKm(0ddxr<3rDKRL4sYC#*L zY!K8HPhNF`9BkUZs4h(sMqc&bDRo@-mo@H+A0`STyT)lNGbFpl#JK@se{xUa8WZOR z%tdyM|IJV$T3S>kV+VtIZjp%=GZVm7m=6k`UAy$ptnNxt&FnqXN9~4?Byf z`lf6wQ5ad(f2$O-d9`~2b%?^qx+hSFD2(hHljgQ*wd4J|#=u4-VPx0%-wcJaW0}ms z!i1pqNUmRis<4IfXFQHq*^7$N#_$-BSDh&5$iJxGx+09M>c3U0&vZ3<@)+QV!pN@i zk!;co$*wVRZa^5>eGF_w6h?lH|HV-GfuaV>@hVa%U2P2gYIDAyGp!{g1S8( zfvXaC4b1njdp`&JP7Mj)jS>KWpnu?JRzVo`EyH|ifcv}$WqKV=A0I^}l>T#04n}>? zRwsn;nCsr68W@n#2gmFF;1tAB-xIpIczmFS0@GbANEua;0zdNrFzS19NSNzgb{hR4 zz#?{|=zmT$!Km+vCinvjT>8;eLMnjbTt~0s9$?gW*iA#H?+|JUj!y^71sLFGVgyEg z%iaG=W<$ee<_v-w;)f+sa=)b9y>{!qu`EC;f{-4`Xtr$ZRq~EalCy1f)c6&k5jG@Y zWC8m3O1X-z<^flQNW#cE_O_K7l67q2+<-8$jty)?6h<}(|C^zV47=#nV-e-}-~uhCReKV*%jerr+w(#rTPcV45Z#D?kWPTLwy z{dYdU)=dRXeG=Crbc)xysmOn}cz?|>Ky!C^t(&^mP0b;7in;#Wu3GD+l3wvqA$5vL z-PA95db@IwacbIkxN9qsPTapS)=CCCvQ3S zSz#nZ@D3*)miT-#?+LtKU=O@aj9Fw&Coo~9e| z{zo!_r?2Kc7ab76PsY77%f+hOFbP}z04Z?)H;^hb!SxDs6(7d{P%*6ezQlz4C!T#Q zV0oZZ>{^H|)J=1`gJupf%MJVqgbZuGJAoy}DqX4T5K4j?i2A0L9YAAQC*xy<7 z7>zjKpB93&VsN~J&ia9e;QnuW^E?WA0j)%nfDr5e6a5B=#QXoNhB3N{Dng(ojB!m! zgem6fo^N*PUNEaz-1BYL0Gf%{naS*Nt9)!k0u)XLCjJT$j82s^h1k3VXeqjoT$mzW z$Gs%8$4x}=E-0&lKZmKmLqwCAI|x&bsNsBUD!DL4ybdiUZ*A3;z`&0EEI3Xf9)10}@IWLW$RRknum2d~9d} z{vjC`{wqX)Odmifkt(E24bwGap9Hw3(5hpMvWWvaP$1 z!c+}{#CZUJA`_;DNc`&0VQRPlTa^GUC*#6@g$R)80|+H@9xiea3OEswU;PMB*Fd`fFZ^??9$cc>N6UCo&L9yuQ{`B0?xR zTL1_xMUXfT;7?>AbgifK147B!0u)OCgqA0OSMi3)K`8P1T2G1eGAOzJT9erU0HJm$ zD4}OW211F~*Lq4s2qkL^o5Tg(0m3_UUWASlXgo1}`2LFR`vFnQuWtFVwfUl3lOFrA;7D8;8i@ppU8x%wVu+CFh$N5Akzo$>8B=u zSMfZ^g(>3owVo0&Op&!kli3UiQ|>5Y&xlNzTI(r&doLPFvelpZYhH;hAk#O+>>%(b zG7w6Kcyk`ujiEh0~1+0>hvEzv$b~A=^sb! z$n}(nE{q@?3;WZtueGC2|2Q*9uBSwVP;zIsz)`2qYe${djynC1I&igi)af5#id;{L zl<5>5y{@PKe zU;d{C)+EJ%}Kq$GM5-HOscV=ttsMD_y`hVA7 z0}#4))M+(@lIlNn^8 z=`!PKy!$ZIVnP)c!gkrj6^lGC{rZ+uf7&vB{+J^-7C-bx`!2rFbTMH8T{xIv1z!~D z!GYglRVaSkzdWFgz&uyMVLzwi%ZG88a>U8y(FN#2l?r}l2LeB>vOHi2#SP8kMg$VWG>PyYTH+xSVwShxCbb99ja0i9swia6uQ| z;U}%|Vb~@v9Oj)0ZoUip6_ttq*pd!idY6v>3dO$lAV~Q%fLLyTE@Pm}g$S$@{^RG~ zD=OgEm}!*@q2Nk7)C@NngHZaE9)w#?N8qq6!#JD@ba}K(1z&D8CV_u5iyIj3MJ$ojiI2(n2sdG zDe&8|3oS9#I6Rhzt177)8-s0yVo@H;EmpYcg>?Lv=`QG}Ir`@kcn<8_VeCv&FWwYC zlZ5xj56$Afbm6}YSOs;f;4ocyYz_j`>45{*TbfkCe&P!9!F(u`NLu(Tm(=@q(L_Z# zXc7BzuF$;;x-3_RX<900F2vtrh6W4;eeMDVPsc6h^h$Wt3@4>?BId{54#bt??;yse z3&j!hBcBH@FW{eCF7HLj;oouLP%#Ls+VUh6*DwpkO{ND0;Lw+P3m-2n&dEDWfW z4`ZiiaUZLO@yor2h$UUT6kV-mUnA-L;fe zp)-!3Qfql@c@^t8`BT+4CRc8=&vWzR)(XDMn~Iq;kH^+|o8-JgZ}54T^+_arOwE|l zN><<|^{8ZyfVjj}+1bG`56Rp^@@YKm@s1&PcIv1w$?|8m|{CJWnazK-|jvW)wTPx)4# z*^-h*)wjj!9UVf_xhS>s>Q*%J`Z*NcUNP0?2OmT_3qL%vKb8(hm@#t~o}|p-8>yIi z+W$GO;;>FcE9@TaKy}&aAnK&|r)VE5g>){-sj6;8cm`x&Ii~f{=zYSq55kQ>`6k?s zha2r5(~0ri$nXfX%QzgYt>}G zb>s9|y9+NAK3KmMHZQVQPc(c#Pw}L2qg^k5$WB(-oh5vF#=O)NVdzKQN8c6(aBnE$ z(>Fd8Zt)=swJD0%s@PZHXk}x2_~`A5`93-^kvseHviPj$F;%f5qeY)b_HLuODAHF% zXWq1bT1*E&p6PL*h`v3+T47zj0j1pF>!3E(hn+Cibju1lF_YqB(|*fL=C0=|!5{n- znNoxtx6U80^yV{hXEO0a?%Yop|8b%UvWa3xyZ)nLKcO%UwjVZD31HWBaW*8#A`P)~2L*1=wDsg8OT%l!PQiOTs^xr9ER@>jl<~C2_R)kX6Qb z(^i^+^Zw^y<}{V1fkO}NJJO5&%o=j~YsNa#?Tg6sE{kP~o$!_gQU93Fb*gx=Rh?{Yu_9hCJ2UQVRPzIj?)NM1<}47CcH*JaN@8 z(@_Q?d4;a*xIs$G#v@75%3F0#A28m^=cX#!C7mGHJFXvT8%D$DrOG=~)4GW>zL)i@ zxHyc)DI|iPFZ4J!v*RAW{_r>*>e)ST4Aq9)UwwvSKFO+QjO zbI~rB_Wg+1z$Q4acn1x84pXRU5tAc4v7C!$+rT}zy;ykF4M<vKSal9spkDm-l#!SR;yN*SR%7Dmq=Xhla`>@zrOa|6+4 zqd&HuP4jMSgN($3o11g=!>nw5%LVA`Sq4z-vb|`}z1E4N@KB78sS#!Jm0Rvgj%g}_ zhGQ}(`X?*4uwSsvSuYsCFJ`RyuqnN)ykhj-)~iEPs;~xUzQm(+8=do%+8%W^ys7`l zNO^p0_X)3j6#ns$hhM|uqv6t|)B$&RgR1#lCib9OoHErNOf!^8;fC?x#;*$(m=ubP zb;Im?T;m=^+ztL5&?yr8+2yQGB6I$DS1+SNu`y+g{c`Oz(~_!g2aC6F!Nm5$q{*fS z!>?z@_J67p+ZosTiEXp;&4}KJYMx-ahdl{SsIjckEYrt9Wyh$+3KYv95jZ4CwsZs{vqe2a|kS|&dg7*L-G*%H7Q z1aq;ePjh9z$CRB&+bz9UE%~X54a+?y{;9UtumGDwY0jKr?6Mh@%fC^9vgj-rdtHF_ zh~s8@^x@&wt>6Y%wtLL{V@6*gE+Jvi4Z>S_U)Eo#rWQC_D!HeyUSD5KyEPA;Xh;q2 zk7?U#;}Ut(Nv5qOBe3;QKL2k2W8oSq_jmf+@p|33=)6x)YW%Hvq>;X-#e{24erm2P zh1bnm?e?S2-lt8?f(NyG!#vQQ55>(WZ@Mb!J-x;KW=gh0-LmPt?!{!?gJ;sO?-zI? zb2{+zEoS~&BY$1bMce2Ay5@()qsN{!LMb!WHJ!?-8d(0M(Xl_-dk_7q!%JJl7V|dH zZ$J4)WnK5hz2YO*-k~;>UGOZ&u^UnDkC#gjrZ=}A{CYU7LicukkoP;)69_oudYS=b)C1d{{TH&nq?9PaB}sASQZJgg*s!+=BWA)A?Dc4HeR)B7v> z1%^jHV9&@+N*eK_^aTR);b{r}{Tn)AULp5{-l4boYC~ru^aEMgubrhjJgfP@tlB@P zWDeQTsJ@*t`@I=$673t~OZ%(B_dUT>QKs!J8!ZpAHC@*Rrxb2-FGmFAUh}UpRNE@D zd%v;$XU?6O)U7%R)ar-&TXXgOOWyEn1~=wW@)RR|UVcEO-XD-VDBYx-DnR_Dv zpLZOpm`(T_l`GCmN2*oA(kJQuoc=P>oP zW=1ar?^VWK3dYGbBQwf@#n^3*yPLt!CTU{2@7WYg@9!Vjm#l!k!~id@ZSC62Xv>te z)#ocxO=GK=q<4v@a@_jx(TPvj(t7y>jpa|coZS+|BS-W6rEb3I{$U53tguun;VDt+ zyM$kBz068m=Y1>INI)_gD{3V0Fl@ntf+Y4?^c}VXViG49OZJ^AeW$)9Is=xaAAeBL z+%(N{*0ZzaBK}kVm0DPg19w6tBJ8@djzI#yt;4#ucJ!Ak1C`elwn=DHFcgUTw^h6< zPYOldGMTP${D_h9DmfUE6>_WVbSK;LKB>~$)|d4Xeq6w4!0vc1FW;*EUY@bB{~a_(uX=hSaB7>1k-`ML<_uVGY17ibHbL-*rq zRcb$_zPI#VHvdu>k8DAf%)`pFPQS72jy>;?xVMr*9Al!B*X-@pnq|4I!0$D0jr28t z^_UJ3`b{*86(<^du8vJLsxh}Fcy`y-PwTx#e}eHdF^QR(HjCeRFL34q{jU4sn}*zt z{b&UF8KS!i_kAjKZbR5+`rJ34!tJUlW6dhI6Vxe5{wT0$k}T{JeyK3S#nz@fBg7$1 z*5>#bI98+T{LWznPKa%MJ69RzgWeLe+_J4ge&NE7n69eV+uE%{&vsR#;VRVu{;w{y zb&U;7T}8-FHrURUS#d26y=|DY44f|B;(^^LYgbhrNX@d#4qyYq<=-_dBTSVnPGgO60n6eDlxL8A``x-R0~8M|uXDT>akf_<`^c(H zqKsy$GN!?5IWGxA8~3$o@$GYJJ!^Sv8Rmj1r#qUyN(b>;C1NMEi;l~;Mc2x`rT|*? zp_l8ShhsxXcU2#UZ^Y=uVcXIQEcSB%W~tNjJy(EFrTIza0|SyOF;mmy z^GtZo7N@ApliQmR1T7xHlhAq3P{A8mtg*zUeVtbb-sz<64_Gn+?-F zk0_;}$U3=+;<(m2N(KrBip`rhQ{0W+XBKip=Ee*K1;rCe3JMzV-_>7M-VUxl65@pK zzYcWS#W%hY4Dwq~L9t`iD1mhp6z5ze{5-r*+j@AM7C-0a`s-jzmy3tkHc(K+@1daB zwra2o5C;bPobh*c@cG@)829a$xv42AZl_XE@T?kIyXpILeViQ}&iF`>)F=KRMUeH| ziRgaB1Uv(R_`qaXR|%A+BMKx*`FT3OmD82~YB?K>_;`u}*!SnJWAvmsIoo(U*c+Vj zKIQK8+o|b2n6}ji#tR3U(EcodVjn*Rg}sN}ac>V#9|=1TZ-?Jm=J>fu!zD26CJ?c6 z)$nG4pN89bdj4+oXb;83Brxg|_y_d;=?gFT(`dW1K4(1KekY(kSXR^%Jlc5UuL637 zC@9R;JlxMXxSz2y^!Ie|vG|>UpWSrVPtT{IxF+)J%Kli><62bUfduEJq38yNGaDuR G^uGW~1 Date: Sun, 22 Sep 2024 09:07:56 +0200 Subject: [PATCH 3/3] Added model 235 - breast cancer signalling pathways MDAMB231 complete --- .../README.md | 46 +++ .../metadata.json | 17 + .../model.aeon | 380 ++++++++++++++++++ .../model.bnet | 111 +++++ .../model.sbml | 1 + models/summary.csv | 1 + report/.~lock.online_only_table_1.xlsx# | 2 +- report/online_only_table_1.xlsx | Bin 58474 -> 58516 bytes .../citation.bib | 8 + .../metadata.json | 7 + .../notes.md | 10 + .../source.bnet | 111 +++++ 12 files changed, 693 insertions(+), 1 deletion(-) create mode 100644 models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/README.md create mode 100644 models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/metadata.json create mode 100644 models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.aeon create mode 100644 models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.bnet create mode 100644 models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.sbml create mode 100644 sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/citation.bib create mode 100644 sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/metadata.json create mode 100644 sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/notes.md create mode 100644 sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/source.bnet diff --git a/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/README.md b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/README.md new file mode 100644 index 0000000..df179f7 --- /dev/null +++ b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/README.md @@ -0,0 +1,46 @@ +# \[235\] BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE + + - Variables: 110 + - Inputs: 7 + - Regulations: 270 + - Publication: