diff --git a/pathways/WP3844/WP3844.gpml b/pathways/WP3844/WP3844.gpml index 556aa91180..c9c950be9a 100644 --- a/pathways/WP3844/WP3844.gpml +++ b/pathways/WP3844/WP3844.gpml @@ -1,15 +1,19 @@ - + This pathway is based on figure 1 from Merritt et al. (See Bibliography). The PI3K-AKT-mTOR signaling pathway has been shown to have a significant correlation with the development of castration-resistant prostate cancer. The signaling pathway regulates many cellular processes such as protein synthesis, proliferation, survival, metabolism, and differentiation, all factors that would increase a cancerous cell's ability to survive. Scientists have explored the use of various inhibitors for different parts of the signaling pathway, and have been faced with varying success. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3844 CPTAC Assay Portal] e9f - + - + + + + + @@ -18,8 +22,8 @@ Proteins on this pathway have targeted assays available via the [https://assays. - - + + @@ -31,7 +35,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + @@ -43,6 +47,7 @@ Proteins on this pathway have targeted assays available via the [https://assays. + @@ -58,6 +63,10 @@ Proteins on this pathway have targeted assays available via the [https://assays. + + + + @@ -67,11 +76,12 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + + - - + + @@ -79,11 +89,11 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - - + + @@ -95,15 +105,15 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - - + + @@ -135,181 +145,185 @@ Proteins on this pathway have targeted assays available via the [https://assays. - + - + - + - + + + + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + - - + + @@ -317,36 +331,28 @@ Proteins on this pathway have targeted assays available via the [https://assays. + - - - - mTORC1 - - - - mTORC2 - - + + + + + + + - - phosphatidylinositol 3-kinase-Akt signaling pathway - PW:0000232 - Pathway Ontology - - - phosphatidylinositol 3-kinase signaling pathway - PW:0000595 - Pathway Ontology - signaling pathway PW:0000003 @@ -361,5 +367,16 @@ Proteins on this pathway have targeted assays available via the [https://assays. Merritt P Edlind Andrew C Hsieh + + phosphatidylinositol 3-kinase signaling pathway + PW:0000595 + Pathway Ontology + + + phosphatidylinositol 3-kinase-Akt signaling pathway + PW:0000232 + Pathway Ontology + + diff --git a/pathways/WP5365/WP5365.gpml b/pathways/WP5365/WP5365.gpml new file mode 100644 index 0000000000..b074469dd1 --- /dev/null +++ b/pathways/WP5365/WP5365.gpml @@ -0,0 +1,1283 @@ + + + The Wolf-Hirschhorn syndrome is a rare genetic disorder caused by a microdeletion in the chromosomal region 4p16.3. Typical symptoms are a distinct facial morphology, intellectual disability, psychiatric disorders, seizures, and heart defects. 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