From 0abccb2fc7d7f8b926a3f285197455fcea6b83af Mon Sep 17 00:00:00 2001 From: GitHub Action Date: Sat, 14 Sep 2024 02:44:52 +0000 Subject: [PATCH] Process GPML changes --- pathways/WP5489/WP5489.gpml | 235 ++++++++++++++++++++++++++++++++++++ 1 file changed, 235 insertions(+) create mode 100644 pathways/WP5489/WP5489.gpml diff --git a/pathways/WP5489/WP5489.gpml b/pathways/WP5489/WP5489.gpml new file mode 100644 index 000000000..96b87fe1f --- /dev/null +++ b/pathways/WP5489/WP5489.gpml @@ -0,0 +1,235 @@ + + + Regulation of activation and differentiation of cytotoxic T cells by long non-coding RNA Malat1 (Metastasis Associated Lung Adenocarcinoma Transcript 1) and the microRNA family miR-15/16. + +This pathway model is developed based on Figure 8 in (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10735224/ Wheeler et al). + da4 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + d89 + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + cytotoxic T cell + CL:0000910 + Cell Type + + + adaptive immune response pathway + PW:0000235 + Pathway Ontology + + + memory T cell + CL:0000813 + Cell Type + + + 38127070 + PubMed + The lncRNA Malat1 inhibits miR-15/16 to enhance cytotoxic T cell activation and memory cell formation. + Elife + 2023 + Wheeler BD + Gagnon JD + Zhu WS + Muñoz-Sandoval P + Wong SK + Simeonov DS + Li Z + DeBarge R + Spitzer MH + Marson A + Ansel KM + + + 9199340 + PubMed + CD28 mediates transcriptional upregulation of the interleukin-2 (IL-2) promoter through a composite element containing the CD28RE and NF-IL-2B AP-1 sites. + Mol Cell Biol + 1997 + Shapiro VS + Truitt KE + Imboden JB + Weiss A + + + +