https://doi.org/10.1371/journal.pone.0298788 + - Source: https://github.com/Ktaoma/BoolSyn + - Keywords: source (?), curated (?), repaired (?), multi-valued (?) + + +### Modifications + +Removed regulations: +PG, PG +NRG1, NRG1 +INS, INS +ES, ES +EGF, EGF +DLL_i, DLL_i +IGF1, IGF1 + +Regulation: + +CYCLIN_D_c, (((TEAD1 | TCF4 | STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3) + +was updated to: + +CYCLIN_D_c, (((STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3) + +as the analysis stated that TEAD1 and TCF4 have no effect on CYCLIN_D_c. + + +### Model citation + +``` +@article{bbm-235, + author = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan}, + year = {2024}, + doi = {https://doi.org/10.1371/journal.pone.0298788}, + title = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy}, + publisher = {PLOS ONE} +} + + +``` + diff --git a/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/metadata.json b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/metadata.json new file mode 100644 index 0000000..b11bf95 --- /dev/null +++ b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/metadata.json @@ -0,0 +1,17 @@ +{ + "id": 235, + "name": "BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE", + "url-publication": "https://doi.org/10.1371/journal.pone.0298788", + "url-model": "https://github.com/Ktaoma/BoolSyn", + "keywords": [ + "source (?)", + "curated (?)", + "repaired (?)", + "multi-valued (?)" + ], + "variables": 110, + "inputs": 7, + "regulations": 270, + "notes": "### Modifications\n\nRemoved regulations:\nPG, PG\nNRG1, NRG1\nINS, INS\nES, ES\nEGF, EGF\nDLL_i, DLL_i\nIGF1, IGF1\n\nRegulation:\n\nCYCLIN_D_c, (((TEAD1 | TCF4 | STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3)\n\nwas updated to:\n\nCYCLIN_D_c, (((STAT3) & !(GSK3B & (CDKN2A & P21)))) & (EIF4E & MYC & STAT3)\n\nas the analysis stated that TEAD1 and TCF4 have no effect on CYCLIN_D_c.\n", + "bib": "@article{bbm-235,\n\tauthor = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan},\n\tyear = {2024},\n\tdoi = {https://doi.org/10.1371/journal.pone.0298788},\n\ttitle = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy},\n\tpublisher = {PLOS ONE}\n}\n\n" +} \ No newline at end of file diff --git a/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.aeon b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.aeon new file mode 100644 index 0000000..1764fb6 --- /dev/null +++ b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.aeon @@ -0,0 +1,380 @@ +v_GRB2 -? v_ABL1 +v_JUN -? v_ABL1 +v_SRC -? v_ABL1 +v_ABL1 -? v_ABL2 +v_EGFR -? v_AKT_i +v_IGF1R -? v_AKT_i +v_IRS1 -? v_AKT_i +v_MTORC2_c -? v_AKT_i +v_PDPK1 -? v_AKT_i +v_PIP3 -? v_AKT_i +v_AXIN1 -? v_APC +v_FOXO1 -? v_APC +v_CREB1 -? v_AXIN1 +v_DVL1 -? v_AXIN1 +v_GSK3B -? v_AXIN1 +v_JUN -? v_AXIN1 +v_AKT_i -? v_BAD +v_ERK_i -? v_BAD +v_PAK1 -? v_BAD +v_PIM -? v_BAD +v_BCL2 -? v_BAK1 +v_BID -? v_BAK1 +v_BIM -? v_BAK1 +v_MCL1 -? v_BAK1 +v_P53 -? v_BAK1 +v_BCL2 -? v_BAX +v_BID -? v_BAX +v_BIM -? v_BAX +v_MCL1 -? v_BAX +v_P53 -? v_BAX +v_BAD -? v_BCL2 +v_BCLXL -? v_BCL2 +v_BIM -? v_BCL2 +v_CREB1 -? v_BCL2 +v_ERK_i -? v_BCL2 +v_BAD -? v_BCLXL +v_BCL2 -? v_BCLXL +v_BIM -? v_BCLXL +v_CREB1 -? v_BCLXL +v_BCLXL -? v_BID +v_CASP8 -? v_BID +v_BCL2 -? v_BIM +v_BCLXL -? v_BIM +v_FOXO1 -? v_BIM +v_FOXO3 -? v_BIM +v_CASP9 -? v_CASP3 +v_ERK_i -? v_CASP8 +v_FADD -? v_CASP8 +v_SRC -? v_CASP8 +v_AKT_i -? v_CASP9 +v_CASP3 -? v_CASP9 +v_CASP8 -? v_CASP9 +v_CYCS -? v_CASP9 +v_ERK_i -? v_CASP9 +v_PRKACA -? v_CASP9 +v_MYC -? v_CDKN2A +v_ABL2 -? v_CEBPB +v_ESR1 -? v_CEBPB +v_AKT_i -? v_CREB1 +v_DC -? v_CTNNB1 +v_RELA -? v_CTNNB1 +v_WNT1 -? v_CTNNB1 +v_CDKN2A -? v_CYCLIN_D_c +v_GSK3B -? v_CYCLIN_D_c +v_MYC -? v_CYCLIN_D_c +v_P21 -? v_CYCLIN_D_c +v_STAT3 -? v_CYCLIN_D_c +v_TCF4 -? v_CYCLIN_D_c +v_TEAD1 -? v_CYCLIN_D_c +v_BAK1 -? v_CYCS +v_BAX -? v_CYCS +v_P53 -? v_CYCS +v_APC -? v_DC +v_GSK3B -? v_DC +v_FZD3 -? v_DVL1 +v_JUN -? v_DVL1 +v_PRB -? v_E2F1 +v_EGF -? v_EGFR +v_HER2 -? v_EGFR +v_HER3 -? v_EGFR +v_MEK_i -? v_EGFR +v_IVEBP1 -? v_EIF4E +v_MEK_i -? v_ERK_i +v_AKT_i -? v_ESR1 +v_ES -? v_ESR1 +v_FOXO3 -? v_ESR1 +v_KMT2D -? v_ESR1 +v_PGR -? v_ESR1 +v_FAS -? v_FADD +v_JUN -? v_FADD +v_TRADD -? v_FADD +v_AKT_i -? v_FAS +v_FASLG -? v_FAS +v_P53 -? v_FAS +v_FASLG -? v_FASLG +v_FOXO3 -? v_FASLG +v_P53 -? v_FASLG +v_AKT_i -? v_FOXO1 +v_ESR1 -? v_FOXO1 +v_SGK1 -? v_FOXO1 +v_AKT_i -? v_FOXO3 +v_WNT1 -? v_FZD3 +v_ESR1 -? v_GATA3 +v_STAT1 -? v_GATA3 +v_EGFR -? v_GRB2 +v_IRS1 -? v_GRB2 +v_SRC -? v_GRB2 +v_ESR1 -? v_GRB7 +v_INSR -? v_GRB7 +v_AKT_i -? v_GSK3B +v_ERK_i -? v_GSK3B +v_EGFR -? v_HER2 +v_HER3 -? v_HER2 +v_HER2 -? v_HER3 +v_NRG1 -? v_HER3 +v_NCID -? v_HES1 +v_WNT1 -? v_HES1 +v_NCID -? v_HEY1 +v_NF1 -? v_HRAS +v_PIP3 -? v_HRAS +v_SOS1 -? v_HRAS +v_PDPK1 -? v_HSP90AA1 +v_STAT1 -? v_HSP90AA1 +v_ESR1 -? v_IGF1R +v_FOXO3 -? v_IGF1R +v_IGF1 -? v_IGF1R +v_NOS3 -? v_IL1B +v_RELA -? v_IL1B +v_STAT1 -? v_IL1B +v_IL1B -? v_IL6 +v_IL6 -? v_IL6 +v_ESR1 -? v_IL6R +v_IL6 -? v_IL6R +v_ERK_i -? v_IL8 +v_ESR1 -? v_IL8 +v_JAK2 -? v_IL8 +v_STAT5 -? v_IL8 +v_INS -? v_INSR +v_INSR -? v_INSR +v_IGF1R -? v_IRS1 +v_INSR -? v_IRS1 +v_S6K1 -? v_IRS1 +v_MTORC1_c -? v_IVEBP1 +v_ABL1 -? v_JAK2 +v_IL6R -? v_JAK2 +v_IL8 -? v_JAK2 +v_IRS1 -? v_JAK2 +v_ERK_i -? v_JUN +v_MAPK8 -? v_JUN +v_PPARG -? v_JUN +v_RELA -? v_JUN +v_AKT_i -? v_KMT2D +v_PAX7 -? v_KMT2D +v_EGFR -? v_KRT14 +v_PAK2 -? v_KRT14 +v_LCK -? v_LATS1 +v_NF2 -? v_LATS1 +v_ERK_i -? v_LCK +v_JUN -? v_MAPK8 +v_RAC1 -? v_MAPK8 +v_RND1 -? v_MAPK8 +v_ERK_i -? v_MCL1 +v_GSK3B -? v_MCL1 +v_MAPK8 -? v_MCL1 +v_P53 -? v_MDM2 +v_RAF1 -? v_MEK_i +v_ERK_i -? v_MTORC1_c +v_PIM -? v_MTORC1_c +v_RHEB -? v_MTORC1_c +v_PIP3 -? v_MTORC2_c +v_S6K1 -? v_MTORC2_c +v_CTNNB1 -? v_MYC +v_EIF4E -? v_MYC +v_GSK3B -? v_MYC +v_JAK2 -? v_MYC +v_PIM -? v_MYC +v_STAT3 -? v_MYC +v_ESR1 -? v_MYOD1 +v_HES1 -? v_MYOD1 +v_HEY1 -? v_MYOG +v_MYOD1 -? v_MYOG +v_NOTCH1 -? v_NCID +v_SGK1 -? v_NEDD4L +v_TWIST1 -? v_NF1 +v_NEDD4L -? v_NF2 +v_NOTCH1 -? v_NFKB1 +v_AKT_i -? v_NOS3 +v_HSP90AA1 -? v_NOS3 +v_CTNNB1 -? v_NOTCH1 +v_DLL_i -? v_NOTCH1 +v_LCK -? v_NOTCH1 +v_AKT_i -? v_P21 +v_ERK_i -? v_P21 +v_MDM2 -? v_P53 +v_TCF4 -? v_PAK1 +v_RAC1 -? v_PAK2 +v_SRC -? v_PAK2 +v_FOXO1 -? v_PAX7 +v_MYOG -? v_PAX7 +v_IGF1R -? v_PDPK1 +v_PIP3 -? v_PDPK1 +v_ESR1 -? v_PGR +v_GATA3 -? v_PGR +v_PG -? v_PGR +v_EGFR -? v_PI3K_c +v_ESR1 -? v_PI3K_c +v_HRAS -? v_PI3K_c +v_IGF1R -? v_PI3K_c +v_IRS1 -? v_PI3K_c +v_RAS_i -? v_PI3K_c +v_GATA3 -? v_PIM +v_STAT5 -? v_PIM +v_PI3K_c -? v_PIP3 +v_PTEN -? v_PIP3 +v_CEBPB -? v_PPARG +v_GATA3 -? v_PPARG +v_CYCLIN_D_c -? v_PRB +v_STK11 -? v_PRKAA2 +v_AKT_i -? v_PRKACA +v_EGFR -? v_PRKACA +v_WNT1 -? v_PRKACA +v_S6K1 -? v_PTEN +v_SRC -? v_PTEN +v_PI3K_c -? v_RAC1 +v_AKT_i -? v_RAF1 +v_HRAS -? v_RAF1 +v_RAS_i -? v_RAF1 +v_PIP3 -? v_RAS_i +v_SOS1 -? v_RAS_i +v_NFKB1 -? v_RELA +v_PIM -? v_RELA +v_TSC2 -? v_RHEB +v_DVL1 -? v_RND1 +v_GRB7 -? v_RND1 +v_ESR1 -? v_S6K1 +v_MTORC1_c -? v_S6K1 +v_MTORC1_c -? v_SGK1 +v_MTORC2_c -? v_SGK1 +v_PDPK1 -? v_SGK1 +v_GRB2 -? v_SOS1 +v_PRKACA -? v_SRC +v_EGFR -? v_STAT1 +v_JAK2 -? v_STAT1 +v_MAPK8 -? v_STAT1 +v_SRC -? v_STAT1 +v_IL1B -? v_STAT3 +v_JAK2 -? v_STAT3 +v_MAPK8 -? v_STAT3 +v_SRC -? v_STAT3 +v_EGFR -? v_STAT5 +v_JAK2 -? v_STAT5 +v_MAPK8 -? v_STAT5 +v_SRC -? v_STAT5 +v_ERK_i -? v_STK11 +v_STAT5 -? v_STK11 +v_CTNNB1 -? v_TCF4 +v_JUN -? v_TCF4 +v_PGR -? v_TCF4 +v_YAP1 -? v_TEAD1 +v_KRT14 -? v_TRADD +v_P53 -? v_TRADD +v_AKT_i -? v_TSC2 +v_ERK_i -? v_TSC2 +v_PRKAA2 -? v_TSC2 +v_ERK_i -? v_TWIST1 +v_STAT3 -? v_TWIST1 +v_PGR -? v_WNT1 +v_WNT1 -? v_WNT1 +v_ABL1 -? v_YAP1 +v_LATS1 -? v_YAP1 +$v_ABL1: (v_SRC | (v_GRB2 | v_JUN)) +$v_ABL2: v_ABL1 +$v_AKT_i: (((v_MTORC2_c | v_PDPK1) & v_PIP3) | (v_IRS1 | (v_IGF1R | v_EGFR))) +$v_APC: (v_AXIN1 & v_FOXO1) +$v_AXIN1: (!v_DVL1 | (v_GSK3B | (v_CREB1 & v_JUN))) +$v_BAD: !