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--- | ||
annotations: | ||
- id: DOID:332 | ||
parent: central nervous system disease | ||
type: Disease Ontology | ||
value: amyotrophic lateral sclerosis | ||
- id: PW:0000018 | ||
parent: disease pathway | ||
type: Pathway Ontology | ||
value: Parkinson's disease pathway | ||
- id: PW:0000015 | ||
parent: disease pathway | ||
type: Pathway Ontology | ||
value: Alzheimer's disease pathway | ||
- id: DOID:14330 | ||
parent: central nervous system disease | ||
type: Disease Ontology | ||
value: Parkinson's disease | ||
- id: DOID:10652 | ||
parent: central nervous system disease | ||
type: Disease Ontology | ||
value: Alzheimer's disease | ||
- id: DOID:1289 | ||
parent: central nervous system disease | ||
type: Disease Ontology | ||
value: neurodegenerative disease | ||
- id: DOID:9255 | ||
parent: central nervous system disease | ||
type: Disease Ontology | ||
value: frontotemporal dementia | ||
authors: | ||
- Pat hofer | ||
- Tamara Fitzinger | ||
- Marlenef97 | ||
- DeSl | ||
description: 'Mammalian asparagine endopeptidase, also known as δ-secretase , is a | ||
key player in a number of neurodegenerative illnesses, including Alzheimer''s, Parkinson''s | ||
or ALS. The enzyme can get activated in the aging brain and starts to cleave amyloid | ||
precursor protein (APP) and promotes the production of amyloid-β (Aβ). δ-secretase | ||
also breaks down tau, alpha-synuclein, SET, and TAR DNA-binding protein 43, generating | ||
neurotoxic fragments and impairing their physiological processes. Each fragment | ||
has either been identified in patient samples with the relevant disease or has undergone | ||
testing to determine whether it can cause the disease pathology. This pathway is | ||
based on Figure 1 from the paper:"δ-secretase in neurodegenerative diseases: mechanisms, | ||
regulators and therapeutic opportunities. published by Zhang Z, Tian Y, Ye K.' | ||
last-edited: 2023-07-01 | ||
organisms: | ||
- Homo sapiens | ||
redirect_from: | ||
- /index.php/Pathway:WP5372 | ||
- /instance/WP5372 | ||
- /instance/WP5372_r126830 | ||
revision: r126830 | ||
schema-jsonld: | ||
- '@context': https://schema.org/ | ||
'@id': https://wikipathways.github.io/pathways/WP5372.html | ||
'@type': Dataset | ||
creator: | ||
'@type': Organization | ||
name: WikiPathways | ||
description: 'Mammalian asparagine endopeptidase, also known as δ-secretase , is | ||
a key player in a number of neurodegenerative illnesses, including Alzheimer''s, | ||
Parkinson''s or ALS. The enzyme can get activated in the aging brain and starts | ||
to cleave amyloid precursor protein (APP) and promotes the production of amyloid-β | ||
(Aβ). δ-secretase also breaks down tau, alpha-synuclein, SET, and TAR DNA-binding | ||
protein 43, generating neurotoxic fragments and impairing their physiological | ||
processes. Each fragment has either been identified in patient samples with the | ||
relevant disease or has undergone testing to determine whether it can cause the | ||
disease pathology. This pathway is based on Figure 1 from the paper:"δ-secretase | ||
in neurodegenerative diseases: mechanisms, regulators and therapeutic opportunities. | ||
published by Zhang Z, Tian Y, Ye K.' | ||
keywords: | ||
- AKT 1 | ||
- AKT 2 | ||
- AKT 3 | ||
- APP | ||
- BACE1 | ||
- BDNF | ||
- "C/EBP10A\U0001D6FD" | ||
- DOPAL | ||
- LGMN | ||
- MAO B | ||
- Microtubule-associated protein tau | ||
- PP2A | ||
- Prolegumain | ||
- SET | ||
- SRPK2 | ||
- STAT1 | ||
- TDP-43 | ||
- TrkB | ||
- beta-amyloid | ||
- dopamine | ||
- α-synuclein | ||
- δ-secretase | ||
license: CC0 | ||
name: Involvement of δ-secretase in neurodegenerative diseases | ||
seo: CreativeWork | ||
title: Involvement of δ-secretase in neurodegenerative diseases | ||
wpid: WP5372 | ||
--- |