diff --git a/pathways/WP5385/WP5385.gpml b/pathways/WP5385/WP5385.gpml new file mode 100644 index 0000000000..54ab686473 --- /dev/null +++ b/pathways/WP5385/WP5385.gpml @@ -0,0 +1,804 @@ + + + Several growth factors and hormones interact with particular beta-cell receptors to start intracellular signaling pathways that encourage cell division and growth. Hormones including prolactin (PRL), thyroid hormone (TH), growth hormone (GH), glucagon-like peptide-1 (GLP-1), insulin-like growth factor-1 (IGF-1), and others have been closely linked. The modulation of B-cell proliferation has been linked to growth factors such as IGF-1, members of the epidermal growth factor (EGF) family, nerve growth factor (NGF), members of the transforming growth factor (TGF)-superfamily, placental growth factor (PLGF), and their corresponding receptors. This pathway provides information on how these various factors are realized. The figure is based on Jiang et al. (2018, doi: 10.3892/etm.2018.6603). + Growh factors and hormones in Beta-cell proliferation + + b5f + + + a64 + b5f + + + + + The InterPro indentifier for the family was selected, as no specifc protein of the family was stated in the publication. + + + + + There are two types of Cyclin D: D1,D2 and D3. There is no specifcation about which type is important and no InterPro identifiers is found. + + + + + b23 + + + + + In contrast to the pathway figure, the specific receptor was included as DataNode. + a64 + + + + + a51 + + + + + ac6 + + + + + + + + + + + + + a51 + + + + + No identifier was found. + + + + + ac6 + + + + + ae8 + + + + + a64 + + + + + The InterPro indentifier for the family was selected, as no specifc protein of the family was stated in the publication. + + + + + b5f + + + + + a64 + + + + + + + + + a64 + + + + + ae8 + + + + + In contrast to the pathway figure, the specific receptor was included as DataNode. + f43 + + + + + + + + + a77 + + + + + + + + + + + + + + + + + The pathway figure namesthe receptor for PLGF as PLGF. The UniProt websites states that the receptor for PLGF is VEGFR-1. But the original publication (PMID: 25924650) states VEGFR-1 as receptor. + + + + + + + + + In contrast to the pathway figure, the specific receptor was included as DataNode. + b5f + + + + + There are two types of Cyclin A: A1 and A2. There is no specifcation about which type is important and no InterPro identifiers is found. + + + + + f43 + + + + + Synonyms: Dlk-1 + + + + + ae8 + + + + + UniProt provides different types of Calmodulin proteins. The publication does not state which CaM is involved in the ß-proliferation. While searching for a family identifier with InterPro, no results were retrieved. + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + + be1 + + + + + + + + b5f + + + + + + + + ac6 + + + + + + + + a64 + + + + + + + + dc9 + + + + + + + + db5 + + + + + + + + f43 + + + + + + + + de2 + + + + + + + + ac6 + + + + + + + + f89 + + + + + + + + b5f + + + + + + + + de2 + + + + + + + + be1 + + + + + + + + a96 + + + + + + + + a64 + + + + + + + + ae8 + + + + + + + + a64 + + + + + + + + a51 + + + + + + + + a51 + + + + + + + + a64 + + + + + + + + b5f + + + + + + + + a64 + + + + + + + + ac6 + + + + + + + + ae8 + + + + + + + + ae8 + + + + + + + + be1 + + + + + + + + d4c + + + + + + + + a77 + + + + + + + + ae8 + + + + + + + + dc9 + + + + + + + + f43 + + + + + + + + be1 + + + + + + + + b5f + + + + + + + + de2 + + + + + + + + cd5 + + + + + + + + dc9 + a96 + db5 + + + + + + + + + + + + + + The pathway figure just states thyroid hormones (TH). There are two THs: T3 and T4. 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