(v_PAK1 & (v_AKT_i & (v_ERK_i & v_PIM))) +$v_BAK1: (((v_BIM | v_P53) | v_BID) | !(v_MCL1 & v_BCL2)) +$v_BAX: (((v_BIM | v_P53) | v_BID) | !(v_MCL1 & v_BCL2)) +$v_BCL2: (!(v_BAD | v_BIM) & (v_CREB1 & (v_ERK_i & v_BCLXL))) +$v_BCLXL: (!(v_BAD & v_BIM) | (v_CREB1 | v_BCL2)) +$v_BID: (v_CASP8 & !v_BCLXL) +$v_BIM: (!(v_BCL2 | v_BCLXL) & (v_FOXO3 | v_FOXO1)) +$v_CASP3: v_CASP9 +$v_CASP8: (v_FADD | !(v_ERK_i & v_SRC)) +$v_CASP9: (((v_CYCS & v_CASP8) | v_CASP3) & !(v_AKT_i & (v_ERK_i & v_PRKACA))) +$v_CDKN2A: !v_MYC +$v_CEBPB: (v_ABL2 & v_ESR1) +$v_CREB1: v_AKT_i +$v_CTNNB1: (!v_DC | (v_WNT1 | v_RELA)) +$v_CYCLIN_D_c: ((v_TCF4 | (v_TEAD1 | (v_STAT3 | v_MYC))) & !(v_GSK3B | (v_CDKN2A | v_P21))) +$v_CYCS: (v_BAK1 & (v_BAX & v_P53)) +$v_DC: (v_APC & v_GSK3B) +$v_DVL1: (v_FZD3 | v_JUN) +$v_E2F1: !v_PRB +$v_EGFR: ((v_EGF | (v_HER2 & v_HER3)) | !v_MEK_i) +$v_EIF4E: !v_IVEBP1 +$v_ERK_i: v_MEK_i +$v_ESR1: ((v_ES & (v_AKT_i & v_KMT2D)) & (v_PGR & v_FOXO3)) +$v_FADD: (v_TRADD | (v_FAS | v_JUN)) +$v_FAS: ((v_FASLG | v_P53) & !v_AKT_i) +$v_FASLG: (v_FASLG & (v_P53 & v_FOXO3)) +$v_FOXO1: (!(v_SGK1 | v_AKT_i) & v_ESR1) +$v_FOXO3: !v_AKT_i +$v_FZD3: v_WNT1 +$v_GATA3: (!v_STAT1 & v_ESR1) +$v_GRB2: ((v_IRS1 & v_SRC) | v_EGFR) +$v_GRB7: (v_INSR & v_ESR1) +$v_GSK3B: !(v_AKT_i | v_ERK_i) +$v_HER2: (v_HER3 & v_EGFR) +$v_HER3: (v_NRG1 & v_HER2) +$v_HES1: (v_NCID & v_WNT1) +$v_HEY1: v_NCID +$v_HRAS: (v_SOS1 | (v_PIP3 | !v_NF1)) +$v_HSP90AA1: (!v_PDPK1 | v_STAT1) +$v_IGF1R: (v_IGF1 & (v_FOXO3 & v_ESR1)) +$v_IL1B: (v_NOS3 & (v_RELA & v_STAT1)) +$v_IL6: (v_IL1B | v_IL6) +$v_IL6R: (v_IL6 & v_ESR1) +$v_IL8: ((v_JAK2 & v_STAT5) & (v_ERK_i & v_ESR1)) +$v_INSR: (v_INS | v_INSR) +$v_IRS1: (!v_S6K1 & (v_INSR | v_IGF1R)) +$v_IVEBP1: !v_MTORC1_c +$v_JAK2: ((v_IL6R & (v_ABL1 & v_IL8)) & v_IRS1) +$v_JUN: ((v_RELA | (v_MAPK8 | v_PPARG)) | v_ERK_i) +$v_KMT2D: (v_PAX7 & !v_AKT_i) +$v_KRT14: (v_PAK2 & v_EGFR) +$v_LATS1: (v_NF2 & v_LCK) +$v_LCK: v_ERK_i +$v_MAPK8: (v_RAC1 | (v_RND1 | v_JUN)) +$v_MCL1: (!v_GSK3B | (v_ERK_i | v_MAPK8)) +$v_MDM2: v_P53 +$v_MEK_i: v_RAF1 +$v_MTORC1_c: (v_RHEB | (v_ERK_i & v_PIM)) +$v_MTORC2_c: (v_PIP3 | !v_S6K1) +$v_MYC: ((((v_CTNNB1 | v_PIM) & v_EIF4E) & !v_GSK3B) | (v_STAT3 & (v_JAK2 & v_EIF4E))) +$v_MYOD1: (!v_HES1 & v_ESR1) +$v_MYOG: (!v_HEY1 & v_MYOD1) +$v_NCID: v_NOTCH1 +$v_NEDD4L: !v_SGK1 +$v_NF1: !v_TWIST1 +$v_NF2: v_NEDD4L +$v_NFKB1: v_NOTCH1 +$v_NOS3: (v_HSP90AA1 | v_AKT_i) +$v_NOTCH1: (v_DLL_i | (v_CTNNB1 | v_LCK)) +$v_P21: !(v_ERK_i & v_AKT_i) +$v_P53: !v_MDM2 +$v_PAK1: v_TCF4 +$v_PAK2: (v_RAC1 | v_SRC) +$v_PAX7: (!v_MYOG & v_FOXO1) +$v_PDPK1: (v_PIP3 | v_IGF1R) +$v_PGR: ((v_GATA3 & v_PG) & !v_ESR1) +$v_PI3K_c: (v_EGFR | ((v_ESR1 & (v_IRS1 | v_IGF1R)) & (v_HRAS & v_RAS_i))) +$v_PIM: (v_STAT5 | !v_GATA3) +$v_PIP3: (v_PI3K_c | !v_PTEN) +$v_PPARG: (!v_GATA3 | v_CEBPB) +$v_PRB: !v_CYCLIN_D_c +$v_PRKAA2: v_STK11 +$v_PRKACA: ((v_AKT_i & v_WNT1) | v_EGFR) +$v_PTEN: (v_S6K1 | !v_SRC) +$v_RAC1: v_PI3K_c +$v_RAF1: ((v_HRAS | v_RAS_i) | !v_AKT_i) +$v_RAS_i: (v_SOS1 | v_PIP3) +$v_RELA: (v_NFKB1 | v_PIM) +$v_RHEB: !v_TSC2 +$v_RND1: (v_GRB7 & v_DVL1) +$v_S6K1: (v_MTORC1_c & v_ESR1) +$v_SGK1: ((v_MTORC2_c | v_MTORC1_c) & v_PDPK1) +$v_SOS1: v_GRB2 +$v_SRC: v_PRKACA +$v_STAT1: ((v_SRC & v_MAPK8) | (v_JAK2 & v_EGFR)) +$v_STAT3: ((v_IL1B & (v_SRC & v_MAPK8)) & v_JAK2) +$v_STAT5: (v_JAK2 | (v_SRC | (v_EGFR | v_MAPK8))) +$v_STK11: (!v_ERK_i | v_STAT5) +$v_TCF4: ((v_CTNNB1 & v_JUN) & v_PGR) +$v_TEAD1: v_YAP1 +$v_TRADD: (!v_KRT14 & v_P53) +$v_TSC2: (!(v_AKT_i | v_ERK_i) & v_PRKAA2) +$v_TWIST1: (v_ERK_i & v_STAT3) +$v_WNT1: (v_PGR | v_WNT1) +$v_YAP1: (!v_LATS1 | v_ABL1) diff --git a/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.bnet b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.bnet new file mode 100644 index 0000000..9bbf0fd --- /dev/null +++ b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.bnet @@ -0,0 +1,111 @@ +targets,factors +v_ABL1, (v_SRC | (v_GRB2 | v_JUN)) +v_ABL2, v_ABL1 +v_AKT_i, (((v_MTORC2_c | v_PDPK1) & v_PIP3) | (v_IRS1 | (v_IGF1R | v_EGFR))) +v_APC, (v_AXIN1 & v_FOXO1) +v_AXIN1, (!v_DVL1 | (v_GSK3B | (v_CREB1 & v_JUN))) +v_BAD, !(v_PAK1 & (v_AKT_i & (v_ERK_i & v_PIM))) +v_BAK1, (((v_BIM | v_P53) | v_BID) | !(v_MCL1 & v_BCL2)) +v_BAX, (((v_BIM | v_P53) | v_BID) | !(v_MCL1 & v_BCL2)) +v_BCL2, (!(v_BAD | v_BIM) & (v_CREB1 & (v_ERK_i & v_BCLXL))) +v_BCLXL, (!(v_BAD & v_BIM) | (v_CREB1 | v_BCL2)) +v_BID, (v_CASP8 & !v_BCLXL) +v_BIM, (!(v_BCL2 | v_BCLXL) & (v_FOXO3 | v_FOXO1)) +v_CASP3, v_CASP9 +v_CASP8, (v_FADD | !(v_ERK_i & v_SRC)) +v_CASP9, (((v_CYCS & v_CASP8) | v_CASP3) & !(v_AKT_i & (v_ERK_i & v_PRKACA))) +v_CDKN2A, !v_MYC +v_CEBPB, (v_ABL2 & v_ESR1) +v_CREB1, v_AKT_i +v_CTNNB1, (!v_DC | (v_WNT1 | v_RELA)) +v_CYCLIN_D_c, ((v_TCF4 | (v_TEAD1 | (v_STAT3 | v_MYC))) & !(v_GSK3B | (v_CDKN2A | v_P21))) +v_CYCS, (v_BAK1 & (v_BAX & v_P53)) +v_DC, (v_APC & v_GSK3B) +v_DVL1, (v_FZD3 | v_JUN) +v_E2F1, !v_PRB +v_EGFR, ((v_EGF | (v_HER2 & v_HER3)) | !v_MEK_i) +v_EIF4E, !v_IVEBP1 +v_ERK_i, v_MEK_i +v_ESR1, ((v_ES & (v_AKT_i & v_KMT2D)) & (v_PGR & v_FOXO3)) +v_FADD, (v_TRADD | (v_FAS | v_JUN)) +v_FAS, ((v_FASLG | v_P53) & !v_AKT_i) +v_FASLG, (v_FASLG & (v_P53 & v_FOXO3)) +v_FOXO1, (!(v_SGK1 | v_AKT_i) & v_ESR1) +v_FOXO3, !v_AKT_i +v_FZD3, v_WNT1 +v_GATA3, (!v_STAT1 & v_ESR1) +v_GRB2, ((v_IRS1 & v_SRC) | v_EGFR) +v_GRB7, (v_INSR & v_ESR1) +v_GSK3B, !(v_AKT_i | v_ERK_i) +v_HER2, (v_HER3 & v_EGFR) +v_HER3, (v_NRG1 & v_HER2) +v_HES1, (v_NCID & v_WNT1) +v_HEY1, v_NCID +v_HRAS, (v_SOS1 | (v_PIP3 | !v_NF1)) +v_HSP90AA1, (!v_PDPK1 | v_STAT1) +v_IGF1R, (v_IGF1 & (v_FOXO3 & v_ESR1)) +v_IL1B, (v_NOS3 & (v_RELA & v_STAT1)) +v_IL6, (v_IL1B | v_IL6) +v_IL6R, (v_IL6 & v_ESR1) +v_IL8, ((v_JAK2 & v_STAT5) & (v_ERK_i & v_ESR1)) +v_INSR, (v_INS | v_INSR) +v_IRS1, (!v_S6K1 & (v_INSR | v_IGF1R)) +v_IVEBP1, !v_MTORC1_c +v_JAK2, ((v_IL6R & (v_ABL1 & v_IL8)) & v_IRS1) +v_JUN, ((v_RELA | (v_MAPK8 | v_PPARG)) | v_ERK_i) +v_KMT2D, (v_PAX7 & !v_AKT_i) +v_KRT14, (v_PAK2 & v_EGFR) +v_LATS1, (v_NF2 & v_LCK) +v_LCK, v_ERK_i +v_MAPK8, (v_RAC1 | (v_RND1 | v_JUN)) +v_MCL1, (!v_GSK3B | (v_ERK_i | v_MAPK8)) +v_MDM2, v_P53 +v_MEK_i, v_RAF1 +v_MTORC1_c, (v_RHEB | (v_ERK_i & v_PIM)) +v_MTORC2_c, (v_PIP3 | !v_S6K1) +v_MYC, ((((v_CTNNB1 | v_PIM) & v_EIF4E) & !v_GSK3B) | (v_STAT3 & (v_JAK2 & v_EIF4E))) +v_MYOD1, (!v_HES1 & v_ESR1) +v_MYOG, (!v_HEY1 & v_MYOD1) +v_NCID, v_NOTCH1 +v_NEDD4L, !v_SGK1 +v_NF1, !v_TWIST1 +v_NF2, v_NEDD4L +v_NFKB1, v_NOTCH1 +v_NOS3, (v_HSP90AA1 | v_AKT_i) +v_NOTCH1, (v_DLL_i | (v_CTNNB1 | v_LCK)) +v_P21, !(v_ERK_i & v_AKT_i) +v_P53, !v_MDM2 +v_PAK1, v_TCF4 +v_PAK2, (v_RAC1 | v_SRC) +v_PAX7, (!v_MYOG & v_FOXO1) +v_PDPK1, (v_PIP3 | v_IGF1R) +v_PGR, ((v_GATA3 & v_PG) & !v_ESR1) +v_PI3K_c, (v_EGFR | ((v_ESR1 & (v_IRS1 | v_IGF1R)) & (v_HRAS & v_RAS_i))) +v_PIM, (v_STAT5 | !v_GATA3) +v_PIP3, (v_PI3K_c | !v_PTEN) +v_PPARG, (!v_GATA3 | v_CEBPB) +v_PRB, !v_CYCLIN_D_c +v_PRKAA2, v_STK11 +v_PRKACA, ((v_AKT_i & v_WNT1) | v_EGFR) +v_PTEN, (v_S6K1 | !v_SRC) +v_RAC1, v_PI3K_c +v_RAF1, ((v_HRAS | v_RAS_i) | !v_AKT_i) +v_RAS_i, (v_SOS1 | v_PIP3) +v_RELA, (v_NFKB1 | v_PIM) +v_RHEB, !v_TSC2 +v_RND1, (v_GRB7 & v_DVL1) +v_S6K1, (v_MTORC1_c & v_ESR1) +v_SGK1, ((v_MTORC2_c | v_MTORC1_c) & v_PDPK1) +v_SOS1, v_GRB2 +v_SRC, v_PRKACA +v_STAT1, ((v_SRC & v_MAPK8) | (v_JAK2 & v_EGFR)) +v_STAT3, ((v_IL1B & (v_SRC & v_MAPK8)) & v_JAK2) +v_STAT5, (v_JAK2 | (v_SRC | (v_EGFR | v_MAPK8))) +v_STK11, (!v_ERK_i | v_STAT5) +v_TCF4, ((v_CTNNB1 & v_JUN) & v_PGR) +v_TEAD1, v_YAP1 +v_TRADD, (!v_KRT14 & v_P53) +v_TSC2, (!