diff --git a/pathways/WP5329/WP5329.md b/pathways/WP5329/WP5329.md
index 25183079f0..f8693857dc 100644
--- a/pathways/WP5329/WP5329.md
+++ b/pathways/WP5329/WP5329.md
@@ -1,30 +1,33 @@
 ---
 annotations:
-- id: CL:0000182
-  parent: native cell
-  type: Cell Type Ontology
-  value: hepatocyte
 - id: PW:0000454
   parent: classic metabolic pathway
   type: Pathway Ontology
   value: cholesterol biosynthetic pathway
+- id: CL:0000182
+  parent: native cell
+  type: Cell Type Ontology
+  value: hepatocyte
 authors:
 - LLadeira
 - Susan
+- DeSl
+- Jmillanacosta
+- Egonw
 description: This pathway was constructed based on the Brown et al 2021 book chapter
   (Cholesterol Synthesis), combined with the Reactome Cholesterol Synthesis pathway
   (DOI:10.3180/R-HSA-191273.7) and the WikiPathways WP4718 (Cholesterol metabolism
   with Bloch and Kandutsch-Russell pathways (Homo sapiens)). Additional information
   was incorporated based on the literature. All protein were curated for cell-specific
   (hepatocyte) isoforms.
-last-edited: 2023-02-27
+last-edited: 2023-07-01
 organisms:
 - Homo sapiens
 redirect_from:
 - /index.php/Pathway:WP5329
 - /instance/WP5329
-- /instance/WP5329_r125476
-revision: r125476
+- /instance/WP5329_r126886
+revision: r126886
 schema-jsonld:
 - '@context': https://schema.org/
   '@id': https://wikipathways.github.io/pathways/WP5329.html
@@ -60,6 +63,7 @@ schema-jsonld:
   - Acetoacetyl-CoA
   - Acetyl-CoA
   - CH25H
+  - CP7A1
   - CYP27A1
   - CYP46A1
   - CYP51A1
diff --git a/pathways/WP5372/WP5372.md b/pathways/WP5372/WP5372.md
new file mode 100644
index 0000000000..b3cbd01b26
--- /dev/null
+++ b/pathways/WP5372/WP5372.md
@@ -0,0 +1,100 @@
+---
+annotations:
+- id: DOID:332
+  parent: central nervous system disease
+  type: Disease Ontology
+  value: amyotrophic lateral sclerosis
+- id: PW:0000018
+  parent: disease pathway
+  type: Pathway Ontology
+  value: Parkinson's disease pathway
+- id: PW:0000015
+  parent: disease pathway
+  type: Pathway Ontology
+  value: Alzheimer's disease pathway
+- id: DOID:14330
+  parent: central nervous system disease
+  type: Disease Ontology
+  value: Parkinson's disease
+- id: DOID:10652
+  parent: central nervous system disease
+  type: Disease Ontology
+  value: Alzheimer's disease
+- id: DOID:1289
+  parent: central nervous system disease
+  type: Disease Ontology
+  value: neurodegenerative disease
+- id: DOID:9255
+  parent: central nervous system disease
+  type: Disease Ontology
+  value: frontotemporal dementia
+authors:
+- Pat hofer
+- Tamara Fitzinger
+- Marlenef97
+- DeSl
+description: 'Mammalian asparagine endopeptidase, also known as δ-secretase , is a
+  key player in a number of neurodegenerative illnesses, including Alzheimer''s, Parkinson''s
+  or ALS. The enzyme can get activated in the aging brain and starts to cleave amyloid
+  precursor protein (APP) and promotes the production of amyloid-β (Aβ). δ-secretase
+  also breaks down tau, alpha-synuclein, SET, and TAR DNA-binding protein 43, generating
+  neurotoxic fragments and impairing their physiological processes. Each fragment
+  has either been identified in patient samples with the relevant disease or has undergone
+  testing to determine whether it can cause the disease pathology. This pathway is
+  based on Figure 1 from the paper:"δ-secretase in neurodegenerative diseases: mechanisms,
+  regulators and therapeutic opportunities. published by Zhang Z, Tian Y, Ye K.'
+last-edited: 2023-07-01
+organisms:
+- Homo sapiens
+redirect_from:
+- /index.php/Pathway:WP5372
+- /instance/WP5372
+- /instance/WP5372_r126830
+revision: r126830
+schema-jsonld:
+- '@context': https://schema.org/
+  '@id': https://wikipathways.github.io/pathways/WP5372.html
+  '@type': Dataset
+  creator:
+    '@type': Organization
+    name: WikiPathways
+  description: 'Mammalian asparagine endopeptidase, also known as δ-secretase , is
+    a key player in a number of neurodegenerative illnesses, including Alzheimer''s,
+    Parkinson''s or ALS. The enzyme can get activated in the aging brain and starts
+    to cleave amyloid precursor protein (APP) and promotes the production of amyloid-β
+    (Aβ). δ-secretase also breaks down tau, alpha-synuclein, SET, and TAR DNA-binding
+    protein 43, generating neurotoxic fragments and impairing their physiological
+    processes. Each fragment has either been identified in patient samples with the
+    relevant disease or has undergone testing to determine whether it can cause the
+    disease pathology. This pathway is based on Figure 1 from the paper:"δ-secretase
+    in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities.
+    published by Zhang Z, Tian Y, Ye K.'
+  keywords:
+  - AKT 1
+  - AKT 2
+  - AKT 3
+  - APP
+  - BACE1
+  - BDNF
+  - "C/EBP10A\U0001D6FD"
+  - DOPAL
+  - LGMN
+  - MAO B
+  - Microtubule-associated protein tau
+  - PP2A
+  - Prolegumain
+  - SET
+  - SRPK2
+  - STAT1
+  - TDP-43
+  - TrkB
+  - beta-amyloid
+  - dopamine
+  - α-synuclein
+  - δ-secretase
+  license: CC0
+  name: Involvement of δ-secretase in neurodegenerative diseases
+seo: CreativeWork
+title: Involvement of δ-secretase in neurodegenerative diseases
+wpid: WP5372
+---
\ No newline at end of file