(v_AKT_i | v_ERK_i) & v_PRKAA2) +v_TWIST1, (v_ERK_i & v_STAT3) +v_WNT1, (v_PGR | v_WNT1) +v_YAP1, (!v_LATS1 | v_ABL1) diff --git a/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.sbml b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.sbml new file mode 100644 index 0000000..f284be7 --- /dev/null +++ b/models/[id-235]__[var-110]__[in-7]__[BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE]/model.sbml @@ -0,0 +1 @@ +v_SRC1v_GRB21v_JUN1v_ABL11v_MTORC2_c1v_PDPK11v_PIP31v_IRS11v_IGF1R1v_EGFR1v_AXIN11v_FOXO11v_DVL11v_GSK3B1v_CREB11v_JUN1v_PAK11v_AKT_i1v_ERK_i1v_PIM1v_BIM1v_P531v_BID1v_MCL11v_BCL21v_BIM1v_P531v_BID1v_MCL11v_BCL21v_BAD1v_BIM1v_CREB11v_ERK_i1v_BCLXL1v_BAD1v_BIM1v_CREB11v_BCL21v_CASP81v_BCLXL1v_BCL21v_BCLXL1v_FOXO31v_FOXO11v_CASP91v_FADD1v_ERK_i1v_SRC1v_CYCS1v_CASP81v_CASP31v_AKT_i1v_ERK_i1v_PRKACA1v_MYC1v_ABL21v_ESR11v_AKT_i1v_DC1v_WNT11v_RELA1v_TCF41v_TEAD11v_STAT31v_MYC1v_GSK3B1v_CDKN2A1v_P211v_BAK11v_BAX1v_P531v_APC1v_GSK3B1v_FZD31v_JUN1v_PRB1v_EGF1v_HER21v_HER31v_MEK_i1v_IVEBP11v_MEK_i1v_ES1v_AKT_i1v_KMT2D1v_PGR1v_FOXO31v_TRADD1v_FAS1v_JUN1v_FASLG1v_P531v_AKT_i1v_FASLG1v_P531v_FOXO31v_SGK11v_AKT_i1v_ESR11v_AKT_i1v_WNT11v_STAT11v_ESR11v_IRS11v_SRC1v_EGFR1v_INSR1v_ESR11v_AKT_i1v_ERK_i1v_HER31v_EGFR1v_NRG11v_HER21v_NCID1v_WNT11v_NCID1v_SOS11v_PIP31v_NF11v_PDPK11v_STAT11v_IGF11v_FOXO31v_ESR11v_NOS31v_RELA1v_STAT11v_IL1B1v_IL61v_IL61v_ESR11v_JAK21v_STAT51v_ERK_i1v_ESR11v_INS1v_INSR1v_S6K11v_INSR1v_IGF1R1v_MTORC1_c1v_IL6R1v_ABL11v_IL81v_IRS11v_RELA1v_MAPK81v_PPARG1v_ERK_i1v_PAX71v_AKT_i1v_PAK21v_EGFR1v_NF21v_LCK1v_ERK_i1v_RAC11v_RND11v_JUN1v_GSK3B1v_ERK_i1v_MAPK81v_P531v_RAF11v_RHEB1v_ERK_i1v_PIM1v_PIP31v_S6K11v_CTNNB11v_PIM1v_EIF4E1v_GSK3B1v_STAT31v_JAK21v_EIF4E1v_HES11v_ESR11v_HEY11v_MYOD11v_NOTCH11v_SGK11v_TWIST11v_NEDD4L1v_NOTCH11v_HSP90AA11v_AKT_i1v_DLL_i1v_CTNNB11v_LCK1v_ERK_i1v_AKT_i1v_MDM21v_TCF41v_RAC11v_SRC1v_MYOG1v_FOXO11v_PIP31v_IGF1R1v_GATA31v_PG1v_ESR11v_EGFR1v_ESR11v_IRS11v_IGF1R1v_HRAS1v_RAS_i1v_STAT51v_GATA31v_PI3K_c1v_PTEN1v_GATA31v_CEBPB1v_CYCLIN_D_c1v_STK111v_AKT_i1v_WNT11v_EGFR1v_S6K11v_SRC1v_PI3K_c1v_HRAS1v_RAS_i1v_AKT_i1v_SOS11v_PIP31v_NFKB11v_PIM1v_TSC21v_GRB71v_DVL11v_MTORC1_c1v_ESR11v_MTORC2_c1v_MTORC1_c1v_PDPK11v_GRB21v_PRKACA1v_SRC1v_MAPK81v_JAK21v_EGFR1v_IL1B1v_SRC1v_MAPK81v_JAK21v_JAK21v_SRC1v_EGFR1v_MAPK81v_ERK_i1v_STAT51v_CTNNB11v_JUN1v_PGR1v_YAP11v_KRT141v_P531v_AKT_i1v_ERK_i1v_PRKAA21v_ERK_i1v_STAT31v_PGR1v_WNT11v_LATS11v_ABL11 \ No newline at end of file diff --git a/models/summary.csv b/models/summary.csv index d56ca1d..9e48638 100644 --- a/models/summary.csv +++ b/models/summary.csv @@ -233,3 +233,4 @@ ID, name, variables, regulations 232, BREAST-CANCER-PATHWAYS-MCF7-COMPLETE, 109, 8, 275 233, BREAST-CANCER-SIGNALLING-PATHWAYS-T47D-COMPLETE, 109, 8, 260 234, BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB468-COMPLETE, 111, 6, 271 +235, BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE, 110, 7, 270 diff --git a/report/.~lock.online_only_table_1.xlsx# b/report/.~lock.online_only_table_1.xlsx# index edf08c8..e4678b5 100644 --- a/report/.~lock.online_only_table_1.xlsx# +++ b/report/.~lock.online_only_table_1.xlsx# @@ -1 +1 @@ -,natalie,natalie-IdeaPad-5-Pro-14ITL6,21.09.2024 21:23,file:///home/natalie/.config/libreoffice/4; \ No newline at end of file +,natalie,natalie-IdeaPad-5-Pro-14ITL6,22.09.2024 09:06,file:///home/natalie/.config/libreoffice/4; \ No newline at end of file diff --git a/report/online_only_table_1.xlsx b/report/online_only_table_1.xlsx index 8582a9c2083f2faaf1ec7d1da80d82ad3f013dab..3b3ff8889933aafe2c06047ee0a10f285c09de7d 100644 GIT binary patch delta 20167 zcmZ^~bzGF)^FD5&0s@LO2-4k1hk`6fcXxNGG~ACUAh5*JjewMNgS$vKh=_E<0!r%A z{ks?R@p*r~uirn*?Q)+vGjnFHxn_>6c3qF{zK)|JfBgo*mD{&(U+EO&FUO&~dL8^( z$#?bfwTlOj>*_Zy9{O)7V{z2nazD5`IBIgfX?aTGw|@kv$ltn+n40OP(a{$*}|5@WFN4OY#5KNN_cJY3T5Dxvlk!nWw>>OL=!E=9% zINRk(KZzs5tqEU$m6v6=)-1BIqn~nPKHi4N8WJKM8*b;(xpY;Tyv)vgDC1&bB#xZ2 zK$QQqBfm~WU)OZYHo;Xriao2F>7_4rXnmJR6|q3L<{hyr!becxybQ~Rtn>bdD@i6@ zHpC>!)UZ@q3@V!b&m(^S%n{hByc-;(llz`Q+|1&!|G3mZD6TF06?`O2untcNx1+`} z+x?sV>FNEWa$nuu>>xFd!iC2@20x+tCSzkfd819E*C=YgzB4|2hM*QLNh)#om!SXt z({Wh;=7&k&ehQ9La%V@nx1HGob**UvumWDxOE)ch(1840LR;E zSFc%CG%K}o-3i(fl_uPnc)#(kIG6AKZP(-*!91>ok_%2xZ1Erc_|_mc z&QO!~t9#GcuLk&-ek+Z_WTz+j=8~WkCW&bd5B#QIjk9eyK2;seK>s?9aDa^c-eU>K zn#mn3Uwq6C0UN3S{d)`Tls7kBV-+>LMQ}yi+@|hL?#ne55&}b47@}x;<*q%yLi;3l z6YDAQ!s^{K>^QB|&F#s(?=+EvL^t!iu0Xok9UbRBYF;lxe8_fT|55o|50f&B(INYj zjHd)AHKEZ07I9cO&(M_Lu%)&*gU5A4--TOGAND%@;$dbV3W)X@3qdp__M;e6+XeAX zcA4rAd;G7WokL26bMw{7l`B_LK@a^;c*l@24_~APin-)6YqD9{t^NoSfyYoS%>GpC6cHdA6J%;|afi?LP4Y$m8TlSW)kGK9>ZJanFuU zM}dQB&aJbv@gc8h?dh z=u_Twu!mQke*erFL#m&w+INuYw<~b=BLp=)M0`A&@#g%b^b7#LfAY3TIXgd?PM8&o zEZu1Hq;w4L+$`+WCUYFZ6ey|bnDDFqG(xhXs$(k;0JA$+*K1a1{Hhz((%t}g`t#pE z2^%pRyvbA2pI`qZY|PAunpHXOsrwkP_Q|bOg52~}V#5Bwe1DkAxYRWE{H9}w{r>PH z{Wk}Bi;kGHeoMykZ?E1uj=4RpJzw2I?%ET&M`O0H>B~;t@r#pv;7W}D&F^*@S3hdc zDofbTipv9?>H!DGVlNi%dmkNn(Kcpv*|rsFsRb#WOpf_4LQA!2E!>x67c!VgTi|)! zE@@muB*6Qivi)JvPyy0r0~rM}W31BM>V}b4`xZKRywd6g=j|`gKOT5f%jkteP4Av> z)>3NO2g2Mfxm)ZkWDAq-jHYO12UR6ksQoG(OTh*(mnF@BR(mPOQk2WCCf5ARP~xCLia83~w&G;_|#7QV1ef$V*zQOP2Y?K%2PswiPEkygHn}#bzO6 zhUcqI0E%njzODW*pMBNE+l8>Ne9mo*wc&gzcf3O*xX4MrIxw_`=Z@!7E8F)3(; z8b#HRimzEPsA#+y=!;8bXzkA(PzW#V{&`{fHco~glN^h27;rr=7Okt88xWbg zeypCXI6oIE%G?k&F7C$D*lqFdyKL)tta_$wuiyKr?bKqoYUY{T8$Rs6Vz8jvK;sQN z6ND~V9%lt%Fo;GcC25>XlwaQfefHBU_$3`riL`}9NEd1Gfxq44CvuoAK zevIP<4}?kBC4HK6j9_#O=XJ50CR6c?bVHso`;ZKcImD`%RBP4~tz-Gt4^KX>W~zF> zF%phUeI~42zbD@0?Lh9G#KuQ$D+YHiV=gHtzooxqr;bp>+|yfNB-APO-T=Ooc|;k< z$hR(M%5=;H!9*Z9!10g_{;KTK^mj!$ai8IuQhdWc zZ-b=YoG3Q(714OVxnsmhRN|5*Jjn13vOrSnif^VVbFN#Akl6%_7v!oTxdM;1f%PbuZCd7vf-l$#F~lyxaA!lYbMFB zK3LM;1G#l0n>-G2g?sx%GnJYF4e?_$t2`5{hLBzksTqRWDxjy5j>ozR@m0LLGQ9;R z!KNKf+o)I@Z+Y{R>m%wPV(>oj+^T!;fak_JI?2*(B=6uHN9uUmsi|YtWxOZf%VSRR zem|B-a%QZ+#o~(!Qw+3@y%%a4`?<3BPT;kbaZ8AO0%=Xpuu)0v<@PMR6RVbxULL8L zJD;l90A8fn5?=9F%C6K*7mL@0D#%kMeejn?FK4QkWWnV@imt_mR-gw{798cuM)4&I zn!JX4p;}&clJTVIo#H>M_q+z<&5KP^IFi6?bxO~j6eS*Ls2}knecBTA;DjOCg9&Sn zahFN6{lSBj9e&3vc-i*vrmYz1TbA50%X9BDbiC*9=0;zNp1}IR++elc#%} zX`ulj7EO?$C6hhO1GlR71GL6FZm^;!N?C!8y%1U+)1mHtwM~DU^tEPo)mJYEo(?17 z0Vf^;EF~}Zn867}aC=QA@Hj2Nl-Vd|$S$6-sB+*z7N^PgG63dJn^Y)?ng&GOkZD_3 zIY~=mS)j~&n5`wCfFf&c(qco)zt&IcYeMuJdTewpyX0-;ds)n%wy2b}_2&5yL?DQb zGP^Qj^?ND7FUx%Hq_|CByBANJkKOt>aSO#yf3Z0wxVd@NIycf>PrjE@YBLA;^@XMV z6~bD2aqc*tB1oTz^gd{*#f9nK?yw8fYg)^~?)b2mH)vYC0HZHLI*5%p9{fb8oP1$! zc!iMBnD3&Lih(UTc9LEHJoMttwnI;W%KL3$c*pOw0UhsNYX>dy4j(Mi_AcHxZai*+t!YoUB6 zu6cC7W2gMO;8K$IyfzR>uk zW7?&!N-3P<6Ga%*0sE}3hwH%Gfn^@OAIt(~>@y)ktW;}l5-{F#JyY=4tJ{=WT#R8h;EiPeql8O>N@RQiBwuZ><7R{AU*M}G zZ1T#aeaL?de|-!Zz8GN7B4_>3`HQ-s;0la}>SRn<3m^fp+!PJ5C0xSrmj9j?3wU0E zgXJwz$G6!YutKp*3YbQJ%!}q^M17_OHx2|hCcM}fE4z~Qa$_{Gn|TzreE*@=A?*K5?t?g$PzaS?#75&%fjK$!bCyW#pc5aWjC@8c$2 z57^?GAm>USKtI8a7$M)kKjool_n$^N7idLRiIAX=o^(i+5N=(m;#F$L5O zoNGxY^ca4K`xrBWN7mkUrWHP@UCQk}LgIEFn`0gB3ac&Lkz;YO6x~drJpi^2-RR{{?~?M{YRh;9p81$yQs9~2gnv_oV9<%X+0KK+{uR_)4H*4 zl{SufYmrv2f2n#6Jljs1Zn6cn&?XJ-kxm{c;c@s4bH2lc&~y-sh&_MkTK1t9544AjwLhGUA8Ni^vc-VJ;_uZxTwvR7Z8bJXRSfoeync^I8ddAwR%x z9`8}Sv)4)#iFIqMM?Jl>sX8uTg}Vw}Tn5aU05I~Mc&i#?z+z!FhNe|}wG+@x?-cH` z{wP;B(lM(()I?8H*oNEvcyx(2F(Sm><0IFxp3AX@yK~Kpf!O2C-;U#+0YYWRMZan>D1Kc;l__c5Zp1^r^cm%!UPhotemS z9P~fh%SZ23vf`vH+=PDx(-#XPPaJ$0#Shkx>riRmoqP8#ra$5Pu^eK)-2__sYS-~j^jdt!pG~S zb-kwnAV>4xW{$K*z-G*I1`#mB5}F%Z<7r?fyq>mYVoBRcfA(un4@}5|XBabuGq!iu z`H)^#q+_;x&UXc4iLTC6&L(84{Ph0t3dn)b`qUfhNA9Fg+l>(jj1~W(JC^Jy%lK8Pze(}Wy3bez{TJvUNw?N23mp#Up1LfsWmw3kI3q~JDjN2RhYOk3?1&c zm;cv|gyd4YX67nJNcOPsSM6X!VTbp+Mmm-+$JC zzHTL@+MG}_?J#D4d6eTM9|Xv+r{L7n|Kcedw?U3f;=M*~I@LFVgeh(7gA3WSiJR`^ z;Zyz2qp|Og*WFrk>zX+Pu+EmXk7YroZ^@04b*xaGUxRH{QjL}|JC$MMN=p+_fOP-2B6B2##1ypHxL#Xb zJQZ^`NRQRld;%<#a7GJkMxE*BOg;ex3Nj2j^JjWP>QHXoAcr8B7m~1)v~e_Zqi`mq zFy9R@w`iuW)i8kM%tZ}c1;n6;6OLLTe+@yDy>=#_n^dBs1{rSs`9TTuv+Z%5U`5yL zX%{Az2EL4jjo5~GFhL?}$s)?VTe&OdqkJkjv%k7@v3lZVqquG=`7S>?(FA314moNZ z;drezU&uHG!y`%bX|qYJc7P56o8(9fo!(v-~vL^)|O?pl)PKP%RKZ64l{l zt1-^$Cs5SSr%N{be3!|YiGrgxF3uHP>zZxojHW`Dh2kPEjhvxHfB;e+D;_OC={;Hi z7}4q9JUnXE7ifn z0{*zOVXDC~w^(J}c-J744;8x4&$1DOV6_JW>u`OAAKg*ZlK*8FzqH`oTFwHH8gf+V z1P}PCZ{mWfM#*fimEwFCeB}`qBJTyc+e(q)y@367ConDtH~9$&bsfigcQ4XYa0amB z?^x~c=(3VB8q$H}j7RM!ib9vwNh7f^X6xmsUgc*Jkh@*aHoPA_QWtHw)=Rl&Yohu6VPEcC6|+-C*#E^zPJRX=a@2-K?|TArlqxFt88bW5{t*Fgf1Zm) zCqhxKnwpAx<`Ml5argw7+7*T1`VT6|`vB`qJm#Jm*bR@Bde?H7PeyI!>oMd^Mj3y= zi}|YGHMs&p?GB7)|I--y+n5PL>coLfeg{H<@#!GHcZGX{eP4au>rFWslxllGKh$%V zPeqj$fFh=%jDtWC40B| zE9F-Kg%|nk`yFzWZH%FM^d^WR=s1{F(LlZ?-*aoY04Al{qj33M|HT%6sTuxSgIIql z@#$YKsz)~tD}SoeK09VkeXq|Q9rn-91D`T}aaCCFY?^-05OfF$y!2W&1Sob$GyznpOsSQ=I_rd1bG*O8=nwITZ|v#`9-N)nb5cWPPKp${44omSd1V`Gx?U!5O!+H&XQ>I>XpokCAB>@T?oh;}1d@Y&zIS%3+9a!~ttF)Kh(|B*JTRxGjsgO@aZg8gd z&~+NnEt{2Lgek!PO86#jdT1!dIy=l+(XUmwE0PjCzD`aFcFUOH zoWgizvPgs5bF1F3NJ=E0tEhOv3Lg5~yBxh-kXrOG8DG8XK0lZ3M2kRWd*nN z0?WKZfl66sXVDH9O6_|IaJ$)O`8qRbi4{Ef?|N{yxc_0FnfI9Bu)VHNE`x?sOuSES z>!JSR!0TJE0Fe^w9L3E2b$)66ik8TE0o zwMgSWDl`l1pk$lvb^fjfK;DODmac3Ps|(icK3N31f=_C6nN2LpCJ5<0M>tGCWSzu-{yTDW{WRRz zH+-CsbQ!n$z|oJzD*t}!HBYXM+SfN2sg?gM;;*FRVZSKBpfGO2#8?Yi{nF;#(bf&{ee%u2 z#M9<9Psd{x1K1`LpL%c1?}ZncLOm16AU+%`+b2mmOiFAqhBP5HIFrvr?pIIRL zM5y4|Aat)#2}_W}bu(pbXrajQhWThP0i=w zbhF_Vc62jADLVBJmg1f(hPm?zSzqm>|Li9+F|ByDlh`GohVsy~lbHIb-23&muk3-U zyI@G%v8s4Xlul9@a)ciA3cj|`NqIMAUL0ozXvD`sC$|d?;Di2Le~j=2&R4>4`*j*p zyu|7Hm?o3jdit51AIcZ4Bblfahh;?t?34$87AE6_FGJv2%yX$26bXX+(>9}g7haw4 z_OwH24)ZyG@OU&3{D$08KSrmX+|m&I44H#OAHY?;s@~*5wD^mw)=NMqEPpn)eib2~ zdTdqYLBu+Da7_td(oyyu%p@%wZx^YcMKz-+Nh9g`;RQs4PuE1E?&` zV|2ztlxJ=gz$^^&U6GHzu){z#CLl3c3vpe1RsmY9 zREU@JTf~42{WD$`3WT;0%#AmzQT4qEB=GfYI6ruth5+xxT0N1AZ?iXepsA!1KfXYB z!xDp}6=)Z`qjl;@@0pR+T$lZZwSt4l=M%0Q8)K4&P9>Ug3QlEG;u^6rnI#9%bc~=S zTxBFEV*K>|OBlEw!fa;2W(fMwEbPt@lSpK9nANK?I|>KUc-eSjY;Tecm!D=&@P-I> zxPY3^)#!k}bfZzxY%8A}9&HQ?+?!Yxi(k$s;6^sgWghJLAN1Ee?U{b7r2@+$$F?I$ z0n_0#r3t|H<#KbIwM=s78ZO0CqFhxy5-&16d{z%yy=I7)QjqabPl@^csr(%w6mBhh zIhzR44j2Cl+gx2+y)z*5Jf+gUx%}c3G9Nhaff6WlRlP~P=B=I;O+~yN3RlbMvN_8y zM~V{_LhP14+vuC=`m@=XIegY_at(Pt8;PL^?f-?5`mQ+GA2Hs>x0{j(u{A@|!@+!% z$a?P-dkurQkuZA7*>hOdGrJ{TC;kEUN0OB1L>DmtWH-FlZ7xR~kv2zQ7%Duk46|MJ z;12)V-ZkqcZ?@!)#GuTPoF7-E9*mGHY@LmeBhIcXe-~E%I~xUvUU2hYX5-Y%*wngN z@{yrJ_6u$l7TSa4u0v0=*Eu_MiV65nN=C5A533Z+blus$|EqiifMEz~PZrE5b6lT9 z{9vNopKypt6Dpd`9uhYRBc_OxF()aicI-BhSz6*j^ns#7$^WYFVg7{J{5j%Cs3rWj z@@pR4#h~(~pXtka1bX1*RQRlgDnENwsed8!qv~Re%t+les!U{ln_ry`6hCK2=i!%; z>moG*lZiF{_@bx&F+pRw?gQ4 zR_(4OY89AU6qcir%;1{y_`R;_O-fDtP`kiy-EfZDwu*I~FI{7o(ERBEHW_KkB7nwH zybaGvnC+SXPx05TuI(?N=N`B!>-I)J-n_n>4@>+2o}Q7TJY8=%MmV%z2pbKf@bY)C zav`HriusNJ$Z`zsv`!<;HVy*e2f$NvdP+M~K^sNxCSgZc4{QGbySZMHfIfF{$KU5} z{)EnUc|^Zzu7)-OQg* znLq!04GmvTY~RftA~@%6IEuYk>=(~1p6#rXqoNJ_4#u27R-|n;qxpehaT#*->_hnh zM{!%l9o@f%Q)8z`lna3splbI^6d*vJRO3%O#1alI%1UVK!3lxnYEt^n*H#-&7Lh%3 z3ag=yUII<*SpE&YXb)19`bW5!HxF@d^h3bCyQ<`9|LhGqfilpkYL=tYj_we5j~&J) zKt#avJKMG(m9q6j6rkCX&E5-PXr}>DwsDe>y)PGDqXxb9{Rd>}Dw)wW?TMRS#zz;~ z^4DwGsH;s8;32fwnsx?2avR3GUhI-5DcM?B6x7mbS;=?_v`U#xi{yye(IF;eX&<4Y zkK=WM9uTsR4PNT+v0<}jfQ>GHRl7|Q)BO-2w{W)W#UK4evS2@AaXRi65#py)Xb2+W z@>uOG2$+*E4jWxOFCH#k2L(M>0(y=)9J-zfdanO1Bv;+&z7#KuCH6pg4=?LfVG(*Y z`^2BslmA&A@q0A@EPN9=FcSv{p5V%B_p@)gj~tt(fcu0}bIU&55dpJa)|@QE9zD0PJ#fLa{B zmy!SjPB;e!z#8}B+j>qx<;|b{lfp=VyP2jUh*Fwkhw*UsFg|ow3^f9St%|-m3_~Pt zyz}D)(%Y;xOPx)Ffmb-&`2q|)pc712pL+?7B1?nBqT=~56UfpuPhHaxvmw;Cpaore z(Kv&K%ZmpPE>+6X53;0qfsrjU;hZoSE{N9xv?T)WJ!?juRvNNg*=nmM*%e9!WNC*ROxH*Q-LWFUE9d8_VkxANgCcZn>|o32--jZR@(`jV>3mTn%3{=8hsDExQi_ z>CVF)LSo_fNFlHQa>vVZF&h56;DHS8q-Ze=xVxd#81e(ulOLS}?oZ$Th>KprS(nA< z*kVe(r%mpY69V&C+Ds;x*7?$A0|?ZWn-uaK>x^EzOn=@!&&rS=zjeTJ0(F4i<`#or z^-5UJhAgm)Vqs2-IETcIyFP`gR@rn0Fmx=V%ihHU8g_vZT8Z@onx_&YrDon>n}o3w zt&>ExL~crnzvj=I9~EUz5aDZqX13v7+@YWnD(y@Z=@k8|i;)<=gWx zt~Q|27nwLS^LAa8z8R{Q_d0C0L9MNebH{K9tlXg_j*2eXy1pmnb7&)g3lOV2IDH0k zDC4#rxqGw&)@U%WfU4F|OMTFi{c2Mv7acwu4}x-%Io99Gd0BcoewfJQgptm7rdTQ% zH$s2J@j$fDj`X*PP^I*lce2Ei51QAc-6a+c|HA4AEvocT3=6tIPY_1I2jBun-vsQo z5kEL8_oo^{zw{1F=hH5x)`)+cDKup3zUR9hEGHT#-e$qH>kLZn|sek$WLP5-GydL!iMkk!8{u5Nv)FAlESh z{FgdK?6M{q6<8p}?x91$BDQ=oUMBpFHFyLkSIaNa0HQC@r}NWB!5G|J_#y}{bx(B7 zH}1M4M@{P-bV2=`Tq(xx8Mwe?sOP`syO7mq9Doia|7B-#>>2DW`U9emCVv7G!oYuI zd<5<1W%7d}q^!X>3is>+RD`h&u4&8G^<=x$Ew;Ve;SMFmJ|c0P<}z=N;g$mH(Qh!l z%%zSazdrCC)JPG!6`|3<>yhF-NY|3(qZOLccws_LyCpjLh~B$=ZkW3UUBy89Xbzyu z*rf^H<^IIHOomW|z5}>@m?r{IIl?-07|!l!*{H$FOQ zA~J}n;TOg1QiaYV$G&$}+$g>(upD&ul8>p58$+GwLYy?nQm~y^$Yc2-uI5k3vt7P- z1az7O1@Hs^OJ2iwCljC8nj@#f&@tGyo7Oz@8Xd;ra)bXo7DFrd_!EdG+4b)$AEUb= z-rxM|vYz$pG=`GKvOs34K3-6eY49I6BWalE(#hg#mT~&>cesdmzJ(I>+kASp#P$UZ zhX52q?1IGn#>0^<)0;WLFoCZeA#o}9#CG2y)-dpFnd$bvVHM0jhr z7dH*#w*%h(j{~Ip-VtzDJObgYmiB(NTEPDxu8zW(2q!AQ0Ta(1iY` zZx>zEs|TG&ntk~i+^G07kp7AE?AM9XjjZ9_W`@ka3sDuE3bNJ+C8;+(HFBwwT5JkK z2LS*#s(Se!K;JPtrLh9vI*e^bw*cj=-|`()gY0LqFhM_3Hf@cHK#2hRwX=$g(d#7PO)bjAIcR&B&r#??osd;fFp6Zx!)`5J4kgaW2!}2i?MJ6&W`x$YIcCM4)4zCOt4|3~O%WLEvjn+rZZ221X*T=@d*5 zvP`O4K`w;Rr=imHe|5jg%ZvdPZD2!lq0yHNOZ417vru(+5cwJpn65J}JtJuk!`KLO z7xXNjQ%x**=Lh-@_%j{i6b3_o&r%JXj7^=OL*G@`+Kjqs+w93wu4emLUght6 zR0Vg;p6v4wzTo`7jdO#7+&<0LBQWZ=vk-EpQ9An#I%UjBEihXjuyqN;n7-Kfolg?h zN8;Zx17Z#Uk}%GZE%4^a2SyIL&|I5@aqlW3MU~ps-ZH!`40^veK`GgN6wMyQx*gEK z?apRn{1>+;%KeXdm^Z?vc+9{NE(WoEx=l$I0qE>m`qd^N8%p_kU=892k>N=GNiSTrnyhxAychx2vx;hwzSHeQPY(43( z+fW*5UZQWD7i9}Rpm(PlRksdN9vlyC zs|u{y)+P>M^6rCNxaFc3`oq15mb0q3P~&+QQ-?`ID*QF4C&exYkBVJfrjN5kuhBL% z+NIR@LdTy)GKc3)$o!WuIpx;-*=o&9Mr`>e1h@@4D$NF1 zEPv4Yvf6WwlmaFkAm#`lK-RcV(^|EM#Olj;(7MUX!Wo`P8ixfjIv;<8?mq)AN{xW| z6Abg`e@aag^!X{4l@<$0{q!{Y%~lP>B{Ga0s!iQymN-uU>oxGCff7 zkAwd+sSDo~Nd$C%m>~Is(QM~waym9;fT~~@C)usid#Q2Pa;4(6-hXcoxON#aAn5%b zx7->iKwH~T9&Tg?FR$j8iFJae6wG}4Cc;Kyev42jwy#TfXPE} z>3J&tEVayj6Cm6sI*I`#ZHh#k<|LzQZ351W|i47RldPx=MH-}rj$U9^v2)}rer zDK^$$$PczEGH&XVyGpx%6&#xg(6;OpIX>x7&(?iVM3%P*udvDqP+bQdZ^Ih=0GlPT z9__{daE&VSQ!L=ZfA_wF{(At+v$iDWK?F#FSu>$z={yI?34jS;Z6p(cT)+9^=;7#- zxSXB*v|jATvMMod?gJ07_5f_*J!r32qfW41C1QB-!35%1AsJNIt`Pd<#cumiG$zUf5f8q;-Ztj-J5QK8Ir#n9SLpfg_RW#NT+4- z8w=wETDn>t(E{KwX0!m}OC34_IR2(T%*kO^W6LZZ4^yCrg8@A(e+bU5RhG1?A<^Y} zi*rw!pMrD!=L*g9xG$$$pclk7sr)g>T!6o$0IgEA0Nx%JPylZaMU0L|*pu+5ywSAE zqxv*URvb1pJhf6r|p@Gxfd-0;u%-h+D}n83TY;j{8)-|58*iAy6reB|iC zO(tXXasqviqQI35GIzJj37i$5PX-#oi_lYVB8oNT5MGOnonB|p`T14C&)d}Vrn>VW z14Vzv|Jrb>p)c%#!DB%`rsz1qvTO(27%mL~oXz0Pe=V6Ot-iQUsZ-?#uT$WvPB5?? zCtq4tB@1!-wkHz9EsAz7yBhi?Vy36);!cQs<7VF95juDiF?VqjfujVTWUN3YcoRXc z>U85B>^mf<3FZ?8P6OboGeNnwgW-EdRv`blxKJS${C%NfkpVIS0WD6Ki^IIeh#uoU zNCC&V@c35al)XX=J|)`yTNCIeS3wq@D=m=xd!9;Oz}p<|?x%in*M)9~caK1ix?~qQ zgPDA`%_owWgbq3+9>?BrmH^PkI*;a3ks2cQe3{MY*p zr@lG+k=2M7`-ZoGX&!dZpDai0RTv>YM-?jtFvSroTOSPbTW@{v`_ir?_;+=_Y$=oq z6i-L;OxK2b_L(kf^LU=={buzKk}cJWfv<}VYCzKPc0Jo>FdU;g@?yk=erRcKSJeM~ zBND!Ap8+ZGLlSw(n^`)=g5ya#Eq@`IPazQVU%*tpV*o^ir9EbH z{!?Q*kJ^>92_#Utp%*R537=fZ!+jj@Z#q@9LfMGeMzk*ur=*&H{Y$bUa{s+pQB6xe zX&7f39w-#^d=s{&EfKDE+SRWC)>=a-0Ed$0lxK#-`QK*Hs?k|w*0l9UGEjn$jYrHU zfxaU0yL|XFvsEteNXgg?>jfH#;}&H0WUdA$ea`I+lC&Z zJ*$(-S3M#j4WN8PRD!{rs`crug*;pDGukw|%$O*7m1Vl_kNBuJEny@5jW7Dncum9L zyWJ8?H?pf3-HzXb3_!n2=9CJ*w*o`ADiCE6j9_*EmlNH0q`p{gh5cu_nEuo{z?}>i z>yT(Ck_)F6I0A=|wHQwGcCoh}c@|c;MEh{rrp9{^@XNt6#}*{@WxvxQ@ngp&D@xvo zX8z22xy|{Y@?2qT!72Nva(SQ{Q|!(=2`GsE>nbZ=dp13!_G`&A?+hFv?9zC-PtVc2~^hap1R zNYKRd|JXEdiTC)gyb%XZirzqTSo7)sF)A?O!4)sbS9;v$A?4p1oy*gN;*-GF4*&0K z<&|3=;#ieI&jFGr=jV(aPTEfTpO2L?LVtPa`+OR({rW11a<}6Hi_Osur01kor)&gW zFmm1JnA@1D3FBNnsk~PR{_w9cDH1^#OV{GAXE;CA>UZzJj4c^2Aw0{7Ejp52(_Yc%UD)j5jWN0m;+8J8cij+{+@ zV&7r)knnFmDjhqB+qXi93{;67pKqk}Jv}&ww$tvo@OTY8Rb?-yHx~ z{=R=)o8-Tp2b>(PNSsqOo^Cq>^+&B+=bL~Ba5hcle?AEu)fSwcz-P}}jZc0wp8Q&A zJRfcBpFNqp-Z*u7dVa`xzO!w7a@csjJ#ap0e3qAS{v%^G;|#@lb{N@s+)4%PubiKi zo2Y`*dA1Qc(4RtW$HhxRQQ z;P)qc8K1yEHJ%@6WINyOG)_NImN-8fFb2*Roq_X=#`V=CYXuTd8`!D~FMZCq$Pn;-QbI=7bC-8;?mKTSNxkU*gtkuuA@ zvsLFF5~xp$GDhdX87y)dkT*KB_D4#bp=!?-InVcw2Y{o!mBxdkkRJ)>xM#nd{r7v< zfFfYO_Z)G)=>Z(A07n~~jo+!xPga1lq1lsV0boCP_H>u(>;SK^{$yt~q4)SOrFYHs zv@nBG!tZSLNV|5W@hoNTWZ`r&Z1lW2OrpW5@o;7Kd`}rT9Rk)81ZKB-l_QOPP`@_1 zC(pkbqxQ5DjD3C{ZZsdC&oxi3p;ExVNe;UT(+e@wX zwSO7%Dp`W22ru!POV16i5Uwn!Ut(O`Rq?y@HV=HMQ}x2kGXD|9I2 zn>7CTMqwae{S8q1JS2mJPq*Jn>ZX^KEW!;lDgL4P%1+$!$_vAa+yR~0B5as8$EzWH z7X!hny_1I=upt^Z3!66nfsJIU7J6^Jr<{1E+h>X@cUw7A)0s_&@Er)f>CHZ3l~b+7 zy(PWJty}uESJsC4K74oKr{ySX231`zX8cpqko?7kfNcPHEj9fp)0Is=$l>k^yG}W# zuZa9x=nd5ztB^?8&w_7k&D{8camn<2kbqpJq4+rx%v8C4d`jAu*8WUmNsAR)eK!mG z2&Mk&kLBX4sV~ZoS@bI`q~kTd?_K%ac5}Z(5sR8{9r7jqsVc@tS?L_28B_O$< z*n8liVp6nR??$ifM5OJ}a~DShr!Jb6(d8x9`pd{@fJCP+(9N#zLv%ExKf3x>T0o~z z?<3NGf~I9Z;&`^tiRPpWKE&2*k4 z(3D|NSdEiT%zkhCk-c`rHRQ{iw5BiStZx|eEMs)o{Gi9iGck|A$#OnG4kx5~xt_9k z@LZKiMEUCS$EJF5*9$YeN(kG<3TbkB?zkz`&rz3&>>Dkz!jr9owm*F!6#G6<_hl>G zh&MTdL=sa!zo5_jb+&xx?bk!ev#deUH4o!glH`C``{&G%^0vU}x`+54#>ne?8+z+_V#Ct{z};NZu6<(+1T-sHw#83Fz^DM;|uq!%8g2n+^4C8 zo5a7}e(^It{0UnK_BMZndW;mCE_S6(Z*OE^5RM(2ZrH+yT-80dF}zWsqOkVQp5j^M zH`qggcbdKN@1(hz3**@_!>*Y&3r+4e;%fVmSB?5w$9cBvdM<5arj5Sr6sT@v9U)u+ z|6gOZmD5^}34n^NHu9Jvs}7144Mu6SK=#9FU^x%r=W!84Km>jYfNg z@K)BCTKXb)Oaosm1H-4eBbgd%3F&J43LE$hzz#u!wOzsqJxqcaZm#v}wNkA!aOQly zraAESwEX+%=AGDP)ynW^A6gB2EE`+BaI1cWN`$aKQ_wt|JlzwfvheEsoLumptKS&O z#f*A2E%!dUmCxB&s60)M-akZlI{nUVYlnpAV+Osg&Hv~Ib>7}yDf@7P3zK!aZa@@J z$p^Y@tExs^uL~Zv;oef&QP3-jH3^e&barhXAiV=0drcEOD9089rbFATd? z`}SklYn%4+`15`D#%Y|jHUCi~CntD2u88AsBY{{_T22gF0xBc zj6OQ4QgM|d8te1gqf*(=g~LL+MrFwo#@Ya~PY+Wx`tW*!KJ;}u2`_S8Z}@=`=V+K= zV}o(`%LQ%yhYYYqfx9%RVWVLPngDlStZQvlZVnBJDY4$@ez* zljs#4X*4kuusKZmi#4+yZsSO7s3yDxe?hGvOJGRD`v%j!Li4>*;upqA>D53?Z$iKy zW@p-x?m$sMlpB9+f*{$h7w$SstZtgwFzCTcnL0!VkDEX zx_uw@bhhgb_<{p@0Wkwo^8jKO7y{g2xkESH@&8I zeaF-enrhA0-I;X~AE=}F7zHE~h@9q2BEw;Aw%4+TpSCAPI=hxe2dt@Ci&#!St-ktp z@rIS2l4Oj2YY#rs>Z6ix4E*)WZu~im#gKr_D%#IZtp-R<#Qu%9hc}+?V-`GLkge&5I?*D@^h%kzR^_|+f`*C4#D3G`!|ER6(T9&yq z|JGIR5C5!d6sXX>4~MeE$*?+Q(a9oMxOfUhwbP6~6@2ugefs(f{e_4%dO{-kNHs4EWk zwT2Z2s=09X$M^St-L|C7z!D(pnSf&@TJxMCmqH2dZu$nlTI*p*+!|JWGZ z8R?gE_OzfHq{_{SHpTe)^~ zIU9T34#~uTL=bWCcu8>^h*1u1f4tF-B_m(V0sfh$m8s-uTWHRn1<>M*D!9jDwLU*yxYrO_gaLa-?-*QJFe4*hJo@p!N& zIu9D==i{X_<24-d{APyoeHm;G9lfz%h!Mn~@qKk{r~&)Qi+yf=GxFfmGiA%OoC@PN zvqLruPFDwK+>B*wS+*=t8+Z@$Vt**Q95NYt2)>@TbMk9b1vX!$q4>D#Y`W*%ir$-- zIbS_j(d{?(V%Q_daf?wC}lXQ*SF?%Pr-`vv_$+S#5r z6}x$hcqiA_8$*6ZugzuwIU3?xxz&*fcEkJoq486!m9gCzF5Qi8$&cd0q&Rl%Y#O#1 zelL^Fi(wW zs4#c8n6A#}Eu77Zx>M(wEetT(bmp>}Ojq1A`OI?uN58Mzr!Kx<|M0Mx{nxDjkCw&j zw155j@8QP!>$?+wzTWU|X1LwA_Hcdv-TFTxn`Ynra6PRyV$Hp8ubuZ-*JwQGUSDg* z-*^8&T8{YjzrT;Zt2)3R_ci?I!`NJhbqDYNKOI|I#ijW9T;k@l>z8+|Y5QHju|n&{ zkF|fk{)(+T{cy**F#l%H&8OTg>%(WCZLEL2Zt0KG{WojnLR%(v+~WiZ~yWAhJE&%r<=6@ z)$f&!+iS8j^Ly=wAE%zCS%3N7pJC(r^sXU;#fo+7Hq5`)UVb?5|Bpa^{rU*K`k%jk zY&dbjB(Y@KB?>mBecs&h;Xljl9u0-ZiJ`Se38FwODEf)B`#L>$L9+3%6F zJV?m@!_TTqKy9kP1HPnyGy>R8-tb6M0i*``;58A10w60~cygYw*ku04JYd6+PYV-7 zQRq9_>ahY?4f2^;0w`+kO|E<_4|ebD$I^@vlea%s0`u-XmS*~(Ihj#QbTZ!)h(*W& TA%SAZ!pW9TwAt1^1PKBFOMh`O delta 20116 zcmZ^JbzD^2_qK5nY3bGrLwAEx3eung(%m2_A`M4cV2F{BMnFIbVQ2)TVJIo-)}gzl ze`f~0-urz&@BL%$nc?iU*Ix0gXRU2)$MqG&b-X7^*Z(59a`WcRE89tea6E>q*TMgn z3S7N^4gKJDUHvcgLl5R-Y}NzYV&JgE7y8BPO!A2m=FOvt&{|@EP~E zugnuU_(I01&t5)w!@_jcx?eFn-@leKXHFc8#+lP&>KO|HpC&O@tC~l-jLgv9wjuKx z`Om-C6L>Im=%{2r60=)Zh1W`ZJs%qn&I+l>3=RkG7+zKR@iSiNmA*5wi~zSMK^`Bb z28CJLuhQMe#ugNK*Wb^exRg%bD75k2@4?;YLfCFMxOAhwFHPSQq^kK8{@Jeh_=I`S z?11l%EMDA(7UQefY7%Ab+0k*n+}wr{qLkv!cSc8sVi2)U)t`oaB^j5t>?O2i^Jctz zXuqCP1DvFY_SD|023n!Ur0e8A2}gZrv-Z-&#kq6dEC1NL2ffoIpz|I}i9deI`#`1l zdhk~=p}Y&W`Kdmaz_Y@s<5lXvHsq-Mid0STypFZcPbB8KQ8sr@E4!|C^~#m7YyV?& zoh$$P@79$oF(=H#fQn-i4{q@038_X)xr&}p*b}NUn{g}~Q5Wk!wl`oZgb-iW5fl)Tb3if3}{wm8MKsM`P zN+{mcp-x&@luE&Q#_HHhratfH^tYm&f-b$j>i7W4K=nAS3ePZ-*eWdW!bSKaOSs8M; zOEgKco5{K|CY$tpr9M8~cROJUZ*MvD&MaYX*H{-z9KzOr(}a2Fz*ML(EsU?#W41_c zt4He?2W6{H3Yxo2C!kqUK!g1!&|?@`htTzZN)E^nYDa=PSl^z zbcj!s7Nz4JJ=cC5a14C8I5;y(lc+ri|G3QUBaD|Wdt{#SV;xgZ>}-3hHAM1f5pz4k zQkLBGnPu?mM19@a+_I#*;h^o>@~wK6xh^{l;OErfEZ}nvNNUf96anY^0UZ)yzPlqv z=@J1^N+&(C0C03Z;W%^t{`SF9f~4Y%K*nCO2zzV7L7DLM1MM};&^(05NCzscMPX;=T;5HJs zcbhL79!v-uDgTh1d)EPvupC?1X(c|N0s81@%Lei9`2f$W#nKghPsooa+_pwG>(84v zeLW5jd(*zIs@&UiyhxCwT^|aSD)=FMoXX$6du>bD`#2mBnGSieRMZ>da~uWuNL?I+ z2-lzNINs6x34@=uSsU>trEG6eXL+?+zi5L{8hq96SbEXc_7eB5S#DbbKR#bh%JVnR zJ194VWiNm*-bJXSS{C7*6^)G7kB8Vvw&6FpvI)~|pFVBDJmIca4IYVo`}m-X+0573 zN^c@{UCzxnv3qm?YT8Dyo?pNH_;KuJ+LzJ#bB5DJVE^Jo`fx~kV(+4T^ULXmhqpa* z+pe{(n5&WamjUbKM^(?u1&25C_siQvqM8)-j!$v`0^>@J!;Sp2xD|#|uTgBd!=Y`( zIeM{|DLr}8l!KK zq;*vKxxs#+D}^gEn*MO<3w9Cd^lNp^GIGM2qVKj?ype#7$Bl$N{`*=dxP5iUzQ+nD z2RirC0HT(e%?#r7zQK`R>LXH_M-a>MH+(MNXW9;^t-R}~=t|k;h%O#>+?p0w30@6^ zH~fSM2G$iVsMdDeT)1aC@KepbuxP#fwjnW-j;DJeDUckJHrP6Xb9dmGIc~sDxBC5J zU3O?0dpMycL|V7UylT3PO7Q(qY+M-7I;}6y1CSG)P#aP|^Rj<6(voOSxg==P9?~dg zCC)}-BFJ~+!Pt#^Dg~~>Q7@wDQZ4x=jqmm7w-1Sh2~#%e%h5Pc*caHB5y}!@?8U=m ziDN?u)8!|^W@@6S=>1mi&|s0zI;L9=hrhB+sc17o_~F zqrp&ens_>4Pdv$FS*h%jtn5TADX?v@B_H-vUXzc?V_=*~S4G)M%RF$XJ3ED`StVzv z`=x%ztvhwXBZS>ATb6?dxyn;r{RRUg;&D=$0va*W5iBqKqzE5DvOFNEt{H>o98b&x z2NBVa_$fC`@AZ7EO2T#I^RJF{ubwNbt^futMO0E4;wc}+NFLp>Ts2yRQ0~Oa2G_<{ z_H5}e^ZRAeds}`&3Q#%-`B*;FR|!U+JjLAE`Ied?tOs z4jWSosjwW>eE^F&QenC-BS-Z$Ck0zZcLOq?wrCfZud*$~IBFZ3{?xekm=Sn#{YTG$ zdx6otM53e{>EX3Y#~+-`t>DjSQkEs&@U3RtQVV>)FArlDP5z$LR+0A6xtw)6=PxhL z?HKF=t-3iIUG2y57D~;-xiN_uFs;Vre7PV9ah}vN@?~XIO1B4}kaZXAD+J>!KkFwL zhW~dl_4#M&wJKPhx>U=x2l2Z=o-j^?8YjXb!=$>e1Gk@Lr2qLae^Gf6wv48mUbAaP z46jtb-|m`kV@_3@0|ltQluh>T+M7m0rPKG<7Bx00smSn3#*L^n@dh*qA_gFP10G1_ z0guk|!>hw)6MbFg8CVLdV?F^Y&m*QpM%lEIzuPMoj}S?IZ15bi4G9M70#1|kse}l` z`EC@!x@dMjIBmUD3Ue76F7{c1@va>|$Y}6zz1lyD7g%_CbPLWxm+3;P%#YL30vz;6 z$Kz}h(te2fmgmu{nA>+nmRV_=IEuyv*XYgvniiz95sz_ZBhl{Nfc&w1PvN7?kA{i@ zc8pXyfRex(qo+CUJiS;!ZY=qLC$>zyF$SEf&Fb;4{R-5n zll97F)axp(we_o#i?Z52iO|8ttR|S?X5Mq80j6FTms#{(X~H+t>MR3ZLapVl zZ%y*`%j+w*(h7;z%3BUJ-}Y;6^69!#?&MTuYoq~;u)A6FaR&-%`y`R4Ce_bqj_f~| zbMS9P$rpa3%EfLYW*PkO}BB>AMKi+6Pz7G*>E(0GktZ&Onn9SdlxK-vJ#-_uFG6a`e-abL}1cn=0VTw^kxICYjL zLx&wu+e?A&WNJ24vU3!qwBKjSvWTH`T-VnXqJ#j~f_I9q_%6U8o8DS1Jsg{a_Ml98 z3fDL=e#C1!t=HN9oPKmVk8gZML$-@e+E7YQSCbM#6zt4sC^41ggsj`bmN|bvse3>H z{y1ee8arrMY`cEDS)y-9BD#_l%vU?deG2>i+gTP-baw`I!55vmBSHX8R(zy5I~C?k zC6Z^d1d#xqlpcNb;nHyQ(Tiz=4a`BjS}&x}$~QE3;ovi`E(Sl5LEl3jE#o1@GqL3k zD3YKYj-ta9PH8!i6f5;dLG-C3V}ilIQr3$TUZY{=GGq&l6bu&Y;GngIDrj2M7Qwrm zfcz)OICIeNantu)DFo7{Oh#kXGaB4oL%^_IFL&2NLFH5-epddpiOU)fvKgw>jxSAy zLy+oBYIy!tU4+k+g~a0qYO%}j#UALz_F?E#uQ|M=Fxbb>G7F)*V`u=r7GviiYG~Td z+FOfV&qe}_K^$q>p$gM?@|NX)B%-Xgx`zG7)|A?@rKiJo`dFs| z3U~w}UD5`ejgxsbDPn3RpMn{y-1+gztXNGG81F)@6S2lcjJ|4qyLnm^sU>)^1w8jO zDRvr*Lp~WZvjjo9_=D)V6YOXKQ7D$^=q@cCH!FujR<&DMYdJ zs5{##;5qCtZ?99v-J@nGOVUB^rxxy}Yc%>J4j zFX*&&s(+nfCXe@cMNqbvO8UG?*K-)$u12w_?Ane^rd$NWrn07p`&sL7X=j2(NDi%X z641ML<5BW=&zjCBPq_xXUE@rC!Q4W=p~W7EMRg5Iy=-Rj6tJmh z5yFJt#X`21Pr3qA3H)@Z-tA+T394l`oSS{0 z`^3Dka^H^MeYkW2H^{#`hb-CXtcPghFgtB07&jHsH?GP!y!?k;6#jBtY zG&wua{qB_CLy=cWd3^%6TIB~{aZiI6;`WVf$%dF2Y=wBz{I)qS=`m~Li2(z>H)ZJt zHlrlMqj6yRYOsjxkHrPo#fwbl2?VdiwKXV8fAyr)wh?edlE(XuOw5~oj>5*wl?d|J zLt+Y1^#Ig5^W&JJB-q_nT2uj`pnod;cV^OrBF}8z;(_R^FVPar2WZ_}4K~R4K#rFD z*hB0`#NKW8h=qtXXHq)%-VFh}FzU5O(yGhv50%3zM^Fj*m~G2&|B;z-E?qBwSHq($ zkAQ}ZvYT6JXJ0_yji}>s2m(}NUF+kX?+@2B!60sQ5d1}VSZraBt#K=LBQiYmd5edl z>%YbO70N=mX(VwwOG$UWmozoL{UiljEVDN*>PM&uxtgb?k6Cgs42!yeP^zGv6PrReG?KlvM-Q!|`f`oJWQsbyku&ChC*M!qj2dUtHEL z!Ey~Uwh+A@(3N8pqjm_+(6@d)vXIJYUy4{ax2`jgFs*rO1r5p%2o+CQBOQEeau}wp z-ck#-;<;9`yXoVPLV8F;uhpCZ&6;o1o11y~K%x>3ySyLSMu<25k_mvEcdPE%1_`854R$t+y2&nUzzK2I?xv!U)axJux^z7lbZPd{ntkqC zIhY{NYlobmL)4KlypYKlAIi93X~RY@intJ7r|Ko zFNhD%($fXfryRk0{-e;>tYF#^x+aVSNZ(jIJ;pm?KQKYIx{2lGJb!;A|6rUp&Qsa} zQNu2^m8Ni)6uZ`Hg!&iE$Ce|s9)flCFmHq!vWj=e?fp>jR4C`!`w4vt&p$9PGMy*fwzA)b@Ra@nGo=L8WqK6?8=0P;dJ59W-pnUR zN>}PQXX$C@a(1cWGy?}PL&xWT7g!6<)UxS9XR`uBzyZo3jHKp^S7jAOnpqQMIbXe# zD}E9*3mQ_Zwo=tb7-^sb23C)iWF@+znEJymA}hxu;GQ+SB~#H_-{MiPHj{t?&J2ZY zvE`=4i&SUDvnQfOt=7YC)mpiMaT(!SnehSftl99>WqNLFmIAz*jzY3R)H_LSd~7|z zwe3g~f%H!Irz}6eY8>Buh?hMYO--?$6kV2PV23(F>+d6=B0tEsp>Cmuv!XQe)AP7eA}BLktUALd6dNPT+%9Io7C~e&5)0vwD_*Bg&A$D47TB68lD=Uhm`mj|9 z{59p&G@x{_UyC;e>cUlRUTK;?V10L%%{4O0~IHHug1d$gW7 zC@WUerN10URSGUJnUdF>(UbwWY>fY4#}*)!3P zlh=~oxS&u3jDxe_O!_;M#cx;F(ZKY1$WcGqbxLjK^KD?ecBn|Vn96%#2cO_e-(tg;FrZDMg z-dg?GFlmX|ZKr;r+&7gxwhW_DDGKMllU#~jble?lVFT1Qk~Q|PQb#aBGGQPS9~%|@8)*&{@SL7qa2r= z9MX&FZTLVW0-)Bo!=*^>wWP3gUoJ}6ktG79;ViO(t{B(jFRcwRyFl)|lYSd_0&lI~tzsWE` z$~fA)A#VrDpbZ6GE>uZ?L`NMd>2toLK{-V-O~Wb9IIjxNQfHG=dLzwh{a8zxY3E%h zRW?EoKh-(J38g?-ZLPa%7^w$&8<<0ISGcMAWGk1Z9e|q0VQ0rgmWRi66`Ibg)oE83 zYr~2d4Y(BH^o}0xRV+PMzP@#ZgNRwa{Fl7#kDoww&4e@C2!H3vBf7%~)oKHG1`~o6(NL z15NBng(ozi|8(2Wzi6~}59KE$YCyd!H~H8#ptW0PJQJK=-!ek4rnzG|uS4vy8_@*Yys64kyKk%cnZ)CPjaIC&#EB|# z@^{M`CDo_Mp@%{AMntAXsDZ(O?)e_<4P&epxr%d_rlYZ?5YLXrQdfZh51*%GHwUIu zeL_=XApw<~1c0pUQM?KX82ZH0Sn7J!EWc`u%lH=u1qJOEo?CpHuJ2wmLJrDz73^{I zb%=GlR)SMXr>3XRXgnr*3d*>5M%KZY@^U=^W6G|Qd)x}-l9k-(A@2e1xd8imm-i1% zc(vyVU#Snw&7HG!;0t2rDgl4ZRS!ZyEd%jcH^aETN{7`5dDmAf&{*56i%YMy$Mwkc zpROjwF^>Di{*Hy^5q&znj%Btt%<5Z+jt$?e_=&+Pwv0q(Z4ZYL(!)c`1)Ldq!8IoB z+_?X=#YdWld|I1^mag187=v8}F5Elce)8;weJMC22?J0cwH#$Vire%T)oWq53asjF zr!=3J8r1#*4)m~AepS#h&yA%wBz7T&QIURrBZiU@UZT&k89gMw)6|;>L*n7-(a+zG z<&}wf!^AP0fkv*IRzsWDICy z7_cR%bTp@p(M}Y%ApZbE7Fx2&NhHL{kC9h-$DMvs=x;h`=0(fnv^(U(pfPH|8uvuf zR&w7HOV{MKN+V#c9hFb!42?@x4Nhq3>}IL&6C~;Zr|2><^3{~{y$UK}mSsjS)f%3M zzLV@TRPWS zic)NK%d$G|;)rlP-5OvC;bW>DGvqHgS)J|exOQ$|V zC0D=v&YP;vxhRzbkwWhy)FC2VW7N?aL>vTwr@1`Di6mg;V%@ef)xAq+B0Kh#LDNCj zBYXRYLQkAQV9J5s|)tj<4IjktF_6;|y|0vAM@ldbJ z_mE(iWSK~6>6~I&1wU2(5`NP%6VaK)C?;4^Vv}v*1{y)Y?Y1b6i~jdX;jFq+?W^tN zPEw74=l5{@9__kdP(U|JINE+b2hrMzAqgLPtnO+?1Zed;hQ`&XO5kSM^hX^0;6Zz0 z%KGi4Coon+x$n7{?OQG!MLT7!SrW0kW!0{8z)S9ULBDmD^47|JEMpp76oEU7b}pI; zaE|v+dltO{+ii8le>YWFo;hXj!0cqZh$3xU4`KA~d) zZN@#*v)ehUo)n3(Z(BO+UaJ+WjuSIbLjl%DptmW~GuRVxS2z*asSbx*uDp^9A2&lBO$d@~mujFU+mVKGb3i4(@x` z>S{aVS0B+NU?Rl;CvqO;1%h?=(h!@KLr_990!LWMbl&x0ibL%2L)l%q2*yLWwxAlj zo9qNp*N)i(VzU=tuSF`QocMBBo7zQk&;DgEzW1YtDd*!1czj|A_ZXOuCxnbIvq)H~ zeilX}eVg-To2W@ET1wWm`&vg+N`J)wK--NSIX~2U)0Jb%G%49YS-n2oCYDR~JYJ88 zy%NH`#X^eR8;Kq2`c#+p-1X^aiq;4W18C1>HrBx3g~RWnvvKyIZNZX!@Y|*-RdzT` zD;l)m)azs>Dhq(O?OAs5oLjl(C?eN_sH?>60r_v`!94*``wz_Fy(g*3NzqqiQxTv{$+z%EtY6&f<1;m-2d`@^M_U zzAw2#eBJf?87dh`NfiGBHHQFOUC;);<-mMdhJ?#qCje-B?@M z{zQVNjTy4z8EXHkYtv+F>NzmvjXf$kL&q7S4nDI7w7-?NE8nu@x z(n9ni7(pcaPUPMdd4I$8@WY!YPubr;ntoZ$7;n+;FWa_o3C-);eTY#Ig#Zvst=p3$ zl=bRiHgU4DX(3?TufO){)Q$hk`OXKqh?b|I_YR)v(d#&HSex5@)wu*Qj0kAY_R8W- zVKM=}beE;J;|S$^0ltzW&}(iGs>FC&zscwmRY*q!hh~I;v0EM5?}&f=jzdLxqK$GK zu-_LcOr2Qa3mIgKfYN|jQ%&2CDC?BwKArpUO^D?t=^JmE$$0sAYMf(=A2!SZoF~a#oJ8LL!6Rl3OuB$@khGeNe!ro3+w(zZeux^a}rN6D5 z-l8t5{Jks0bX{{0;xhn1{ndZzKS3CwoNLDuY+M+pVfdl z^6mFar@L@qIVFP()$QmLmBNio(DM9bB)={1*yb}4N(Rjh zIRQRerE8O78BR`{fuIK097AJ0R3)y$ZPoTnAKb~}#4_X<{n#xrj7EA8DsS&>IvnsC zfPtreOmQUY0H$kr)#(&#)R)=q2N8eqvu(yVVx&DVpK~@8(3kt6(pVz_F4G)|6v!whflEFZpJ9>YV_nBNg3a-36@ zAD#A4D(H@cm_jpUz@*_7LYF=C0~&ULBa?P=Ixrka2f;Rp;~iKxPFZGd?nY}LCO-%Y zqycYMAvhqjb$A%5ic*42c5Vx4t$7FF5V;J7%d!vBhSohrQV7lx3VrF@_YP#uqu8)4 zzulwNKi!CHKXuRdA5j>WhX6njYi!+o405P5`W&q=3J(c1gqlH1 z@F>;FrQXQuX}qyJtpGt8L8Jb!%84#Lf{!po*$ldGN=|c_9UohO#^WvV2Mu`$c>&!S z#c^X-*XF}5qWV}rYZGX=Y-XNXXR9k$jzVE(ey7qx$qfO-i7Oy>5eP?I8IlA2)yJBS`JRK%`zJ=c`jgAo#~Y+Cx20zAbHP zkt<+0ubLDgT%0v9j`(388aDw`&3X5xpA18kOpIob{3##EoPa;n$+f_!V^5J0vKgw4 z3WY4_R0TLs5TgcNK=Aq(8jOE7Y4eveI|jjExEdVzy~HfRuW)>4V$16tQ7+C{(pP!Jx!2a>UA-=?9==}#fZLlQr%b`^ z4O@Pk1q^5*tnzOQk~vgrh}6|$m?;&UeiLbq#IT1}IFI&!Lm@Hh3#y1+svtV-2&xbP z%gsQQ0mJEr$j)<97l?vO*1)K~lls`ZGTtz1oN*8WgvrFn_({tC%UJ=3f|)j4MQX^V zp+2e*ecHr5xQz;5ho@mT{#rpPhp~e~ksiiW43y=PfAcPM9kXsb*64osly@g*2u(d! zzJg!eNgmK`fBR4-=x8jP9a8-+SM$BK>@FUMmESKIG(mBfOBe(|93kA5861(X>sf5!F4di3}H+%4UbbD)&GF zGN$^aeVz_(2;7(F#l}>DHq8l%WvR6w@Kz7~n`x;q4a-nLu%B7@PiO26^k$aL70J(faM%TzY9_Q+a>w^-S>bY)CyH3 zhh(*bCZs0Jlgl2sPo5S1Q$q#cjhI%ab?cFyOsFBMS)c_619hl#T=u~3mbJiG3v@p@ zLDj|-xvParf`^&6<8pP}EuTIk2&S;e=TD>5X=Skl7ndvN1fy8IPHWkCp3b)}4=~X*V#&D8AOAn#)dz&{izcWp z8zcEYqE3&@rmZpb_$J?(O&j!H|IiXMVB`i^JV3_Yh-&)|FCV}G0y=t&e>|-ZNQ}jo zl?bl|X_%b;cp~;ailFOYlk3383lEq}R8{pSCB-kWUIk|dwlZk!qQWHDpFnl)Wu|A? zmVg=?#gWS%=s41Cj_wxCE0r58G~NpAG}D{n@K?*z%3!B^HH#MCkb}iI$N$=Yl@H&? zNl;)lMlM^RInXD5R_;(g^0;;juw!1iPbtFsxQPYyyHQzlV>m`slQPD7_`gCQ75S9_ zcMLcYTUY?wDJ)IO7Y z6g8r{?Rkxrke1Jzt^O(+oN%^sYX{wbG{`x9>!Y>bfcgrL)0 zTY^#*Ypc%LHtj-mLM&garTK>NpC=0U3eS5s$CG*h;d4oyG z)WS0Mt=?@Sc2Pn4C+rLf;J_VP&!}eEM%LTFqQ;ZexxlV$1LmAI6H=rI+le5dgS$$A73nz3^#s;Oo z`?UqrO6DjkEI-{j77)ECT2W9@;gA4-7hFy9jpsj;A{1um$5P2|tN~@H{t3ApUJ^o4 zpQ9j!ljTJ9rDZ*{jED1Dd8Q0lv#*<>k{9G$Wau8~H|MJ4APeMG5r-|i zZTbKs%W0|AAA3RVN#p-!9>xn*Hj3)GDG+kVDRY2wW-Vh`i&DM>RSz57o)1rXc8+_& zktq~|^s>}Y;;?~pmS3d?(=ugMi>Fkr5wX63_8E`(L`{e|$P@(&ov4nojFmW=Bf`ig zKhQn~86K$kNW_2a4pyqhZbeK;IJ8naX_h|h2sFC1fZgKs%6wt{4fyR*;{75M!0^(+jvl`3?epQ-Y}E zdG$MauKvsNP!Kb9K+H@_2BE|9A&`(3_vYGFS-QET%BDHTHq@VLN>LMA)ZVCi*`xiW z0bMWAkS}0%cFj@~o1&Uv2{a%jVUCqO4qqBo&x-Mo2<=RqAUi44wA~+DR_`vzdK$Y? zR{TRY`ZH*MnJ?l#2)OI7#l!*jn&>%F8Zc|Vxw3g(7iJ@c)~Z^Ml!5II_ND71KpDSg zCX&>SnmjMSs-X#buyqksfSU3{+@jW!?3?!%T5&C+ZkAw7x&>WUtR^&D0m()X$X1Md z9_T$L5S_L&SvcnGE-2&KfybcI7WlrstTS;R7o)uCO+B_&#J8^6T1L$Uxg+{4u=l)! z6Gowj>e?j9NWk{ZHigWWgT-_qS*BaR{&gbQT1~IkGoao+?*hBul(s=|I+^99>*4W2 zsbDgqsz|jzlN!}QUvd`I!ynFK)Y=U;Z9t_0*fY67(sWbf))C-Aei{_k63X6oKnWO) zP(}&(e5r#lnG2}Huk?>}F+0ieBnK}ts#INhQA6?@i7lPMZ1s79Z=ge9jm2hCbC69m z!^U^}uu5i$Ca%3uj7#S7djjA|x@+bwpP;G<3P@I6NND-2hx?2n2}a}bd76k-I7^uq zBSaKieA_AruiCFowyx;bq zGKndM&Wsueq_iLhuURN9w0-3Z*18czHZ|e>B0G75@!&;?g?~Rt(PJ)0Y{FS%Cn&5o z76<48TAag4RKl5r zeodH(C-5Hq)))xK@BMIjUlLK$2x3lzb9ih^=Ol}8)PTH8R>e#rbPi=j2UsTRszKB8 z*HweC$e$TGc-3%Y5p~sI=LEVes}_qBUNZCA8FD4!p)eapr6 zb*kOgmBJXmCf$@hb(7$%zkTO-&&IFm=!m{~IzZn%fuAL&!CFDFIS+@0sXo578skJ= znHevCa5BYkibj6nWjcc z^vRx$#%{iZ5o8DEcVxmHI6nBGXIQ8Q5_~R)@q3rE4~GJy69L6_NF@TCT)fDdWL>9& z?{wYWQ4ydDUzD{c78qA$^+m?(cma*uk=K5o1*0|U-wiCcFIDzWn6L&I#}kBexvGkP zRXg@&wPn(FP|jzcqHVEw8$0qJHsvbtr-fVjhTQCt{pf4B-U!jxuRpelU6FIhDFLS# zrjr)mSR(LL3ihOV;3YsS)#HzfyAa{+Q9)MEs&_}|PRI-W@Ovohu2?s5>SCmSep2^= zM6%=p1cpO;2fk-zD!qNuY#h~Rui9+pv(G?#>waNYa( zt{i@MZhlKxGB=@6S7h12b`an_KNMA9wMPPwVG!>hHPK2%474L|?R|hdamvq??Z`0b znd&^ET4umX4b=DNV^$cBi)JPDku46JU_W^PpNVz?ua%p&b+!)-*FT*8(x^QyOrdmg!|ZAq z(fEh*n3uQiVa4nP5CYs}m3Zv~P8@jc^cit|vW2My0euPxMi%ODa|0|7DL-9avrzcA z`e)-6G)i6YGMex}O)2Vf*AjfRa&{bO=t?o^#N)4?O1}(#5j>Hr{dX zCdz~*@JkzfAmxvzP&(@}vG0ZN(J1x8<*j3yt*HPpobn^Cw*xRY9`~f5Z!e}_oC2o@z4d4FD+Kiy zH8a53ksI*y%<*D*Cg*r})Axb^*v`G!X-~g6H@Xl4b{z>$oevK$7VA$3dx7o6i}PN| z3rFB6-S<2f$ODeM>VGauo^KEUr&H+{C-vvVN8ysEyS>2adiupym)yl%l;p($xMcg{ zxP9jQocrQ?C2$gQal8wP2abBr=YYi`ECBp{X976J2md5_QF1zR2k`hVd3Fk3(Vrbf z)t{XK=f}52skX-xpUDxbFrg!_7*r^2TqqIPc6^3B~KS-&ciN_ zLyS&TF4E7wO&q2l@0*>IpCY<0-rPy#1_sY(&JZV&cRbE6j^rdyM_mi!R{jQ`{H3=QT5D%jp-(mG!5Y!0B%K#nEG6 zH+klC>W=T>2=Ma|8Dr9Be&rNCinT? z=d*=$;9^4ZZ2xf)U^MMr&n+qLyWY`W$?SNc4s=Wy8ThU@E>>c0UIbt|7IitEZ%Uqa z-2sk5jz=y|LuM{cM2_kjBfAI{|jwAg5z^F)!~+t%>B#6HWHM(HFxzg+q)to}IrgmN3R{U?px~XnM_eV4|sc zNBe{X@^?tQhqDcC>En+v zPj{#&W!E+REM6*2-bePl-{7nTvQiGVB8S*nuVa;}i^2~NXAVQo4@6v5@@ZTtMVFU| z1VzFHZATmPm4@%XDx}B%+@h?M(0{I2SW-A(2P_luiQ@nz#9zKL`kMBc3nt@HA`|Jh zI~mP&{h_IYT1n}HFFTSX%zR3@9vW8v^+>7V`CQ-lZa~$;N8t!q2H}KQrLFJHw@WsJ zbz*@%C&CXN;MO~N<^-xJ6>BWTyoD^2IrtGd5}_R+{(1I&OygV^e`@oQ9`yUSFQA~cKO+-&*J+i zu#)bn==qy5II#&TxkGOf2#5G$!BV5_I$&`k_XI~)+KxZG7--zcx9fOAs-u=Mab1L% zda_1{HL$Ok`hgyig-qs^XqF=CRDtt6=8F3j4?7j*;Q)Uf+&dSBv>jeyV14VZ^IVkW zt53zlE=B8}XEs;~KIeHz#i}*2D&^*Dvx*f3EtpN^CNG*q9T=`((r8;?AwbRBj#7ATp`PfW%@mNGUgg~=cX1)pY(g0 zWX!Kp3ElkC(v=!xqC-8F8qUr7g5F}>HNE2OD&Sl=EaYxj_ON@Tz~C-+^av$1u-`A8 z(7PjnoFXgxtylxpLUot%*?9qO*OpEOx9YBGa1gLwS6hcD44Tya;-Jm9(5q8ZFsE*B z{xakmW@oro(^Fo( zC{QyS{D$ACG)esLIX*Jtm&hk?$SjBOHa&Z+eNAsN+GXVMMd3wq(L!(^+4>eyD31GU zrvX-Ms-JqYDO!oh6~Ft-Px`FK54pOfHp)ntQ-9v&j70>! z5Q^l|mY{lXctIjY@#!AMxE--=5(w-tB8+ zKWC_5;MJISJe*kdj-IC#wat0cBmlsg-y<+x*wD9!zTejB)&Kj(Q_T`Pv9 z70;R}K^ToJJ6!pVQ$R&$K*5O^2N$jp-4z-9OwxAU^O=b=SK)%969cd6>UA>FwK5IK zP67deG4)$Xj;B_zESpx&SHO%F3}U+rL4qLUgy)0~)uq;t7 z)@w~-QZtD!t#yjnpOjM9V_y;v-S|6_IKk#FmWl%&yHa%W^1W@94g6t7rB^W#%-Ej? zBSmWPUcj`rr-}bwAig!l{Qhewq=#z8doc*hNn@Ir=1W3WTHy1Eu`MR6?~+&hUwtnd zoLWD3XRxGIu8zjC12WG7$<8$Vu`s!|(_dNNrzCgcscyEv)(g+JL?#6})SZ>pYp3Af z|M@Vq>hZfKU+2XKPb`}zmDia6K7Q8JMd0!GrK2ck#qCK}C zpJs<@>)hWd5fh(tahhAMibW?e?F&&kXE-7j`!j1D;E>m;3 z!THtu0HItprfcV5%WNiNKo|T?WaAf%Q)vr9U_NnFPr%mEL_jNfb@NImo9OeHBoQ5f zRdW*p*6*wpgjRH4d<#MyWum;=B@-z0oCbwV)Bxvm+fLgxi#qXj@W$f(bzdjOk@zcj5r{$QW zn&+&S9B66EWW?zjWh6NZHy(Ij9Ov4#iF%JN zFazrAMw5Ht^Tl7LCB>39J%u>{+F|kC&i3=Im3fmxM#)XbQtI>Z0)p_N316QjwJ6hH_@wdgFtNW{F z%Ex!cud%n|6l85XoIm@1`_qSN_PlSty#8Cv_wl>V$HekKU!Fd@{cHQ|y1$IcpFgp- z@i}ik@v;7E(e9hFW!(=O?k8>C@#oLys-M5l7QB#OwDXScI=T6?XUs4CR#sfyUElwA z^RYO+-H-0yet6Zpe)8Z@%@*fBo>O z{pqLa>-+gjYW`kM+xh2wAj9#{kH-Hhf^7Ew`B3~b@yF}!XWxDPXxX~{KR@UsD49ur zGL~;;V5p5{2Ob2)$Rxr5KRhk6b(YDjcfdoU&H+!<;s&0Zb>^WO=xC_PUmse5X`@FL zd_aCA;?%Us6_1?3Qu`iBGg?f(^+;15qyYIiG!dl3xEL6MCM!Kw2CG3nzDp2Ajq~J` z#|p6^b50?hS_M4F3kh6NXJAOlPYx)`FDTYeEGW>c$jw3b&ckaA4by>oJ_4~Yl3oS| z-pLOiD}h~cy2(tZ0C*-=7#q5pr<0YQC@FwkfgEHKDCSJlp1fCEYI5BZ0k-CcAQ=G8 CLsgsr diff --git a/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/citation.bib b/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/citation.bib new file mode 100644 index 0000000..fac7a46 --- /dev/null +++ b/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/citation.bib @@ -0,0 +1,8 @@ +@article{bbm-235, + author = {Taoma, Kittisak and Ruengjitchatchawalya, Marasri and Liangruksa, Monrudee and Laomettachit, Teeraphan}, + year = {2024}, + doi = {https://doi.org/10.1371/journal.pone.0298788}, + title = {Boolean modeling of breast cancer signaling pathways uncovers mechanisms of drug synergy}, + publisher = {PLOS ONE} +} + diff --git a/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/metadata.json b/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/metadata.json new file mode 100644 index 0000000..cc42f7d --- /dev/null +++ b/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/metadata.json @@ -0,0 +1,7 @@ +{ + "id": 235, + "name": "BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE", + "url-publication": "https://doi.org/10.1371/journal.pone.0298788", + "url-model": "https://github.com/Ktaoma/BoolSyn", + "keywords": ["source (?)","curated (?)","repaired (?)", "multi-valued (?)"] +} diff --git a/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/notes.md b/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/notes.md new file mode 100644 index 0000000..aaba544 --- /dev/null +++ b/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/notes.md @@ -0,0 +1,10 @@ +### Modifications + +Removed regulations: +PG, PG +NRG1, NRG1 +INS, INS +ES, ES +EGF, EGF +DLL_i, DLL_i +IGF1, IGF1 diff --git a/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/source.bnet b/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/source.bnet new file mode 100644 index 0000000..01fb1ff --- /dev/null +++ b/sources/235_BREAST-CANCER-SIGNALLING-PATHWAYS-MDAMB231-COMPLETE/source.bnet @@ -0,0 +1,111 @@ +IL6, IL1B | IL6 +IL6R, IL6 & ESR1 +JAK2, (IL6R & ABL1 & IL8) & IRS1 +STAT5, JAK2 | SRC | EGFR | MAPK8 +IL8, (JAK2 & STAT5) & ERK_i & ESR1 +PIM, STAT5 | !GATA3 +STAT3, (IL1B & SRC & MAPK8) & JAK2 +STAT1, (SRC & MAPK8) | (JAK2 & EGFR) +GATA3, !STAT1 & ESR1 +PPARG, !GATA3 | CEBPB +WNT1, PGR | WNT1 +FZD3, WNT1 +DVL1, FZD3 | JUN +AXIN1, !DVL1 | (GSK3B | (CREB1 & JUN)) +APC, AXIN1 & FOXO1 +DC, APC & GSK3B +CTNNB1, !DC | (WNT1 | RELA) +TCF4, (CTNNB1 & JUN) & PGR +PAK1, TCF4 +NOTCH1, DLL_i | CTNNB1 | LCK +NFKB1, NOTCH1 +RELA, NFKB1 | PIM +JUN, (RELA | MAPK8 | PPARG) | ERK_i +NCID, NOTCH1 +HES1, NCID & WNT1 +HEY1, NCID +MYOD1, !HES1 & ESR1 +MYOG, !HEY1 & MYOD1 +PAX7, !MYOG & FOXO1 +KMT2D, PAX7 & !AKT_i +IGF1R, IGF1 & (FOXO3 & ESR1) +HER3, NRG1 & HER2 +HER2, HER3 & EGFR +PGR, (GATA3 & PG) & !ESR1 +ESR1, (ES & AKT_i & KMT2D) & (PGR & FOXO3) +EGFR, (EGF | (HER2 & HER3)) | !MEK_i +GRB2, (IRS1 & SRC) | EGFR +SOS1, GRB2 +HRAS, SOS1 | (PIP3 | !NF1) +RAS_i, SOS1 | PIP3 +RAF1, (HRAS | RAS_i) | !AKT_i +MEK_i, RAF1 +ERK_i, MEK_i +LCK, ERK_i +TWIST1, ERK_i & STAT3 +NF1, !TWIST1 +PI3K_c, EGFR | ((ESR1 & (IRS1 | IGF1R)) & (HRAS & RAS_i)) +PTEN, S6K1 | !SRC +PIP3, PI3K_c | !PTEN +PDPK1, PIP3 | IGF1R +MTORC2_c, PIP3 | !S6K1 +AKT_i, ((MTORC2_c | PDPK1) & PIP3) | (IRS1 | IGF1R | EGFR) +FOXO3, !AKT_i +FOXO1, !(SGK1 | AKT_i) & ESR1 +CREB1, AKT_i +GSK3B, !(AKT_i | ERK_i) +TSC2, !(AKT_i | ERK_i) & PRKAA2 +RHEB, !TSC2 +MTORC1_c, (RHEB | (ERK_i & PIM)) +S6K1, MTORC1_c & ESR1 +IRS1, !S6K1 & (INSR | IGF1R) +SGK1, (MTORC2_c | MTORC1_c) & PDPK1 +NEDD4L, !SGK1 +NF2, NEDD4L +LATS1, NF2 & LCK +YAP1, !LATS1 | ABL1 +TEAD1, YAP1 +IVEBP1, !MTORC1_c +EIF4E, !IVEBP1 +MYC, (((CTNNB1 | PIM) & EIF4E) & !GSK3B) | (STAT3 & JAK2 & EIF4E) +P21, !(ERK_i & AKT_i) +CYCLIN_D_c, (TCF4 | TEAD1 | (STAT3 | MYC)) & !(GSK3B | (CDKN2A | P21)) +PRB, !CYCLIN_D_c +E2F1, !PRB +P53, !MDM2 +MDM2, P53 +MCL1, !GSK3B | ERK_i | MAPK8 +BAD, !( PAK1 & AKT_i & ERK_i & PIM) +BCL2, !(BAD | BIM) & (CREB1 & ERK_i & BCLXL) +BCLXL, !(BAD & BIM) | (CREB1 | BCL2) +BIM, !(BCL2 | BCLXL) & (FOXO3 | FOXO1) +BID, CASP8 & !BCLXL +BAK1, ((BIM | P53) | BID) | !(MCL1 & BCL2) +BAX, ((BIM | P53) | BID) | !(MCL1 & BCL2) +CYCS, BAK1 & BAX & P53 +CASP9, ((CYCS & CASP8) | CASP3) & !(AKT_i & ERK_i & PRKACA) +CASP3, CASP9 +HSP90AA1, !PDPK1 | STAT1 +NOS3, HSP90AA1 | AKT_i +IL1B, NOS3 & RELA & STAT1 +STK11, !ERK_i | STAT5 +PRKAA2, STK11 +PAK2, RAC1 | SRC +KRT14, PAK2 & EGFR +TRADD, !KRT14 & P53 +FASLG, FASLG & P53 & FOXO3 +FAS, (FASLG | P53) & !AKT_i +FADD, TRADD | FAS | JUN +CASP8, FADD | !(ERK_i & SRC) +PRKACA, (AKT_i & WNT1) | EGFR +SRC, PRKACA +ABL1, SRC | GRB2 | JUN +ABL2, ABL1 +CEBPB, ABL2 & ESR1 +CDKN2A, !MYC +INSR, INS | INSR +GRB7, INSR & ESR1 +RND1, GRB7 & DVL1 +RAC1, PI3K_c +MAPK8, RAC1 | RND1 | JUN +